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Drug Metabolism & Disposition

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Table of Contents

December 01, 2010; Volume 38,Issue 12

Minireview

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    Pregnane X Receptor and Constitutive Androstane Receptor at the Crossroads of Drug Metabolism and Energy Metabolism
    Jie Gao and Wen Xie
    Drug Metabolism and Disposition December 2010, 38 (12) 2091-2095; DOI: https://doi.org/10.1124/dmd.110.035568

Short Communications

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    Expression of the Anthracycline-Metabolizing Enzyme Carbonyl Reductase 1 in Hearts from Donors with Down Syndrome
    James L. Kalabus, Carrie C. Sanborn, Raqeeb G. Jamil, Qiuying Cheng and Javier G. Blanco
    Drug Metabolism and Disposition December 2010, 38 (12) 2096-2099; DOI: https://doi.org/10.1124/dmd.110.035550
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    CYP3A4*16 and CYP3A4*18 Alleles Found in East Asians Exhibit Differential Catalytic Activities for Seven CYP3A4 Substrate Drugs
    Keiko Maekawa, Noriko Harakawa, Takuya Yoshimura, Su-Ryang Kim, Yoshiyuki Fujimura, Fumika Aohara, Kimie Sai, Noriko Katori, Masahiro Tohkin, Mikihiko Naito, Ryuichi Hasegawa, Haruhiro Okuda, Jun-ichi Sawada, Takuro Niwa and Yoshiro Saito
    Drug Metabolism and Disposition December 2010, 38 (12) 2100-2104; DOI: https://doi.org/10.1124/dmd.110.034140
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    Forkhead Box Protein A1 Regulates UDP-Glucuronosyltransferase 2B15 Gene Transcription in LNCaP Prostate Cancer Cells
    Dong Gui Hu and Peter I. Mackenzie
    Drug Metabolism and Disposition December 2010, 38 (12) 2105-2109; DOI: https://doi.org/10.1124/dmd.110.035436

Articles

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    The Effects of Single Nucleotide Polymorphisms in CYP2A13 on Metabolism of 5-Methoxypsoralen
    Tatsushi Goto, Hiroshi Moriuchi, Xuejun Fu, Tomoyo Ikegawa, Toshiyuki Matsubara, Gang Chang, Tomohide Uno, Kenichi Morigaki, Kunio Isshiki and Hiromasa Imaishi
    Drug Metabolism and Disposition December 2010, 38 (12) 2110-2116; DOI: https://doi.org/10.1124/dmd.110.034553
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    Metabolism of Sesamin by Cytochrome P450 in Human Liver Microsomes
    Kaori Yasuda, Shinichi Ikushiro, Masaki Kamakura, Miho Ohta and Toshiyuki Sakaki
    Drug Metabolism and Disposition December 2010, 38 (12) 2117-2123; DOI: https://doi.org/10.1124/dmd.110.035659
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    Superior Plasma Retention of a Cross-Linked Human Serum Albumin Dimer in Nephrotic Rats as a New Type of Plasma Expander
    Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Hiroshi Watanabe, Keiichi Kawai, Teruyuki Komatsu, Eishun Tsuchida, Toru Maruyama and Masaki Otagiri
    Drug Metabolism and Disposition December 2010, 38 (12) 2124-2129; DOI: https://doi.org/10.1124/dmd.109.031989
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    Electrochemistry-Mass Spectrometry Unveils the Formation of Reactive Triclocarban Metabolites
    A. Baumann, W. Lohmann, T. Rose, K. C. Ahn, B. D. Hammock, U. Karst and N. H. Schebb
    Drug Metabolism and Disposition December 2010, 38 (12) 2130-2138; DOI: https://doi.org/10.1124/dmd.110.034546
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    Comparative Use of Isolated Hepatocytes and Hepatic Microsomes for Cytochrome P450 Inhibition Studies: Transporter-Enzyme Interplay
    Hayley S. Brown, Alison J. Wilby, Jane Alder and J. Brian Houston
    Drug Metabolism and Disposition December 2010, 38 (12) 2139-2146; DOI: https://doi.org/10.1124/dmd.110.035824
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    A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments
    Hongying Gao, Shibing Deng and R. Scott Obach
    Drug Metabolism and Disposition December 2010, 38 (12) 2147-2156; DOI: https://doi.org/10.1124/dmd.110.034637
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    Metabolism of Ebracteolata Compound B Studied In Vitro with Human Liver Microsomes, HepG2 Cells, and Recombinant Human Enzymes
    Xia Zhang, Yan Yao, Yan Lou, Huidi Jiang, Xiaowen Wang, Xiaojuan Chai and Su Zeng
    Drug Metabolism and Disposition December 2010, 38 (12) 2157-2165; DOI: https://doi.org/10.1124/dmd.110.034496
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    Metabolism and Action of Proteasome Inhibitors in Primary Human Hepatocytes
    Choon-Myung Lee, Vikas Kumar, Rochelle I. Riley and Edward T. Morgan
    Drug Metabolism and Disposition December 2010, 38 (12) 2166-2172; DOI: https://doi.org/10.1124/dmd.110.035501
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    In Vitro Evaluation of Inhibitory Effects of Antidiabetic and Antihyperlipidemic Drugs on Human Carboxylesterase Activities
    Tatsuki Fukami, Shiori Takahashi, Nao Nakagawa, Taiga Maruichi, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition December 2010, 38 (12) 2173-2178; DOI: https://doi.org/10.1124/dmd.110.034454
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    20(S)-Ginsenoside Rh2 Noncompetitively Inhibits P-Glycoprotein In Vitro and In Vivo: A Case for Herb-Drug Interactions
    Jingwei Zhang, Fang Zhou, Xiaolan Wu, Yi Gu, Hua Ai, Yuanting Zheng, Yannan Li, Xiaoxuan Zhang, Gang Hao, Jianguo Sun, Ying Peng and Guangji Wang
    Drug Metabolism and Disposition December 2010, 38 (12) 2179-2187; DOI: https://doi.org/10.1124/dmd.110.034793
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    Absorption and Metabolization of Cytoprotective Epicatechin Thio Conjugates in Rats
    Ariadna Selga, María Pilar Vinardell, Raquel Martín-Venegas, Olga Jáuregui, Josefina Casas and Josep Lluís Torres
    Drug Metabolism and Disposition December 2010, 38 (12) 2188-2194; DOI: https://doi.org/10.1124/dmd.110.035279
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    Quantifying and Predicting the Promiscuity and Isoform Specificity of Small-Molecule Cytochrome P450 Inhibitors
    Abhinav Nath, Michael A. Zientek, Benjamin J. Burke, Ying Jiang and William M. Atkins
    Drug Metabolism and Disposition December 2010, 38 (12) 2195-2203; DOI: https://doi.org/10.1124/dmd.110.034645
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    Sex Differences in UDP-Glucuronosyltransferase 2B17 Expression and Activity
    Carla J. Gallagher, Renee M. Balliet, Dongxiao Sun, Gang Chen and Philip Lazarus
    Drug Metabolism and Disposition December 2010, 38 (12) 2204-2209; DOI: https://doi.org/10.1124/dmd.110.035345
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    Involvement of Carboxylesterase 1 and 2 in the Hydrolysis of Mycophenolate Mofetil
    Nobuhiro Fujiyama, Masatomo Miura, Shoutaro Kato, Tomomichi Sone, Masakazu Isobe and Shigeru Satoh
    Drug Metabolism and Disposition December 2010, 38 (12) 2210-2217; DOI: https://doi.org/10.1124/dmd.110.034249
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    Prediction of Efficacious Inhalation Lung Doses via the Use of In Silico Lung Retention Quantitative Structure-Activity Relationship Models and In Vitro Potency Screens
    Anne Cooper, Tim Potter and Tim Luker
    Drug Metabolism and Disposition December 2010, 38 (12) 2218-2225; DOI: https://doi.org/10.1124/dmd.110.034462
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    The Chinese Herbal Medicine Sophora flavescens Activates Pregnane X Receptor
    Laiyou Wang, Feng Li, Jie Lu, Guodong Li, Dan Li, Xiao-bo Zhong, Grace L. Guo and Xiaochao Ma
    Drug Metabolism and Disposition December 2010, 38 (12) 2226-2231; DOI: https://doi.org/10.1124/dmd.110.035253
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    Differences between Human and Rat Intestinal and Hepatic Bisphenol A Glucuronidation and the Influence of Alamethicin on In Vitro Kinetic Measurements
    Christopher S. Mazur, John F. Kenneke, Janet K. Hess-Wilson and John C. Lipscomb
    Drug Metabolism and Disposition December 2010, 38 (12) 2232-2238; DOI: https://doi.org/10.1124/dmd.110.034819
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    Characterization of Human Flavin-Containing Monooxygenase (FMO) 3 and FMO5 Expressed as Maltose-Binding Protein Fusions
    Robert R. Reddy, Erik C. Ralph, Meike S. Motika, Jun Zhang and John R. Cashman
    Drug Metabolism and Disposition December 2010, 38 (12) 2239-2245; DOI: https://doi.org/10.1124/dmd.110.033639
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    Nanosilver Particle Effects on Drug Metabolism In Vitro
    John G. Lamb, Laura B. Hathaway, Mark A. Munger, Judy L. Raucy and Michael R. Franklin
    Drug Metabolism and Disposition December 2010, 38 (12) 2246-2251; DOI: https://doi.org/10.1124/dmd.110.035238
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    Expression and Functional Analysis of Hepatic Cytochromes P450, Nuclear Receptors, and Membrane Transporters in 10- and 25-Week-Old db/db Mice
    Justine L. Lam, Ying Jiang, Tao Zhang, Eric Y. Zhang and Bill J. Smith
    Drug Metabolism and Disposition December 2010, 38 (12) 2252-2258; DOI: https://doi.org/10.1124/dmd.110.034223
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    Evaluation of the Effects of Cytochrome P450 Nonsynonymous Single-Nucleotide Polymorphisms on Tanshinol Borneol Ester Metabolism and Inhibition Potential
    Duan Liu, Yiwen Gao, Huijuan Wang, Jing Zi, He Huang, Jing Ji, Ruimin Zhou, Yefei Nan, Shixiang Wang, Xiaohui Zheng, Juanli Zhu, Yali Cui and Chao Chen
    Drug Metabolism and Disposition December 2010, 38 (12) 2259-2265; DOI: https://doi.org/10.1124/dmd.110.034439
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    Metabolism of Vabicaserin in Mice, Rats, Dogs, Monkeys, and Humans
    Zeen Tong, Appavu Chandrasekaran, William DeMaio, Robert Espina, Wei Lu, Ronald Jordan and JoAnn Scatina
    Drug Metabolism and Disposition December 2010, 38 (12) 2266-2277; DOI: https://doi.org/10.1124/dmd.110.033670
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    A Mechanism-Based Mathematical Model of Aryl Hydrocarbon Receptor-Mediated CYP1A Induction in Rats Using β-Naphthoflavone as a Tool Compound
    Emile P. Chen, Liangfu Chen, Yan Ji, Guoying Tai, Yuan H. Wen and Harma Ellens
    Drug Metabolism and Disposition December 2010, 38 (12) 2278-2285; DOI: https://doi.org/10.1124/dmd.110.034421
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    Mechanism-Based Inactivation of Human CYP2E1 by Diethyldithocarbamate
    Matthew Pratt-Hyatt, Hsia-lien Lin and Paul F. Hollenberg
    Drug Metabolism and Disposition December 2010, 38 (12) 2286-2292; DOI: https://doi.org/10.1124/dmd.110.034710
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    Diversity in Antioxidant Response Enzymes in Progressive Stages of Human Nonalcoholic Fatty Liver Disease
    Rhiannon N. Hardwick, Craig D. Fisher, Mark J. Canet, April D. Lake and Nathan J. Cherrington
    Drug Metabolism and Disposition December 2010, 38 (12) 2293-2301; DOI: https://doi.org/10.1124/dmd.110.035006
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    A Predictive Ligand-Based Bayesian Model for Human Drug-Induced Liver Injury
    Sean Ekins, Antony J. Williams and Jinghai J. Xu
    Drug Metabolism and Disposition December 2010, 38 (12) 2302-2308; DOI: https://doi.org/10.1124/dmd.110.035113
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    Effect of Immune Complex Formation on the Distribution of a Novel Antibody to the Ovarian Tumor Antigen CA125
    Cinthia V. Pastuskovas, William Mallet, Suzanna Clark, Margaret Kenrick, Mohammed Majidy, Michelle Schweiger, Marjie Van Hoy, Siao Ping Tsai, Gregory Bennett, Ben-Quan Shen, Sarajane Ross, Paul Fielder, Leslie Khawli and Jay Tibbitts
    Drug Metabolism and Disposition December 2010, 38 (12) 2309-2319; DOI: https://doi.org/10.1124/dmd.110.034330
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    Receptor for Activated C-Kinase 1 Regulates the Cell Surface Expression and Function of ATP Binding Cassette G2
    Yuki Ikebuchi, Kousei Ito, Tappei Takada, Naohiko Anzai, Yoshikatsu Kanai and Hiroshi Suzuki
    Drug Metabolism and Disposition December 2010, 38 (12) 2320-2328; DOI: https://doi.org/10.1124/dmd.110.034603
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    Ecto-5′-Nucleotidase and Thiopurine Cellular Circulation: Association with Cytotoxicity
    Fang Li, Brooke L. Fridley, Alice Matimba, Krishna R. Kalari, Linda Pelleymounter, Irene Moon, Yuan Ji, Gregory D. Jenkins, Anthony Batzler, Liewei Wang and Richard M. Weinshilboum
    Drug Metabolism and Disposition December 2010, 38 (12) 2329-2338; DOI: https://doi.org/10.1124/dmd.110.035220
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    Antigen-Dependent Internalization Is Related to Rapid Elimination from Plasma of Humanized Anti-HM1.24 Monoclonal Antibody
    Jun Amano, Naoko Masuyama, Yuko Hirota, Yoshitaka Tanaka, Yuriko Igawa, Rie Shiokawa, Taichi Okutani, Takashi Miyayama, Masahiko Nanami and Masaki Ishigai
    Drug Metabolism and Disposition December 2010, 38 (12) 2339-2346; DOI: https://doi.org/10.1124/dmd.110.035709

Erratum

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    Correction to “Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide”
    Drug Metabolism and Disposition December 2010, 38 (12) 2347; DOI: https://doi.org/10.1124/dmd.38.12.2347
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Drug Metabolism and Disposition: 38 (12)
Drug Metabolism and Disposition
Vol. 38, Issue 12
1 Dec 2010
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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