Research ArticleArticle
Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters Jr., S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
Drug Metabolism and Disposition July 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680
Harvey Wong
Frank-Peter Theil
Yong Cui
James C. Marsters Jr.
S. Cyrus Khojasteh
Laurent Vernillet
Hank La
Xiling Song
Hong Wang
Eric J. Morinello
Yuzhong Deng
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Research ArticleArticle
Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
Drug Metabolism and Disposition July 1, 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680
Research ArticleArticle
Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
Harvey Wong, Frank-Peter Theil, Yong Cui, James C. Marsters, S. Cyrus Khojasteh, Laurent Vernillet, Hank La, Xiling Song, Hong Wang, Eric J. Morinello, Yuzhong Deng and Cornelis E. C. A. Hop
Drug Metabolism and Disposition July 1, 2010, 38 (7) 1029-1038; DOI: https://doi.org/10.1124/dmd.110.032680
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