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Research ArticleArticle

Identification of Novel Metabolic Pathways of Pioglitazone in Hepatocytes: N-Glucuronidation of Thiazolidinedione Ring and Sequential Ring-Opening Pathway

Minoru Uchiyama, Thomas Fischer, Juergen Mueller, Minoru Oguchi, Naotoshi Yamamura, Hiroko Koda, Haruo Iwabuchi and Takashi Izumi
Drug Metabolism and Disposition June 2010, 38 (6) 946-956; DOI: https://doi.org/10.1124/dmd.109.031583
Minoru Uchiyama
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Thomas Fischer
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Juergen Mueller
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Minoru Oguchi
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Naotoshi Yamamura
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Hiroko Koda
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Haruo Iwabuchi
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Takashi Izumi
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Article Information

vol. 38 no. 6 946-956
DOI 
https://doi.org/10.1124/dmd.109.031583
PubMed 
20185540

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 8, 2009
  • Accepted February 25, 2010
  • Published online May 13, 2010.

Article Versions

  • Earlier version (February 25, 2010 - 06:30).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Minoru Uchiyama,
  2. Thomas Fischer,
  3. Juergen Mueller,
  4. Minoru Oguchi,
  5. Naotoshi Yamamura,
  6. Hiroko Koda,
  7. Haruo Iwabuchi and
  8. Takashi Izumi
  1. Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan (M.U., N.Y., H.K., H.I., T.I.); Drug Metabolism Department, Daiichi Sankyo Europe GmbH, Martinsried, Germany (T.F., J.M.); and Research Department I, Daiichi Sankyo RD Associe Co., Ltd., Tokyo, Japan (M.O.)
  1. Address correspondence to:
    Takashi Izumi, Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan. E-mail: izumi.takashi.ka{at}daiichisankyo.co.jp
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Drug Metabolism and Disposition: 38 (6)
Drug Metabolism and Disposition
Vol. 38, Issue 6
1 Jun 2010
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Research ArticleArticle

Identification of Novel Metabolic Pathways of Pioglitazone in Hepatocytes: N-Glucuronidation of Thiazolidinedione Ring and Sequential Ring-Opening Pathway

Minoru Uchiyama, Thomas Fischer, Juergen Mueller, Minoru Oguchi, Naotoshi Yamamura, Hiroko Koda, Haruo Iwabuchi and Takashi Izumi
Drug Metabolism and Disposition June 1, 2010, 38 (6) 946-956; DOI: https://doi.org/10.1124/dmd.109.031583

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Research ArticleArticle

Identification of Novel Metabolic Pathways of Pioglitazone in Hepatocytes: N-Glucuronidation of Thiazolidinedione Ring and Sequential Ring-Opening Pathway

Minoru Uchiyama, Thomas Fischer, Juergen Mueller, Minoru Oguchi, Naotoshi Yamamura, Hiroko Koda, Haruo Iwabuchi and Takashi Izumi
Drug Metabolism and Disposition June 1, 2010, 38 (6) 946-956; DOI: https://doi.org/10.1124/dmd.109.031583
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