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Index by author

July 01, 2010; Volume 38,Issue 7

A

  1. Ahmad, Syed

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

  2. Akabane, Takafumi

    1. Quantitative Prediction of Intestinal Metabolism in Humans from a Simplified Intestinal Availability Model and Empirical Scaling Factor
      Keitaro Kadono, Takafumi Akabane, Kenji Tabata, Katsuhiko Gato, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition July 2010, 38 (7) 1230-1237; DOI: https://doi.org/10.1124/dmd.109.029322

  3. Albertí, Joan

    1. Identification of the Human Enzymes Responsible for the Enzymatic Hydrolysis of Aclidinium Bromide
      Joan Albertí, Audrey Martinet, Sònia Sentellas and Miquel Salvà
      Drug Metabolism and Disposition July 2010, 38 (7) 1202-1210; DOI: https://doi.org/10.1124/dmd.109.031724

  4. Allentoff, Alban

    1. Metabolism and Disposition of [14C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs
      Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V. Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher
      Drug Metabolism and Disposition July 2010, 38 (7) 1189-1201; DOI: https://doi.org/10.1124/dmd.110.032755

  5. Antolino-Lobo, Irene

    1. Differential Roles of Phase I and Phase II Enzymes in 3,4-Methylendioxymethamphetamine-Induced Cytotoxicity
      Irene Antolino-Lobo, Jan Meulenbelt, Sandra M. Nijmeijer, Peter Scherpenisse, Martin van den Berg and Majorie B. M. van Duursen
      Drug Metabolism and Disposition July 2010, 38 (7) 1105-1112; DOI: https://doi.org/10.1124/dmd.110.032359

  6. Aoki, Makoto

    1. Contribution of Rat Pulmonary Metabolism to the Elimination of Lidocaine, Midazolam, and Nifedipine
      Makoto Aoki, Kazuho Okudaira, Makoto Haga, Ryuichiro Nishigaki and Masahiro Hayashi
      Drug Metabolism and Disposition July 2010, 38 (7) 1183-1188; DOI: https://doi.org/10.1124/dmd.110.032227

  7. Aprile, Silvio

    1. Identification of the Human UDP-Glucuronosyltransferases Involved in the Glucuronidation of Combretastatin A-4
      Silvio Aprile, Erika Del Grosso and Giorgio Grosa
      Drug Metabolism and Disposition July 2010, 38 (7) 1141-1146; DOI: https://doi.org/10.1124/dmd.109.031435

  8. Atherton, Jim

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

  9. Atkinson, Anthony C.

    1. Potential Application of d-Optimal Designs in the Efficient Investigation of Cytochrome P450 Inhibition Kinetic Models
      Kuresh A. Youdim, Anthony C. Atkinson, Maciej Patan, Barbara Bogacka and Patrick J. Johnson
      Drug Metabolism and Disposition July 2010, 38 (7) 1019-1023; DOI: https://doi.org/10.1124/dmd.110.033142

B

  1. Baluom, Muhammad

    1. Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
      David J. Sweeny, Weiqun Li, Jeffrey Clough, Somasekhar Bhamidipati, Rajinder Singh, Gary Park, Muhammad Baluom, Elliott Grossbard and David T.-W. Lau
      Drug Metabolism and Disposition July 2010, 38 (7) 1166-1176; DOI: https://doi.org/10.1124/dmd.110.032151

  2. Bhamidipati, Somasekhar

    1. Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
      David J. Sweeny, Weiqun Li, Jeffrey Clough, Somasekhar Bhamidipati, Rajinder Singh, Gary Park, Muhammad Baluom, Elliott Grossbard and David T.-W. Lau
      Drug Metabolism and Disposition July 2010, 38 (7) 1166-1176; DOI: https://doi.org/10.1124/dmd.110.032151

  3. Boddy, Alan V.

    1. Role of UDP-Glucuronosyltransferase Isoforms in 13-cis Retinoic Acid Metabolism in Humans
      Sophie E. Rowbotham, Nicola A. Illingworth, Ann K. Daly, Gareth J. Veal and Alan V. Boddy
      Drug Metabolism and Disposition July 2010, 38 (7) 1211-1217; DOI: https://doi.org/10.1124/dmd.109.031625

  4. Bogacka, Barbara

    1. Potential Application of d-Optimal Designs in the Efficient Investigation of Cytochrome P450 Inhibition Kinetic Models
      Kuresh A. Youdim, Anthony C. Atkinson, Maciej Patan, Barbara Bogacka and Patrick J. Johnson
      Drug Metabolism and Disposition July 2010, 38 (7) 1019-1023; DOI: https://doi.org/10.1124/dmd.110.033142

  5. Booth-Genthe, Catherine L.

    1. Expression and Characterization of Dog Cytochrome P450 2A13 and 2A25 in Baculovirus-Infected Insect Cells
      Diansong Zhou, Alban J. Linnenbach, Ruifeng Liu, Rick A. Luzietti, Jennifer J. Harris, Catherine L. Booth-Genthe and Scott W. Grimm
      Drug Metabolism and Disposition July 2010, 38 (7) 1015-1018; DOI: https://doi.org/10.1124/dmd.110.033068

  6. Bowalgaha, Kushari

    1. Spironolactone and Canrenone Inhibit UGT2B7-Catalyzed Human Liver and Kidney Microsomal Aldosterone 18β-Glucuronidation: A Potential Drug Interaction
      Kathleen M. Knights, Kushari Bowalgaha and John O. Miners
      Drug Metabolism and Disposition July 2010, 38 (7) 1011-1014; DOI: https://doi.org/10.1124/dmd.110.032870

  7. Brom, Manuela

    1. Vectorial Transport of Nucleoside Analogs from the Apical to the Basolateral Membrane in Double-Transfected Cells Expressing the Human Concentrative Nucleoside Transporter hCNT3 and the Export Pump ABCC4
      Maria Rius, Daniela Keller, Manuela Brom, Johanna Hummel-Eisenbeiss, Frank Lyko and Dietrich Keppler
      Drug Metabolism and Disposition July 2010, 38 (7) 1054-1063; DOI: https://doi.org/10.1124/dmd.110.032664

  8. Busler, Dennis

    1. Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Kidney Drug Transporters
      Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
      Drug Metabolism and Disposition July 2010, 38 (7) 1064-1071; DOI: https://doi.org/10.1124/dmd.109.031526
    2. Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Liver Drug Transporters
      Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
      Drug Metabolism and Disposition July 2010, 38 (7) 1072-1082; DOI: https://doi.org/10.1124/dmd.109.031518

C

  1. Caceres-Cortes, Janet

    1. Metabolism and Disposition of [14C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs
      Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V. Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher
      Drug Metabolism and Disposition July 2010, 38 (7) 1189-1201; DOI: https://doi.org/10.1124/dmd.110.032755

  2. Cameron, Michael D.

    1. Cytochrome P450-Mediated Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Erlotinib to a Reactive Electrophile
      Xiaohai Li, Theodore M. Kamenecka and Michael D. Cameron
      Drug Metabolism and Disposition July 2010, 38 (7) 1238-1245; DOI: https://doi.org/10.1124/dmd.109.030361

  3. Chando, Theodore

    1. Metabolism and Disposition of [14C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs
      Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V. Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher
      Drug Metabolism and Disposition July 2010, 38 (7) 1189-1201; DOI: https://doi.org/10.1124/dmd.110.032755

  4. Chandrasekaran, Appavu

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

  5. Chen, Cliff

    1. Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Kidney Drug Transporters
      Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
      Drug Metabolism and Disposition July 2010, 38 (7) 1064-1071; DOI: https://doi.org/10.1124/dmd.109.031526
    2. Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Liver Drug Transporters
      Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
      Drug Metabolism and Disposition July 2010, 38 (7) 1072-1082; DOI: https://doi.org/10.1124/dmd.109.031518

  6. Christopher, Lisa J.

    1. Metabolism and Disposition of [14C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs
      Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V. Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher
      Drug Metabolism and Disposition July 2010, 38 (7) 1189-1201; DOI: https://doi.org/10.1124/dmd.110.032755

  7. Clough, Jeffrey

    1. Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
      David J. Sweeny, Weiqun Li, Jeffrey Clough, Somasekhar Bhamidipati, Rajinder Singh, Gary Park, Muhammad Baluom, Elliott Grossbard and David T.-W. Lau
      Drug Metabolism and Disposition July 2010, 38 (7) 1166-1176; DOI: https://doi.org/10.1124/dmd.110.032151

  8. Cui, Yong

    1. Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
      Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680

D

  1. Daly, Ann K.

    1. Role of UDP-Glucuronosyltransferase Isoforms in 13-cis Retinoic Acid Metabolism in Humans
      Sophie E. Rowbotham, Nicola A. Illingworth, Ann K. Daly, Gareth J. Veal and Alan V. Boddy
      Drug Metabolism and Disposition July 2010, 38 (7) 1211-1217; DOI: https://doi.org/10.1124/dmd.109.031625

  2. Del Grosso, Erika

    1. Identification of the Human UDP-Glucuronosyltransferases Involved in the Glucuronidation of Combretastatin A-4
      Silvio Aprile, Erika Del Grosso and Giorgio Grosa
      Drug Metabolism and Disposition July 2010, 38 (7) 1141-1146; DOI: https://doi.org/10.1124/dmd.109.031435

  3. Deng, Lin

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

  4. Deng, Yuzhong

    1. Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
      Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680

  5. Desta, Zeruesenay

    1. Efavirenz Primary and Secondary Metabolism In Vitro and In Vivo: Identification of Novel Metabolic Pathways and Cytochrome P450 2A6 as the Principal Catalyst of Efavirenz 7-Hydroxylation
      Evan T. Ogburn, David R. Jones, Andrea R. Masters, Cong Xu, Yingying Guo and Zeruesenay Desta
      Drug Metabolism and Disposition July 2010, 38 (7) 1218-1229; DOI: https://doi.org/10.1124/dmd.109.031393

E

  1. Ehmer, Ursula

    1. Shared Regulation of UGT1A7 by Hepatocyte Nuclear Factor (HNF) 1α and HNF4α
      Ursula Ehmer, Sandra Kalthoff, Tim O. Lankisch, Nicole Freiberg, Michael P. Manns and Christian P. Strassburg
      Drug Metabolism and Disposition July 2010, 38 (7) 1246-1257; DOI: https://doi.org/10.1124/dmd.109.030403

  2. Ekhato, Ihoezo V.

    1. Metabolism and Disposition of [14C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs
      Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V. Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher
      Drug Metabolism and Disposition July 2010, 38 (7) 1189-1201; DOI: https://doi.org/10.1124/dmd.110.032755

  3. Espina, Robert

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

F

  1. Freiberg, Nicole

    1. Shared Regulation of UGT1A7 by Hepatocyte Nuclear Factor (HNF) 1α and HNF4α
      Ursula Ehmer, Sandra Kalthoff, Tim O. Lankisch, Nicole Freiberg, Michael P. Manns and Christian P. Strassburg
      Drug Metabolism and Disposition July 2010, 38 (7) 1246-1257; DOI: https://doi.org/10.1124/dmd.109.030403

G

  1. Galetin, Aleksandra

    1. Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data
      Michael Gertz, Anthony Harrison, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition July 2010, 38 (7) 1147-1158; DOI: https://doi.org/10.1124/dmd.110.032649

  2. Gato, Katsuhiko

    1. Quantitative Prediction of Intestinal Metabolism in Humans from a Simplified Intestinal Availability Model and Empirical Scaling Factor
      Keitaro Kadono, Takafumi Akabane, Kenji Tabata, Katsuhiko Gato, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition July 2010, 38 (7) 1230-1237; DOI: https://doi.org/10.1124/dmd.109.029322

  3. Gertz, Michael

    1. Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data
      Michael Gertz, Anthony Harrison, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition July 2010, 38 (7) 1147-1158; DOI: https://doi.org/10.1124/dmd.110.032649

  4. Goldstein, Joyce A.

    1. The Nuclear Receptors Constitutive Active/Androstane Receptor and Pregnane X Receptor Activate the Cyp2c55 Gene in Mouse Liver
      Yoshihiro Konno, Hiroki Kamino, Rick Moore, Fred Lih, Kenneth B. Tomer, Darryl C. Zeldin, Joyce A. Goldstein and Masahiko Negishi
      Drug Metabolism and Disposition July 2010, 38 (7) 1177-1182; DOI: https://doi.org/10.1124/dmd.110.032334

  5. Grimm, Scott W.

    1. Expression and Characterization of Dog Cytochrome P450 2A13 and 2A25 in Baculovirus-Infected Insect Cells
      Diansong Zhou, Alban J. Linnenbach, Ruifeng Liu, Rick A. Luzietti, Jennifer J. Harris, Catherine L. Booth-Genthe and Scott W. Grimm
      Drug Metabolism and Disposition July 2010, 38 (7) 1015-1018; DOI: https://doi.org/10.1124/dmd.110.033068

  6. Grosa, Giorgio

    1. Identification of the Human UDP-Glucuronosyltransferases Involved in the Glucuronidation of Combretastatin A-4
      Silvio Aprile, Erika Del Grosso and Giorgio Grosa
      Drug Metabolism and Disposition July 2010, 38 (7) 1141-1146; DOI: https://doi.org/10.1124/dmd.109.031435

  7. Grossbard, Elliott

    1. Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
      David J. Sweeny, Weiqun Li, Jeffrey Clough, Somasekhar Bhamidipati, Rajinder Singh, Gary Park, Muhammad Baluom, Elliott Grossbard and David T.-W. Lau
      Drug Metabolism and Disposition July 2010, 38 (7) 1166-1176; DOI: https://doi.org/10.1124/dmd.110.032151

  8. Grube, Markus

    1. Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA: Role of Human Organic Anion Transporters
      Mirko Leonhardt, Markus Keiser, Stefan Oswald, Jens Kühn, Jia Jia, Markus Grube, Heyo K. Kroemer, Werner Siegmund and Werner Weitschies
      Drug Metabolism and Disposition July 2010, 38 (7) 1024-1028; DOI: https://doi.org/10.1124/dmd.110.032862

  9. Guo, Yingying

    1. Efavirenz Primary and Secondary Metabolism In Vitro and In Vivo: Identification of Novel Metabolic Pathways and Cytochrome P450 2A6 as the Principal Catalyst of Efavirenz 7-Hydroxylation
      Evan T. Ogburn, David R. Jones, Andrea R. Masters, Cong Xu, Yingying Guo and Zeruesenay Desta
      Drug Metabolism and Disposition July 2010, 38 (7) 1218-1229; DOI: https://doi.org/10.1124/dmd.109.031393

H

  1. Haga, Makoto

    1. Contribution of Rat Pulmonary Metabolism to the Elimination of Lidocaine, Midazolam, and Nifedipine
      Makoto Aoki, Kazuho Okudaira, Makoto Haga, Ryuichiro Nishigaki and Masahiro Hayashi
      Drug Metabolism and Disposition July 2010, 38 (7) 1183-1188; DOI: https://doi.org/10.1124/dmd.110.032227

  2. Han, Yong-Hae

    1. Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Kidney Drug Transporters
      Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
      Drug Metabolism and Disposition July 2010, 38 (7) 1064-1071; DOI: https://doi.org/10.1124/dmd.109.031526
    2. Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Liver Drug Transporters
      Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
      Drug Metabolism and Disposition July 2010, 38 (7) 1072-1082; DOI: https://doi.org/10.1124/dmd.109.031518

  3. Hao, Haiping

    1. Regioselective Glucuronidation of Tanshinone IIa after Quinone Reduction: Identification of Human UDP-Glucuronosyltransferases, Species Differences, and Interaction Potential
      Qiong Wang, Haiping Hao, Xuanxuan Zhu, Guo Yu, Li Lai, Yitong Liu, Yuxin Wang, Shan Jiang and Guangji Wang
      Drug Metabolism and Disposition July 2010, 38 (7) 1132-1140; DOI: https://doi.org/10.1124/dmd.109.031864

  4. Harris, Jennifer J.

    1. Expression and Characterization of Dog Cytochrome P450 2A13 and 2A25 in Baculovirus-Infected Insect Cells
      Diansong Zhou, Alban J. Linnenbach, Ruifeng Liu, Rick A. Luzietti, Jennifer J. Harris, Catherine L. Booth-Genthe and Scott W. Grimm
      Drug Metabolism and Disposition July 2010, 38 (7) 1015-1018; DOI: https://doi.org/10.1124/dmd.110.033068

  5. Harrison, Anthony

    1. Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data
      Michael Gertz, Anthony Harrison, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition July 2010, 38 (7) 1147-1158; DOI: https://doi.org/10.1124/dmd.110.032649

  6. Hayashi, Masahiro

    1. Contribution of Rat Pulmonary Metabolism to the Elimination of Lidocaine, Midazolam, and Nifedipine
      Makoto Aoki, Kazuho Okudaira, Makoto Haga, Ryuichiro Nishigaki and Masahiro Hayashi
      Drug Metabolism and Disposition July 2010, 38 (7) 1183-1188; DOI: https://doi.org/10.1124/dmd.110.032227

  7. Hong, Haizheng

    1. Metabolism and Disposition of [14C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs
      Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V. Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher
      Drug Metabolism and Disposition July 2010, 38 (7) 1189-1201; DOI: https://doi.org/10.1124/dmd.110.032755

  8. Hong, Yang

    1. Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Kidney Drug Transporters
      Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
      Drug Metabolism and Disposition July 2010, 38 (7) 1064-1071; DOI: https://doi.org/10.1124/dmd.109.031526
    2. Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Liver Drug Transporters
      Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
      Drug Metabolism and Disposition July 2010, 38 (7) 1072-1082; DOI: https://doi.org/10.1124/dmd.109.031518

  9. Hop, Cornelis E. C. A.

    1. Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
      Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680

  10. Horwatt, Peter

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

  11. Houston, J. Brian

    1. Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data
      Michael Gertz, Anthony Harrison, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition July 2010, 38 (7) 1147-1158; DOI: https://doi.org/10.1124/dmd.110.032649

  12. Huang, Qingbiao

    1. Significant Increase in Phenacetin Oxidation on L382V Substitution in Human Cytochrome P450 1A2
      Qingbiao Huang and Grazyna D. Szklarz
      Drug Metabolism and Disposition July 2010, 38 (7) 1039-1045; DOI: https://doi.org/10.1124/dmd.109.030767

  13. Hummel-Eisenbeiss, Johanna

    1. Vectorial Transport of Nucleoside Analogs from the Apical to the Basolateral Membrane in Double-Transfected Cells Expressing the Human Concentrative Nucleoside Transporter hCNT3 and the Export Pump ABCC4
      Maria Rius, Daniela Keller, Manuela Brom, Johanna Hummel-Eisenbeiss, Frank Lyko and Dietrich Keppler
      Drug Metabolism and Disposition July 2010, 38 (7) 1054-1063; DOI: https://doi.org/10.1124/dmd.110.032664

  14. Humphreys, W. Griffith

    1. Metabolism and Disposition of [14C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs
      Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V. Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher
      Drug Metabolism and Disposition July 2010, 38 (7) 1189-1201; DOI: https://doi.org/10.1124/dmd.110.032755

I

  1. Illingworth, Nicola A.

    1. Role of UDP-Glucuronosyltransferase Isoforms in 13-cis Retinoic Acid Metabolism in Humans
      Sophie E. Rowbotham, Nicola A. Illingworth, Ann K. Daly, Gareth J. Veal and Alan V. Boddy
      Drug Metabolism and Disposition July 2010, 38 (7) 1211-1217; DOI: https://doi.org/10.1124/dmd.109.031625

  2. Iyer, Ramaswamy A.

    1. Metabolism and Disposition of [14C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs
      Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V. Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher
      Drug Metabolism and Disposition July 2010, 38 (7) 1189-1201; DOI: https://doi.org/10.1124/dmd.110.032755

J

  1. Jia, Jia

    1. Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA: Role of Human Organic Anion Transporters
      Mirko Leonhardt, Markus Keiser, Stefan Oswald, Jens Kühn, Jia Jia, Markus Grube, Heyo K. Kroemer, Werner Siegmund and Werner Weitschies
      Drug Metabolism and Disposition July 2010, 38 (7) 1024-1028; DOI: https://doi.org/10.1124/dmd.110.032862

  2. Jiang, Shan

    1. Regioselective Glucuronidation of Tanshinone IIa after Quinone Reduction: Identification of Human UDP-Glucuronosyltransferases, Species Differences, and Interaction Potential
      Qiong Wang, Haiping Hao, Xuanxuan Zhu, Guo Yu, Li Lai, Yitong Liu, Yuxin Wang, Shan Jiang and Guangji Wang
      Drug Metabolism and Disposition July 2010, 38 (7) 1132-1140; DOI: https://doi.org/10.1124/dmd.109.031864

  3. Johnson, Patrick J.

    1. Potential Application of d-Optimal Designs in the Efficient Investigation of Cytochrome P450 Inhibition Kinetic Models
      Kuresh A. Youdim, Anthony C. Atkinson, Maciej Patan, Barbara Bogacka and Patrick J. Johnson
      Drug Metabolism and Disposition July 2010, 38 (7) 1019-1023; DOI: https://doi.org/10.1124/dmd.110.033142

  4. Jones, David R.

    1. Efavirenz Primary and Secondary Metabolism In Vitro and In Vivo: Identification of Novel Metabolic Pathways and Cytochrome P450 2A6 as the Principal Catalyst of Efavirenz 7-Hydroxylation
      Evan T. Ogburn, David R. Jones, Andrea R. Masters, Cong Xu, Yingying Guo and Zeruesenay Desta
      Drug Metabolism and Disposition July 2010, 38 (7) 1218-1229; DOI: https://doi.org/10.1124/dmd.109.031393

K

  1. Kadono, Keitaro

    1. Quantitative Prediction of Intestinal Metabolism in Humans from a Simplified Intestinal Availability Model and Empirical Scaling Factor
      Keitaro Kadono, Takafumi Akabane, Kenji Tabata, Katsuhiko Gato, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition July 2010, 38 (7) 1230-1237; DOI: https://doi.org/10.1124/dmd.109.029322

  2. Kalthoff, Sandra

    1. Shared Regulation of UGT1A7 by Hepatocyte Nuclear Factor (HNF) 1α and HNF4α
      Ursula Ehmer, Sandra Kalthoff, Tim O. Lankisch, Nicole Freiberg, Michael P. Manns and Christian P. Strassburg
      Drug Metabolism and Disposition July 2010, 38 (7) 1246-1257; DOI: https://doi.org/10.1124/dmd.109.030403

  3. Kamenecka, Theodore M.

    1. Cytochrome P450-Mediated Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Erlotinib to a Reactive Electrophile
      Xiaohai Li, Theodore M. Kamenecka and Michael D. Cameron
      Drug Metabolism and Disposition July 2010, 38 (7) 1238-1245; DOI: https://doi.org/10.1124/dmd.109.030361

  4. Kamino, Hiroki

    1. The Nuclear Receptors Constitutive Active/Androstane Receptor and Pregnane X Receptor Activate the Cyp2c55 Gene in Mouse Liver
      Yoshihiro Konno, Hiroki Kamino, Rick Moore, Fred Lih, Kenneth B. Tomer, Darryl C. Zeldin, Joyce A. Goldstein and Masahiko Negishi
      Drug Metabolism and Disposition July 2010, 38 (7) 1177-1182; DOI: https://doi.org/10.1124/dmd.110.032334

  5. Kapelyukh, Yury

    1. In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice
      Nico Scheer, Jillian Ross, Yury Kapelyukh, Anja Rode and C. Roland Wolf
      Drug Metabolism and Disposition July 2010, 38 (7) 1046-1053; DOI: https://doi.org/10.1124/dmd.109.031872

  6. Keiser, Markus

    1. Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA: Role of Human Organic Anion Transporters
      Mirko Leonhardt, Markus Keiser, Stefan Oswald, Jens Kühn, Jia Jia, Markus Grube, Heyo K. Kroemer, Werner Siegmund and Werner Weitschies
      Drug Metabolism and Disposition July 2010, 38 (7) 1024-1028; DOI: https://doi.org/10.1124/dmd.110.032862

  7. Keller, Daniela

    1. Vectorial Transport of Nucleoside Analogs from the Apical to the Basolateral Membrane in Double-Transfected Cells Expressing the Human Concentrative Nucleoside Transporter hCNT3 and the Export Pump ABCC4
      Maria Rius, Daniela Keller, Manuela Brom, Johanna Hummel-Eisenbeiss, Frank Lyko and Dietrich Keppler
      Drug Metabolism and Disposition July 2010, 38 (7) 1054-1063; DOI: https://doi.org/10.1124/dmd.110.032664

  8. Keppler, Dietrich

    1. Vectorial Transport of Nucleoside Analogs from the Apical to the Basolateral Membrane in Double-Transfected Cells Expressing the Human Concentrative Nucleoside Transporter hCNT3 and the Export Pump ABCC4
      Maria Rius, Daniela Keller, Manuela Brom, Johanna Hummel-Eisenbeiss, Frank Lyko and Dietrich Keppler
      Drug Metabolism and Disposition July 2010, 38 (7) 1054-1063; DOI: https://doi.org/10.1124/dmd.110.032664

  9. Khojasteh, S. Cyrus

    1. Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
      Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680

  10. Klaassen, Curtis D.

    1. Energy Restriction Does Not Compensate for the Reduced Expression of Hepatic Drug-Processing Genes in Mice with Aging
      Yu-Kun Jennifer Zhang, Kurt W. Saupe and Curtis D. Klaassen
      Drug Metabolism and Disposition July 2010, 38 (7) 1122-1131; DOI: https://doi.org/10.1124/dmd.110.032599

  11. Knights, Kathleen M.

    1. Spironolactone and Canrenone Inhibit UGT2B7-Catalyzed Human Liver and Kidney Microsomal Aldosterone 18β-Glucuronidation: A Potential Drug Interaction
      Kathleen M. Knights, Kushari Bowalgaha and John O. Miners
      Drug Metabolism and Disposition July 2010, 38 (7) 1011-1014; DOI: https://doi.org/10.1124/dmd.110.032870

  12. Konno, Yoshihiro

    1. The Nuclear Receptors Constitutive Active/Androstane Receptor and Pregnane X Receptor Activate the Cyp2c55 Gene in Mouse Liver
      Yoshihiro Konno, Hiroki Kamino, Rick Moore, Fred Lih, Kenneth B. Tomer, Darryl C. Zeldin, Joyce A. Goldstein and Masahiko Negishi
      Drug Metabolism and Disposition July 2010, 38 (7) 1177-1182; DOI: https://doi.org/10.1124/dmd.110.032334

  13. Kroemer, Heyo K.

    1. Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA: Role of Human Organic Anion Transporters
      Mirko Leonhardt, Markus Keiser, Stefan Oswald, Jens Kühn, Jia Jia, Markus Grube, Heyo K. Kroemer, Werner Siegmund and Werner Weitschies
      Drug Metabolism and Disposition July 2010, 38 (7) 1024-1028; DOI: https://doi.org/10.1124/dmd.110.032862

  14. Kühn, Jens

    1. Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA: Role of Human Organic Anion Transporters
      Mirko Leonhardt, Markus Keiser, Stefan Oswald, Jens Kühn, Jia Jia, Markus Grube, Heyo K. Kroemer, Werner Siegmund and Werner Weitschies
      Drug Metabolism and Disposition July 2010, 38 (7) 1024-1028; DOI: https://doi.org/10.1124/dmd.110.032862

L

  1. La, Hank

    1. Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
      Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680

  2. Lai, Li

    1. Regioselective Glucuronidation of Tanshinone IIa after Quinone Reduction: Identification of Human UDP-Glucuronosyltransferases, Species Differences, and Interaction Potential
      Qiong Wang, Haiping Hao, Xuanxuan Zhu, Guo Yu, Li Lai, Yitong Liu, Yuxin Wang, Shan Jiang and Guangji Wang
      Drug Metabolism and Disposition July 2010, 38 (7) 1132-1140; DOI: https://doi.org/10.1124/dmd.109.031864

  3. Lankisch, Tim O.

    1. Shared Regulation of UGT1A7 by Hepatocyte Nuclear Factor (HNF) 1α and HNF4α
      Ursula Ehmer, Sandra Kalthoff, Tim O. Lankisch, Nicole Freiberg, Michael P. Manns and Christian P. Strassburg
      Drug Metabolism and Disposition July 2010, 38 (7) 1246-1257; DOI: https://doi.org/10.1124/dmd.109.030403

  4. Lau, David T.-W.

    1. Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
      David J. Sweeny, Weiqun Li, Jeffrey Clough, Somasekhar Bhamidipati, Rajinder Singh, Gary Park, Muhammad Baluom, Elliott Grossbard and David T.-W. Lau
      Drug Metabolism and Disposition July 2010, 38 (7) 1166-1176; DOI: https://doi.org/10.1124/dmd.110.032151

  5. Leonhardt, Mirko

    1. Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA: Role of Human Organic Anion Transporters
      Mirko Leonhardt, Markus Keiser, Stefan Oswald, Jens Kühn, Jia Jia, Markus Grube, Heyo K. Kroemer, Werner Siegmund and Werner Weitschies
      Drug Metabolism and Disposition July 2010, 38 (7) 1024-1028; DOI: https://doi.org/10.1124/dmd.110.032862

  6. Li, Weiqun

    1. Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
      David J. Sweeny, Weiqun Li, Jeffrey Clough, Somasekhar Bhamidipati, Rajinder Singh, Gary Park, Muhammad Baluom, Elliott Grossbard and David T.-W. Lau
      Drug Metabolism and Disposition July 2010, 38 (7) 1166-1176; DOI: https://doi.org/10.1124/dmd.110.032151

  7. Li, Xiaohai

    1. Cytochrome P450-Mediated Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Erlotinib to a Reactive Electrophile
      Xiaohai Li, Theodore M. Kamenecka and Michael D. Cameron
      Drug Metabolism and Disposition July 2010, 38 (7) 1238-1245; DOI: https://doi.org/10.1124/dmd.109.030361

  8. Li-Chan, Xiao Xian

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

  9. Lih, Fred

    1. The Nuclear Receptors Constitutive Active/Androstane Receptor and Pregnane X Receptor Activate the Cyp2c55 Gene in Mouse Liver
      Yoshihiro Konno, Hiroki Kamino, Rick Moore, Fred Lih, Kenneth B. Tomer, Darryl C. Zeldin, Joyce A. Goldstein and Masahiko Negishi
      Drug Metabolism and Disposition July 2010, 38 (7) 1177-1182; DOI: https://doi.org/10.1124/dmd.110.032334

  10. Linder, Collette D.

    1. In Vitro-In Vivo Correlation and Translation to the Clinical Outcome for CJ-13,610, a Novel Inhibitor of 5-Lipoxygenase
      J. Matthew Hutzler, Collette D. Linder, Roger J. Melton, John Vincent and J. Scott Daniels
      Drug Metabolism and Disposition July 2010, 38 (7) 1113-1121; DOI: https://doi.org/10.1124/dmd.110.032706

  11. Linnenbach, Alban J.

    1. Expression and Characterization of Dog Cytochrome P450 2A13 and 2A25 in Baculovirus-Infected Insect Cells
      Diansong Zhou, Alban J. Linnenbach, Ruifeng Liu, Rick A. Luzietti, Jennifer J. Harris, Catherine L. Booth-Genthe and Scott W. Grimm
      Drug Metabolism and Disposition July 2010, 38 (7) 1015-1018; DOI: https://doi.org/10.1124/dmd.110.033068

  12. Liu, Ruifeng

    1. Expression and Characterization of Dog Cytochrome P450 2A13 and 2A25 in Baculovirus-Infected Insect Cells
      Diansong Zhou, Alban J. Linnenbach, Ruifeng Liu, Rick A. Luzietti, Jennifer J. Harris, Catherine L. Booth-Genthe and Scott W. Grimm
      Drug Metabolism and Disposition July 2010, 38 (7) 1015-1018; DOI: https://doi.org/10.1124/dmd.110.033068

  13. Liu, Yitong

    1. Regioselective Glucuronidation of Tanshinone IIa after Quinone Reduction: Identification of Human UDP-Glucuronosyltransferases, Species Differences, and Interaction Potential
      Qiong Wang, Haiping Hao, Xuanxuan Zhu, Guo Yu, Li Lai, Yitong Liu, Yuxin Wang, Shan Jiang and Guangji Wang
      Drug Metabolism and Disposition July 2010, 38 (7) 1132-1140; DOI: https://doi.org/10.1124/dmd.109.031864

  14. Lockhead, Susan

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

  15. Lombardo, Franco

    1. Use of the Øie-Tozer Model in Understanding Mechanisms and Determinants of Drug Distribution
      Nigel J. Waters and Franco Lombardo
      Drug Metabolism and Disposition July 2010, 38 (7) 1159-1165; DOI: https://doi.org/10.1124/dmd.110.032458

  16. Luzietti, Rick A.

    1. Expression and Characterization of Dog Cytochrome P450 2A13 and 2A25 in Baculovirus-Infected Insect Cells
      Diansong Zhou, Alban J. Linnenbach, Ruifeng Liu, Rick A. Luzietti, Jennifer J. Harris, Catherine L. Booth-Genthe and Scott W. Grimm
      Drug Metabolism and Disposition July 2010, 38 (7) 1015-1018; DOI: https://doi.org/10.1124/dmd.110.033068

  17. Lyko, Frank

    1. Vectorial Transport of Nucleoside Analogs from the Apical to the Basolateral Membrane in Double-Transfected Cells Expressing the Human Concentrative Nucleoside Transporter hCNT3 and the Export Pump ABCC4
      Maria Rius, Daniela Keller, Manuela Brom, Johanna Hummel-Eisenbeiss, Frank Lyko and Dietrich Keppler
      Drug Metabolism and Disposition July 2010, 38 (7) 1054-1063; DOI: https://doi.org/10.1124/dmd.110.032664

M

  1. Manns, Michael P.

    1. Shared Regulation of UGT1A7 by Hepatocyte Nuclear Factor (HNF) 1α and HNF4α
      Ursula Ehmer, Sandra Kalthoff, Tim O. Lankisch, Nicole Freiberg, Michael P. Manns and Christian P. Strassburg
      Drug Metabolism and Disposition July 2010, 38 (7) 1246-1257; DOI: https://doi.org/10.1124/dmd.109.030403

  2. Marsters, James C.

    1. Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
      Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680

  3. Martinet, Audrey

    1. Identification of the Human Enzymes Responsible for the Enzymatic Hydrolysis of Aclidinium Bromide
      Joan Albertí, Audrey Martinet, Sònia Sentellas and Miquel Salvà
      Drug Metabolism and Disposition July 2010, 38 (7) 1202-1210; DOI: https://doi.org/10.1124/dmd.109.031724

  4. Masters, Andrea R.

    1. Efavirenz Primary and Secondary Metabolism In Vitro and In Vivo: Identification of Novel Metabolic Pathways and Cytochrome P450 2A6 as the Principal Catalyst of Efavirenz 7-Hydroxylation
      Evan T. Ogburn, David R. Jones, Andrea R. Masters, Cong Xu, Yingying Guo and Zeruesenay Desta
      Drug Metabolism and Disposition July 2010, 38 (7) 1218-1229; DOI: https://doi.org/10.1124/dmd.109.031393

  5. Matthew Hutzler, J.

    1. In Vitro-In Vivo Correlation and Translation to the Clinical Outcome for CJ-13,610, a Novel Inhibitor of 5-Lipoxygenase
      J. Matthew Hutzler, Collette D. Linder, Roger J. Melton, John Vincent and J. Scott Daniels
      Drug Metabolism and Disposition July 2010, 38 (7) 1113-1121; DOI: https://doi.org/10.1124/dmd.110.032706

  6. Melton, Roger J.

    1. In Vitro-In Vivo Correlation and Translation to the Clinical Outcome for CJ-13,610, a Novel Inhibitor of 5-Lipoxygenase
      J. Matthew Hutzler, Collette D. Linder, Roger J. Melton, John Vincent and J. Scott Daniels
      Drug Metabolism and Disposition July 2010, 38 (7) 1113-1121; DOI: https://doi.org/10.1124/dmd.110.032706

  7. Meulenbelt, Jan

    1. Differential Roles of Phase I and Phase II Enzymes in 3,4-Methylendioxymethamphetamine-Induced Cytotoxicity
      Irene Antolino-Lobo, Jan Meulenbelt, Sandra M. Nijmeijer, Peter Scherpenisse, Martin van den Berg and Majorie B. M. van Duursen
      Drug Metabolism and Disposition July 2010, 38 (7) 1105-1112; DOI: https://doi.org/10.1124/dmd.110.032359

  8. Miners, John O.

    1. Spironolactone and Canrenone Inhibit UGT2B7-Catalyzed Human Liver and Kidney Microsomal Aldosterone 18β-Glucuronidation: A Potential Drug Interaction
      Kathleen M. Knights, Kushari Bowalgaha and John O. Miners
      Drug Metabolism and Disposition July 2010, 38 (7) 1011-1014; DOI: https://doi.org/10.1124/dmd.110.032870

  9. Moore, Rick

    1. The Nuclear Receptors Constitutive Active/Androstane Receptor and Pregnane X Receptor Activate the Cyp2c55 Gene in Mouse Liver
      Yoshihiro Konno, Hiroki Kamino, Rick Moore, Fred Lih, Kenneth B. Tomer, Darryl C. Zeldin, Joyce A. Goldstein and Masahiko Negishi
      Drug Metabolism and Disposition July 2010, 38 (7) 1177-1182; DOI: https://doi.org/10.1124/dmd.110.032334

  10. Morinello, Eric J.

    1. Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
      Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680

  11. Mutlib, Abdul

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

N

  1. Negishi, Masahiko

    1. The Nuclear Receptors Constitutive Active/Androstane Receptor and Pregnane X Receptor Activate the Cyp2c55 Gene in Mouse Liver
      Yoshihiro Konno, Hiroki Kamino, Rick Moore, Fred Lih, Kenneth B. Tomer, Darryl C. Zeldin, Joyce A. Goldstein and Masahiko Negishi
      Drug Metabolism and Disposition July 2010, 38 (7) 1177-1182; DOI: https://doi.org/10.1124/dmd.110.032334

  2. Nijmeijer, Sandra M.

    1. Differential Roles of Phase I and Phase II Enzymes in 3,4-Methylendioxymethamphetamine-Induced Cytotoxicity
      Irene Antolino-Lobo, Jan Meulenbelt, Sandra M. Nijmeijer, Peter Scherpenisse, Martin van den Berg and Majorie B. M. van Duursen
      Drug Metabolism and Disposition July 2010, 38 (7) 1105-1112; DOI: https://doi.org/10.1124/dmd.110.032359

  3. Nishigaki, Ryuichiro

    1. Contribution of Rat Pulmonary Metabolism to the Elimination of Lidocaine, Midazolam, and Nifedipine
      Makoto Aoki, Kazuho Okudaira, Makoto Haga, Ryuichiro Nishigaki and Masahiro Hayashi
      Drug Metabolism and Disposition July 2010, 38 (7) 1183-1188; DOI: https://doi.org/10.1124/dmd.110.032227

O

  1. Oganesian, Aram

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

  2. Ogburn, Evan T.

    1. Efavirenz Primary and Secondary Metabolism In Vitro and In Vivo: Identification of Novel Metabolic Pathways and Cytochrome P450 2A6 as the Principal Catalyst of Efavirenz 7-Hydroxylation
      Evan T. Ogburn, David R. Jones, Andrea R. Masters, Cong Xu, Yingying Guo and Zeruesenay Desta
      Drug Metabolism and Disposition July 2010, 38 (7) 1218-1229; DOI: https://doi.org/10.1124/dmd.109.031393

  3. Okudaira, Kazuho

    1. Contribution of Rat Pulmonary Metabolism to the Elimination of Lidocaine, Midazolam, and Nifedipine
      Makoto Aoki, Kazuho Okudaira, Makoto Haga, Ryuichiro Nishigaki and Masahiro Hayashi
      Drug Metabolism and Disposition July 2010, 38 (7) 1183-1188; DOI: https://doi.org/10.1124/dmd.110.032227

  4. Oswald, Stefan

    1. Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA: Role of Human Organic Anion Transporters
      Mirko Leonhardt, Markus Keiser, Stefan Oswald, Jens Kühn, Jia Jia, Markus Grube, Heyo K. Kroemer, Werner Siegmund and Werner Weitschies
      Drug Metabolism and Disposition July 2010, 38 (7) 1024-1028; DOI: https://doi.org/10.1124/dmd.110.032862

P

  1. Park, Gary

    1. Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
      David J. Sweeny, Weiqun Li, Jeffrey Clough, Somasekhar Bhamidipati, Rajinder Singh, Gary Park, Muhammad Baluom, Elliott Grossbard and David T.-W. Lau
      Drug Metabolism and Disposition July 2010, 38 (7) 1166-1176; DOI: https://doi.org/10.1124/dmd.110.032151

  2. Patan, Maciej

    1. Potential Application of d-Optimal Designs in the Efficient Investigation of Cytochrome P450 Inhibition Kinetic Models
      Kuresh A. Youdim, Anthony C. Atkinson, Maciej Patan, Barbara Bogacka and Patrick J. Johnson
      Drug Metabolism and Disposition July 2010, 38 (7) 1019-1023; DOI: https://doi.org/10.1124/dmd.110.033142

R

  1. Rius, Maria

    1. Vectorial Transport of Nucleoside Analogs from the Apical to the Basolateral Membrane in Double-Transfected Cells Expressing the Human Concentrative Nucleoside Transporter hCNT3 and the Export Pump ABCC4
      Maria Rius, Daniela Keller, Manuela Brom, Johanna Hummel-Eisenbeiss, Frank Lyko and Dietrich Keppler
      Drug Metabolism and Disposition July 2010, 38 (7) 1054-1063; DOI: https://doi.org/10.1124/dmd.110.032664

  2. Rode, Anja

    1. In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice
      Nico Scheer, Jillian Ross, Yury Kapelyukh, Anja Rode and C. Roland Wolf
      Drug Metabolism and Disposition July 2010, 38 (7) 1046-1053; DOI: https://doi.org/10.1124/dmd.109.031872

  3. Rodrigues, A. David

    1. Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Kidney Drug Transporters
      Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
      Drug Metabolism and Disposition July 2010, 38 (7) 1064-1071; DOI: https://doi.org/10.1124/dmd.109.031526
    2. Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Liver Drug Transporters
      Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
      Drug Metabolism and Disposition July 2010, 38 (7) 1072-1082; DOI: https://doi.org/10.1124/dmd.109.031518

  4. Roongta, Vikram

    1. Metabolism and Disposition of [14C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs
      Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V. Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher
      Drug Metabolism and Disposition July 2010, 38 (7) 1189-1201; DOI: https://doi.org/10.1124/dmd.110.032755

  5. Ross, Jillian

    1. In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice
      Nico Scheer, Jillian Ross, Yury Kapelyukh, Anja Rode and C. Roland Wolf
      Drug Metabolism and Disposition July 2010, 38 (7) 1046-1053; DOI: https://doi.org/10.1124/dmd.109.031872

  6. Ross, Steven

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

  7. Rowbotham, Sophie E.

    1. Role of UDP-Glucuronosyltransferase Isoforms in 13-cis Retinoic Acid Metabolism in Humans
      Sophie E. Rowbotham, Nicola A. Illingworth, Ann K. Daly, Gareth J. Veal and Alan V. Boddy
      Drug Metabolism and Disposition July 2010, 38 (7) 1211-1217; DOI: https://doi.org/10.1124/dmd.109.031625

S

  1. Salvà, Miquel

    1. Identification of the Human Enzymes Responsible for the Enzymatic Hydrolysis of Aclidinium Bromide
      Joan Albertí, Audrey Martinet, Sònia Sentellas and Miquel Salvà
      Drug Metabolism and Disposition July 2010, 38 (7) 1202-1210; DOI: https://doi.org/10.1124/dmd.109.031724

  2. Saupe, Kurt W.

    1. Energy Restriction Does Not Compensate for the Reduced Expression of Hepatic Drug-Processing Genes in Mice with Aging
      Yu-Kun Jennifer Zhang, Kurt W. Saupe and Curtis D. Klaassen
      Drug Metabolism and Disposition July 2010, 38 (7) 1122-1131; DOI: https://doi.org/10.1124/dmd.110.032599

  3. Scatina, JoAnn

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

  4. Scheer, Nico

    1. In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice
      Nico Scheer, Jillian Ross, Yury Kapelyukh, Anja Rode and C. Roland Wolf
      Drug Metabolism and Disposition July 2010, 38 (7) 1046-1053; DOI: https://doi.org/10.1124/dmd.109.031872

  5. Scherpenisse, Peter

    1. Differential Roles of Phase I and Phase II Enzymes in 3,4-Methylendioxymethamphetamine-Induced Cytotoxicity
      Irene Antolino-Lobo, Jan Meulenbelt, Sandra M. Nijmeijer, Peter Scherpenisse, Martin van den Berg and Majorie B. M. van Duursen
      Drug Metabolism and Disposition July 2010, 38 (7) 1105-1112; DOI: https://doi.org/10.1124/dmd.110.032359

  6. Scott Daniels, J.

    1. In Vitro-In Vivo Correlation and Translation to the Clinical Outcome for CJ-13,610, a Novel Inhibitor of 5-Lipoxygenase
      J. Matthew Hutzler, Collette D. Linder, Roger J. Melton, John Vincent and J. Scott Daniels
      Drug Metabolism and Disposition July 2010, 38 (7) 1113-1121; DOI: https://doi.org/10.1124/dmd.110.032706

  7. Sentellas, Sònia

    1. Identification of the Human Enzymes Responsible for the Enzymatic Hydrolysis of Aclidinium Bromide
      Joan Albertí, Audrey Martinet, Sònia Sentellas and Miquel Salvà
      Drug Metabolism and Disposition July 2010, 38 (7) 1202-1210; DOI: https://doi.org/10.1124/dmd.109.031724

  8. Siegmund, Werner

    1. Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA: Role of Human Organic Anion Transporters
      Mirko Leonhardt, Markus Keiser, Stefan Oswald, Jens Kühn, Jia Jia, Markus Grube, Heyo K. Kroemer, Werner Siegmund and Werner Weitschies
      Drug Metabolism and Disposition July 2010, 38 (7) 1024-1028; DOI: https://doi.org/10.1124/dmd.110.032862

  9. Singh, Rajinder

    1. Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
      David J. Sweeny, Weiqun Li, Jeffrey Clough, Somasekhar Bhamidipati, Rajinder Singh, Gary Park, Muhammad Baluom, Elliott Grossbard and David T.-W. Lau
      Drug Metabolism and Disposition July 2010, 38 (7) 1166-1176; DOI: https://doi.org/10.1124/dmd.110.032151

  10. Song, Xiling

    1. Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
      Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680

  11. Strassburg, Christian P.

    1. Shared Regulation of UGT1A7 by Hepatocyte Nuclear Factor (HNF) 1α and HNF4α
      Ursula Ehmer, Sandra Kalthoff, Tim O. Lankisch, Nicole Freiberg, Michael P. Manns and Christian P. Strassburg
      Drug Metabolism and Disposition July 2010, 38 (7) 1246-1257; DOI: https://doi.org/10.1124/dmd.109.030403

  12. Su, Hong

    1. Metabolism and Disposition of [14C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs
      Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V. Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher
      Drug Metabolism and Disposition July 2010, 38 (7) 1189-1201; DOI: https://doi.org/10.1124/dmd.110.032755

  13. Sun, Haojun

    1. Metabolism and Disposition of [14C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs
      Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V. Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher
      Drug Metabolism and Disposition July 2010, 38 (7) 1189-1201; DOI: https://doi.org/10.1124/dmd.110.032755

  14. Sweeny, David J.

    1. Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
      David J. Sweeny, Weiqun Li, Jeffrey Clough, Somasekhar Bhamidipati, Rajinder Singh, Gary Park, Muhammad Baluom, Elliott Grossbard and David T.-W. Lau
      Drug Metabolism and Disposition July 2010, 38 (7) 1166-1176; DOI: https://doi.org/10.1124/dmd.110.032151

  15. Szklarz, Grazyna D.

    1. Significant Increase in Phenacetin Oxidation on L382V Substitution in Human Cytochrome P450 1A2
      Qingbiao Huang and Grazyna D. Szklarz
      Drug Metabolism and Disposition July 2010, 38 (7) 1039-1045; DOI: https://doi.org/10.1124/dmd.109.030767

T

  1. Tabata, Kenji

    1. Quantitative Prediction of Intestinal Metabolism in Humans from a Simplified Intestinal Availability Model and Empirical Scaling Factor
      Keitaro Kadono, Takafumi Akabane, Kenji Tabata, Katsuhiko Gato, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition July 2010, 38 (7) 1230-1237; DOI: https://doi.org/10.1124/dmd.109.029322

  2. Talaat, Rasmy

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

  3. Teramura, Toshio

    1. Quantitative Prediction of Intestinal Metabolism in Humans from a Simplified Intestinal Availability Model and Empirical Scaling Factor
      Keitaro Kadono, Takafumi Akabane, Kenji Tabata, Katsuhiko Gato, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition July 2010, 38 (7) 1230-1237; DOI: https://doi.org/10.1124/dmd.109.029322

  4. Terashita, Shigeyuki

    1. Quantitative Prediction of Intestinal Metabolism in Humans from a Simplified Intestinal Availability Model and Empirical Scaling Factor
      Keitaro Kadono, Takafumi Akabane, Kenji Tabata, Katsuhiko Gato, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition July 2010, 38 (7) 1230-1237; DOI: https://doi.org/10.1124/dmd.109.029322

  5. Theil, Frank-Peter

    1. Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
      Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680

  6. Tian, Yuan

    1. Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Kidney Drug Transporters
      Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
      Drug Metabolism and Disposition July 2010, 38 (7) 1064-1071; DOI: https://doi.org/10.1124/dmd.109.031526
    2. Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Liver Drug Transporters
      Yong-Hae Han, Dennis Busler, Yang Hong, Yuan Tian, Cliff Chen and A. David Rodrigues
      Drug Metabolism and Disposition July 2010, 38 (7) 1072-1082; DOI: https://doi.org/10.1124/dmd.109.031518

  7. Tomer, Kenneth B.

    1. The Nuclear Receptors Constitutive Active/Androstane Receptor and Pregnane X Receptor Activate the Cyp2c55 Gene in Mouse Liver
      Yoshihiro Konno, Hiroki Kamino, Rick Moore, Fred Lih, Kenneth B. Tomer, Darryl C. Zeldin, Joyce A. Goldstein and Masahiko Negishi
      Drug Metabolism and Disposition July 2010, 38 (7) 1177-1182; DOI: https://doi.org/10.1124/dmd.110.032334

V

  1. van den Berg, Martin

    1. Differential Roles of Phase I and Phase II Enzymes in 3,4-Methylendioxymethamphetamine-Induced Cytotoxicity
      Irene Antolino-Lobo, Jan Meulenbelt, Sandra M. Nijmeijer, Peter Scherpenisse, Martin van den Berg and Majorie B. M. van Duursen
      Drug Metabolism and Disposition July 2010, 38 (7) 1105-1112; DOI: https://doi.org/10.1124/dmd.110.032359

  2. van Duursen, Majorie B. M.

    1. Differential Roles of Phase I and Phase II Enzymes in 3,4-Methylendioxymethamphetamine-Induced Cytotoxicity
      Irene Antolino-Lobo, Jan Meulenbelt, Sandra M. Nijmeijer, Peter Scherpenisse, Martin van den Berg and Majorie B. M. van Duursen
      Drug Metabolism and Disposition July 2010, 38 (7) 1105-1112; DOI: https://doi.org/10.1124/dmd.110.032359

  3. Veal, Gareth J.

    1. Role of UDP-Glucuronosyltransferase Isoforms in 13-cis Retinoic Acid Metabolism in Humans
      Sophie E. Rowbotham, Nicola A. Illingworth, Ann K. Daly, Gareth J. Veal and Alan V. Boddy
      Drug Metabolism and Disposition July 2010, 38 (7) 1211-1217; DOI: https://doi.org/10.1124/dmd.109.031625

  4. Vernillet, Laurent

    1. Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
      Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680

  5. Vincent, John

    1. In Vitro-In Vivo Correlation and Translation to the Clinical Outcome for CJ-13,610, a Novel Inhibitor of 5-Lipoxygenase
      J. Matthew Hutzler, Collette D. Linder, Roger J. Melton, John Vincent and J. Scott Daniels
      Drug Metabolism and Disposition July 2010, 38 (7) 1113-1121; DOI: https://doi.org/10.1124/dmd.110.032706

W

  1. Wang, Guangji

    1. Regioselective Glucuronidation of Tanshinone IIa after Quinone Reduction: Identification of Human UDP-Glucuronosyltransferases, Species Differences, and Interaction Potential
      Qiong Wang, Haiping Hao, Xuanxuan Zhu, Guo Yu, Li Lai, Yitong Liu, Yuxin Wang, Shan Jiang and Guangji Wang
      Drug Metabolism and Disposition July 2010, 38 (7) 1132-1140; DOI: https://doi.org/10.1124/dmd.109.031864

  2. Wang, Hong

    1. Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
      Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680

  3. Wang, Jianyao

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

  4. Wang, Qiong

    1. Regioselective Glucuronidation of Tanshinone IIa after Quinone Reduction: Identification of Human UDP-Glucuronosyltransferases, Species Differences, and Interaction Potential
      Qiong Wang, Haiping Hao, Xuanxuan Zhu, Guo Yu, Li Lai, Yitong Liu, Yuxin Wang, Shan Jiang and Guangji Wang
      Drug Metabolism and Disposition July 2010, 38 (7) 1132-1140; DOI: https://doi.org/10.1124/dmd.109.031864

  5. Wang, Ying-Hong

    1. Confidence Assessment of the Simcyp Time-Based Approach and a Static Mathematical Model in Predicting Clinical Drug-Drug Interactions for Mechanism-Based CYP3A Inhibitors
      Ying-Hong Wang
      Drug Metabolism and Disposition July 2010, 38 (7) 1094-1104; DOI: https://doi.org/10.1124/dmd.110.032177

  6. Wang, Yuxin

    1. Regioselective Glucuronidation of Tanshinone IIa after Quinone Reduction: Identification of Human UDP-Glucuronosyltransferases, Species Differences, and Interaction Potential
      Qiong Wang, Haiping Hao, Xuanxuan Zhu, Guo Yu, Li Lai, Yitong Liu, Yuxin Wang, Shan Jiang and Guangji Wang
      Drug Metabolism and Disposition July 2010, 38 (7) 1132-1140; DOI: https://doi.org/10.1124/dmd.109.031864

  7. Waters, Nigel J.

    1. Use of the Øie-Tozer Model in Understanding Mechanisms and Determinants of Drug Distribution
      Nigel J. Waters and Franco Lombardo
      Drug Metabolism and Disposition July 2010, 38 (7) 1159-1165; DOI: https://doi.org/10.1124/dmd.110.032458

  8. Weitschies, Werner

    1. Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA: Role of Human Organic Anion Transporters
      Mirko Leonhardt, Markus Keiser, Stefan Oswald, Jens Kühn, Jia Jia, Markus Grube, Heyo K. Kroemer, Werner Siegmund and Werner Weitschies
      Drug Metabolism and Disposition July 2010, 38 (7) 1024-1028; DOI: https://doi.org/10.1124/dmd.110.032862

  9. Wolf, C. Roland

    1. In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice
      Nico Scheer, Jillian Ross, Yury Kapelyukh, Anja Rode and C. Roland Wolf
      Drug Metabolism and Disposition July 2010, 38 (7) 1046-1053; DOI: https://doi.org/10.1124/dmd.109.031872

  10. Wong, Harvey

    1. Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
      Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
      Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680

X

  1. Xu, Cong

    1. Efavirenz Primary and Secondary Metabolism In Vitro and In Vivo: Identification of Novel Metabolic Pathways and Cytochrome P450 2A6 as the Principal Catalyst of Efavirenz 7-Hydroxylation
      Evan T. Ogburn, David R. Jones, Andrea R. Masters, Cong Xu, Yingying Guo and Zeruesenay Desta
      Drug Metabolism and Disposition July 2010, 38 (7) 1218-1229; DOI: https://doi.org/10.1124/dmd.109.031393

Y

  1. Youdim, Kuresh A.

    1. Potential Application of d-Optimal Designs in the Efficient Investigation of Cytochrome P450 Inhibition Kinetic Models
      Kuresh A. Youdim, Anthony C. Atkinson, Maciej Patan, Barbara Bogacka and Patrick J. Johnson
      Drug Metabolism and Disposition July 2010, 38 (7) 1019-1023; DOI: https://doi.org/10.1124/dmd.110.033142

  2. Yu, Guo

    1. Regioselective Glucuronidation of Tanshinone IIa after Quinone Reduction: Identification of Human UDP-Glucuronosyltransferases, Species Differences, and Interaction Potential
      Qiong Wang, Haiping Hao, Xuanxuan Zhu, Guo Yu, Li Lai, Yitong Liu, Yuxin Wang, Shan Jiang and Guangji Wang
      Drug Metabolism and Disposition July 2010, 38 (7) 1132-1140; DOI: https://doi.org/10.1124/dmd.109.031864

  3. Yu, Linning

    1. Characterization of HKI-272 Covalent Binding to Human Serum Albumin
      Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu, Peter Horwatt, Steven Ross, Susan Lockhead, Syed Ahmad, Appavu Chandrasekaran, Aram Oganesian, JoAnn Scatina, Abdul Mutlib and Rasmy Talaat
      Drug Metabolism and Disposition July 2010, 38 (7) 1083-1093; DOI: https://doi.org/10.1124/dmd.110.032292

Z

  1. Zeldin, Darryl C.

    1. The Nuclear Receptors Constitutive Active/Androstane Receptor and Pregnane X Receptor Activate the Cyp2c55 Gene in Mouse Liver
      Yoshihiro Konno, Hiroki Kamino, Rick Moore, Fred Lih, Kenneth B. Tomer, Darryl C. Zeldin, Joyce A. Goldstein and Masahiko Negishi
      Drug Metabolism and Disposition July 2010, 38 (7) 1177-1182; DOI: https://doi.org/10.1124/dmd.110.032334

  2. Zhang, Yu-Kun Jennifer

    1. Energy Restriction Does Not Compensate for the Reduced Expression of Hepatic Drug-Processing Genes in Mice with Aging
      Yu-Kun Jennifer Zhang, Kurt W. Saupe and Curtis D. Klaassen
      Drug Metabolism and Disposition July 2010, 38 (7) 1122-1131; DOI: https://doi.org/10.1124/dmd.110.032599

  3. Zhou, Diansong

    1. Expression and Characterization of Dog Cytochrome P450 2A13 and 2A25 in Baculovirus-Infected Insect Cells
      Diansong Zhou, Alban J. Linnenbach, Ruifeng Liu, Rick A. Luzietti, Jennifer J. Harris, Catherine L. Booth-Genthe and Scott W. Grimm
      Drug Metabolism and Disposition July 2010, 38 (7) 1015-1018; DOI: https://doi.org/10.1124/dmd.110.033068

  4. Zhu, Xuanxuan

    1. Regioselective Glucuronidation of Tanshinone IIa after Quinone Reduction: Identification of Human UDP-Glucuronosyltransferases, Species Differences, and Interaction Potential
      Qiong Wang, Haiping Hao, Xuanxuan Zhu, Guo Yu, Li Lai, Yitong Liu, Yuxin Wang, Shan Jiang and Guangji Wang
      Drug Metabolism and Disposition July 2010, 38 (7) 1132-1140; DOI: https://doi.org/10.1124/dmd.109.031864
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