Table of Contents

Articles

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  Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans

  Takao Watanabe, Hiroyuki Kusuhara, Kazuya Maeda, Hiroshi Kanamaru, Yoshikazu Saito, Zhuohan Hu and Yuichi Sugiyama

  Drug Metabolism and Disposition February 2010, 38 (2) 215-222; DOI: https://doi.org/10.1124/dmd.109.030254
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  Relationship between Passive Permeability, Efflux, and Predictability of Clearance from In Vitro Metabolic Intrinsic Clearance

  Liyue Huang, Loren Berry, Sindhura Ganga, Brett Janosky, April Chen, Jonathan Roberts, Adria E. Colletti and Min-Hwa Jasmine Lin

  Drug Metabolism and Disposition February 2010, 38 (2) 223-231; DOI: https://doi.org/10.1124/dmd.109.029066
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  Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers

  Florian Gillotin, Patrice Chiap, Michel Frédérich, Jean-Claude Van Heugen, Pierre Francotte, Philippe Lebrun, Bernard Pirotte and Pascal de Tullio

  Drug Metabolism and Disposition February 2010, 38 (2) 232-240; DOI: https://doi.org/10.1124/dmd.109.028928
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  Physiologically Based Pharmacokinetic Model of Mechanism-Based Inhibition of CYP3A by Clarithromycin

  Sara K. Quinney, Xin Zhang, Aroonrut Lucksiri, J. Christopher Gorski, Lang Li and Stephen D. Hall

  Drug Metabolism and Disposition February 2010, 38 (2) 241-248; DOI: https://doi.org/10.1124/dmd.109.028746
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  Time-Dependent Inhibitory Effects of (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-Dihydroxy-12-(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(2-oxopropyl)-11,28-dioxa-4-azatricyclo[22.3.1.0^4.9]octacos-18-ene-2,3,10,16-tetrone (FK1706), a Novel Nonimmunosuppressive Immunophilin Ligand, on CYP3A4/5 Activity in Humans in Vivo and in Vitro

  Tsuyoshi Minematsu, Jennifer Lee, Jiuhong Zha, Selina Moy, Donna Kowalski, Katsuyuki Hori, Koji Ishibashi, Takashi Usui and Hidetaka Kamimura

  Drug Metabolism and Disposition February 2010, 38 (2) 249-259; DOI: https://doi.org/10.1124/dmd.109.029280
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  If the K_I Is Defined by the Free Energy of Binding to P-Glycoprotein, Which Kinetic Parameters Define the IC₅₀ for the Madin-Darby Canine Kidney II Cell Line Overexpressing Human Multidrug Resistance 1 Confluent Cell Monolayer?

  Annie Albin Lumen, Poulomi Acharya, Joseph W. Polli, Andrew Ayrton, Harma Ellens and Joe Bentz

  Drug Metabolism and Disposition February 2010, 38 (2) 260-269; DOI: https://doi.org/10.1124/dmd.109.029843
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  Inhibition of Intestinal and Hepatic Glucuronidation of Mycophenolic Acid by Ginkgo biloba Extract and Flavonoids

  Mohamed-Eslam F. Mohamed and Reginald F. Frye

  Drug Metabolism and Disposition February 2010, 38 (2) 270-275; DOI: https://doi.org/10.1124/dmd.109.030080
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  An In Vitro Assay to Assess Transporter-Based Cholestatic Hepatotoxicity Using Sandwich-Cultured Rat Hepatocytes

  John H. Ansede, William R. Smith, Cassandra H. Perry, Robert L. St. Claire and Kenneth R. Brouwer

  Drug Metabolism and Disposition February 2010, 38 (2) 276-280; DOI: https://doi.org/10.1124/dmd.109.028407
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  Isolation and Identification of Urinary Metabolites of Kakkalide in Rats

  Xue Bai, Yuanyuan Xie, Jia Liu, Jialin Qu, Yoshihiro Kano and Dan Yuan

  Drug Metabolism and Disposition February 2010, 38 (2) 281-286; DOI: https://doi.org/10.1124/dmd.109.028555
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  In Vivo Bioavailability, Absorption, Excretion, and Pharmacokinetics of [¹⁴C]Procyanidin B2 in Male Rats

  Stavroula Stoupi, Gary Williamson, Florian Viton, Denis Barron, Laurence J. King, Jonathan E. Brown and Michael N. Clifford

  Drug Metabolism and Disposition February 2010, 38 (2) 287-291; DOI: https://doi.org/10.1124/dmd.109.030304
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  Species Differences in the Biotransformation of an α₄β₂ Nicotinic Acetylcholine Receptor Partial Agonist: The Effects of Distinct Glucuronide Metabolites on Overall Compound Disposition

  Christopher L. Shaffer, Mithat Gunduz, Tim F. Ryder and Thomas N. O'Connell

  Drug Metabolism and Disposition February 2010, 38 (2) 292-301; DOI: https://doi.org/10.1124/dmd.109.030171
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  A Single Amino Acid Substitution Confers High Cinchonidine Oxidation Activity Comparable with That of Rabbit to Monkey Aldehyde Oxidase 1

  Kensuke Fukiya, Kunio Itoh, Satoshi Yamaguchi, Akiko Kishiba, Mayuko Adachi, Nobuaki Watanabe and Yorihisa Tanaka

  Drug Metabolism and Disposition February 2010, 38 (2) 302-307; DOI: https://doi.org/10.1124/dmd.109.030064
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  A Comparison of Pharmacokinetics between Humans and Monkeys

  Takafumi Akabane, Kenji Tabata, Keitaro Kadono, Shuichi Sakuda, Shigeyuki Terashita and Toshio Teramura

  Drug Metabolism and Disposition February 2010, 38 (2) 308-316; DOI: https://doi.org/10.1124/dmd.109.028829
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  The Effect of Ethanol on Oral Cocaine Pharmacokinetics Reveals an Unrecognized Class of Ethanol-Mediated Drug Interactions

  Robert B. Parker and S. Casey Laizure

  Drug Metabolism and Disposition February 2010, 38 (2) 317-322; DOI: https://doi.org/10.1124/dmd.109.030056
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  Development of a Novel System for Estimating Human Intestinal Absorption Using Caco-2 Cells in the Absence of Esterase Activity

  Kayoko Ohura, Hisae Sakamoto, Shin-ichi Ninomiya and Teruko Imai

  Drug Metabolism and Disposition February 2010, 38 (2) 323-331; DOI: https://doi.org/10.1124/dmd.109.029413
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  Human Cytochrome P450 Oxidoreductase Deficiency Caused by the Y181D Mutation: Molecular Consequences and Rescue of Defect

  Christopher C. Marohnic, Satya P. Panda, Karen McCammon, José Rueff, Bettie Sue Siler Masters and Michel Kranendonk

  Drug Metabolism and Disposition February 2010, 38 (2) 332-340; DOI: https://doi.org/10.1124/dmd.109.030445
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  Expression and Localization of Rat Aldo-Keto Reductases and Induction of the 1B13 and 1D2 Isoforms by Phenolic Antioxidants

  A. Kenneth MacLeod, Vincent P. Kelly, Larry G. Higgins, Michael O. Kelleher, Sally A. Price, Alison L. Bigley, Graham R. Betton and John D. Hayes

  Drug Metabolism and Disposition February 2010, 38 (2) 341-346; DOI: https://doi.org/10.1124/dmd.109.030544
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  Identification of Novel Substrates for Human Cytochrome P450 2J2

  Caroline A. Lee, David Neul, Andrea Clouser-Roche, Deepak Dalvie, Michael R. Wester, Ying Jiang, J. P. Jones, Sascha Freiwald, Michael Zientek and Rheem A. Totah

  Drug Metabolism and Disposition February 2010, 38 (2) 347-356; DOI: https://doi.org/10.1124/dmd.109.030270