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Research ArticleArticle

A Mechanism-Based Mathematical Model of Aryl Hydrocarbon Receptor-Mediated CYP1A Induction in Rats Using β-Naphthoflavone as a Tool Compound

Emile P. Chen, Liangfu Chen, Yan Ji, Guoying Tai, Yuan H. Wen and Harma Ellens
Drug Metabolism and Disposition December 2010, 38 (12) 2278-2285; DOI: https://doi.org/10.1124/dmd.110.034421

Article Information

vol. 38 no. 12 2278-2285
DOI 
https://doi.org/10.1124/dmd.110.034421
PubMed 
20843940
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 11, 2010
  • Accepted September 14, 2010
  • Published online November 17, 2010.

Article Versions

Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Emile P. Chen,
  2. Liangfu Chen,
  3. Yan Ji,
  4. Guoying Tai,
  5. Yuan H. Wen and
  6. Harma Ellens
  1. Department of Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (E.P.C., L.C., G.T., H.E.); Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana (Y.J.); and Cancer Metabolism Drug Discovery, GlaxoSmithKline, Collegeville, Pennsylvania (Y.H.W.)
  1. Address correspondence to:
    Dr. Emile P. Chen, GlaxoSmithKline, 709 Swedeland Rd., UW2720, King of Prussia, PA 19473. E-mail: emile.p.chen{at}gsk.com
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Research ArticleArticle

A Mechanism-Based Mathematical Model of Aryl Hydrocarbon Receptor-Mediated CYP1A Induction in Rats Using β-Naphthoflavone as a Tool Compound

Emile P. Chen, Liangfu Chen, Yan Ji, Guoying Tai, Yuan H. Wen and Harma Ellens
Drug Metabolism and Disposition December 1, 2010, 38 (12) 2278-2285; DOI: https://doi.org/10.1124/dmd.110.034421
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