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Drug Metabolism & Disposition

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Table of Contents

July 01, 2010; Volume 38,Issue 7

Short Communications

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    Spironolactone and Canrenone Inhibit UGT2B7-Catalyzed Human Liver and Kidney Microsomal Aldosterone 18β-Glucuronidation: A Potential Drug Interaction
    Kathleen M. Knights, Kushari Bowalgaha and John O. Miners
    Drug Metabolism and Disposition July 2010, 38 (7) 1011-1014; DOI: https://doi.org/10.1124/dmd.110.032870
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    Expression and Characterization of Dog Cytochrome P450 2A13 and 2A25 in Baculovirus-Infected Insect Cells
    Diansong Zhou, Alban J. Linnenbach, Ruifeng Liu, Rick A. Luzietti, Jennifer J. Harris, Catherine L. Booth-Genthe and Scott W. Grimm
    Drug Metabolism and Disposition July 2010, 38 (7) 1015-1018; DOI: https://doi.org/10.1124/dmd.110.033068
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    Potential Application of d-Optimal Designs in the Efficient Investigation of Cytochrome P450 Inhibition Kinetic Models
    Kuresh A. Youdim, Anthony C. Atkinson, Maciej Patan, Barbara Bogacka and Patrick J. Johnson
    Drug Metabolism and Disposition July 2010, 38 (7) 1019-1023; DOI: https://doi.org/10.1124/dmd.110.033142
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    Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA: Role of Human Organic Anion Transporters
    Mirko Leonhardt, Markus Keiser, Stefan Oswald, Jens Kühn, Jia Jia, Markus Grube, Heyo K. Kroemer, Werner Siegmund and Werner Weitschies
    Drug Metabolism and Disposition July 2010, 38 (7) 1024-1028; DOI: https://doi.org/10.1124/dmd.110.032862

Articles

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    Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
    Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
    Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680
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    Significant Increase in Phenacetin Oxidation on L382V Substitution in Human Cytochrome P450 1A2
    Qingbiao Huang and Grazyna D. Szklarz
    Drug Metabolism and Disposition July 2010, 38 (7) 1039-1045; DOI: https://doi.org/10.1124/dmd.109.030767
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    In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice
    Nico Scheer, Jillian Ross, Yury Kapelyukh, Anja Rode and C. Roland Wolf
    Drug Metabolism and Disposition July 2010, 38 (7) 1046-1053; DOI: https://doi.org/10.1124/dmd.109.031872
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    Vectorial Transport of Nucleoside Analogs from the Apical to the Basolateral Membrane in Double-Transfected Cells Expressing the Human Concentrative Nucleoside Transporter hCNT3 and the Export Pump ABCC4
    Maria Rius, Daniela Keller, Manuela Brom, Johanna Hummel-Eisenbeiss, Frank Lyko and Dietrich Keppler
    Drug Metabolism and Disposition July 2010, 38 (7) 1054-1063; DOI: https://doi.org/10.1124/dmd.110.032664
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    Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Kidney Drug Transporters
    Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
    Drug Metabolism and Disposition July 2010, 38 (7) 1064-1071; DOI: https://doi.org/10.1124/dmd.109.031526
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    Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Liver Drug Transporters
    Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
    Drug Metabolism and Disposition July 2010, 38 (7) 1072-1082; DOI: https://doi.org/10.1124/dmd.109.031518
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    Characterization of HKI-272 Covalent Binding to Human Serum Albumin
    Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
    Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292
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    Confidence Assessment of the Simcyp Time-Based Approach and a Static Mathematical Model in Predicting Clinical Drug-Drug Interactions for Mechanism-Based CYP3A Inhibitors
    Ying-Hong Wang
    Drug Metabolism and Disposition July 2010, 38 (7) 1094-1104; DOI: https://doi.org/10.1124/dmd.110.032177
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    Differential Roles of Phase I and Phase II Enzymes in 3,4-Methylendioxymethamphetamine-Induced Cytotoxicity
    Irene Antolino-Lobo, Jan Meulenbelt, Sandra M. Nijmeijer, Peter Scherpenisse, Martin van den Berg and Majorie B. M. van Duursen
    Drug Metabolism and Disposition July 2010, 38 (7) 1105-1112; DOI: https://doi.org/10.1124/dmd.110.032359
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    In Vitro-In Vivo Correlation and Translation to the Clinical Outcome for CJ-13,610, a Novel Inhibitor of 5-Lipoxygenase
    J. Matthew Hutzler, Collette D. Linder, Roger J. Melton, John Vincent and J. Scott Daniels
    Drug Metabolism and Disposition July 2010, 38 (7) 1113-1121; DOI: https://doi.org/10.1124/dmd.110.032706
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    Energy Restriction Does Not Compensate for the Reduced Expression of Hepatic Drug-Processing Genes in Mice with Aging
    Yu-Kun Jennifer Zhang, Kurt W. Saupe and Curtis D. Klaassen
    Drug Metabolism and Disposition July 2010, 38 (7) 1122-1131; DOI: https://doi.org/10.1124/dmd.110.032599
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    Regioselective Glucuronidation of Tanshinone IIa after Quinone Reduction: Identification of Human UDP-Glucuronosyltransferases, Species Differences, and Interaction Potential
    Qiong Wang, Haiping Hao, Xuanxuan Zhu, Guo Yu, Li Lai, Yitong Liu, Yuxin Wang, Shan Jiang and Guangji Wang
    Drug Metabolism and Disposition July 2010, 38 (7) 1132-1140; DOI: https://doi.org/10.1124/dmd.109.031864
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    Identification of the Human UDP-Glucuronosyltransferases Involved in the Glucuronidation of Combretastatin A-4
    Silvio Aprile, Erika Del Grosso and Giorgio Grosa
    Drug Metabolism and Disposition July 2010, 38 (7) 1141-1146; DOI: https://doi.org/10.1124/dmd.109.031435
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    Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data
    Michael Gertz, Anthony Harrison, J. Brian Houston and Aleksandra Galetin
    Drug Metabolism and Disposition July 2010, 38 (7) 1147-1158; DOI: https://doi.org/10.1124/dmd.110.032649
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    Use of the Øie-Tozer Model in Understanding Mechanisms and Determinants of Drug Distribution
    Nigel J. Waters and Franco Lombardo
    Drug Metabolism and Disposition July 2010, 38 (7) 1159-1165; DOI: https://doi.org/10.1124/dmd.110.032458
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    Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
    David J. Sweeny, Weiqun Li, Jeffrey Clough, Somasekhar Bhamidipati, Rajinder Singh, Gary Park, Muhammad Baluom, Elliott Grossbard and David T.-W. Lau
    Drug Metabolism and Disposition July 2010, 38 (7) 1166-1176; DOI: https://doi.org/10.1124/dmd.110.032151
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    The Nuclear Receptors Constitutive Active/Androstane Receptor and Pregnane X Receptor Activate the Cyp2c55 Gene in Mouse Liver
    Yoshihiro Konno, Hiroki Kamino, Rick Moore, Fred Lih, Kenneth B. Tomer, Darryl C. Zeldin, Joyce A. Goldstein and Masahiko Negishi
    Drug Metabolism and Disposition July 2010, 38 (7) 1177-1182; DOI: https://doi.org/10.1124/dmd.110.032334
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    Contribution of Rat Pulmonary Metabolism to the Elimination of Lidocaine, Midazolam, and Nifedipine
    Makoto Aoki, Kazuho Okudaira, Makoto Haga, Ryuichiro Nishigaki and Masahiro Hayashi
    Drug Metabolism and Disposition July 2010, 38 (7) 1183-1188; DOI: https://doi.org/10.1124/dmd.110.032227
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    Metabolism and Disposition of [14C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs
    Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V. Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher
    Drug Metabolism and Disposition July 2010, 38 (7) 1189-1201; DOI: https://doi.org/10.1124/dmd.110.032755
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    Identification of the Human Enzymes Responsible for the Enzymatic Hydrolysis of Aclidinium Bromide
    Joan Albertí, Audrey Martinet, Sònia Sentellas and Miquel Salvà
    Drug Metabolism and Disposition July 2010, 38 (7) 1202-1210; DOI: https://doi.org/10.1124/dmd.109.031724
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    Role of UDP-Glucuronosyltransferase Isoforms in 13-cis Retinoic Acid Metabolism in Humans
    Sophie E. Rowbotham, Nicola A. Illingworth, Ann K. Daly, Gareth J. Veal and Alan V. Boddy
    Drug Metabolism and Disposition July 2010, 38 (7) 1211-1217; DOI: https://doi.org/10.1124/dmd.109.031625
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    Efavirenz Primary and Secondary Metabolism In Vitro and In Vivo: Identification of Novel Metabolic Pathways and Cytochrome P450 2A6 as the Principal Catalyst of Efavirenz 7-Hydroxylation
    Evan T. Ogburn, David R. Jones, Andrea R. Masters, Cong Xu, Yingying Guo and Zeruesenay Desta
    Drug Metabolism and Disposition July 2010, 38 (7) 1218-1229; DOI: https://doi.org/10.1124/dmd.109.031393
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    Quantitative Prediction of Intestinal Metabolism in Humans from a Simplified Intestinal Availability Model and Empirical Scaling Factor
    Keitaro Kadono, Takafumi Akabane, Kenji Tabata, Katsuhiko Gato, Shigeyuki Terashita and Toshio Teramura
    Drug Metabolism and Disposition July 2010, 38 (7) 1230-1237; DOI: https://doi.org/10.1124/dmd.109.029322
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    Cytochrome P450-Mediated Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Erlotinib to a Reactive Electrophile
    Xiaohai Li, Theodore M. Kamenecka and Michael D. Cameron
    Drug Metabolism and Disposition July 2010, 38 (7) 1238-1245; DOI: https://doi.org/10.1124/dmd.109.030361
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    Shared Regulation of UGT1A7 by Hepatocyte Nuclear Factor (HNF) 1α and HNF4α
    Ursula Ehmer, Sandra Kalthoff, Tim O. Lankisch, Nicole Freiberg, Michael P. Manns and Christian P. Strassburg
    Drug Metabolism and Disposition July 2010, 38 (7) 1246-1257; DOI: https://doi.org/10.1124/dmd.109.030403

Errata

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    Correction to “5′-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms: Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters”
    Drug Metabolism and Disposition July 2010, 38 (7) 1258; DOI: https://doi.org/10.1124/dmd.38.7.1258
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    Correction to “Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries”
    Drug Metabolism and Disposition July 2010, 38 (7) 1259; DOI: https://doi.org/10.1124/dmd.38.7.1259
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Drug Metabolism and Disposition: 38 (7)
Drug Metabolism and Disposition
Vol. 38, Issue 7
1 Jul 2010
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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