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Index by author

May 01, 2010; Volume 38,Issue 5

A

  1. Ahn, Taeho

    1. Engineering Bacterial Cytochrome P450 (P450) BM3 into a Prototype with Human P450 Enzyme Activity Using Indigo Formation
      Sun-Ha Park, Dong-Hyun Kim, Dooil Kim, Dae-Hwan Kim, Heung-Chae Jung, Jae-Gu Pan, Taeho Ahn, Donghak Kim and Chul-Ho Yun
      Drug Metabolism and Disposition May 2010, 38 (5) 732-739; DOI: https://doi.org/10.1124/dmd.109.030759

  2. Anger, Gregory

    1. Breast Cancer Resistance Protein (BCRP)-Mediated Glyburide Transport: Effect of the C421A/Q141K BCRP Single-Nucleotide Polymorphism
      Erika K. Pollex, Gregory Anger, Janine Hutson, Gideon Koren and Micheline Piquette-Miller
      Drug Metabolism and Disposition May 2010, 38 (5) 740-744; DOI: https://doi.org/10.1124/dmd.109.030791

B

  1. Beaton La Placa, Deirdre

    1. A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation
      Hongliang Cai, Nghia Nguyen, Vincent Peterkin, Young-Sun Yang, Kathy Hotz, Deirdre Beaton La Placa, Shujuan Chen, Robert H. Tukey and Jeffrey C. Stevens
      Drug Metabolism and Disposition May 2010, 38 (5) 879-886; DOI: https://doi.org/10.1124/dmd.109.030130

  2. Beaumont, C.

    1. Use of the Entero-Test, a Novel Approach for the Noninvasive Capture of Biliary Metabolites in Dogs
      W. J. Guiney, C. Beaumont and S. R. Thomas
      Drug Metabolism and Disposition May 2010, 38 (5) 851-856; DOI: https://doi.org/10.1124/dmd.109.031062

  3. Bies, Robert R.

    1. Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers
      David Hostler, Jiangquan Zhou, Michael A. Tortorici, Robert R. Bies, Jon C. Rittenberger, Philip E. Empey, Patrick M. Kochanek, Clifton W. Callaway and Samuel M. Poloyac
      Drug Metabolism and Disposition May 2010, 38 (5) 781-788; DOI: https://doi.org/10.1124/dmd.109.031377

  4. Booth-Genthe, Catherine L.

    1. Role of Human UGT2B10 in N-Glucuronidation of Tricyclic Antidepressants, Amitriptyline, Imipramine, Clomipramine, and Trimipramine
      Diansong Zhou, Jian Guo, Alban J. Linnenbach, Catherine L. Booth-Genthe and Scott W. Grimm
      Drug Metabolism and Disposition May 2010, 38 (5) 863-870; DOI: https://doi.org/10.1124/dmd.109.030981

  5. Bruin, Gerard J.

    1. Pharmacokinetics, Metabolism, and Disposition of Deferasirox in β-Thalassemic Patients with Transfusion-Dependent Iron Overload Who Are at Pharmacokinetic Steady State
      Felix Waldmeier, Gerard J. Bruin, Ulrike Glaenzel, Katharine Hazell, Romain Sechaud, Steve Warrington and John B. Porter
      Drug Metabolism and Disposition May 2010, 38 (5) 808-816; DOI: https://doi.org/10.1124/dmd.109.030833

C

  1. Cai, Hongliang

    1. A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation
      Hongliang Cai, Nghia Nguyen, Vincent Peterkin, Young-Sun Yang, Kathy Hotz, Deirdre Beaton La Placa, Shujuan Chen, Robert H. Tukey and Jeffrey C. Stevens
      Drug Metabolism and Disposition May 2010, 38 (5) 879-886; DOI: https://doi.org/10.1124/dmd.109.030130

  2. Callaway, Clifton W.

    1. Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers
      David Hostler, Jiangquan Zhou, Michael A. Tortorici, Robert R. Bies, Jon C. Rittenberger, Philip E. Empey, Patrick M. Kochanek, Clifton W. Callaway and Samuel M. Poloyac
      Drug Metabolism and Disposition May 2010, 38 (5) 781-788; DOI: https://doi.org/10.1124/dmd.109.031377

  3. Caritis, Steve N.

    1. Metabolism of 17α-Hydroxyprogesterone Caproate, an Agent for Preventing Preterm Birth, by Fetal Hepatocytes
      Shringi Sharma, Ewa C. S. Ellis, Kenneth Dorko, Shimin Zhang, Donald R. Mattison, Steve N. Caritis, Raman Venkataramanan and Stephen C. Strom
      Drug Metabolism and Disposition May 2010, 38 (5) 723-727; DOI: https://doi.org/10.1124/dmd.109.029918

  4. Carr, Darcy

    1. Pharmacokinetics of Metformin during Pregnancy
      Sara Eyal, Thomas R. Easterling, Darcy Carr, Jason G. Umans, Menachem Miodovnik, Gary D. V. Hankins, Shannon M. Clark, Linda Risler, Joanne Wang, Edward J. Kelly, Danny D. Shen and Mary F. Hebert
      Drug Metabolism and Disposition May 2010, 38 (5) 833-840; DOI: https://doi.org/10.1124/dmd.109.031245

  5. Chandrasekaran, Appavu

    1. In Vitro Metabolism and Identification of Human Enzymes Involved in the Metabolism of Methylnaltrexone
      Zeen Tong, Appavu Chandrasekaran, Hongshan Li, Yakov Rotshteyn, John C. L. Erve, William DeMaio, Rasmy Talaat, Theresa Hultin and JoAnn Scatina
      Drug Metabolism and Disposition May 2010, 38 (5) 801-807; DOI: https://doi.org/10.1124/dmd.110.032169

  6. Chen, Shujuan

    1. A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation
      Hongliang Cai, Nghia Nguyen, Vincent Peterkin, Young-Sun Yang, Kathy Hotz, Deirdre Beaton La Placa, Shujuan Chen, Robert H. Tukey and Jeffrey C. Stevens
      Drug Metabolism and Disposition May 2010, 38 (5) 879-886; DOI: https://doi.org/10.1124/dmd.109.030130

  7. Clark, Shannon M.

    1. Pharmacokinetics of Metformin during Pregnancy
      Sara Eyal, Thomas R. Easterling, Darcy Carr, Jason G. Umans, Menachem Miodovnik, Gary D. V. Hankins, Shannon M. Clark, Linda Risler, Joanne Wang, Edward J. Kelly, Danny D. Shen and Mary F. Hebert
      Drug Metabolism and Disposition May 2010, 38 (5) 833-840; DOI: https://doi.org/10.1124/dmd.109.031245

  8. Collins, Claire

    1. Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [14C]Lersivirine to Healthy Volunteers
      Manoli Vourvahis, Michelle Gleave, Angus N. R. Nedderman, Ruth Hyland, Iain Gardner, Martin Howard, Sarah Kempshall, Claire Collins and Robert LaBadie
      Drug Metabolism and Disposition May 2010, 38 (5) 789-800; DOI: https://doi.org/10.1124/dmd.109.031252

D

  1. DeMaio, William

    1. In Vitro Metabolism and Identification of Human Enzymes Involved in the Metabolism of Methylnaltrexone
      Zeen Tong, Appavu Chandrasekaran, Hongshan Li, Yakov Rotshteyn, John C. L. Erve, William DeMaio, Rasmy Talaat, Theresa Hultin and JoAnn Scatina
      Drug Metabolism and Disposition May 2010, 38 (5) 801-807; DOI: https://doi.org/10.1124/dmd.110.032169

  2. Dickman, Kathleen G.

    1. Cytochrome P450 1A2 Detoxicates Aristolochic Acid in the Mouse
      Thomas A. Rosenquist, Heidi J. Einolf, Kathleen G. Dickman, Lai Wang, Amanda Smith and Arthur P. Grollman
      Drug Metabolism and Disposition May 2010, 38 (5) 761-768; DOI: https://doi.org/10.1124/dmd.110.032201

  3. Dorko, Kenneth

    1. Metabolism of 17α-Hydroxyprogesterone Caproate, an Agent for Preventing Preterm Birth, by Fetal Hepatocytes
      Shringi Sharma, Ewa C. S. Ellis, Kenneth Dorko, Shimin Zhang, Donald R. Mattison, Steve N. Caritis, Raman Venkataramanan and Stephen C. Strom
      Drug Metabolism and Disposition May 2010, 38 (5) 723-727; DOI: https://doi.org/10.1124/dmd.109.029918

E

  1. Easterling, Thomas R.

    1. Pharmacokinetics of Metformin during Pregnancy
      Sara Eyal, Thomas R. Easterling, Darcy Carr, Jason G. Umans, Menachem Miodovnik, Gary D. V. Hankins, Shannon M. Clark, Linda Risler, Joanne Wang, Edward J. Kelly, Danny D. Shen and Mary F. Hebert
      Drug Metabolism and Disposition May 2010, 38 (5) 833-840; DOI: https://doi.org/10.1124/dmd.109.031245

  2. Einolf, Heidi J.

    1. Cytochrome P450 1A2 Detoxicates Aristolochic Acid in the Mouse
      Thomas A. Rosenquist, Heidi J. Einolf, Kathleen G. Dickman, Lai Wang, Amanda Smith and Arthur P. Grollman
      Drug Metabolism and Disposition May 2010, 38 (5) 761-768; DOI: https://doi.org/10.1124/dmd.110.032201

  3. Ellis, Ewa C. S.

    1. Metabolism of 17α-Hydroxyprogesterone Caproate, an Agent for Preventing Preterm Birth, by Fetal Hepatocytes
      Shringi Sharma, Ewa C. S. Ellis, Kenneth Dorko, Shimin Zhang, Donald R. Mattison, Steve N. Caritis, Raman Venkataramanan and Stephen C. Strom
      Drug Metabolism and Disposition May 2010, 38 (5) 723-727; DOI: https://doi.org/10.1124/dmd.109.029918

  4. Empey, Philip E.

    1. Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers
      David Hostler, Jiangquan Zhou, Michael A. Tortorici, Robert R. Bies, Jon C. Rittenberger, Philip E. Empey, Patrick M. Kochanek, Clifton W. Callaway and Samuel M. Poloyac
      Drug Metabolism and Disposition May 2010, 38 (5) 781-788; DOI: https://doi.org/10.1124/dmd.109.031377

  5. Erve, John C. L.

    1. In Vitro Metabolism and Identification of Human Enzymes Involved in the Metabolism of Methylnaltrexone
      Zeen Tong, Appavu Chandrasekaran, Hongshan Li, Yakov Rotshteyn, John C. L. Erve, William DeMaio, Rasmy Talaat, Theresa Hultin and JoAnn Scatina
      Drug Metabolism and Disposition May 2010, 38 (5) 801-807; DOI: https://doi.org/10.1124/dmd.110.032169

  6. Evans, Allan M.

    1. Inhibition of Morphine Metabolism by Ketamine
      Xiaoxin Qi, Allan M. Evans, Jiping Wang, John O. Miners, Richard N. Upton and Robert W. Milne
      Drug Metabolism and Disposition May 2010, 38 (5) 728-731; DOI: https://doi.org/10.1124/dmd.109.030957

  7. Eyal, Sara

    1. Pharmacokinetics of Metformin during Pregnancy
      Sara Eyal, Thomas R. Easterling, Darcy Carr, Jason G. Umans, Menachem Miodovnik, Gary D. V. Hankins, Shannon M. Clark, Linda Risler, Joanne Wang, Edward J. Kelly, Danny D. Shen and Mary F. Hebert
      Drug Metabolism and Disposition May 2010, 38 (5) 833-840; DOI: https://doi.org/10.1124/dmd.109.031245

F

  1. Fan, Peter W.

    1. Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/d-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction
      Simon G. Wong, Peter W. Fan, Raju Subramanian, George R. Tonn, Kirk R. Henne, Michael G. Johnson, Michelle Tadano Lohr and Bradley K. Wong
      Drug Metabolism and Disposition May 2010, 38 (5) 841-850; DOI: https://doi.org/10.1124/dmd.109.031344

G

  1. Gardner, Iain

    1. Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [14C]Lersivirine to Healthy Volunteers
      Manoli Vourvahis, Michelle Gleave, Angus N. R. Nedderman, Ruth Hyland, Iain Gardner, Martin Howard, Sarah Kempshall, Claire Collins and Robert LaBadie
      Drug Metabolism and Disposition May 2010, 38 (5) 789-800; DOI: https://doi.org/10.1124/dmd.109.031252

  2. Glaenzel, Ulrike

    1. Pharmacokinetics, Metabolism, and Disposition of Deferasirox in β-Thalassemic Patients with Transfusion-Dependent Iron Overload Who Are at Pharmacokinetic Steady State
      Felix Waldmeier, Gerard J. Bruin, Ulrike Glaenzel, Katharine Hazell, Romain Sechaud, Steve Warrington and John B. Porter
      Drug Metabolism and Disposition May 2010, 38 (5) 808-816; DOI: https://doi.org/10.1124/dmd.109.030833

  3. Gleave, Michelle

    1. Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [14C]Lersivirine to Healthy Volunteers
      Manoli Vourvahis, Michelle Gleave, Angus N. R. Nedderman, Ruth Hyland, Iain Gardner, Martin Howard, Sarah Kempshall, Claire Collins and Robert LaBadie
      Drug Metabolism and Disposition May 2010, 38 (5) 789-800; DOI: https://doi.org/10.1124/dmd.109.031252

  4. Grimm, Scott W.

    1. Role of Human UGT2B10 in N-Glucuronidation of Tricyclic Antidepressants, Amitriptyline, Imipramine, Clomipramine, and Trimipramine
      Diansong Zhou, Jian Guo, Alban J. Linnenbach, Catherine L. Booth-Genthe and Scott W. Grimm
      Drug Metabolism and Disposition May 2010, 38 (5) 863-870; DOI: https://doi.org/10.1124/dmd.109.030981

  5. Grollman, Arthur P.

    1. Cytochrome P450 1A2 Detoxicates Aristolochic Acid in the Mouse
      Thomas A. Rosenquist, Heidi J. Einolf, Kathleen G. Dickman, Lai Wang, Amanda Smith and Arthur P. Grollman
      Drug Metabolism and Disposition May 2010, 38 (5) 761-768; DOI: https://doi.org/10.1124/dmd.110.032201

  6. Guiney, W. J.

    1. Use of the Entero-Test, a Novel Approach for the Noninvasive Capture of Biliary Metabolites in Dogs
      W. J. Guiney, C. Beaumont and S. R. Thomas
      Drug Metabolism and Disposition May 2010, 38 (5) 851-856; DOI: https://doi.org/10.1124/dmd.109.031062

  7. Guo, Grace L.

    1. Metabolism-Mediated Drug Interactions Associated with Ritonavir-Boosted Tipranavir in Mice
      Feng Li, Laiyou Wang, Grace L. Guo and Xiaochao Ma
      Drug Metabolism and Disposition May 2010, 38 (5) 871-878; DOI: https://doi.org/10.1124/dmd.109.030817

  8. Guo, Jian

    1. Role of Human UGT2B10 in N-Glucuronidation of Tricyclic Antidepressants, Amitriptyline, Imipramine, Clomipramine, and Trimipramine
      Diansong Zhou, Jian Guo, Alban J. Linnenbach, Catherine L. Booth-Genthe and Scott W. Grimm
      Drug Metabolism and Disposition May 2010, 38 (5) 863-870; DOI: https://doi.org/10.1124/dmd.109.030981

H

  1. Hankins, Gary D. V.

    1. Pharmacokinetics of Metformin during Pregnancy
      Sara Eyal, Thomas R. Easterling, Darcy Carr, Jason G. Umans, Menachem Miodovnik, Gary D. V. Hankins, Shannon M. Clark, Linda Risler, Joanne Wang, Edward J. Kelly, Danny D. Shen and Mary F. Hebert
      Drug Metabolism and Disposition May 2010, 38 (5) 833-840; DOI: https://doi.org/10.1124/dmd.109.031245

  2. Hazell, Katharine

    1. Pharmacokinetics, Metabolism, and Disposition of Deferasirox in β-Thalassemic Patients with Transfusion-Dependent Iron Overload Who Are at Pharmacokinetic Steady State
      Felix Waldmeier, Gerard J. Bruin, Ulrike Glaenzel, Katharine Hazell, Romain Sechaud, Steve Warrington and John B. Porter
      Drug Metabolism and Disposition May 2010, 38 (5) 808-816; DOI: https://doi.org/10.1124/dmd.109.030833

  3. Hebert, Mary F.

    1. Pharmacokinetics of Metformin during Pregnancy
      Sara Eyal, Thomas R. Easterling, Darcy Carr, Jason G. Umans, Menachem Miodovnik, Gary D. V. Hankins, Shannon M. Clark, Linda Risler, Joanne Wang, Edward J. Kelly, Danny D. Shen and Mary F. Hebert
      Drug Metabolism and Disposition May 2010, 38 (5) 833-840; DOI: https://doi.org/10.1124/dmd.109.031245

  4. Hecht, Stephen S.

    1. Formation and Distribution of NNK Metabolites in an Isolated Perfused Rat Lung
      Laura A. Maertens, Pramod Upadhyaya, Stephen S. Hecht and Cheryl L. Zimmerman
      Drug Metabolism and Disposition May 2010, 38 (5) 752-760; DOI: https://doi.org/10.1124/dmd.109.031492

  5. Henne, Kirk R.

    1. Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/d-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction
      Simon G. Wong, Peter W. Fan, Raju Subramanian, George R. Tonn, Kirk R. Henne, Michael G. Johnson, Michelle Tadano Lohr and Bradley K. Wong
      Drug Metabolism and Disposition May 2010, 38 (5) 841-850; DOI: https://doi.org/10.1124/dmd.109.031344

  6. Hostler, David

    1. Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers
      David Hostler, Jiangquan Zhou, Michael A. Tortorici, Robert R. Bies, Jon C. Rittenberger, Philip E. Empey, Patrick M. Kochanek, Clifton W. Callaway and Samuel M. Poloyac
      Drug Metabolism and Disposition May 2010, 38 (5) 781-788; DOI: https://doi.org/10.1124/dmd.109.031377

  7. Hotz, Kathy

    1. A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation
      Hongliang Cai, Nghia Nguyen, Vincent Peterkin, Young-Sun Yang, Kathy Hotz, Deirdre Beaton La Placa, Shujuan Chen, Robert H. Tukey and Jeffrey C. Stevens
      Drug Metabolism and Disposition May 2010, 38 (5) 879-886; DOI: https://doi.org/10.1124/dmd.109.030130

  8. Howard, Martin

    1. Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [14C]Lersivirine to Healthy Volunteers
      Manoli Vourvahis, Michelle Gleave, Angus N. R. Nedderman, Ruth Hyland, Iain Gardner, Martin Howard, Sarah Kempshall, Claire Collins and Robert LaBadie
      Drug Metabolism and Disposition May 2010, 38 (5) 789-800; DOI: https://doi.org/10.1124/dmd.109.031252

  9. Hu, Zhe-Yi

    1. Sex-Dependent Differences in Cytochrome P450 3A Activity as Assessed by Midazolam Disposition in Humans: A Meta-Analysis
      Zhe-Yi Hu and Yuan-Sheng Zhao
      Drug Metabolism and Disposition May 2010, 38 (5) 817-823; DOI: https://doi.org/10.1124/dmd.109.031328

  10. Hultin, Theresa

    1. In Vitro Metabolism and Identification of Human Enzymes Involved in the Metabolism of Methylnaltrexone
      Zeen Tong, Appavu Chandrasekaran, Hongshan Li, Yakov Rotshteyn, John C. L. Erve, William DeMaio, Rasmy Talaat, Theresa Hultin and JoAnn Scatina
      Drug Metabolism and Disposition May 2010, 38 (5) 801-807; DOI: https://doi.org/10.1124/dmd.110.032169

  11. Hutson, Janine

    1. Breast Cancer Resistance Protein (BCRP)-Mediated Glyburide Transport: Effect of the C421A/Q141K BCRP Single-Nucleotide Polymorphism
      Erika K. Pollex, Gregory Anger, Janine Hutson, Gideon Koren and Micheline Piquette-Miller
      Drug Metabolism and Disposition May 2010, 38 (5) 740-744; DOI: https://doi.org/10.1124/dmd.109.030791

  12. Hyland, Ruth

    1. Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [14C]Lersivirine to Healthy Volunteers
      Manoli Vourvahis, Michelle Gleave, Angus N. R. Nedderman, Ruth Hyland, Iain Gardner, Martin Howard, Sarah Kempshall, Claire Collins and Robert LaBadie
      Drug Metabolism and Disposition May 2010, 38 (5) 789-800; DOI: https://doi.org/10.1124/dmd.109.031252

I

  1. Ismail, Rusli

    1. Functional Characterization of Cytochrome P450 2A6 Allelic Variants CYP2A6*15, CYP2A6*16, CYP2A6*21, and CYP2A6*22
      Kai Hung Tiong, Beow Chin Yiap, Eng Lai Tan, Rusli Ismail and Chin Eng Ong
      Drug Metabolism and Disposition May 2010, 38 (5) 745-751; DOI: https://doi.org/10.1124/dmd.109.031054

  2. Isobe, Naohiko

    1. Metabolism of 2,6-Dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl Ether (Pyridalyl) in Rats after Repeated Oral Administration and a Simple Physiologically Based Pharmacokinetic Modeling in Brown and White Adipose Tissues
      Hirohisa Nagahori, Haruyuki Matsunaga, Yoshitaka Tomigahara, Naohiko Isobe and Hideo Kaneko
      Drug Metabolism and Disposition May 2010, 38 (5) 824-832; DOI: https://doi.org/10.1124/dmd.109.031914

J

  1. Johnson, Michael G.

    1. Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/d-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction
      Simon G. Wong, Peter W. Fan, Raju Subramanian, George R. Tonn, Kirk R. Henne, Michael G. Johnson, Michelle Tadano Lohr and Bradley K. Wong
      Drug Metabolism and Disposition May 2010, 38 (5) 841-850; DOI: https://doi.org/10.1124/dmd.109.031344

  2. Jung, Heung-Chae

    1. Engineering Bacterial Cytochrome P450 (P450) BM3 into a Prototype with Human P450 Enzyme Activity Using Indigo Formation
      Sun-Ha Park, Dong-Hyun Kim, Dooil Kim, Dae-Hwan Kim, Heung-Chae Jung, Jae-Gu Pan, Taeho Ahn, Donghak Kim and Chul-Ho Yun
      Drug Metabolism and Disposition May 2010, 38 (5) 732-739; DOI: https://doi.org/10.1124/dmd.109.030759

K

  1. Kaneko, Hideo

    1. Metabolism of 2,6-Dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl Ether (Pyridalyl) in Rats after Repeated Oral Administration and a Simple Physiologically Based Pharmacokinetic Modeling in Brown and White Adipose Tissues
      Hirohisa Nagahori, Haruyuki Matsunaga, Yoshitaka Tomigahara, Naohiko Isobe and Hideo Kaneko
      Drug Metabolism and Disposition May 2010, 38 (5) 824-832; DOI: https://doi.org/10.1124/dmd.109.031914

  2. Kelly, Edward J.

    1. Pharmacokinetics of Metformin during Pregnancy
      Sara Eyal, Thomas R. Easterling, Darcy Carr, Jason G. Umans, Menachem Miodovnik, Gary D. V. Hankins, Shannon M. Clark, Linda Risler, Joanne Wang, Edward J. Kelly, Danny D. Shen and Mary F. Hebert
      Drug Metabolism and Disposition May 2010, 38 (5) 833-840; DOI: https://doi.org/10.1124/dmd.109.031245

  3. Kempshall, Sarah

    1. Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [14C]Lersivirine to Healthy Volunteers
      Manoli Vourvahis, Michelle Gleave, Angus N. R. Nedderman, Ruth Hyland, Iain Gardner, Martin Howard, Sarah Kempshall, Claire Collins and Robert LaBadie
      Drug Metabolism and Disposition May 2010, 38 (5) 789-800; DOI: https://doi.org/10.1124/dmd.109.031252

  4. Kim, Dae-Hwan

    1. Engineering Bacterial Cytochrome P450 (P450) BM3 into a Prototype with Human P450 Enzyme Activity Using Indigo Formation
      Sun-Ha Park, Dong-Hyun Kim, Dooil Kim, Dae-Hwan Kim, Heung-Chae Jung, Jae-Gu Pan, Taeho Ahn, Donghak Kim and Chul-Ho Yun
      Drug Metabolism and Disposition May 2010, 38 (5) 732-739; DOI: https://doi.org/10.1124/dmd.109.030759

  5. Kim, Dong-Hyun

    1. Engineering Bacterial Cytochrome P450 (P450) BM3 into a Prototype with Human P450 Enzyme Activity Using Indigo Formation
      Sun-Ha Park, Dong-Hyun Kim, Dooil Kim, Dae-Hwan Kim, Heung-Chae Jung, Jae-Gu Pan, Taeho Ahn, Donghak Kim and Chul-Ho Yun
      Drug Metabolism and Disposition May 2010, 38 (5) 732-739; DOI: https://doi.org/10.1124/dmd.109.030759

  6. Kim, Donghak

    1. Engineering Bacterial Cytochrome P450 (P450) BM3 into a Prototype with Human P450 Enzyme Activity Using Indigo Formation
      Sun-Ha Park, Dong-Hyun Kim, Dooil Kim, Dae-Hwan Kim, Heung-Chae Jung, Jae-Gu Pan, Taeho Ahn, Donghak Kim and Chul-Ho Yun
      Drug Metabolism and Disposition May 2010, 38 (5) 732-739; DOI: https://doi.org/10.1124/dmd.109.030759

  7. Kim, Dooil

    1. Engineering Bacterial Cytochrome P450 (P450) BM3 into a Prototype with Human P450 Enzyme Activity Using Indigo Formation
      Sun-Ha Park, Dong-Hyun Kim, Dooil Kim, Dae-Hwan Kim, Heung-Chae Jung, Jae-Gu Pan, Taeho Ahn, Donghak Kim and Chul-Ho Yun
      Drug Metabolism and Disposition May 2010, 38 (5) 732-739; DOI: https://doi.org/10.1124/dmd.109.030759

  8. Kochanek, Patrick M.

    1. Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers
      David Hostler, Jiangquan Zhou, Michael A. Tortorici, Robert R. Bies, Jon C. Rittenberger, Philip E. Empey, Patrick M. Kochanek, Clifton W. Callaway and Samuel M. Poloyac
      Drug Metabolism and Disposition May 2010, 38 (5) 781-788; DOI: https://doi.org/10.1124/dmd.109.031377

  9. Koren, Gideon

    1. Breast Cancer Resistance Protein (BCRP)-Mediated Glyburide Transport: Effect of the C421A/Q141K BCRP Single-Nucleotide Polymorphism
      Erika K. Pollex, Gregory Anger, Janine Hutson, Gideon Koren and Micheline Piquette-Miller
      Drug Metabolism and Disposition May 2010, 38 (5) 740-744; DOI: https://doi.org/10.1124/dmd.109.030791

L

  1. LaBadie, Robert

    1. Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [14C]Lersivirine to Healthy Volunteers
      Manoli Vourvahis, Michelle Gleave, Angus N. R. Nedderman, Ruth Hyland, Iain Gardner, Martin Howard, Sarah Kempshall, Claire Collins and Robert LaBadie
      Drug Metabolism and Disposition May 2010, 38 (5) 789-800; DOI: https://doi.org/10.1124/dmd.109.031252

  2. Li, Feng

    1. Metabolism-Mediated Drug Interactions Associated with Ritonavir-Boosted Tipranavir in Mice
      Feng Li, Laiyou Wang, Grace L. Guo and Xiaochao Ma
      Drug Metabolism and Disposition May 2010, 38 (5) 871-878; DOI: https://doi.org/10.1124/dmd.109.030817

  3. Li, Hongshan

    1. In Vitro Metabolism and Identification of Human Enzymes Involved in the Metabolism of Methylnaltrexone
      Zeen Tong, Appavu Chandrasekaran, Hongshan Li, Yakov Rotshteyn, John C. L. Erve, William DeMaio, Rasmy Talaat, Theresa Hultin and JoAnn Scatina
      Drug Metabolism and Disposition May 2010, 38 (5) 801-807; DOI: https://doi.org/10.1124/dmd.110.032169

  4. Linnenbach, Alban J.

    1. Role of Human UGT2B10 in N-Glucuronidation of Tricyclic Antidepressants, Amitriptyline, Imipramine, Clomipramine, and Trimipramine
      Diansong Zhou, Jian Guo, Alban J. Linnenbach, Catherine L. Booth-Genthe and Scott W. Grimm
      Drug Metabolism and Disposition May 2010, 38 (5) 863-870; DOI: https://doi.org/10.1124/dmd.109.030981

M

  1. Ma, Xiaochao

    1. Metabolism-Mediated Drug Interactions Associated with Ritonavir-Boosted Tipranavir in Mice
      Feng Li, Laiyou Wang, Grace L. Guo and Xiaochao Ma
      Drug Metabolism and Disposition May 2010, 38 (5) 871-878; DOI: https://doi.org/10.1124/dmd.109.030817

  2. Maertens, Laura A.

    1. Formation and Distribution of NNK Metabolites in an Isolated Perfused Rat Lung
      Laura A. Maertens, Pramod Upadhyaya, Stephen S. Hecht and Cheryl L. Zimmerman
      Drug Metabolism and Disposition May 2010, 38 (5) 752-760; DOI: https://doi.org/10.1124/dmd.109.031492

  3. Matsunaga, Haruyuki

    1. Metabolism of 2,6-Dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl Ether (Pyridalyl) in Rats after Repeated Oral Administration and a Simple Physiologically Based Pharmacokinetic Modeling in Brown and White Adipose Tissues
      Hirohisa Nagahori, Haruyuki Matsunaga, Yoshitaka Tomigahara, Naohiko Isobe and Hideo Kaneko
      Drug Metabolism and Disposition May 2010, 38 (5) 824-832; DOI: https://doi.org/10.1124/dmd.109.031914

  4. Mattison, Donald R.

    1. Metabolism of 17α-Hydroxyprogesterone Caproate, an Agent for Preventing Preterm Birth, by Fetal Hepatocytes
      Shringi Sharma, Ewa C. S. Ellis, Kenneth Dorko, Shimin Zhang, Donald R. Mattison, Steve N. Caritis, Raman Venkataramanan and Stephen C. Strom
      Drug Metabolism and Disposition May 2010, 38 (5) 723-727; DOI: https://doi.org/10.1124/dmd.109.029918

  5. Milne, Robert W.

    1. Inhibition of Morphine Metabolism by Ketamine
      Xiaoxin Qi, Allan M. Evans, Jiping Wang, John O. Miners, Richard N. Upton and Robert W. Milne
      Drug Metabolism and Disposition May 2010, 38 (5) 728-731; DOI: https://doi.org/10.1124/dmd.109.030957

  6. Miners, John O.

    1. Inhibition of Morphine Metabolism by Ketamine
      Xiaoxin Qi, Allan M. Evans, Jiping Wang, John O. Miners, Richard N. Upton and Robert W. Milne
      Drug Metabolism and Disposition May 2010, 38 (5) 728-731; DOI: https://doi.org/10.1124/dmd.109.030957

  7. Miodovnik, Menachem

    1. Pharmacokinetics of Metformin during Pregnancy
      Sara Eyal, Thomas R. Easterling, Darcy Carr, Jason G. Umans, Menachem Miodovnik, Gary D. V. Hankins, Shannon M. Clark, Linda Risler, Joanne Wang, Edward J. Kelly, Danny D. Shen and Mary F. Hebert
      Drug Metabolism and Disposition May 2010, 38 (5) 833-840; DOI: https://doi.org/10.1124/dmd.109.031245

N

  1. Nagahori, Hirohisa

    1. Metabolism of 2,6-Dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl Ether (Pyridalyl) in Rats after Repeated Oral Administration and a Simple Physiologically Based Pharmacokinetic Modeling in Brown and White Adipose Tissues
      Hirohisa Nagahori, Haruyuki Matsunaga, Yoshitaka Tomigahara, Naohiko Isobe and Hideo Kaneko
      Drug Metabolism and Disposition May 2010, 38 (5) 824-832; DOI: https://doi.org/10.1124/dmd.109.031914

  2. Nedderman, Angus N. R.

    1. Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [14C]Lersivirine to Healthy Volunteers
      Manoli Vourvahis, Michelle Gleave, Angus N. R. Nedderman, Ruth Hyland, Iain Gardner, Martin Howard, Sarah Kempshall, Claire Collins and Robert LaBadie
      Drug Metabolism and Disposition May 2010, 38 (5) 789-800; DOI: https://doi.org/10.1124/dmd.109.031252

  3. Nguyen, Nghia

    1. A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation
      Hongliang Cai, Nghia Nguyen, Vincent Peterkin, Young-Sun Yang, Kathy Hotz, Deirdre Beaton La Placa, Shujuan Chen, Robert H. Tukey and Jeffrey C. Stevens
      Drug Metabolism and Disposition May 2010, 38 (5) 879-886; DOI: https://doi.org/10.1124/dmd.109.030130

O

  1. Ong, Chin Eng

    1. Functional Characterization of Cytochrome P450 2A6 Allelic Variants CYP2A6*15, CYP2A6*16, CYP2A6*21, and CYP2A6*22
      Kai Hung Tiong, Beow Chin Yiap, Eng Lai Tan, Rusli Ismail and Chin Eng Ong
      Drug Metabolism and Disposition May 2010, 38 (5) 745-751; DOI: https://doi.org/10.1124/dmd.109.031054

P

  1. Pan, Jae-Gu

    1. Engineering Bacterial Cytochrome P450 (P450) BM3 into a Prototype with Human P450 Enzyme Activity Using Indigo Formation
      Sun-Ha Park, Dong-Hyun Kim, Dooil Kim, Dae-Hwan Kim, Heung-Chae Jung, Jae-Gu Pan, Taeho Ahn, Donghak Kim and Chul-Ho Yun
      Drug Metabolism and Disposition May 2010, 38 (5) 732-739; DOI: https://doi.org/10.1124/dmd.109.030759

  2. Pang, K. Sandy

    1. Interplay of Phase II Enzymes and Transporters in Futile Cycling: Influence of Multidrug Resistance-Associated Protein 2-Mediated Excretion of Estradiol 17β-d-Glucuronide and Its 3-Sulfate Metabolite on Net Sulfation in Perfused TR− and Wistar Rat Liver Preparations
      Huadong Sun, Ying-Ying Zeng and K. Sandy Pang
      Drug Metabolism and Disposition May 2010, 38 (5) 769-780; DOI: https://doi.org/10.1124/dmd.109.029959

  3. Park, Sun-Ha

    1. Engineering Bacterial Cytochrome P450 (P450) BM3 into a Prototype with Human P450 Enzyme Activity Using Indigo Formation
      Sun-Ha Park, Dong-Hyun Kim, Dooil Kim, Dae-Hwan Kim, Heung-Chae Jung, Jae-Gu Pan, Taeho Ahn, Donghak Kim and Chul-Ho Yun
      Drug Metabolism and Disposition May 2010, 38 (5) 732-739; DOI: https://doi.org/10.1124/dmd.109.030759

  4. Peterkin, Vincent

    1. A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation
      Hongliang Cai, Nghia Nguyen, Vincent Peterkin, Young-Sun Yang, Kathy Hotz, Deirdre Beaton La Placa, Shujuan Chen, Robert H. Tukey and Jeffrey C. Stevens
      Drug Metabolism and Disposition May 2010, 38 (5) 879-886; DOI: https://doi.org/10.1124/dmd.109.030130

  5. Piquette-Miller, Micheline

    1. Breast Cancer Resistance Protein (BCRP)-Mediated Glyburide Transport: Effect of the C421A/Q141K BCRP Single-Nucleotide Polymorphism
      Erika K. Pollex, Gregory Anger, Janine Hutson, Gideon Koren and Micheline Piquette-Miller
      Drug Metabolism and Disposition May 2010, 38 (5) 740-744; DOI: https://doi.org/10.1124/dmd.109.030791

  6. Pollex, Erika K.

    1. Breast Cancer Resistance Protein (BCRP)-Mediated Glyburide Transport: Effect of the C421A/Q141K BCRP Single-Nucleotide Polymorphism
      Erika K. Pollex, Gregory Anger, Janine Hutson, Gideon Koren and Micheline Piquette-Miller
      Drug Metabolism and Disposition May 2010, 38 (5) 740-744; DOI: https://doi.org/10.1124/dmd.109.030791

  7. Poloyac, Samuel M.

    1. Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers
      David Hostler, Jiangquan Zhou, Michael A. Tortorici, Robert R. Bies, Jon C. Rittenberger, Philip E. Empey, Patrick M. Kochanek, Clifton W. Callaway and Samuel M. Poloyac
      Drug Metabolism and Disposition May 2010, 38 (5) 781-788; DOI: https://doi.org/10.1124/dmd.109.031377

  8. Porter, John B.

    1. Pharmacokinetics, Metabolism, and Disposition of Deferasirox in β-Thalassemic Patients with Transfusion-Dependent Iron Overload Who Are at Pharmacokinetic Steady State
      Felix Waldmeier, Gerard J. Bruin, Ulrike Glaenzel, Katharine Hazell, Romain Sechaud, Steve Warrington and John B. Porter
      Drug Metabolism and Disposition May 2010, 38 (5) 808-816; DOI: https://doi.org/10.1124/dmd.109.030833

Q

  1. Qi, Xiaoxin

    1. Inhibition of Morphine Metabolism by Ketamine
      Xiaoxin Qi, Allan M. Evans, Jiping Wang, John O. Miners, Richard N. Upton and Robert W. Milne
      Drug Metabolism and Disposition May 2010, 38 (5) 728-731; DOI: https://doi.org/10.1124/dmd.109.030957

R

  1. Risler, Linda

    1. Pharmacokinetics of Metformin during Pregnancy
      Sara Eyal, Thomas R. Easterling, Darcy Carr, Jason G. Umans, Menachem Miodovnik, Gary D. V. Hankins, Shannon M. Clark, Linda Risler, Joanne Wang, Edward J. Kelly, Danny D. Shen and Mary F. Hebert
      Drug Metabolism and Disposition May 2010, 38 (5) 833-840; DOI: https://doi.org/10.1124/dmd.109.031245

  2. Rittenberger, Jon C.

    1. Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers
      David Hostler, Jiangquan Zhou, Michael A. Tortorici, Robert R. Bies, Jon C. Rittenberger, Philip E. Empey, Patrick M. Kochanek, Clifton W. Callaway and Samuel M. Poloyac
      Drug Metabolism and Disposition May 2010, 38 (5) 781-788; DOI: https://doi.org/10.1124/dmd.109.031377

  3. Rosenquist, Thomas A.

    1. Cytochrome P450 1A2 Detoxicates Aristolochic Acid in the Mouse
      Thomas A. Rosenquist, Heidi J. Einolf, Kathleen G. Dickman, Lai Wang, Amanda Smith and Arthur P. Grollman
      Drug Metabolism and Disposition May 2010, 38 (5) 761-768; DOI: https://doi.org/10.1124/dmd.110.032201

  4. Rotshteyn, Yakov

    1. In Vitro Metabolism and Identification of Human Enzymes Involved in the Metabolism of Methylnaltrexone
      Zeen Tong, Appavu Chandrasekaran, Hongshan Li, Yakov Rotshteyn, John C. L. Erve, William DeMaio, Rasmy Talaat, Theresa Hultin and JoAnn Scatina
      Drug Metabolism and Disposition May 2010, 38 (5) 801-807; DOI: https://doi.org/10.1124/dmd.110.032169

S

  1. Scatina, JoAnn

    1. In Vitro Metabolism and Identification of Human Enzymes Involved in the Metabolism of Methylnaltrexone
      Zeen Tong, Appavu Chandrasekaran, Hongshan Li, Yakov Rotshteyn, John C. L. Erve, William DeMaio, Rasmy Talaat, Theresa Hultin and JoAnn Scatina
      Drug Metabolism and Disposition May 2010, 38 (5) 801-807; DOI: https://doi.org/10.1124/dmd.110.032169

  2. Sechaud, Romain

    1. Pharmacokinetics, Metabolism, and Disposition of Deferasirox in β-Thalassemic Patients with Transfusion-Dependent Iron Overload Who Are at Pharmacokinetic Steady State
      Felix Waldmeier, Gerard J. Bruin, Ulrike Glaenzel, Katharine Hazell, Romain Sechaud, Steve Warrington and John B. Porter
      Drug Metabolism and Disposition May 2010, 38 (5) 808-816; DOI: https://doi.org/10.1124/dmd.109.030833

  3. Sharma, Shringi

    1. Metabolism of 17α-Hydroxyprogesterone Caproate, an Agent for Preventing Preterm Birth, by Fetal Hepatocytes
      Shringi Sharma, Ewa C. S. Ellis, Kenneth Dorko, Shimin Zhang, Donald R. Mattison, Steve N. Caritis, Raman Venkataramanan and Stephen C. Strom
      Drug Metabolism and Disposition May 2010, 38 (5) 723-727; DOI: https://doi.org/10.1124/dmd.109.029918

  4. Shen, Danny D.

    1. Pharmacokinetics of Metformin during Pregnancy
      Sara Eyal, Thomas R. Easterling, Darcy Carr, Jason G. Umans, Menachem Miodovnik, Gary D. V. Hankins, Shannon M. Clark, Linda Risler, Joanne Wang, Edward J. Kelly, Danny D. Shen and Mary F. Hebert
      Drug Metabolism and Disposition May 2010, 38 (5) 833-840; DOI: https://doi.org/10.1124/dmd.109.031245

  5. Smith, Amanda

    1. Cytochrome P450 1A2 Detoxicates Aristolochic Acid in the Mouse
      Thomas A. Rosenquist, Heidi J. Einolf, Kathleen G. Dickman, Lai Wang, Amanda Smith and Arthur P. Grollman
      Drug Metabolism and Disposition May 2010, 38 (5) 761-768; DOI: https://doi.org/10.1124/dmd.110.032201

  6. Squires, E. J.

    1. Chlorzoxazone Metabolism by Porcine Cytochrome P450 Enzymes and the Effect of Cytochrome b5
      P. Wiercinska and E. J. Squires
      Drug Metabolism and Disposition May 2010, 38 (5) 857-862; DOI: https://doi.org/10.1124/dmd.109.030528

  7. Stevens, Jeffrey C.

    1. A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation
      Hongliang Cai, Nghia Nguyen, Vincent Peterkin, Young-Sun Yang, Kathy Hotz, Deirdre Beaton La Placa, Shujuan Chen, Robert H. Tukey and Jeffrey C. Stevens
      Drug Metabolism and Disposition May 2010, 38 (5) 879-886; DOI: https://doi.org/10.1124/dmd.109.030130

  8. Strom, Stephen C.

    1. Metabolism of 17α-Hydroxyprogesterone Caproate, an Agent for Preventing Preterm Birth, by Fetal Hepatocytes
      Shringi Sharma, Ewa C. S. Ellis, Kenneth Dorko, Shimin Zhang, Donald R. Mattison, Steve N. Caritis, Raman Venkataramanan and Stephen C. Strom
      Drug Metabolism and Disposition May 2010, 38 (5) 723-727; DOI: https://doi.org/10.1124/dmd.109.029918

  9. Subramanian, Raju

    1. Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/d-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction
      Simon G. Wong, Peter W. Fan, Raju Subramanian, George R. Tonn, Kirk R. Henne, Michael G. Johnson, Michelle Tadano Lohr and Bradley K. Wong
      Drug Metabolism and Disposition May 2010, 38 (5) 841-850; DOI: https://doi.org/10.1124/dmd.109.031344

  10. Sun, Huadong

    1. Interplay of Phase II Enzymes and Transporters in Futile Cycling: Influence of Multidrug Resistance-Associated Protein 2-Mediated Excretion of Estradiol 17β-d-Glucuronide and Its 3-Sulfate Metabolite on Net Sulfation in Perfused TR− and Wistar Rat Liver Preparations
      Huadong Sun, Ying-Ying Zeng and K. Sandy Pang
      Drug Metabolism and Disposition May 2010, 38 (5) 769-780; DOI: https://doi.org/10.1124/dmd.109.029959

T

  1. Tadano Lohr, Michelle

    1. Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/d-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction
      Simon G. Wong, Peter W. Fan, Raju Subramanian, George R. Tonn, Kirk R. Henne, Michael G. Johnson, Michelle Tadano Lohr and Bradley K. Wong
      Drug Metabolism and Disposition May 2010, 38 (5) 841-850; DOI: https://doi.org/10.1124/dmd.109.031344

  2. Talaat, Rasmy

    1. In Vitro Metabolism and Identification of Human Enzymes Involved in the Metabolism of Methylnaltrexone
      Zeen Tong, Appavu Chandrasekaran, Hongshan Li, Yakov Rotshteyn, John C. L. Erve, William DeMaio, Rasmy Talaat, Theresa Hultin and JoAnn Scatina
      Drug Metabolism and Disposition May 2010, 38 (5) 801-807; DOI: https://doi.org/10.1124/dmd.110.032169

  3. Tan, Eng Lai

    1. Functional Characterization of Cytochrome P450 2A6 Allelic Variants CYP2A6*15, CYP2A6*16, CYP2A6*21, and CYP2A6*22
      Kai Hung Tiong, Beow Chin Yiap, Eng Lai Tan, Rusli Ismail and Chin Eng Ong
      Drug Metabolism and Disposition May 2010, 38 (5) 745-751; DOI: https://doi.org/10.1124/dmd.109.031054

  4. Thomas, S. R.

    1. Use of the Entero-Test, a Novel Approach for the Noninvasive Capture of Biliary Metabolites in Dogs
      W. J. Guiney, C. Beaumont and S. R. Thomas
      Drug Metabolism and Disposition May 2010, 38 (5) 851-856; DOI: https://doi.org/10.1124/dmd.109.031062

  5. Tiong, Kai Hung

    1. Functional Characterization of Cytochrome P450 2A6 Allelic Variants CYP2A6*15, CYP2A6*16, CYP2A6*21, and CYP2A6*22
      Kai Hung Tiong, Beow Chin Yiap, Eng Lai Tan, Rusli Ismail and Chin Eng Ong
      Drug Metabolism and Disposition May 2010, 38 (5) 745-751; DOI: https://doi.org/10.1124/dmd.109.031054

  6. Tomigahara, Yoshitaka

    1. Metabolism of 2,6-Dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl Ether (Pyridalyl) in Rats after Repeated Oral Administration and a Simple Physiologically Based Pharmacokinetic Modeling in Brown and White Adipose Tissues
      Hirohisa Nagahori, Haruyuki Matsunaga, Yoshitaka Tomigahara, Naohiko Isobe and Hideo Kaneko
      Drug Metabolism and Disposition May 2010, 38 (5) 824-832; DOI: https://doi.org/10.1124/dmd.109.031914

  7. Tong, Zeen

    1. In Vitro Metabolism and Identification of Human Enzymes Involved in the Metabolism of Methylnaltrexone
      Zeen Tong, Appavu Chandrasekaran, Hongshan Li, Yakov Rotshteyn, John C. L. Erve, William DeMaio, Rasmy Talaat, Theresa Hultin and JoAnn Scatina
      Drug Metabolism and Disposition May 2010, 38 (5) 801-807; DOI: https://doi.org/10.1124/dmd.110.032169

  8. Tonn, George R.

    1. Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/d-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction
      Simon G. Wong, Peter W. Fan, Raju Subramanian, George R. Tonn, Kirk R. Henne, Michael G. Johnson, Michelle Tadano Lohr and Bradley K. Wong
      Drug Metabolism and Disposition May 2010, 38 (5) 841-850; DOI: https://doi.org/10.1124/dmd.109.031344

  9. Tortorici, Michael A.

    1. Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers
      David Hostler, Jiangquan Zhou, Michael A. Tortorici, Robert R. Bies, Jon C. Rittenberger, Philip E. Empey, Patrick M. Kochanek, Clifton W. Callaway and Samuel M. Poloyac
      Drug Metabolism and Disposition May 2010, 38 (5) 781-788; DOI: https://doi.org/10.1124/dmd.109.031377

  10. Tukey, Robert H.

    1. A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation
      Hongliang Cai, Nghia Nguyen, Vincent Peterkin, Young-Sun Yang, Kathy Hotz, Deirdre Beaton La Placa, Shujuan Chen, Robert H. Tukey and Jeffrey C. Stevens
      Drug Metabolism and Disposition May 2010, 38 (5) 879-886; DOI: https://doi.org/10.1124/dmd.109.030130

U

  1. Umans, Jason G.

    1. Pharmacokinetics of Metformin during Pregnancy
      Sara Eyal, Thomas R. Easterling, Darcy Carr, Jason G. Umans, Menachem Miodovnik, Gary D. V. Hankins, Shannon M. Clark, Linda Risler, Joanne Wang, Edward J. Kelly, Danny D. Shen and Mary F. Hebert
      Drug Metabolism and Disposition May 2010, 38 (5) 833-840; DOI: https://doi.org/10.1124/dmd.109.031245

  2. Upadhyaya, Pramod

    1. Formation and Distribution of NNK Metabolites in an Isolated Perfused Rat Lung
      Laura A. Maertens, Pramod Upadhyaya, Stephen S. Hecht and Cheryl L. Zimmerman
      Drug Metabolism and Disposition May 2010, 38 (5) 752-760; DOI: https://doi.org/10.1124/dmd.109.031492

  3. Upton, Richard N.

    1. Inhibition of Morphine Metabolism by Ketamine
      Xiaoxin Qi, Allan M. Evans, Jiping Wang, John O. Miners, Richard N. Upton and Robert W. Milne
      Drug Metabolism and Disposition May 2010, 38 (5) 728-731; DOI: https://doi.org/10.1124/dmd.109.030957

V

  1. Venkataramanan, Raman

    1. Metabolism of 17α-Hydroxyprogesterone Caproate, an Agent for Preventing Preterm Birth, by Fetal Hepatocytes
      Shringi Sharma, Ewa C. S. Ellis, Kenneth Dorko, Shimin Zhang, Donald R. Mattison, Steve N. Caritis, Raman Venkataramanan and Stephen C. Strom
      Drug Metabolism and Disposition May 2010, 38 (5) 723-727; DOI: https://doi.org/10.1124/dmd.109.029918

  2. Vourvahis, Manoli

    1. Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [14C]Lersivirine to Healthy Volunteers
      Manoli Vourvahis, Michelle Gleave, Angus N. R. Nedderman, Ruth Hyland, Iain Gardner, Martin Howard, Sarah Kempshall, Claire Collins and Robert LaBadie
      Drug Metabolism and Disposition May 2010, 38 (5) 789-800; DOI: https://doi.org/10.1124/dmd.109.031252

W

  1. Waldmeier, Felix

    1. Pharmacokinetics, Metabolism, and Disposition of Deferasirox in β-Thalassemic Patients with Transfusion-Dependent Iron Overload Who Are at Pharmacokinetic Steady State
      Felix Waldmeier, Gerard J. Bruin, Ulrike Glaenzel, Katharine Hazell, Romain Sechaud, Steve Warrington and John B. Porter
      Drug Metabolism and Disposition May 2010, 38 (5) 808-816; DOI: https://doi.org/10.1124/dmd.109.030833

  2. Wang, Jiping

    1. Inhibition of Morphine Metabolism by Ketamine
      Xiaoxin Qi, Allan M. Evans, Jiping Wang, John O. Miners, Richard N. Upton and Robert W. Milne
      Drug Metabolism and Disposition May 2010, 38 (5) 728-731; DOI: https://doi.org/10.1124/dmd.109.030957

  3. Wang, Joanne

    1. Pharmacokinetics of Metformin during Pregnancy
      Sara Eyal, Thomas R. Easterling, Darcy Carr, Jason G. Umans, Menachem Miodovnik, Gary D. V. Hankins, Shannon M. Clark, Linda Risler, Joanne Wang, Edward J. Kelly, Danny D. Shen and Mary F. Hebert
      Drug Metabolism and Disposition May 2010, 38 (5) 833-840; DOI: https://doi.org/10.1124/dmd.109.031245

  4. Wang, Lai

    1. Cytochrome P450 1A2 Detoxicates Aristolochic Acid in the Mouse
      Thomas A. Rosenquist, Heidi J. Einolf, Kathleen G. Dickman, Lai Wang, Amanda Smith and Arthur P. Grollman
      Drug Metabolism and Disposition May 2010, 38 (5) 761-768; DOI: https://doi.org/10.1124/dmd.110.032201

  5. Wang, Laiyou

    1. Metabolism-Mediated Drug Interactions Associated with Ritonavir-Boosted Tipranavir in Mice
      Feng Li, Laiyou Wang, Grace L. Guo and Xiaochao Ma
      Drug Metabolism and Disposition May 2010, 38 (5) 871-878; DOI: https://doi.org/10.1124/dmd.109.030817

  6. Warrington, Steve

    1. Pharmacokinetics, Metabolism, and Disposition of Deferasirox in β-Thalassemic Patients with Transfusion-Dependent Iron Overload Who Are at Pharmacokinetic Steady State
      Felix Waldmeier, Gerard J. Bruin, Ulrike Glaenzel, Katharine Hazell, Romain Sechaud, Steve Warrington and John B. Porter
      Drug Metabolism and Disposition May 2010, 38 (5) 808-816; DOI: https://doi.org/10.1124/dmd.109.030833

  7. Wiercinska, P.

    1. Chlorzoxazone Metabolism by Porcine Cytochrome P450 Enzymes and the Effect of Cytochrome b5
      P. Wiercinska and E. J. Squires
      Drug Metabolism and Disposition May 2010, 38 (5) 857-862; DOI: https://doi.org/10.1124/dmd.109.030528

  8. Wong, Bradley K.

    1. Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/d-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction
      Simon G. Wong, Peter W. Fan, Raju Subramanian, George R. Tonn, Kirk R. Henne, Michael G. Johnson, Michelle Tadano Lohr and Bradley K. Wong
      Drug Metabolism and Disposition May 2010, 38 (5) 841-850; DOI: https://doi.org/10.1124/dmd.109.031344

  9. Wong, Simon G.

    1. Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/d-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction
      Simon G. Wong, Peter W. Fan, Raju Subramanian, George R. Tonn, Kirk R. Henne, Michael G. Johnson, Michelle Tadano Lohr and Bradley K. Wong
      Drug Metabolism and Disposition May 2010, 38 (5) 841-850; DOI: https://doi.org/10.1124/dmd.109.031344

Y

  1. Yang, Young-Sun

    1. A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation
      Hongliang Cai, Nghia Nguyen, Vincent Peterkin, Young-Sun Yang, Kathy Hotz, Deirdre Beaton La Placa, Shujuan Chen, Robert H. Tukey and Jeffrey C. Stevens
      Drug Metabolism and Disposition May 2010, 38 (5) 879-886; DOI: https://doi.org/10.1124/dmd.109.030130

  2. Yiap, Beow Chin

    1. Functional Characterization of Cytochrome P450 2A6 Allelic Variants CYP2A6*15, CYP2A6*16, CYP2A6*21, and CYP2A6*22
      Kai Hung Tiong, Beow Chin Yiap, Eng Lai Tan, Rusli Ismail and Chin Eng Ong
      Drug Metabolism and Disposition May 2010, 38 (5) 745-751; DOI: https://doi.org/10.1124/dmd.109.031054

  3. Yun, Chul-Ho

    1. Engineering Bacterial Cytochrome P450 (P450) BM3 into a Prototype with Human P450 Enzyme Activity Using Indigo Formation
      Sun-Ha Park, Dong-Hyun Kim, Dooil Kim, Dae-Hwan Kim, Heung-Chae Jung, Jae-Gu Pan, Taeho Ahn, Donghak Kim and Chul-Ho Yun
      Drug Metabolism and Disposition May 2010, 38 (5) 732-739; DOI: https://doi.org/10.1124/dmd.109.030759

Z

  1. Zeng, Ying-Ying

    1. Interplay of Phase II Enzymes and Transporters in Futile Cycling: Influence of Multidrug Resistance-Associated Protein 2-Mediated Excretion of Estradiol 17β-d-Glucuronide and Its 3-Sulfate Metabolite on Net Sulfation in Perfused TR− and Wistar Rat Liver Preparations
      Huadong Sun, Ying-Ying Zeng and K. Sandy Pang
      Drug Metabolism and Disposition May 2010, 38 (5) 769-780; DOI: https://doi.org/10.1124/dmd.109.029959

  2. Zhang, Shimin

    1. Metabolism of 17α-Hydroxyprogesterone Caproate, an Agent for Preventing Preterm Birth, by Fetal Hepatocytes
      Shringi Sharma, Ewa C. S. Ellis, Kenneth Dorko, Shimin Zhang, Donald R. Mattison, Steve N. Caritis, Raman Venkataramanan and Stephen C. Strom
      Drug Metabolism and Disposition May 2010, 38 (5) 723-727; DOI: https://doi.org/10.1124/dmd.109.029918

  3. Zhao, Yuan-Sheng

    1. Sex-Dependent Differences in Cytochrome P450 3A Activity as Assessed by Midazolam Disposition in Humans: A Meta-Analysis
      Zhe-Yi Hu and Yuan-Sheng Zhao
      Drug Metabolism and Disposition May 2010, 38 (5) 817-823; DOI: https://doi.org/10.1124/dmd.109.031328

  4. Zhou, Diansong

    1. Role of Human UGT2B10 in N-Glucuronidation of Tricyclic Antidepressants, Amitriptyline, Imipramine, Clomipramine, and Trimipramine
      Diansong Zhou, Jian Guo, Alban J. Linnenbach, Catherine L. Booth-Genthe and Scott W. Grimm
      Drug Metabolism and Disposition May 2010, 38 (5) 863-870; DOI: https://doi.org/10.1124/dmd.109.030981

  5. Zhou, Jiangquan

    1. Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers
      David Hostler, Jiangquan Zhou, Michael A. Tortorici, Robert R. Bies, Jon C. Rittenberger, Philip E. Empey, Patrick M. Kochanek, Clifton W. Callaway and Samuel M. Poloyac
      Drug Metabolism and Disposition May 2010, 38 (5) 781-788; DOI: https://doi.org/10.1124/dmd.109.031377

  6. Zimmerman, Cheryl L.

    1. Formation and Distribution of NNK Metabolites in an Isolated Perfused Rat Lung
      Laura A. Maertens, Pramod Upadhyaya, Stephen S. Hecht and Cheryl L. Zimmerman
      Drug Metabolism and Disposition May 2010, 38 (5) 752-760; DOI: https://doi.org/10.1124/dmd.109.031492
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