Abstract
The effects of route and vehicle on blood and milk levels of decabromodiphenyl ether (DecaBDE; CASRN 1163-19-5) were investigated in the rat to assist in the design and conduct of a developmental neurotoxicity study. Blood plasma and/or milk concentrations were determined in dams, fetuses, and/or nursing pups after repeated DecaBDE administration by gavage throughout gestation or gestation and lactation using corn oil (CO) or soyaphospholipon/Lutrol F 127-water (SPL) as the vehicle. The impact of vehicle on plasma levels was also investigated in pups derived from naive dams after a single postnatal dose. This study reports for the first time fetal and neonatal plasma concentrations concurrent with those of maternal plasma and/or milk. Higher concentrations of DecaBDE were achieved in plasma and in milk with CO than with SPL. Furthermore, pups derived from dams treated with only SPL were lower in body weight, compared with those from dams treated with either CO, CO and DecaBDE, or SPL and DecaBDE. The study further shows that exposure to DecaBDE is relatively consistent across the dose range of 100 to 1000 mg/(kg · day) when administered in CO.
Footnotes
This work was funded by The Bromine Science and Environmental Forum.
J.A.B., J.M.A., H.S., S.J., M.H., and T.S. are employed by specialty chemical manufacturers whose product lines include brominated flame retardants.
M.J.B., N.R.M., E.S.B., D.W.S., and D.G.S. are employed by WIL Research Laboratories, a contract research organization commissioned to conduct the study presented herein.
The views and opinions expressed in this article are those of the authors and not necessarily those of their respective employers.
Article, publication date, and citation information can be found at http://dmd.aspetjournals.org.
doi:10.1124/dmd.110.033431.
↵ The online version of this article (available at http://dmd.aspetjournals.org) contains supplemental material.
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ABBREVIATIONS:
- DecaBDE
- decabromodiphenyl ether
- BDE-209
- 2,2′,3,3′,4,4′,5,5′,6,6′-decabromodiphenyl ether congener
- EU
- European Union
- DNT
- developmental neurotoxicity
- SPL
- soyaphospholipon/Lutrol F 127-water
- GD
- gestation day
- LD
- lactation day
- CO
- corn oil
- PND
- postnatal day
- LOQ
- limit of quantitation
- BDE-28
- 2,3,5-tribromodiphenyl ether
- BDE-33
- 2,3′,4′-tribromodiphenyl ether
- BDE-47
- 2,2′,4,4′-tetrabromodiphenyl ether
- BDE-99
- 2,2′,4,4′,5-pentabromodiphenyl ether
- BDE-100
- 2,2′4,4′,6-pentabromodiphenyl ether
- BDE-138
- 2,2′,3,4,4′,5-hexabromodiphenyl ether
- BDE-153
- 2,2′,4,4′,5,5′-hexabromodiphenyl ether
- BDE-154
- 2,2′,4,4′,5,6′-hexabromodiphenyl ether
- DE-183
- 2,2′,3′,4,4′,5′,6-heptabromodiphenyl ether
- BDE-197
- 2,2′,3,3′,4,4′6,6′-octabromodiphenyl ether.
- Received March 18, 2010.
- Accepted June 24, 2010.
- Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics
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