Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide

Drug Metabolism and Pharmacokinetics Research Laboratories (R.S., N.O., K.W., T.M., Y.K., A.K., O.O.), Translational Medicine and Clinical Pharmacology Department (M.T.), and Lead Discovery and Optimization Research Laboratories I (T.O., K.M.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; and Research Department I, Daiichi Sankyo RD Associe Co., Ltd., Tokyo, Japan (H.H.)

Address correspondence to:
Ryoko Sawamura, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. E-mail: sawamura.ryoko.yi{at}daiichisankyo.co.jp

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