Table of Contents

Articles

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  Impact of Ignoring Extraction Ratio When Predicting Drug-Drug Interactions, Fraction Metabolized, and Intestinal First-Pass Contribution

  Brian J. Kirby and Jashvant D. Unadkat

  Drug Metabolism and Disposition November 2010, 38 (11) 1926-1933; DOI: https://doi.org/10.1124/dmd.110.034736
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  Detection of Phenolic Metabolites of Styrene in Mouse Liver and Lung Microsomal Incubations

  Shuijie Shen, Fan Zhang, Lingbo Gao, Su Zeng and Jiang Zheng

  Drug Metabolism and Disposition November 2010, 38 (11) 1934-1943; DOI: https://doi.org/10.1124/dmd.110.033522
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  Metabolism and Excretion of the Once-Daily Human Glucagon-Like Peptide-1 Analog Liraglutide in Healthy Male Subjects and Its In Vitro Degradation by Dipeptidyl Peptidase IV and Neutral Endopeptidase

  Monika Malm-Erjefält, Inga Bjørnsdottir, Jan Vanggaard, Hans Helleberg, Uffe Larsen, Berend Oosterhuis, Jan Jaap van Lier, Milan Zdravkovic and Anette K. Olsen

  Drug Metabolism and Disposition November 2010, 38 (11) 1944-1953; DOI: https://doi.org/10.1124/dmd.110.034066
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  Effect of Hepatitis C Virus Infection on the mRNA Expression of Drug Transporters and Cytochrome P450 Enzymes in Chimeric Mice with Humanized Liver

  Ryota Kikuchi, Matthew McCown, Pamela Olson, Chise Tateno, Yoshio Morikawa, Yumiko Katoh, David L. Bourdet, Mario Monshouwer and Adrian J. Fretland

  Drug Metabolism and Disposition November 2010, 38 (11) 1954-1961; DOI: https://doi.org/10.1124/dmd.109.031732
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  Metabolism, Excretion, and Pharmacokinetics of Oral Brivanib in Patients with Advanced or Metastatic Solid Tumors

  Tarek Mekhail, Eric Masson, Bruce S. Fischer, Jiachang Gong, Ramaswamy Iyer, Jinping Gan, Janice Pursley, Daniel Patricia, Daphne Williams and Ram Ganapathi

  Drug Metabolism and Disposition November 2010, 38 (11) 1962-1966; DOI: https://doi.org/10.1124/dmd.110.033951
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  Prediction of the Intestinal First-Pass Metabolism of CYP3A Substrates in Humans Using Cynomolgus Monkeys

  Haruka Nishimuta, Kimihiko Sato, Yasuyuki Mizuki, Masashi Yabuki and Setsuko Komuro

  Drug Metabolism and Disposition November 2010, 38 (11) 1967-1975; DOI: https://doi.org/10.1124/dmd.110.034561
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  CYP2C8 Exists as a Dimer in Natural Membranes

  Gang Hu, Eric F. Johnson and Byron Kemper

  Drug Metabolism and Disposition November 2010, 38 (11) 1976-1983; DOI: https://doi.org/10.1124/dmd.110.034942
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  Metabolism, Pharmacokinetics, and Excretion of the 5-Hydroxytryptamine_1B Receptor Antagonist Elzasonan in Humans

  Amin Kamel, R. Scott Obach, Kevin Colizza, Weiwei Wang, Thomas N. O'Connell, Richard V. Coelho, Ryan M. Kelley and Klaas Schildknegt

  Drug Metabolism and Disposition November 2010, 38 (11) 1984-1999; DOI: https://doi.org/10.1124/dmd.110.034595
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  ATP-Binding Cassette B1 Transports Seliciclib (R-Roscovitine), a Cyclin-Dependent Kinase Inhibitor

  Zsuzsanna Rajnai, Dóra Méhn, Erzsébet Beéry, Alper Okyar, Márton Jani, Gábor K. Tóth, Ferenc Fülöp, Francis Lévi and Peter Krajcsi

  Drug Metabolism and Disposition November 2010, 38 (11) 2000-2006; DOI: https://doi.org/10.1124/dmd.110.032805
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  Metabolism of 1′- and 4-Hydroxymidazolam by Glucuronide Conjugation Is Largely Mediated by UDP-Glucuronosyltransferases 1A4, 2B4, and 2B7

  Kyung-Ah Seo, Soo Kyung Bae, Young-Kil Choi, Chang Soo Choi, Kwang-Hyeon Liu and Jae-Gook Shin

  Drug Metabolism and Disposition November 2010, 38 (11) 2007-2013; DOI: https://doi.org/10.1124/dmd.110.035295
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  Isolation and Identification of Phase 1 Metabolites of Curcumol in Rats

  Yan Lou, Hui Zhang, Hao He, Kaifeng Peng, Ning Kang, Xingchuan Wei, Xuegai Li, Lixia Chen, Xinsheng Yao and Feng Qiu

  Drug Metabolism and Disposition November 2010, 38 (11) 2014-2022; DOI: https://doi.org/10.1124/dmd.110.034215
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  Metabolism, Excretion, and Pharmacokinetics of [¹⁴C]INCB018424, a Selective Janus Tyrosine Kinase 1/2 Inhibitor, in Humans

  Adam D. Shilling, Frank M. Nedza, Thomas Emm, Sharon Diamond, Edward McKeever, Naresh Punwani, William Williams, Argyrios Arvanitis, Laurine G. Galya, Mei Li, Stacey Shepard, James Rodgers, Tai-Yuen Yue and Swamy Yeleswaram

  Drug Metabolism and Disposition November 2010, 38 (11) 2023-2031; DOI: https://doi.org/10.1124/dmd.110.033787
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  Drug Metabolism and Pharmacokinetics of 4-Substituted Methoxybenzoyl-aryl-thiazoles

  Chien-Ming Li, Yan Lu, Ramesh Narayanan, Duane D. Miller and James T. Dalton

  Drug Metabolism and Disposition November 2010, 38 (11) 2032-2039; DOI: https://doi.org/10.1124/dmd.110.034348
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  Profiling of the Compounds Absorbed in Human Plasma and Urine after Oral Administration of a Traditional Japanese (Kampo) Medicine, Daikenchuto

  Jun Iwabu, Junko Watanabe, Kazuhiro Hirakura, Yoshinori Ozaki and Kazuhiro Hanazaki

  Drug Metabolism and Disposition November 2010, 38 (11) 2040-2048; DOI: https://doi.org/10.1124/dmd.110.033589
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  Metabolism and Disposition of [¹⁴C]BMS-690514, an ErbB/Vascular Endothelial Growth Factor Receptor Inhibitor, after Oral Administration to Humans

  Lisa J. Christopher, Haizheng Hong, Blisse J. Vakkalagadda, Pamela L. Clemens, Hong Su, Vikram Roongta, Alban Allentoff, Haojun Sun, Kevin Heller, Christopher T. Harbison, Ramaswamy A. Iyer, William G. Humphreys, Tai Wong and Steven Zhang

  Drug Metabolism and Disposition November 2010, 38 (11) 2049-2059; DOI: https://doi.org/10.1124/dmd.110.034850
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  Human Heme Oxygenase-1 Efficiently Catabolizes Heme in the Absence of Biliverdin Reductase

  James R. Reed, Warren J. Huber and Wayne L. Backes

  Drug Metabolism and Disposition November 2010, 38 (11) 2060-2066; DOI: https://doi.org/10.1124/dmd.110.034777
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  Identification of Two Novel Metabolites of SCH 486757, a Nociceptin/Orphanin FQ Peptide Receptor Agonist, in Humans

  Natalia A. Penner, Ginny Ho, Ana Bercovici, Swapan K. Chowdhury and Kevin B. Alton

  Drug Metabolism and Disposition November 2010, 38 (11) 2067-2074; DOI: https://doi.org/10.1124/dmd.110.032516
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  Effects of a Commonly Occurring Genetic Polymorphism of Human CYP3A4 (I118V) on the Metabolism of Anandamide

  Matthew Pratt-Hyatt, Haoming Zhang, Natasha T. Snider and Paul F. Hollenberg

  Drug Metabolism and Disposition November 2010, 38 (11) 2075-2082; DOI: https://doi.org/10.1124/dmd.110.033712
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  Using Open Source Computational Tools for Predicting Human Metabolic Stability and Additional Absorption, Distribution, Metabolism, Excretion, and Toxicity Properties

  Rishi R. Gupta, Eric M. Gifford, Ted Liston, Chris L. Waller, Moses Hohman, Barry A. Bunin and Sean Ekins

  Drug Metabolism and Disposition November 2010, 38 (11) 2083-2090; DOI: https://doi.org/10.1124/dmd.110.034918