Drug Metabolism and Disposition: 38 (12)

December 01, 2010; Volume 38,Issue 12

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Pregnane X Receptor and Constitutive Androstane Receptor at the Crossroads of Drug Metabolism and Energy Metabolism
Jie Gao and Wen Xie

Drug Metabolism and Disposition December 2010, 38 (12) 2091-2095; DOI: https://doi.org/10.1124/dmd.110.035568

Short Communications

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Expression of the Anthracycline-Metabolizing Enzyme Carbonyl Reductase 1 in Hearts from Donors with Down Syndrome
James L. Kalabus, Carrie C. Sanborn, Raqeeb G. Jamil, Qiuying Cheng and Javier G. Blanco

Drug Metabolism and Disposition December 2010, 38 (12) 2096-2099; DOI: https://doi.org/10.1124/dmd.110.035550
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CYP3A4*16 and CYP3A4*18 Alleles Found in East Asians Exhibit Differential Catalytic Activities for Seven CYP3A4 Substrate Drugs
Keiko Maekawa, Noriko Harakawa, Takuya Yoshimura, Su-Ryang Kim, Yoshiyuki Fujimura, Fumika Aohara, Kimie Sai, Noriko Katori, Masahiro Tohkin, Mikihiko Naito, Ryuichi Hasegawa, Haruhiro Okuda, Jun-ichi Sawada, Takuro Niwa and Yoshiro Saito

Drug Metabolism and Disposition December 2010, 38 (12) 2100-2104; DOI: https://doi.org/10.1124/dmd.110.034140
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Forkhead Box Protein A1 Regulates UDP-Glucuronosyltransferase 2B15 Gene Transcription in LNCaP Prostate Cancer Cells
Dong Gui Hu and Peter I. Mackenzie

Drug Metabolism and Disposition December 2010, 38 (12) 2105-2109; DOI: https://doi.org/10.1124/dmd.110.035436

Articles

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The Effects of Single Nucleotide Polymorphisms in CYP2A13 on Metabolism of 5-Methoxypsoralen
Tatsushi Goto, Hiroshi Moriuchi, Xuejun Fu, Tomoyo Ikegawa, Toshiyuki Matsubara, Gang Chang, Tomohide Uno, Kenichi Morigaki, Kunio Isshiki and Hiromasa Imaishi

Drug Metabolism and Disposition December 2010, 38 (12) 2110-2116; DOI: https://doi.org/10.1124/dmd.110.034553
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Metabolism of Sesamin by Cytochrome P450 in Human Liver Microsomes
Kaori Yasuda, Shinichi Ikushiro, Masaki Kamakura, Miho Ohta and Toshiyuki Sakaki

Drug Metabolism and Disposition December 2010, 38 (12) 2117-2123; DOI: https://doi.org/10.1124/dmd.110.035659
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Superior Plasma Retention of a Cross-Linked Human Serum Albumin Dimer in Nephrotic Rats as a New Type of Plasma Expander
Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Hiroshi Watanabe, Keiichi Kawai, Teruyuki Komatsu, Eishun Tsuchida, Toru Maruyama and Masaki Otagiri

Drug Metabolism and Disposition December 2010, 38 (12) 2124-2129; DOI: https://doi.org/10.1124/dmd.109.031989
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Electrochemistry-Mass Spectrometry Unveils the Formation of Reactive Triclocarban Metabolites
A. Baumann, W. Lohmann, T. Rose, K. C. Ahn, B. D. Hammock, U. Karst and N. H. Schebb

Drug Metabolism and Disposition December 2010, 38 (12) 2130-2138; DOI: https://doi.org/10.1124/dmd.110.034546
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Comparative Use of Isolated Hepatocytes and Hepatic Microsomes for Cytochrome P450 Inhibition Studies: Transporter-Enzyme Interplay
Hayley S. Brown, Alison J. Wilby, Jane Alder and J. Brian Houston

Drug Metabolism and Disposition December 2010, 38 (12) 2139-2146; DOI: https://doi.org/10.1124/dmd.110.035824
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A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments
Hongying Gao, Shibing Deng and R. Scott Obach

Drug Metabolism and Disposition December 2010, 38 (12) 2147-2156; DOI: https://doi.org/10.1124/dmd.110.034637
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Metabolism of Ebracteolata Compound B Studied In Vitro with Human Liver Microsomes, HepG2 Cells, and Recombinant Human Enzymes
Xia Zhang, Yan Yao, Yan Lou, Huidi Jiang, Xiaowen Wang, Xiaojuan Chai and Su Zeng

Drug Metabolism and Disposition December 2010, 38 (12) 2157-2165; DOI: https://doi.org/10.1124/dmd.110.034496
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Metabolism and Action of Proteasome Inhibitors in Primary Human Hepatocytes
Choon-Myung Lee, Vikas Kumar, Rochelle I. Riley and Edward T. Morgan

Drug Metabolism and Disposition December 2010, 38 (12) 2166-2172; DOI: https://doi.org/10.1124/dmd.110.035501
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In Vitro Evaluation of Inhibitory Effects of Antidiabetic and Antihyperlipidemic Drugs on Human Carboxylesterase Activities
Tatsuki Fukami, Shiori Takahashi, Nao Nakagawa, Taiga Maruichi, Miki Nakajima and Tsuyoshi Yokoi

Drug Metabolism and Disposition December 2010, 38 (12) 2173-2178; DOI: https://doi.org/10.1124/dmd.110.034454
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20(S)-Ginsenoside Rh2 Noncompetitively Inhibits P-Glycoprotein In Vitro and In Vivo: A Case for Herb-Drug Interactions
Jingwei Zhang, Fang Zhou, Xiaolan Wu, Yi Gu, Hua Ai, Yuanting Zheng, Yannan Li, Xiaoxuan Zhang, Gang Hao, Jianguo Sun, Ying Peng and Guangji Wang

Drug Metabolism and Disposition December 2010, 38 (12) 2179-2187; DOI: https://doi.org/10.1124/dmd.110.034793
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Absorption and Metabolization of Cytoprotective Epicatechin Thio Conjugates in Rats
Ariadna Selga, María Pilar Vinardell, Raquel Martín-Venegas, Olga Jáuregui, Josefina Casas and Josep Lluís Torres

Drug Metabolism and Disposition December 2010, 38 (12) 2188-2194; DOI: https://doi.org/10.1124/dmd.110.035279
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Quantifying and Predicting the Promiscuity and Isoform Specificity of Small-Molecule Cytochrome P450 Inhibitors
Abhinav Nath, Michael A. Zientek, Benjamin J. Burke, Ying Jiang and William M. Atkins

Drug Metabolism and Disposition December 2010, 38 (12) 2195-2203; DOI: https://doi.org/10.1124/dmd.110.034645
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Sex Differences in UDP-Glucuronosyltransferase 2B17 Expression and Activity
Carla J. Gallagher, Renee M. Balliet, Dongxiao Sun, Gang Chen and Philip Lazarus

Drug Metabolism and Disposition December 2010, 38 (12) 2204-2209; DOI: https://doi.org/10.1124/dmd.110.035345
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Involvement of Carboxylesterase 1 and 2 in the Hydrolysis of Mycophenolate Mofetil
Nobuhiro Fujiyama, Masatomo Miura, Shoutaro Kato, Tomomichi Sone, Masakazu Isobe and Shigeru Satoh

Drug Metabolism and Disposition December 2010, 38 (12) 2210-2217; DOI: https://doi.org/10.1124/dmd.110.034249
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Prediction of Efficacious Inhalation Lung Doses via the Use of In Silico Lung Retention Quantitative Structure-Activity Relationship Models and In Vitro Potency Screens
Anne Cooper, Tim Potter and Tim Luker

Drug Metabolism and Disposition December 2010, 38 (12) 2218-2225; DOI: https://doi.org/10.1124/dmd.110.034462
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The Chinese Herbal Medicine Sophora flavescens Activates Pregnane X Receptor
Laiyou Wang, Feng Li, Jie Lu, Guodong Li, Dan Li, Xiao-bo Zhong, Grace L. Guo and Xiaochao Ma

Drug Metabolism and Disposition December 2010, 38 (12) 2226-2231; DOI: https://doi.org/10.1124/dmd.110.035253
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Differences between Human and Rat Intestinal and Hepatic Bisphenol A Glucuronidation and the Influence of Alamethicin on In Vitro Kinetic Measurements
Christopher S. Mazur, John F. Kenneke, Janet K. Hess-Wilson and John C. Lipscomb

Drug Metabolism and Disposition December 2010, 38 (12) 2232-2238; DOI: https://doi.org/10.1124/dmd.110.034819
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Characterization of Human Flavin-Containing Monooxygenase (FMO) 3 and FMO5 Expressed as Maltose-Binding Protein Fusions
Robert R. Reddy, Erik C. Ralph, Meike S. Motika, Jun Zhang and John R. Cashman

Drug Metabolism and Disposition December 2010, 38 (12) 2239-2245; DOI: https://doi.org/10.1124/dmd.110.033639
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Nanosilver Particle Effects on Drug Metabolism In Vitro
John G. Lamb, Laura B. Hathaway, Mark A. Munger, Judy L. Raucy and Michael R. Franklin

Drug Metabolism and Disposition December 2010, 38 (12) 2246-2251; DOI: https://doi.org/10.1124/dmd.110.035238
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Expression and Functional Analysis of Hepatic Cytochromes P450, Nuclear Receptors, and Membrane Transporters in 10- and 25-Week-Old db/db Mice
Justine L. Lam, Ying Jiang, Tao Zhang, Eric Y. Zhang and Bill J. Smith

Drug Metabolism and Disposition December 2010, 38 (12) 2252-2258; DOI: https://doi.org/10.1124/dmd.110.034223
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Evaluation of the Effects of Cytochrome P450 Nonsynonymous Single-Nucleotide Polymorphisms on Tanshinol Borneol Ester Metabolism and Inhibition Potential
Duan Liu, Yiwen Gao, Huijuan Wang, Jing Zi, He Huang, Jing Ji, Ruimin Zhou, Yefei Nan, Shixiang Wang, Xiaohui Zheng, Juanli Zhu, Yali Cui and Chao Chen

Drug Metabolism and Disposition December 2010, 38 (12) 2259-2265; DOI: https://doi.org/10.1124/dmd.110.034439
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Metabolism of Vabicaserin in Mice, Rats, Dogs, Monkeys, and Humans
Zeen Tong, Appavu Chandrasekaran, William DeMaio, Robert Espina, Wei Lu, Ronald Jordan and JoAnn Scatina

Drug Metabolism and Disposition December 2010, 38 (12) 2266-2277; DOI: https://doi.org/10.1124/dmd.110.033670
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A Mechanism-Based Mathematical Model of Aryl Hydrocarbon Receptor-Mediated CYP1A Induction in Rats Using β-Naphthoflavone as a Tool Compound
Emile P. Chen, Liangfu Chen, Yan Ji, Guoying Tai, Yuan H. Wen and Harma Ellens

Drug Metabolism and Disposition December 2010, 38 (12) 2278-2285; DOI: https://doi.org/10.1124/dmd.110.034421
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Mechanism-Based Inactivation of Human CYP2E1 by Diethyldithocarbamate
Matthew Pratt-Hyatt, Hsia-lien Lin and Paul F. Hollenberg

Drug Metabolism and Disposition December 2010, 38 (12) 2286-2292; DOI: https://doi.org/10.1124/dmd.110.034710
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Diversity in Antioxidant Response Enzymes in Progressive Stages of Human Nonalcoholic Fatty Liver Disease
Rhiannon N. Hardwick, Craig D. Fisher, Mark J. Canet, April D. Lake and Nathan J. Cherrington

Drug Metabolism and Disposition December 2010, 38 (12) 2293-2301; DOI: https://doi.org/10.1124/dmd.110.035006
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A Predictive Ligand-Based Bayesian Model for Human Drug-Induced Liver Injury
Sean Ekins, Antony J. Williams and Jinghai J. Xu

Drug Metabolism and Disposition December 2010, 38 (12) 2302-2308; DOI: https://doi.org/10.1124/dmd.110.035113
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Effect of Immune Complex Formation on the Distribution of a Novel Antibody to the Ovarian Tumor Antigen CA125
Cinthia V. Pastuskovas, William Mallet, Suzanna Clark, Margaret Kenrick, Mohammed Majidy, Michelle Schweiger, Marjie Van Hoy, Siao Ping Tsai, Gregory Bennett, Ben-Quan Shen, Sarajane Ross, Paul Fielder, Leslie Khawli and Jay Tibbitts

Drug Metabolism and Disposition December 2010, 38 (12) 2309-2319; DOI: https://doi.org/10.1124/dmd.110.034330
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Receptor for Activated C-Kinase 1 Regulates the Cell Surface Expression and Function of ATP Binding Cassette G2
Yuki Ikebuchi, Kousei Ito, Tappei Takada, Naohiko Anzai, Yoshikatsu Kanai and Hiroshi Suzuki

Drug Metabolism and Disposition December 2010, 38 (12) 2320-2328; DOI: https://doi.org/10.1124/dmd.110.034603
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Ecto-5′-Nucleotidase and Thiopurine Cellular Circulation: Association with Cytotoxicity
Fang Li, Brooke L. Fridley, Alice Matimba, Krishna R. Kalari, Linda Pelleymounter, Irene Moon, Yuan Ji, Gregory D. Jenkins, Anthony Batzler, Liewei Wang and Richard M. Weinshilboum

Drug Metabolism and Disposition December 2010, 38 (12) 2329-2338; DOI: https://doi.org/10.1124/dmd.110.035220
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Antigen-Dependent Internalization Is Related to Rapid Elimination from Plasma of Humanized Anti-HM1.24 Monoclonal Antibody
Jun Amano, Naoko Masuyama, Yuko Hirota, Yoshitaka Tanaka, Yuriko Igawa, Rie Shiokawa, Taichi Okutani, Takashi Miyayama, Masahiko Nanami and Masaki Ishigai

Drug Metabolism and Disposition December 2010, 38 (12) 2339-2346; DOI: https://doi.org/10.1124/dmd.110.035709

Erratum

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Correction to “Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide”
Drug Metabolism and Disposition December 2010, 38 (12) 2347; DOI: https://doi.org/10.1124/dmd.38.12.2347

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