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Research ArticleArticle

Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats

Yi-Tong Liu, Hai-Ping Hao, Hong-Guang Xie, Li Lai, Qiong Wang, Chang-Xiao Liu and Guang-Ji Wang
Drug Metabolism and Disposition October 2010, 38 (10) 1779-1784; DOI: https://doi.org/10.1124/dmd.110.033936
Yi-Tong Liu
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Hai-Ping Hao
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Hong-Guang Xie
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Li Lai
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Qiong Wang
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Chang-Xiao Liu
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Guang-Ji Wang
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Article Information

vol. 38 no. 10 1779-1784
DOI 
https://doi.org/10.1124/dmd.110.033936
PubMed 
20634337

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 14, 2010
  • Accepted July 15, 2010
  • Published online September 20, 2010.

Article Versions

  • Earlier version (July 15, 2010 - 08:07).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yi-Tong Liu,
  2. Hai-Ping Hao,
  3. Hong-Guang Xie,
  4. Li Lai,
  5. Qiong Wang,
  6. Chang-Xiao Liu and
  7. Guang-Ji Wang
  1. Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China (Y.-T.L., H.-P.H., L.L., Q.W., G.-J.W.); Center for Drug Development Science, Department of Biopharmaceutical Sciences, School of Pharmacy, University of California, San Francisco, San Francisco, California (H.-G.X.); University of California Washington Center, Washington, District of Columbia (H.-G.X.); and Research Center of New Drug Evaluation, the National Laboratory of Pharmacodynamics and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.)
  1. Address correspondence to:
    Dr. Guang-Ji Wang, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, Jiangsu, China. E-mail: guangjiwang{at}hotmail.com
  1. Y.-T.L., H.-P.H., and H.-G.X. contributed equally to this work.

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Drug Metabolism and Disposition: 38 (10)
Drug Metabolism and Disposition
Vol. 38, Issue 10
1 Oct 2010
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Research ArticleArticle

Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats

Yi-Tong Liu, Hai-Ping Hao, Hong-Guang Xie, Li Lai, Qiong Wang, Chang-Xiao Liu and Guang-Ji Wang
Drug Metabolism and Disposition October 1, 2010, 38 (10) 1779-1784; DOI: https://doi.org/10.1124/dmd.110.033936

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Research ArticleArticle

Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats

Yi-Tong Liu, Hai-Ping Hao, Hong-Guang Xie, Li Lai, Qiong Wang, Chang-Xiao Liu and Guang-Ji Wang
Drug Metabolism and Disposition October 1, 2010, 38 (10) 1779-1784; DOI: https://doi.org/10.1124/dmd.110.033936
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