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Drug Metabolism & Disposition

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Table of Contents

June 01, 2010; Volume 38,Issue 6

Short Communications

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    Human Liver Expression of CYP2C8: Gender, Age, and Genotype Effects
    Suresh Babu Naraharisetti, Yvonne S. Lin, Mark J. Rieder, Kristin D. Marciante, Bruce M. Psaty, Kenneth E. Thummel and Rheem A. Totah
    Drug Metabolism and Disposition June 2010, 38 (6) 889-893; DOI: https://doi.org/10.1124/dmd.109.031542
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    Impact of the CYP2C19*17 Allele on the Pharmacokinetics of Omeprazole and Pantoprazole in Children: Evidence for a Differential Effect
    Gregory L. Kearns, J. Steven Leeder and Andrea Gaedigk
    Drug Metabolism and Disposition June 2010, 38 (6) 894-897; DOI: https://doi.org/10.1124/dmd.109.030601
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    Biotransformation of Prasugrel, a Novel Thienopyridine Antiplatelet Agent, to the Pharmacologically Active Metabolite
    Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Haruo Iwabuchi, Minoru Ishikawa, Hiroyuki Kobayashi, Naoki Tanaka, Osamu Okazaki, Nagy A. Farid and Toshihiko Ikeda
    Drug Metabolism and Disposition June 2010, 38 (6) 898-904; DOI: https://doi.org/10.1124/dmd.110.032086

Articles

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    In Vitro Characterization of Sarizotan Metabolism: Hepatic Clearance, Identification and Characterization of Metabolites, Drug-Metabolizing Enzyme Identification, and Evaluation of Cytochrome P450 Inhibition
    Dieter Gallemann, Elmar Wimmer, Constance C. Höfer, Achim Freisleben, Markus Fluck, Bernhard Ladstetter and Hugues Dolgos
    Drug Metabolism and Disposition June 2010, 38 (6) 905-916; DOI: https://doi.org/10.1124/dmd.109.029835
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    N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the Blood-Brain Barrier
    Pavitra Kannan, Kyle R. Brimacombe, Sami S. Zoghbi, Jeih-San Liow, Cheryl Morse, Andrew K. Taku, Victor W. Pike, Christer Halldin, Robert B. Innis, Michael M. Gottesman and Matthew D. Hall
    Drug Metabolism and Disposition June 2010, 38 (6) 917-922; DOI: https://doi.org/10.1124/dmd.109.031161
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    Investigation into UDP-Glucuronosyltransferase (UGT) Enzyme Kinetics of Imidazole- and Triazole-Containing Antifungal Drugs in Human Liver Microsomes and Recombinant UGT Enzymes
    Karine Bourcier, Ruth Hyland, Sarah Kempshall, Russell Jones, Jacqueline Maximilien, Nicola Irvine and Barry Jones
    Drug Metabolism and Disposition June 2010, 38 (6) 923-929; DOI: https://doi.org/10.1124/dmd.109.030676
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    Pharmacokinetic Interaction between JBP485 and Cephalexin in Rats
    Jian Zhang, Changyuan Wang, Qi Liu, Qiang Meng, Jian Cang, Huijun Sun, Ying Gao, Taiichi Kaku and Kexin Liu
    Drug Metabolism and Disposition June 2010, 38 (6) 930-938; DOI: https://doi.org/10.1124/dmd.110.032060
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    Intestinal Absorption of γ-Tocotrienol Is Mediated by Niemann-Pick C1-Like 1: In Situ Rat Intestinal Perfusion Studies
    Bilal Abuasal, Paul W. Sylvester and Amal Kaddoumi
    Drug Metabolism and Disposition June 2010, 38 (6) 939-945; DOI: https://doi.org/10.1124/dmd.109.031567
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    Identification of Novel Metabolic Pathways of Pioglitazone in Hepatocytes: N-Glucuronidation of Thiazolidinedione Ring and Sequential Ring-Opening Pathway
    Minoru Uchiyama, Thomas Fischer, Juergen Mueller, Minoru Oguchi, Naotoshi Yamamura, Hiroko Koda, Haruo Iwabuchi and Takashi Izumi
    Drug Metabolism and Disposition June 2010, 38 (6) 946-956; DOI: https://doi.org/10.1124/dmd.109.031583
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    In Vitro Glucuronidation of 2,2-Bis(bromomethyl)-1,3-propanediol by Microsomes and Hepatocytes from Rats and Humans
    Golriz Rad, Simone I. Hoehle, Robert K. Kuester and I. Glenn Sipes
    Drug Metabolism and Disposition June 2010, 38 (6) 957-962; DOI: https://doi.org/10.1124/dmd.110.032110
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    Sequential Metabolism of Secondary Alkyl Amines to Metabolic-Intermediate Complexes: Opposing Roles for the Secondary Hydroxylamine and Primary Amine Metabolites of Desipramine, (S)-Fluoxetine, and N-Desmethyldiltiazem
    Kelsey L. Hanson, Brooke M. VandenBrink, Kantipudi N. Babu, Kyle E. Allen, Wendel L. Nelson and Kent L. Kunze
    Drug Metabolism and Disposition June 2010, 38 (6) 963-972; DOI: https://doi.org/10.1124/dmd.110.032391
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    Identification and Characterization of Human UDP-Glucuronosyltransferases Responsible for the In Vitro Glucuronidation of Daphnetin
    Si-Cheng Liang, Guang-Bo Ge, Hui-Xin Liu, Yan-Yan Zhang, Li-Ming Wang, Jiang-Wei Zhang, Lu Yin, Wei Li, Zhong-Ze Fang, Jing-Jing Wu, Guo-Hui Li and Ling Yang
    Drug Metabolism and Disposition June 2010, 38 (6) 973-980; DOI: https://doi.org/10.1124/dmd.109.030734
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    Selection of Alternative CYP3A4 Probe Substrates for Clinical Drug Interaction Studies Using In Vitro Data and In Vivo Simulation
    Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom
    Drug Metabolism and Disposition June 2010, 38 (6) 981-987; DOI: https://doi.org/10.1124/dmd.110.032094
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    A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues
    Steven N. Hart, Ye Li, Kaori Nakamoto, Eva-anne Subileau, David Steen and Xiao-bo Zhong
    Drug Metabolism and Disposition June 2010, 38 (6) 988-994; DOI: https://doi.org/10.1124/dmd.109.031831
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    CYP3A4 Catalytic Activity Is Induced in Confluent Huh7 Hepatoma Cells
    Louise Sivertsson, Monica Ek, Malin Darnell, Irene Edebert, Magnus Ingelman-Sundberg and Etienne P. A. Neve
    Drug Metabolism and Disposition June 2010, 38 (6) 995-1002; DOI: https://doi.org/10.1124/dmd.110.032367
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    CYP2C9-CYP3A4 Protein-Protein Interactions: Role of the Hydrophobic N Terminus
    Murali Subramanian, Harrison Tam, Helen Zheng and Timothy S. Tracy
    Drug Metabolism and Disposition June 2010, 38 (6) 1003-1009; DOI: https://doi.org/10.1124/dmd.109.030155
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In this issue

Drug Metabolism and Disposition: 38 (6)
Drug Metabolism and Disposition
Vol. 38, Issue 6
1 Jun 2010
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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