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Research ArticleArticle

In Vitro Assessment of Metabolic Drug-Drug Interaction Potential of Apixaban through Cytochrome P450 Phenotyping, Inhibition, and Induction Studies

Lifei Wang, Donglu Zhang, Nirmala Raghavan, Ming Yao, Li Ma, Charles A. Frost, Brad D. Maxwell, Shiang-yuan Chen, Kan He, Theunis C. Goosen, W. Humphreys Griffith and Scott J. Grossman
Drug Metabolism and Disposition March 2010, 38 (3) 448-458; DOI: https://doi.org/10.1124/dmd.109.029694

Article Information

vol. 38 no. 3 448-458
DOI 
https://doi.org/10.1124/dmd.109.029694
PubMed 
19940026
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 24, 2009
  • Accepted November 24, 2009
  • Published online February 17, 2010.

Article Versions

Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lifei Wang,
  2. Donglu Zhang,
  3. Nirmala Raghavan,
  4. Ming Yao,
  5. Li Ma,
  6. Charles A. Frost,
  7. Brad D. Maxwell,
  8. Shiang-yuan Chen,
  9. Kan He1,
  10. Theunis C. Goosen,
  11. W. Humphreys Griffith and
  12. Scott J. Grossman
  1. Pharmaceutical Candidate Optimization (L.W., D.Z., N.R., M.Y., L.M., K.H., W.G.H., S.J.G.), Discovery Medicines and Clinical Pharmacology (C.A.F.), and Discovery Chemical Synthesis (B.D.M., S.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; and Pharmacokinetics, Dynamics, and Metabolism (T.C.G.), Pfizer Global Research and Development, Groton, Connecticut
  1. Address correspondence to:
    Dr. Donglu Zhang, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, P.O. Box 4000, Princeton, NJ 08543. E-mail: donglu.zhang{at}bms.com

  • ↵1 Current affiliation: UniTris Biopharma Co., Shanghai, China.

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Research ArticleArticle

In Vitro Assessment of Metabolic Drug-Drug Interaction Potential of Apixaban through Cytochrome P450 Phenotyping, Inhibition, and Induction Studies

Lifei Wang, Donglu Zhang, Nirmala Raghavan, Ming Yao, Li Ma, Charles A. Frost, Brad D. Maxwell, Shiang-yuan Chen, Kan He, Theunis C. Goosen, W. Humphreys Griffith and Scott J. Grossman
Drug Metabolism and Disposition March 1, 2010, 38 (3) 448-458; DOI: https://doi.org/10.1124/dmd.109.029694
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