Table of Contents

Articles

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  Identification of a Novel N-Carbamoyl Glucuronide: In Vitro, In Vivo, and Mechanistic Studies

  Mithat Gunduz, Upendra A. Argikar, Daniel Baeschlin, Suzie Ferreira, Vinayak Hosagrahara and Shawn Harriman

  Drug Metabolism and Disposition March 2010, 38 (3) 361-367; DOI: https://doi.org/10.1124/dmd.109.030650
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  Identification of Human UGT2B7 as the Major Isoform Involved in the O-Glucuronidation of Chloramphenicol

  Mei Chen, Barbara LeDuc, Stephen Kerr, David Howe and David A. Williams

  Drug Metabolism and Disposition March 2010, 38 (3) 368-375; DOI: https://doi.org/10.1124/dmd.109.029900
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  Identification of Cytochrome P450 Isoforms Involved in the Metabolism of Paroxetine and Estimation of Their Importance for Human Paroxetine Metabolism Using a Population-Based Simulator

  Jakob Jornil, Klaus Gjervig Jensen, Frank Larsen and Kristian Linnet

  Drug Metabolism and Disposition March 2010, 38 (3) 376-385; DOI: https://doi.org/10.1124/dmd.109.030551
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  Glucuronidation of Psilocin and 4-Hydroxyindole by the Human UDP-Glucuronosyltransferases

  Nenad Manevski, Mika Kurkela, Camilla Höglund, Timo Mauriala, Michael H. Court, Jari Yli-Kauhaluoma and Moshe Finel

  Drug Metabolism and Disposition March 2010, 38 (3) 386-395; DOI: https://doi.org/10.1124/dmd.109.031138
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  Current Cytochrome P450 Phenotyping Methods Applied to Metabolic Drug-Drug Interaction Prediction in Dogs

  Beth Miskimins Mills, Matthew J. Zaya, Rodney R. Walters, Kenneth L. Feenstra, Julie A. White, Jason Gagne and Charles W. Locuson

  Drug Metabolism and Disposition March 2010, 38 (3) 396-404; DOI: https://doi.org/10.1124/dmd.109.030429
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  In Vitro Characterization and Pharmacokinetics of Dapagliflozin (BMS-512148), a Potent Sodium-Glucose Cotransporter Type II Inhibitor, in Animals and Humans

  M. Obermeier, M. Yao, A. Khanna, B. Koplowitz, M. Zhu, W. Li, B. Komoroski, S. Kasichayanula, L. Discenza, W. Washburn, W. Meng, B. A. Ellsworth, J. M. Whaley and W. G. Humphreys

  Drug Metabolism and Disposition March 2010, 38 (3) 405-414; DOI: https://doi.org/10.1124/dmd.109.029165
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  New Insights into the Regulation of CYP2C9 Gene Expression: The Role of the Transcription Factor GATA-4

  Jessica Mwinyi, Jana Nekvindová, Isa Cavaco, Yvonne Hofmann, Rasmus Steen Pedersen, Ellie Landman, Souren Mkrtchian and Magnus Ingelman-Sundberg

  Drug Metabolism and Disposition March 2010, 38 (3) 415-421; DOI: https://doi.org/10.1124/dmd.109.029405
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  In Silico Prediction of Biliary Excretion of Drugs in Rats Based on Physicochemical Properties

  Gang Luo, Stephen Johnson, Mei-Mann Hsueh, Joanna Zheng, Hong Cai, Baomin Xin, Saeho Chong, Kan He and Timothy W. Harper

  Drug Metabolism and Disposition March 2010, 38 (3) 422-430; DOI: https://doi.org/10.1124/dmd.108.026260
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  Glucuronidation of Dihydrotestosterone and trans-Androsterone by Recombinant UDP-Glucuronosyltransferase (UGT) 1A4: Evidence for Multiple UGT1A4 Aglycone Binding Sites

  Jin Zhou, Timothy S. Tracy and Rory P. Remmel

  Drug Metabolism and Disposition March 2010, 38 (3) 431-440; DOI: https://doi.org/10.1124/dmd.109.028712
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  Monocarboxylate Transporter-Mediated Transport of γ-Hydroxybutyric Acid in Human Intestinal Caco-2 Cells

  Wing Ki Lam, Melanie A. Felmlee and Marilyn E. Morris

  Drug Metabolism and Disposition March 2010, 38 (3) 441-447; DOI: https://doi.org/10.1124/dmd.109.030775
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  In Vitro Assessment of Metabolic Drug-Drug Interaction Potential of Apixaban through Cytochrome P450 Phenotyping, Inhibition, and Induction Studies

  Lifei Wang, Donglu Zhang, Nirmala Raghavan, Ming Yao, Li Ma, Charles A. Frost, Brad D. Maxwell, Shiang-yuan Chen, Kan He, Theunis C. Goosen, W. Humphreys Griffith and Scott J. Grossman

  Drug Metabolism and Disposition March 2010, 38 (3) 448-458; DOI: https://doi.org/10.1124/dmd.109.029694
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  Pharmacokinetics, Metabolism, and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Rats and Rhesus Monkeys

  Eugene Y. Tan, Georgy Hartmann, Qing Chen, Antonio Pereira, Scott Bradley, George Doss, Andy Shiqiang Zhang, Jonathan Z. Ho, Matthew P. Braun, Dennis C. Dean, Wei Tang and Sanjeev Kumar

  Drug Metabolism and Disposition March 2010, 38 (3) 459-473; DOI: https://doi.org/10.1124/dmd.109.028696
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  Metabolism and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Humans

  Sanjeev Kumar, Eugene Y. Tan, Georgy Hartmann, Zachary Biddle, Arthur J. Bergman, James Dru, Jonathan Z. Ho, Allen N. Jones, Steve J. Staskiewicz, Matthew P. Braun, Bindhu Karanam, Dennis C. Dean, Isaias Noel Gendrano, Mark W. Graves, John A. Wagner and Rajesh Krishna

  Drug Metabolism and Disposition March 2010, 38 (3) 474-483; DOI: https://doi.org/10.1124/dmd.109.028704
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  UDP-Glucuronosyltransferase 1A10: Activity against the Tobacco-Specific Nitrosamine, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a Potential Role for a Novel UGT1A10 Promoter Deletion Polymorphism in Cancer Susceptibility

  Rene M. Balliet, Gang Chen, Ryan W. Dellinger and Philip Lazarus

  Drug Metabolism and Disposition March 2010, 38 (3) 484-490; DOI: https://doi.org/10.1124/dmd.109.030569
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  Investigation of the Involvement of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 in the Efflux of Ximelagatran and Its Metabolites by Using Short Hairpin RNA Knockdown in Caco-2 Cells

  Malin Darnell, Johan E. Karlsson, Albert Owen, Ismael J. Hidalgo, Jibin Li, Wei Zhang and Tommy B. Andersson

  Drug Metabolism and Disposition March 2010, 38 (3) 491-497; DOI: https://doi.org/10.1124/dmd.109.029967
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  Metabolism and Excretion of the Novel Bioreductive Prodrug PR-104 in Mice, Rats, Dogs, and Humans

  Yongchuan Gu, Graham J. Atwell and William R. Wilson

  Drug Metabolism and Disposition March 2010, 38 (3) 498-508; DOI: https://doi.org/10.1124/dmd.109.030973
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  Glucuronide Production by Whole-Cell Biotransformation Using Genetically Engineered Fission Yeast Schizosaccharomyces pombe

  Călin-Aurel Drăgan, Daniela Buchheit, Daniel Bischoff, Thomas Ebner and Matthias Bureik

  Drug Metabolism and Disposition March 2010, 38 (3) 509-515; DOI: https://doi.org/10.1124/dmd.109.030965
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  Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells

  Sébastien Anthérieu, Christophe Chesné, Ruoya Li, Sandrine Camus, Agustin Lahoz, Laura Picazo, Miia Turpeinen, Ari Tolonen, Jouko Uusitalo, Christiane Guguen-Guillouzo and André Guillouzo

  Drug Metabolism and Disposition March 2010, 38 (3) 516-525; DOI: https://doi.org/10.1124/dmd.109.030197
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  Expressions of Cytochrome P450, UDP-Glucuronosyltranferase, and Transporter Genes in Monolayer Carcinoma Cells Change in Subcutaneous Tumors Grown As Xenografts in Immunodeficient Nude Mice

  Michiko Sugawara, Kiyoshi Okamoto, Tadashi Kadowaki, Kazutomi Kusano, Akiyoshi Fukamizu and Tsutomu Yoshimura

  Drug Metabolism and Disposition March 2010, 38 (3) 526-533; DOI: https://doi.org/10.1124/dmd.109.030668