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Drug Metabolism & Disposition

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Table of Contents

November 01, 2010; Volume 38,Issue 11

Short Communications

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    Bilirubin Glucuronidation Revisited: Proper Assay Conditions to Estimate Enzyme Kinetics with Recombinant UGT1A1
    Jin Zhou, Timothy S. Tracy and Rory P. Remmel
    Drug Metabolism and Disposition November 2010, 38 (11) 1907-1911; DOI: https://doi.org/10.1124/dmd.110.033829
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    A 96-Well Plate Assay for CYP4503A Induction Using Cryopreserved Human Hepatocytes
    Naomi Kamiguchi, Eiji Aoyama, Teruaki Okuda and Toshiya Moriwaki
    Drug Metabolism and Disposition November 2010, 38 (11) 1912-1916; DOI: https://doi.org/10.1124/dmd.109.028613
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    Reduction of N-Hydroxy-sulfonamides, Including N-Hydroxy-valdecoxib, by the Molybdenum-Containing Enzyme mARC
    Antje Havemeyer, Sanja Grünewald, Bettina Wahl, Florian Bittner, Ralf Mendel, Péter Erdélyi, János Fischer and Bernd Clement
    Drug Metabolism and Disposition November 2010, 38 (11) 1917-1921; DOI: https://doi.org/10.1124/dmd.110.032813
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    Effect of Regular Organic Solvents on Cytochrome P450-Mediated Metabolic Activities in Rat Liver Microsomes
    Dan Li, Yonglong Han, Xiangle Meng, Xipeng Sun, Qi Yu, Yan Li, Lili Wan, Yan Huo and Cheng Guo
    Drug Metabolism and Disposition November 2010, 38 (11) 1922-1925; DOI: https://doi.org/10.1124/dmd.110.033894

Articles

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    Impact of Ignoring Extraction Ratio When Predicting Drug-Drug Interactions, Fraction Metabolized, and Intestinal First-Pass Contribution
    Brian J. Kirby and Jashvant D. Unadkat
    Drug Metabolism and Disposition November 2010, 38 (11) 1926-1933; DOI: https://doi.org/10.1124/dmd.110.034736
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    Detection of Phenolic Metabolites of Styrene in Mouse Liver and Lung Microsomal Incubations
    Shuijie Shen, Fan Zhang, Lingbo Gao, Su Zeng and Jiang Zheng
    Drug Metabolism and Disposition November 2010, 38 (11) 1934-1943; DOI: https://doi.org/10.1124/dmd.110.033522
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    Metabolism and Excretion of the Once-Daily Human Glucagon-Like Peptide-1 Analog Liraglutide in Healthy Male Subjects and Its In Vitro Degradation by Dipeptidyl Peptidase IV and Neutral Endopeptidase
    Monika Malm-Erjefält, Inga Bjørnsdottir, Jan Vanggaard, Hans Helleberg, Uffe Larsen, Berend Oosterhuis, Jan Jaap van Lier, Milan Zdravkovic and Anette K. Olsen
    Drug Metabolism and Disposition November 2010, 38 (11) 1944-1953; DOI: https://doi.org/10.1124/dmd.110.034066
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    Effect of Hepatitis C Virus Infection on the mRNA Expression of Drug Transporters and Cytochrome P450 Enzymes in Chimeric Mice with Humanized Liver
    Ryota Kikuchi, Matthew McCown, Pamela Olson, Chise Tateno, Yoshio Morikawa, Yumiko Katoh, David L. Bourdet, Mario Monshouwer and Adrian J. Fretland
    Drug Metabolism and Disposition November 2010, 38 (11) 1954-1961; DOI: https://doi.org/10.1124/dmd.109.031732
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    Metabolism, Excretion, and Pharmacokinetics of Oral Brivanib in Patients with Advanced or Metastatic Solid Tumors
    Tarek Mekhail, Eric Masson, Bruce S. Fischer, Jiachang Gong, Ramaswamy Iyer, Jinping Gan, Janice Pursley, Daniel Patricia, Daphne Williams and Ram Ganapathi
    Drug Metabolism and Disposition November 2010, 38 (11) 1962-1966; DOI: https://doi.org/10.1124/dmd.110.033951
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    Prediction of the Intestinal First-Pass Metabolism of CYP3A Substrates in Humans Using Cynomolgus Monkeys
    Haruka Nishimuta, Kimihiko Sato, Yasuyuki Mizuki, Masashi Yabuki and Setsuko Komuro
    Drug Metabolism and Disposition November 2010, 38 (11) 1967-1975; DOI: https://doi.org/10.1124/dmd.110.034561
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    CYP2C8 Exists as a Dimer in Natural Membranes
    Gang Hu, Eric F. Johnson and Byron Kemper
    Drug Metabolism and Disposition November 2010, 38 (11) 1976-1983; DOI: https://doi.org/10.1124/dmd.110.034942
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    Metabolism, Pharmacokinetics, and Excretion of the 5-Hydroxytryptamine1B Receptor Antagonist Elzasonan in Humans
    Amin Kamel, R. Scott Obach, Kevin Colizza, Weiwei Wang, Thomas N. O'Connell, Richard V. Coelho, Ryan M. Kelley and Klaas Schildknegt
    Drug Metabolism and Disposition November 2010, 38 (11) 1984-1999; DOI: https://doi.org/10.1124/dmd.110.034595
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    ATP-Binding Cassette B1 Transports Seliciclib (R-Roscovitine), a Cyclin-Dependent Kinase Inhibitor
    Zsuzsanna Rajnai, Dóra Méhn, Erzsébet Beéry, Alper Okyar, Márton Jani, Gábor K. Tóth, Ferenc Fülöp, Francis Lévi and Peter Krajcsi
    Drug Metabolism and Disposition November 2010, 38 (11) 2000-2006; DOI: https://doi.org/10.1124/dmd.110.032805
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    Metabolism of 1′- and 4-Hydroxymidazolam by Glucuronide Conjugation Is Largely Mediated by UDP-Glucuronosyltransferases 1A4, 2B4, and 2B7
    Kyung-Ah Seo, Soo Kyung Bae, Young-Kil Choi, Chang Soo Choi, Kwang-Hyeon Liu and Jae-Gook Shin
    Drug Metabolism and Disposition November 2010, 38 (11) 2007-2013; DOI: https://doi.org/10.1124/dmd.110.035295
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    Isolation and Identification of Phase 1 Metabolites of Curcumol in Rats
    Yan Lou, Hui Zhang, Hao He, Kaifeng Peng, Ning Kang, Xingchuan Wei, Xuegai Li, Lixia Chen, Xinsheng Yao and Feng Qiu
    Drug Metabolism and Disposition November 2010, 38 (11) 2014-2022; DOI: https://doi.org/10.1124/dmd.110.034215
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    Metabolism, Excretion, and Pharmacokinetics of [14C]INCB018424, a Selective Janus Tyrosine Kinase 1/2 Inhibitor, in Humans
    Adam D. Shilling, Frank M. Nedza, Thomas Emm, Sharon Diamond, Edward McKeever, Naresh Punwani, William Williams, Argyrios Arvanitis, Laurine G. Galya, Mei Li, Stacey Shepard, James Rodgers, Tai-Yuen Yue and Swamy Yeleswaram
    Drug Metabolism and Disposition November 2010, 38 (11) 2023-2031; DOI: https://doi.org/10.1124/dmd.110.033787
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    Drug Metabolism and Pharmacokinetics of 4-Substituted Methoxybenzoyl-aryl-thiazoles
    Chien-Ming Li, Yan Lu, Ramesh Narayanan, Duane D. Miller and James T. Dalton
    Drug Metabolism and Disposition November 2010, 38 (11) 2032-2039; DOI: https://doi.org/10.1124/dmd.110.034348
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    Profiling of the Compounds Absorbed in Human Plasma and Urine after Oral Administration of a Traditional Japanese (Kampo) Medicine, Daikenchuto
    Jun Iwabu, Junko Watanabe, Kazuhiro Hirakura, Yoshinori Ozaki and Kazuhiro Hanazaki
    Drug Metabolism and Disposition November 2010, 38 (11) 2040-2048; DOI: https://doi.org/10.1124/dmd.110.033589
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    Metabolism and Disposition of [14C]BMS-690514, an ErbB/Vascular Endothelial Growth Factor Receptor Inhibitor, after Oral Administration to Humans
    Lisa J. Christopher, Haizheng Hong, Blisse J. Vakkalagadda, Pamela L. Clemens, Hong Su, Vikram Roongta, Alban Allentoff, Haojun Sun, Kevin Heller, Christopher T. Harbison, Ramaswamy A. Iyer, William G. Humphreys, Tai Wong and Steven Zhang
    Drug Metabolism and Disposition November 2010, 38 (11) 2049-2059; DOI: https://doi.org/10.1124/dmd.110.034850
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    Human Heme Oxygenase-1 Efficiently Catabolizes Heme in the Absence of Biliverdin Reductase
    James R. Reed, Warren J. Huber and Wayne L. Backes
    Drug Metabolism and Disposition November 2010, 38 (11) 2060-2066; DOI: https://doi.org/10.1124/dmd.110.034777
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    Identification of Two Novel Metabolites of SCH 486757, a Nociceptin/Orphanin FQ Peptide Receptor Agonist, in Humans
    Natalia A. Penner, Ginny Ho, Ana Bercovici, Swapan K. Chowdhury and Kevin B. Alton
    Drug Metabolism and Disposition November 2010, 38 (11) 2067-2074; DOI: https://doi.org/10.1124/dmd.110.032516
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    Effects of a Commonly Occurring Genetic Polymorphism of Human CYP3A4 (I118V) on the Metabolism of Anandamide
    Matthew Pratt-Hyatt, Haoming Zhang, Natasha T. Snider and Paul F. Hollenberg
    Drug Metabolism and Disposition November 2010, 38 (11) 2075-2082; DOI: https://doi.org/10.1124/dmd.110.033712
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    Using Open Source Computational Tools for Predicting Human Metabolic Stability and Additional Absorption, Distribution, Metabolism, Excretion, and Toxicity Properties
    Rishi R. Gupta, Eric M. Gifford, Ted Liston, Chris L. Waller, Moses Hohman, Barry A. Bunin and Sean Ekins
    Drug Metabolism and Disposition November 2010, 38 (11) 2083-2090; DOI: https://doi.org/10.1124/dmd.110.034918
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In this issue

Drug Metabolism and Disposition: 38 (11)
Drug Metabolism and Disposition
Vol. 38, Issue 11
1 Nov 2010
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
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  • Short Communications
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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