Table of Contents

Articles

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  Breast Cancer Resistance Protein (BCRP)-Mediated Glyburide Transport: Effect of the C421A/Q141K BCRP Single-Nucleotide Polymorphism

  Erika K. Pollex, Gregory Anger, Janine Hutson, Gideon Koren and Micheline Piquette-Miller

  Drug Metabolism and Disposition May 2010, 38 (5) 740-744; DOI: https://doi.org/10.1124/dmd.109.030791
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  Functional Characterization of Cytochrome P450 2A6 Allelic Variants CYP2A6*15, CYP2A6*16, CYP2A6*21, and CYP2A6*22

  Kai Hung Tiong, Beow Chin Yiap, Eng Lai Tan, Rusli Ismail and Chin Eng Ong

  Drug Metabolism and Disposition May 2010, 38 (5) 745-751; DOI: https://doi.org/10.1124/dmd.109.031054
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  Formation and Distribution of NNK Metabolites in an Isolated Perfused Rat Lung

  Laura A. Maertens, Pramod Upadhyaya, Stephen S. Hecht and Cheryl L. Zimmerman

  Drug Metabolism and Disposition May 2010, 38 (5) 752-760; DOI: https://doi.org/10.1124/dmd.109.031492
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  Cytochrome P450 1A2 Detoxicates Aristolochic Acid in the Mouse

  Thomas A. Rosenquist, Heidi J. Einolf, Kathleen G. Dickman, Lai Wang, Amanda Smith and Arthur P. Grollman

  Drug Metabolism and Disposition May 2010, 38 (5) 761-768; DOI: https://doi.org/10.1124/dmd.110.032201
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  Interplay of Phase II Enzymes and Transporters in Futile Cycling: Influence of Multidrug Resistance-Associated Protein 2-Mediated Excretion of Estradiol 17β-d-Glucuronide and Its 3-Sulfate Metabolite on Net Sulfation in Perfused TR⁻ and Wistar Rat Liver Preparations

  Huadong Sun, Ying-Ying Zeng and K. Sandy Pang

  Drug Metabolism and Disposition May 2010, 38 (5) 769-780; DOI: https://doi.org/10.1124/dmd.109.029959
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  Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers

  David Hostler, Jiangquan Zhou, Michael A. Tortorici, Robert R. Bies, Jon C. Rittenberger, Philip E. Empey, Patrick M. Kochanek, Clifton W. Callaway and Samuel M. Poloyac

  Drug Metabolism and Disposition May 2010, 38 (5) 781-788; DOI: https://doi.org/10.1124/dmd.109.031377
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  Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-¹⁴C₂)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [¹⁴C]Lersivirine to Healthy Volunteers

  Manoli Vourvahis, Michelle Gleave, Angus N. R. Nedderman, Ruth Hyland, Iain Gardner, Martin Howard, Sarah Kempshall, Claire Collins and Robert LaBadie

  Drug Metabolism and Disposition May 2010, 38 (5) 789-800; DOI: https://doi.org/10.1124/dmd.109.031252
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  In Vitro Metabolism and Identification of Human Enzymes Involved in the Metabolism of Methylnaltrexone

  Zeen Tong, Appavu Chandrasekaran, Hongshan Li, Yakov Rotshteyn, John C. L. Erve, William DeMaio, Rasmy Talaat, Theresa Hultin and JoAnn Scatina

  Drug Metabolism and Disposition May 2010, 38 (5) 801-807; DOI: https://doi.org/10.1124/dmd.110.032169
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  Pharmacokinetics, Metabolism, and Disposition of Deferasirox in β-Thalassemic Patients with Transfusion-Dependent Iron Overload Who Are at Pharmacokinetic Steady State

  Felix Waldmeier, Gerard J. Bruin, Ulrike Glaenzel, Katharine Hazell, Romain Sechaud, Steve Warrington and John B. Porter

  Drug Metabolism and Disposition May 2010, 38 (5) 808-816; DOI: https://doi.org/10.1124/dmd.109.030833
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  Sex-Dependent Differences in Cytochrome P450 3A Activity as Assessed by Midazolam Disposition in Humans: A Meta-Analysis

  Zhe-Yi Hu and Yuan-Sheng Zhao

  Drug Metabolism and Disposition May 2010, 38 (5) 817-823; DOI: https://doi.org/10.1124/dmd.109.031328
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  Metabolism of 2,6-Dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl Ether (Pyridalyl) in Rats after Repeated Oral Administration and a Simple Physiologically Based Pharmacokinetic Modeling in Brown and White Adipose Tissues

  Hirohisa Nagahori, Haruyuki Matsunaga, Yoshitaka Tomigahara, Naohiko Isobe and Hideo Kaneko

  Drug Metabolism and Disposition May 2010, 38 (5) 824-832; DOI: https://doi.org/10.1124/dmd.109.031914
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  Pharmacokinetics of Metformin during Pregnancy

  Sara Eyal, Thomas R. Easterling, Darcy Carr, Jason G. Umans, Menachem Miodovnik, Gary D. V. Hankins, Shannon M. Clark, Linda Risler, Joanne Wang, Edward J. Kelly, Danny D. Shen and Mary F. Hebert

  Drug Metabolism and Disposition May 2010, 38 (5) 833-840; DOI: https://doi.org/10.1124/dmd.109.031245
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  Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/d-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction

  Simon G. Wong, Peter W. Fan, Raju Subramanian, George R. Tonn, Kirk R. Henne, Michael G. Johnson, Michelle Tadano Lohr and Bradley K. Wong

  Drug Metabolism and Disposition May 2010, 38 (5) 841-850; DOI: https://doi.org/10.1124/dmd.109.031344
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  Use of the Entero-Test, a Novel Approach for the Noninvasive Capture of Biliary Metabolites in Dogs

  W. J. Guiney, C. Beaumont and S. R. Thomas

  Drug Metabolism and Disposition May 2010, 38 (5) 851-856; DOI: https://doi.org/10.1124/dmd.109.031062
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  Chlorzoxazone Metabolism by Porcine Cytochrome P450 Enzymes and the Effect of Cytochrome b₅

  P. Wiercinska and E. J. Squires

  Drug Metabolism and Disposition May 2010, 38 (5) 857-862; DOI: https://doi.org/10.1124/dmd.109.030528
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  Role of Human UGT2B10 in N-Glucuronidation of Tricyclic Antidepressants, Amitriptyline, Imipramine, Clomipramine, and Trimipramine

  Diansong Zhou, Jian Guo, Alban J. Linnenbach, Catherine L. Booth-Genthe and Scott W. Grimm

  Drug Metabolism and Disposition May 2010, 38 (5) 863-870; DOI: https://doi.org/10.1124/dmd.109.030981
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  Metabolism-Mediated Drug Interactions Associated with Ritonavir-Boosted Tipranavir in Mice

  Feng Li, Laiyou Wang, Grace L. Guo and Xiaochao Ma

  Drug Metabolism and Disposition May 2010, 38 (5) 871-878; DOI: https://doi.org/10.1124/dmd.109.030817
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  A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation

  Hongliang Cai, Nghia Nguyen, Vincent Peterkin, Young-Sun Yang, Kathy Hotz, Deirdre Beaton La Placa, Shujuan Chen, Robert H. Tukey and Jeffrey C. Stevens

  Drug Metabolism and Disposition May 2010, 38 (5) 879-886; DOI: https://doi.org/10.1124/dmd.109.030130