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Research ArticleArticle

20(S)-Ginsenoside Rh2 Noncompetitively Inhibits P-Glycoprotein In Vitro and In Vivo: A Case for Herb-Drug Interactions

Jingwei Zhang, Fang Zhou, Xiaolan Wu, Yi Gu, Hua Ai, Yuanting Zheng, Yannan Li, Xiaoxuan Zhang, Gang Hao, Jianguo Sun, Ying Peng and Guangji Wang
Drug Metabolism and Disposition December 2010, 38 (12) 2179-2187; DOI: https://doi.org/10.1124/dmd.110.034793
Jingwei Zhang
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Fang Zhou
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Xiaolan Wu
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Yi Gu
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Hua Ai
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Yuanting Zheng
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Yannan Li
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Xiaoxuan Zhang
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Gang Hao
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Jianguo Sun
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Ying Peng
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Guangji Wang
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Article Information

vol. 38 no. 12 2179-2187
DOI 
https://doi.org/10.1124/dmd.110.034793
PubMed 
20837659

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 29, 2010
  • Accepted September 13, 2010
  • Published online November 17, 2010.

Article Versions

  • Earlier version (September 13, 2010 - 07:04).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jingwei Zhang,
  2. Fang Zhou,
  3. Xiaolan Wu,
  4. Yi Gu,
  5. Hua Ai,
  6. Yuanting Zheng,
  7. Yannan Li,
  8. Xiaoxuan Zhang,
  9. Gang Hao,
  10. Jianguo Sun,
  11. Ying Peng and
  12. Guangji Wang
  1. Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China (J.Z., F.Z., X.W., Y.G., H.A., Y.Z., Y.L., X.Z., G.H., J.S., Y.P., G.W.); and Department of Drug Metabolism and Pharmacokinetics, Hutchison MediPharma Ltd., Shanghai, China (Y.G.)
  1. Address correspondence to:
    Dr. Guangji Wang, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, Jiangsu, 210009, People's Republic of China. E-mail: guangjiwang{at}hotmail.com
  1. J.Z. and F.Z. contributed equally to this work.

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Drug Metabolism and Disposition: 38 (12)
Drug Metabolism and Disposition
Vol. 38, Issue 12
1 Dec 2010
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Research ArticleArticle

20(S)-Ginsenoside Rh2 Noncompetitively Inhibits P-Glycoprotein In Vitro and In Vivo: A Case for Herb-Drug Interactions

Jingwei Zhang, Fang Zhou, Xiaolan Wu, Yi Gu, Hua Ai, Yuanting Zheng, Yannan Li, Xiaoxuan Zhang, Gang Hao, Jianguo Sun, Ying Peng and Guangji Wang
Drug Metabolism and Disposition December 1, 2010, 38 (12) 2179-2187; DOI: https://doi.org/10.1124/dmd.110.034793

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Research ArticleArticle

20(S)-Ginsenoside Rh2 Noncompetitively Inhibits P-Glycoprotein In Vitro and In Vivo: A Case for Herb-Drug Interactions

Jingwei Zhang, Fang Zhou, Xiaolan Wu, Yi Gu, Hua Ai, Yuanting Zheng, Yannan Li, Xiaoxuan Zhang, Gang Hao, Jianguo Sun, Ying Peng and Guangji Wang
Drug Metabolism and Disposition December 1, 2010, 38 (12) 2179-2187; DOI: https://doi.org/10.1124/dmd.110.034793
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