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Drug Metabolism & Disposition

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Table of Contents

August 01, 2010; Volume 38,Issue 8

Short Communication

  • You have access
    Relevance of Nonsynonymous CYP2C8 Polymorphisms to 13-cis Retinoic Acid and Paclitaxel Hydroxylation
    Sophie E. Rowbotham, Alan V. Boddy, Chris P. F. Redfern, Gareth J. Veal and Ann K. Daly
    Drug Metabolism and Disposition August 2010, 38 (8) 1261-1266; DOI: https://doi.org/10.1124/dmd.109.030866

Articles

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    Formation Pathways of γ-Butyrolactone from the Furan Ring of Tegafur during Its Conversion to 5-Fluorouracil
    Ikuo Yamamiya, Kunihiro Yoshisue, Eiji Matsushima and Sekio Nagayama
    Drug Metabolism and Disposition August 2010, 38 (8) 1267-1276; DOI: https://doi.org/10.1124/dmd.110.032797
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    Species-Specific Metabolism of SGX523 by Aldehyde Oxidase and the Toxicological Implications
    Sharon Diamond, Jason Boer, Thomas P. Maduskuie, Nikoo Falahatpisheh, Yu Li and Swamy Yeleswaram
    Drug Metabolism and Disposition August 2010, 38 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.110.032375
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    Furanocoumarin Derivatives in Kampo Extract Medicines Inhibit Cytochrome P450 3A4 and P-Glycoprotein
    Kazunori Iwanaga, Manami Hayashi, Yukimi Hamahata, Makoto Miyazaki, Makio Shibano, Masahiko Taniguchi, Kimiye Baba and Masawo Kakemi
    Drug Metabolism and Disposition August 2010, 38 (8) 1286-1294; DOI: https://doi.org/10.1124/dmd.110.032847
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    Identification of Novel Metoclopramide Metabolites in Humans: In Vitro and In Vivo Studies
    Upendra A. Argikar, Javier Gomez, Din Ung, Henry P. Parkman and Swati Nagar
    Drug Metabolism and Disposition August 2010, 38 (8) 1295-1307; DOI: https://doi.org/10.1124/dmd.110.033357
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    Methadone: A Substrate and Mechanism-Based Inhibitor of CYP19 (Aromatase)
    Wenjie Jessie Lu, Robert Bies, Landry K. Kamden, Zeruesenay Desta and David A. Flockhart
    Drug Metabolism and Disposition August 2010, 38 (8) 1308-1313; DOI: https://doi.org/10.1124/dmd.110.032474
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    The N-Oxide Metabolite Contributes to Bladder Selectivity Resulting from Oral Propiverine: Muscarinic Receptor Binding and Pharmacokinetics
    Shizuo Yamada, Yoshihiko Ito, Yuko Taki, Masanao Seki, Masato Nanri, Fumiaki Yamashita, Kayo Morishita, Ikumi Komoto and Ken-ichiro Yoshida
    Drug Metabolism and Disposition August 2010, 38 (8) 1314-1321; DOI: https://doi.org/10.1124/dmd.110.033233
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    In Vitro-In Vivo Correlation for Intrinsic Clearance for Drugs Metabolized by Human Aldehyde Oxidase
    Michael Zientek, Ying Jiang, Kuresh Youdim and R. Scott Obach
    Drug Metabolism and Disposition August 2010, 38 (8) 1322-1327; DOI: https://doi.org/10.1124/dmd.110.033555
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    Metabolism of Flumatinib, a Novel Antineoplastic Tyrosine Kinase Inhibitor, in Chronic Myelogenous Leukemia Patients
    Aishen Gong, Xiaoyan Chen, Pan Deng and Dafang Zhong
    Drug Metabolism and Disposition August 2010, 38 (8) 1328-1340; DOI: https://doi.org/10.1124/dmd.110.032326
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    In Vitro to In Vivo Comparison of the Substrate Characteristics of Sorafenib Tosylate toward P-Glycoprotein
    M. J. Gnoth, S. Sandmann, K. Engel and M. Radtke
    Drug Metabolism and Disposition August 2010, 38 (8) 1341-1346; DOI: https://doi.org/10.1124/dmd.110.032052
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    Computational Prediction of Binding Affinity for CYP1A2-Ligand Complexes Using Empirical Free Energy Calculations
    Poongavanam Vasanthanathan, Lars Olsen, Flemming Steen Jørgensen, Nico P. E. Vermeulen and Chris Oostenbrink
    Drug Metabolism and Disposition August 2010, 38 (8) 1347-1354; DOI: https://doi.org/10.1124/dmd.110.032946
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    Central Nervous System Penetration for Small Molecule Therapeutic Agents Does Not Increase in Multiple Sclerosis- and Alzheimer's Disease-Related Animal Models Despite Reported Blood-Brain Barrier Disruption
    Ziqiang Cheng, Jinqiang Zhang, Houfu Liu, Yi Li, Yonggang Zhao and Eric Yang
    Drug Metabolism and Disposition August 2010, 38 (8) 1355-1361; DOI: https://doi.org/10.1124/dmd.110.033324
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    In Silico Classification of Major Clearance Pathways of Drugs with Their Physiochemical Parameters
    Makiko Kusama, Kouta Toshimoto, Kazuya Maeda, Yuka Hirai, Satoki Imai, Koji Chiba, Yutaka Akiyama and Yuichi Sugiyama
    Drug Metabolism and Disposition August 2010, 38 (8) 1362-1370; DOI: https://doi.org/10.1124/dmd.110.032789
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    Comparison of ATP-Binding Cassette Transporter Interactions with the Tyrosine Kinase Inhibitors Imatinib, Nilotinib, and Dasatinib
    Marius Dohse, Christian Scharenberg, Suneet Shukla, Robert W. Robey, Thorsten Volkmann, John F. Deeken, Cornelia Brendel, Suresh V. Ambudkar, Andreas Neubauer and Susan E. Bates
    Drug Metabolism and Disposition August 2010, 38 (8) 1371-1380; DOI: https://doi.org/10.1124/dmd.109.031302
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    Metabolism of Ramelteon in Human Liver Microsomes and Correlation with the Effect of Fluvoxamine on Ramelteon Pharmacokinetics
    R. Scott Obach and Tim F. Ryder
    Drug Metabolism and Disposition August 2010, 38 (8) 1381-1391; DOI: https://doi.org/10.1124/dmd.110.034009
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Drug Metabolism and Disposition: 38 (8)
Drug Metabolism and Disposition
Vol. 38, Issue 8
1 Aug 2010
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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