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Research ArticleArticle

Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide

Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173

Article Information

vol. 38 no. 10 1857-1864
DOI 
https://doi.org/10.1124/dmd.110.034173
PubMed 
20606003
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 26, 2010
  • Accepted July 6, 2010
  • Published online September 20, 2010.

Article Versions

Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ryoko Sawamura,
  2. Noriko Okudaira,
  3. Kengo Watanabe,
  4. Takahiro Murai,
  5. Yoshimasa Kobayashi,
  6. Masaya Tachibana,
  7. Takashi Ohnuki,
  8. Kayoko Masuda,
  9. Hidehito Honma,
  10. Atsushi Kurihara and
  11. Osamu Okazaki
  1. Drug Metabolism and Pharmacokinetics Research Laboratories (R.S., N.O., K.W., T.M., Y.K., A.K., O.O.), Translational Medicine and Clinical Pharmacology Department (M.T.), and Lead Discovery and Optimization Research Laboratories I (T.O., K.M.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; and Research Department I, Daiichi Sankyo RD Associe Co., Ltd., Tokyo, Japan (H.H.)
  1. Address correspondence to:
    Ryoko Sawamura, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. E-mail: sawamura.ryoko.yi{at}daiichisankyo.co.jp
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Research ArticleArticle

Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide

Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
Drug Metabolism and Disposition October 1, 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173
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