Table of Contents

Articles

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  In Vitro Characterization of Sarizotan Metabolism: Hepatic Clearance, Identification and Characterization of Metabolites, Drug-Metabolizing Enzyme Identification, and Evaluation of Cytochrome P450 Inhibition

  Dieter Gallemann, Elmar Wimmer, Constance C. Höfer, Achim Freisleben, Markus Fluck, Bernhard Ladstetter and Hugues Dolgos

  Drug Metabolism and Disposition June 2010, 38 (6) 905-916; DOI: https://doi.org/10.1124/dmd.109.029835
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  N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the Blood-Brain Barrier

  Pavitra Kannan, Kyle R. Brimacombe, Sami S. Zoghbi, Jeih-San Liow, Cheryl Morse, Andrew K. Taku, Victor W. Pike, Christer Halldin, Robert B. Innis, Michael M. Gottesman and Matthew D. Hall

  Drug Metabolism and Disposition June 2010, 38 (6) 917-922; DOI: https://doi.org/10.1124/dmd.109.031161
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  Investigation into UDP-Glucuronosyltransferase (UGT) Enzyme Kinetics of Imidazole- and Triazole-Containing Antifungal Drugs in Human Liver Microsomes and Recombinant UGT Enzymes

  Karine Bourcier, Ruth Hyland, Sarah Kempshall, Russell Jones, Jacqueline Maximilien, Nicola Irvine and Barry Jones

  Drug Metabolism and Disposition June 2010, 38 (6) 923-929; DOI: https://doi.org/10.1124/dmd.109.030676
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  Pharmacokinetic Interaction between JBP485 and Cephalexin in Rats

  Jian Zhang, Changyuan Wang, Qi Liu, Qiang Meng, Jian Cang, Huijun Sun, Ying Gao, Taiichi Kaku and Kexin Liu

  Drug Metabolism and Disposition June 2010, 38 (6) 930-938; DOI: https://doi.org/10.1124/dmd.110.032060
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  Intestinal Absorption of γ-Tocotrienol Is Mediated by Niemann-Pick C1-Like 1: In Situ Rat Intestinal Perfusion Studies

  Bilal Abuasal, Paul W. Sylvester and Amal Kaddoumi

  Drug Metabolism and Disposition June 2010, 38 (6) 939-945; DOI: https://doi.org/10.1124/dmd.109.031567
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  Identification of Novel Metabolic Pathways of Pioglitazone in Hepatocytes: N-Glucuronidation of Thiazolidinedione Ring and Sequential Ring-Opening Pathway

  Minoru Uchiyama, Thomas Fischer, Juergen Mueller, Minoru Oguchi, Naotoshi Yamamura, Hiroko Koda, Haruo Iwabuchi and Takashi Izumi

  Drug Metabolism and Disposition June 2010, 38 (6) 946-956; DOI: https://doi.org/10.1124/dmd.109.031583
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  In Vitro Glucuronidation of 2,2-Bis(bromomethyl)-1,3-propanediol by Microsomes and Hepatocytes from Rats and Humans

  Golriz Rad, Simone I. Hoehle, Robert K. Kuester and I. Glenn Sipes

  Drug Metabolism and Disposition June 2010, 38 (6) 957-962; DOI: https://doi.org/10.1124/dmd.110.032110
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  Sequential Metabolism of Secondary Alkyl Amines to Metabolic-Intermediate Complexes: Opposing Roles for the Secondary Hydroxylamine and Primary Amine Metabolites of Desipramine, (S)-Fluoxetine, and N-Desmethyldiltiazem

  Kelsey L. Hanson, Brooke M. VandenBrink, Kantipudi N. Babu, Kyle E. Allen, Wendel L. Nelson and Kent L. Kunze

  Drug Metabolism and Disposition June 2010, 38 (6) 963-972; DOI: https://doi.org/10.1124/dmd.110.032391
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  Identification and Characterization of Human UDP-Glucuronosyltransferases Responsible for the In Vitro Glucuronidation of Daphnetin

  Si-Cheng Liang, Guang-Bo Ge, Hui-Xin Liu, Yan-Yan Zhang, Li-Ming Wang, Jiang-Wei Zhang, Lu Yin, Wei Li, Zhong-Ze Fang, Jing-Jing Wu, Guo-Hui Li and Ling Yang

  Drug Metabolism and Disposition June 2010, 38 (6) 973-980; DOI: https://doi.org/10.1124/dmd.109.030734
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  Selection of Alternative CYP3A4 Probe Substrates for Clinical Drug Interaction Studies Using In Vitro Data and In Vivo Simulation

  Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom

  Drug Metabolism and Disposition June 2010, 38 (6) 981-987; DOI: https://doi.org/10.1124/dmd.110.032094
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  A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues

  Steven N. Hart, Ye Li, Kaori Nakamoto, Eva-anne Subileau, David Steen and Xiao-bo Zhong

  Drug Metabolism and Disposition June 2010, 38 (6) 988-994; DOI: https://doi.org/10.1124/dmd.109.031831
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  CYP3A4 Catalytic Activity Is Induced in Confluent Huh7 Hepatoma Cells

  Louise Sivertsson, Monica Ek, Malin Darnell, Irene Edebert, Magnus Ingelman-Sundberg and Etienne P. A. Neve

  Drug Metabolism and Disposition June 2010, 38 (6) 995-1002; DOI: https://doi.org/10.1124/dmd.110.032367
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  CYP2C9-CYP3A4 Protein-Protein Interactions: Role of the Hydrophobic N Terminus

  Murali Subramanian, Harrison Tam, Helen Zheng and Timothy S. Tracy

  Drug Metabolism and Disposition June 2010, 38 (6) 1003-1009; DOI: https://doi.org/10.1124/dmd.109.030155