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Drug Metabolism & Disposition

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Table of Contents

February 01, 2010; Volume 38,Issue 2

Short Communication

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    Genetic Variants of CYP3A4 and CYP3A5 in Cynomolgus and Rhesus Macaques
    Yasuhiro Uno, Akinori Matsushita, Naoki Osada, Shotaro Uehara, Sakae Kohara, Ryoichi Nagata, Koichiro Fukuzaki, Masahiro Utoh, Norie Murayamay and Hiroshi Yamazaki
    Drug Metabolism and Disposition February 2010, 38 (2) 209-214; DOI: https://doi.org/10.1124/dmd.109.029710

Articles

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    Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans
    Takao Watanabe, Hiroyuki Kusuhara, Kazuya Maeda, Hiroshi Kanamaru, Yoshikazu Saito, Zhuohan Hu and Yuichi Sugiyama
    Drug Metabolism and Disposition February 2010, 38 (2) 215-222; DOI: https://doi.org/10.1124/dmd.109.030254
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    Relationship between Passive Permeability, Efflux, and Predictability of Clearance from In Vitro Metabolic Intrinsic Clearance
    Liyue Huang, Loren Berry, Sindhura Ganga, Brett Janosky, April Chen, Jonathan Roberts, Adria E. Colletti and Min-Hwa Jasmine Lin
    Drug Metabolism and Disposition February 2010, 38 (2) 223-231; DOI: https://doi.org/10.1124/dmd.109.029066
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    Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers
    Florian Gillotin, Patrice Chiap, Michel Frédérich, Jean-Claude Van Heugen, Pierre Francotte, Philippe Lebrun, Bernard Pirotte and Pascal de Tullio
    Drug Metabolism and Disposition February 2010, 38 (2) 232-240; DOI: https://doi.org/10.1124/dmd.109.028928
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    Physiologically Based Pharmacokinetic Model of Mechanism-Based Inhibition of CYP3A by Clarithromycin
    Sara K. Quinney, Xin Zhang, Aroonrut Lucksiri, J. Christopher Gorski, Lang Li and Stephen D. Hall
    Drug Metabolism and Disposition February 2010, 38 (2) 241-248; DOI: https://doi.org/10.1124/dmd.109.028746
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    Time-Dependent Inhibitory Effects of (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-Dihydroxy-12-(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(2-oxopropyl)-11,28-dioxa-4-azatricyclo[22.3.1.04.9]octacos-18-ene-2,3,10,16-tetrone (FK1706), a Novel Nonimmunosuppressive Immunophilin Ligand, on CYP3A4/5 Activity in Humans in Vivo and in Vitro
    Tsuyoshi Minematsu, Jennifer Lee, Jiuhong Zha, Selina Moy, Donna Kowalski, Katsuyuki Hori, Koji Ishibashi, Takashi Usui and Hidetaka Kamimura
    Drug Metabolism and Disposition February 2010, 38 (2) 249-259; DOI: https://doi.org/10.1124/dmd.109.029280
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    If the KI Is Defined by the Free Energy of Binding to P-Glycoprotein, Which Kinetic Parameters Define the IC50 for the Madin-Darby Canine Kidney II Cell Line Overexpressing Human Multidrug Resistance 1 Confluent Cell Monolayer?
    Annie Albin Lumen, Poulomi Acharya, Joseph W. Polli, Andrew Ayrton, Harma Ellens and Joe Bentz
    Drug Metabolism and Disposition February 2010, 38 (2) 260-269; DOI: https://doi.org/10.1124/dmd.109.029843
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    Inhibition of Intestinal and Hepatic Glucuronidation of Mycophenolic Acid by Ginkgo biloba Extract and Flavonoids
    Mohamed-Eslam F. Mohamed and Reginald F. Frye
    Drug Metabolism and Disposition February 2010, 38 (2) 270-275; DOI: https://doi.org/10.1124/dmd.109.030080
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    An In Vitro Assay to Assess Transporter-Based Cholestatic Hepatotoxicity Using Sandwich-Cultured Rat Hepatocytes
    John H. Ansede, William R. Smith, Cassandra H. Perry, Robert L. St. Claire and Kenneth R. Brouwer
    Drug Metabolism and Disposition February 2010, 38 (2) 276-280; DOI: https://doi.org/10.1124/dmd.109.028407
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    Isolation and Identification of Urinary Metabolites of Kakkalide in Rats
    Xue Bai, Yuanyuan Xie, Jia Liu, Jialin Qu, Yoshihiro Kano and Dan Yuan
    Drug Metabolism and Disposition February 2010, 38 (2) 281-286; DOI: https://doi.org/10.1124/dmd.109.028555
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    In Vivo Bioavailability, Absorption, Excretion, and Pharmacokinetics of [14C]Procyanidin B2 in Male Rats
    Stavroula Stoupi, Gary Williamson, Florian Viton, Denis Barron, Laurence J. King, Jonathan E. Brown and Michael N. Clifford
    Drug Metabolism and Disposition February 2010, 38 (2) 287-291; DOI: https://doi.org/10.1124/dmd.109.030304
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    Species Differences in the Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist: The Effects of Distinct Glucuronide Metabolites on Overall Compound Disposition
    Christopher L. Shaffer, Mithat Gunduz, Tim F. Ryder and Thomas N. O'Connell
    Drug Metabolism and Disposition February 2010, 38 (2) 292-301; DOI: https://doi.org/10.1124/dmd.109.030171
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    A Single Amino Acid Substitution Confers High Cinchonidine Oxidation Activity Comparable with That of Rabbit to Monkey Aldehyde Oxidase 1
    Kensuke Fukiya, Kunio Itoh, Satoshi Yamaguchi, Akiko Kishiba, Mayuko Adachi, Nobuaki Watanabe and Yorihisa Tanaka
    Drug Metabolism and Disposition February 2010, 38 (2) 302-307; DOI: https://doi.org/10.1124/dmd.109.030064
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    A Comparison of Pharmacokinetics between Humans and Monkeys
    Takafumi Akabane, Kenji Tabata, Keitaro Kadono, Shuichi Sakuda, Shigeyuki Terashita and Toshio Teramura
    Drug Metabolism and Disposition February 2010, 38 (2) 308-316; DOI: https://doi.org/10.1124/dmd.109.028829
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    The Effect of Ethanol on Oral Cocaine Pharmacokinetics Reveals an Unrecognized Class of Ethanol-Mediated Drug Interactions
    Robert B. Parker and S. Casey Laizure
    Drug Metabolism and Disposition February 2010, 38 (2) 317-322; DOI: https://doi.org/10.1124/dmd.109.030056
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    Development of a Novel System for Estimating Human Intestinal Absorption Using Caco-2 Cells in the Absence of Esterase Activity
    Kayoko Ohura, Hisae Sakamoto, Shin-ichi Ninomiya and Teruko Imai
    Drug Metabolism and Disposition February 2010, 38 (2) 323-331; DOI: https://doi.org/10.1124/dmd.109.029413
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    Human Cytochrome P450 Oxidoreductase Deficiency Caused by the Y181D Mutation: Molecular Consequences and Rescue of Defect
    Christopher C. Marohnic, Satya P. Panda, Karen McCammon, José Rueff, Bettie Sue Siler Masters and Michel Kranendonk
    Drug Metabolism and Disposition February 2010, 38 (2) 332-340; DOI: https://doi.org/10.1124/dmd.109.030445
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    Expression and Localization of Rat Aldo-Keto Reductases and Induction of the 1B13 and 1D2 Isoforms by Phenolic Antioxidants
    A. Kenneth MacLeod, Vincent P. Kelly, Larry G. Higgins, Michael O. Kelleher, Sally A. Price, Alison L. Bigley, Graham R. Betton and John D. Hayes
    Drug Metabolism and Disposition February 2010, 38 (2) 341-346; DOI: https://doi.org/10.1124/dmd.109.030544
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    Identification of Novel Substrates for Human Cytochrome P450 2J2
    Caroline A. Lee, David Neul, Andrea Clouser-Roche, Deepak Dalvie, Michael R. Wester, Ying Jiang, J. P. Jones, Sascha Freiwald, Michael Zientek and Rheem A. Totah
    Drug Metabolism and Disposition February 2010, 38 (2) 347-356; DOI: https://doi.org/10.1124/dmd.109.030270
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In this issue

Drug Metabolism and Disposition: 38 (2)
Drug Metabolism and Disposition
Vol. 38, Issue 2
1 Feb 2010
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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