Table of Contents

Articles

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  Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling

  Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop

  Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680
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  Significant Increase in Phenacetin Oxidation on L382V Substitution in Human Cytochrome P450 1A2

  Qingbiao Huang and Grazyna D. Szklarz

  Drug Metabolism and Disposition July 2010, 38 (7) 1039-1045; DOI: https://doi.org/10.1124/dmd.109.030767
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  In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice

  Nico Scheer, Jillian Ross, Yury Kapelyukh, Anja Rode and C. Roland Wolf

  Drug Metabolism and Disposition July 2010, 38 (7) 1046-1053; DOI: https://doi.org/10.1124/dmd.109.031872
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  Vectorial Transport of Nucleoside Analogs from the Apical to the Basolateral Membrane in Double-Transfected Cells Expressing the Human Concentrative Nucleoside Transporter hCNT3 and the Export Pump ABCC4

  Maria Rius, Daniela Keller, Manuela Brom, Johanna Hummel-Eisenbeiss, Frank Lyko and Dietrich Keppler

  Drug Metabolism and Disposition July 2010, 38 (7) 1054-1063; DOI: https://doi.org/10.1124/dmd.110.032664
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  Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Kidney Drug Transporters

  Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues

  Drug Metabolism and Disposition July 2010, 38 (7) 1064-1071; DOI: https://doi.org/10.1124/dmd.109.031526
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  Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Liver Drug Transporters

  Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues

  Drug Metabolism and Disposition July 2010, 38 (7) 1072-1082; DOI: https://doi.org/10.1124/dmd.109.031518
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  Characterization of HKI-272 Covalent Binding to Human Serum Albumin

  Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat

  Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292
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  Confidence Assessment of the Simcyp Time-Based Approach and a Static Mathematical Model in Predicting Clinical Drug-Drug Interactions for Mechanism-Based CYP3A Inhibitors

  Ying-Hong Wang

  Drug Metabolism and Disposition July 2010, 38 (7) 1094-1104; DOI: https://doi.org/10.1124/dmd.110.032177
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  Differential Roles of Phase I and Phase II Enzymes in 3,4-Methylendioxymethamphetamine-Induced Cytotoxicity

  Irene Antolino-Lobo, Jan Meulenbelt, Sandra M. Nijmeijer, Peter Scherpenisse, Martin van den Berg and Majorie B. M. van Duursen

  Drug Metabolism and Disposition July 2010, 38 (7) 1105-1112; DOI: https://doi.org/10.1124/dmd.110.032359
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  In Vitro-In Vivo Correlation and Translation to the Clinical Outcome for CJ-13,610, a Novel Inhibitor of 5-Lipoxygenase

  J. Matthew Hutzler, Collette D. Linder, Roger J. Melton, John Vincent and J. Scott Daniels

  Drug Metabolism and Disposition July 2010, 38 (7) 1113-1121; DOI: https://doi.org/10.1124/dmd.110.032706
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  Energy Restriction Does Not Compensate for the Reduced Expression of Hepatic Drug-Processing Genes in Mice with Aging

  Yu-Kun Jennifer Zhang, Kurt W. Saupe and Curtis D. Klaassen

  Drug Metabolism and Disposition July 2010, 38 (7) 1122-1131; DOI: https://doi.org/10.1124/dmd.110.032599
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  Regioselective Glucuronidation of Tanshinone IIa after Quinone Reduction: Identification of Human UDP-Glucuronosyltransferases, Species Differences, and Interaction Potential

  Qiong Wang, Haiping Hao, Xuanxuan Zhu, Guo Yu, Li Lai, Yitong Liu, Yuxin Wang, Shan Jiang and Guangji Wang

  Drug Metabolism and Disposition July 2010, 38 (7) 1132-1140; DOI: https://doi.org/10.1124/dmd.109.031864
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  Identification of the Human UDP-Glucuronosyltransferases Involved in the Glucuronidation of Combretastatin A-4

  Silvio Aprile, Erika Del Grosso and Giorgio Grosa

  Drug Metabolism and Disposition July 2010, 38 (7) 1141-1146; DOI: https://doi.org/10.1124/dmd.109.031435
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  Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data

  Michael Gertz, Anthony Harrison, J. Brian Houston and Aleksandra Galetin

  Drug Metabolism and Disposition July 2010, 38 (7) 1147-1158; DOI: https://doi.org/10.1124/dmd.110.032649
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  Use of the Øie-Tozer Model in Understanding Mechanisms and Determinants of Drug Distribution

  Nigel J. Waters and Franco Lombardo

  Drug Metabolism and Disposition July 2010, 38 (7) 1159-1165; DOI: https://doi.org/10.1124/dmd.110.032458
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  Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation

  David J. Sweeny, Weiqun Li, Jeffrey Clough, Somasekhar Bhamidipati, Rajinder Singh, Gary Park, Muhammad Baluom, Elliott Grossbard and David T.-W. Lau

  Drug Metabolism and Disposition July 2010, 38 (7) 1166-1176; DOI: https://doi.org/10.1124/dmd.110.032151
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  The Nuclear Receptors Constitutive Active/Androstane Receptor and Pregnane X Receptor Activate the Cyp2c55 Gene in Mouse Liver

  Yoshihiro Konno, Hiroki Kamino, Rick Moore, Fred Lih, Kenneth B. Tomer, Darryl C. Zeldin, Joyce A. Goldstein and Masahiko Negishi

  Drug Metabolism and Disposition July 2010, 38 (7) 1177-1182; DOI: https://doi.org/10.1124/dmd.110.032334
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  Contribution of Rat Pulmonary Metabolism to the Elimination of Lidocaine, Midazolam, and Nifedipine

  Makoto Aoki, Kazuho Okudaira, Makoto Haga, Ryuichiro Nishigaki and Masahiro Hayashi

  Drug Metabolism and Disposition July 2010, 38 (7) 1183-1188; DOI: https://doi.org/10.1124/dmd.110.032227
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  Metabolism and Disposition of [¹⁴C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs

  Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V. Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher

  Drug Metabolism and Disposition July 2010, 38 (7) 1189-1201; DOI: https://doi.org/10.1124/dmd.110.032755
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  Identification of the Human Enzymes Responsible for the Enzymatic Hydrolysis of Aclidinium Bromide

  Joan Albertí, Audrey Martinet, Sònia Sentellas and Miquel Salvà

  Drug Metabolism and Disposition July 2010, 38 (7) 1202-1210; DOI: https://doi.org/10.1124/dmd.109.031724
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  Role of UDP-Glucuronosyltransferase Isoforms in 13-cis Retinoic Acid Metabolism in Humans

  Sophie E. Rowbotham, Nicola A. Illingworth, Ann K. Daly, Gareth J. Veal and Alan V. Boddy

  Drug Metabolism and Disposition July 2010, 38 (7) 1211-1217; DOI: https://doi.org/10.1124/dmd.109.031625
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  Efavirenz Primary and Secondary Metabolism In Vitro and In Vivo: Identification of Novel Metabolic Pathways and Cytochrome P450 2A6 as the Principal Catalyst of Efavirenz 7-Hydroxylation

  Evan T. Ogburn, David R. Jones, Andrea R. Masters, Cong Xu, Yingying Guo and Zeruesenay Desta

  Drug Metabolism and Disposition July 2010, 38 (7) 1218-1229; DOI: https://doi.org/10.1124/dmd.109.031393
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  Quantitative Prediction of Intestinal Metabolism in Humans from a Simplified Intestinal Availability Model and Empirical Scaling Factor

  Keitaro Kadono, Takafumi Akabane, Kenji Tabata, Katsuhiko Gato, Shigeyuki Terashita and Toshio Teramura

  Drug Metabolism and Disposition July 2010, 38 (7) 1230-1237; DOI: https://doi.org/10.1124/dmd.109.029322
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  Cytochrome P450-Mediated Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Erlotinib to a Reactive Electrophile

  Xiaohai Li, Theodore M. Kamenecka and Michael D. Cameron

  Drug Metabolism and Disposition July 2010, 38 (7) 1238-1245; DOI: https://doi.org/10.1124/dmd.109.030361
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  Shared Regulation of UGT1A7 by Hepatocyte Nuclear Factor (HNF) 1α and HNF4α

  Ursula Ehmer, Sandra Kalthoff, Tim O. Lankisch, Nicole Freiberg, Michael P. Manns and Christian P. Strassburg

  Drug Metabolism and Disposition July 2010, 38 (7) 1246-1257; DOI: https://doi.org/10.1124/dmd.109.030403