Table of Contents

Articles

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  Formation Pathways of γ-Butyrolactone from the Furan Ring of Tegafur during Its Conversion to 5-Fluorouracil

  Ikuo Yamamiya, Kunihiro Yoshisue, Eiji Matsushima and Sekio Nagayama

  Drug Metabolism and Disposition August 2010, 38 (8) 1267-1276; DOI: https://doi.org/10.1124/dmd.110.032797
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  Species-Specific Metabolism of SGX523 by Aldehyde Oxidase and the Toxicological Implications

  Sharon Diamond, Jason Boer, Thomas P. Maduskuie, Nikoo Falahatpisheh, Yu Li and Swamy Yeleswaram

  Drug Metabolism and Disposition August 2010, 38 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.110.032375
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  Furanocoumarin Derivatives in Kampo Extract Medicines Inhibit Cytochrome P450 3A4 and P-Glycoprotein

  Kazunori Iwanaga, Manami Hayashi, Yukimi Hamahata, Makoto Miyazaki, Makio Shibano, Masahiko Taniguchi, Kimiye Baba and Masawo Kakemi

  Drug Metabolism and Disposition August 2010, 38 (8) 1286-1294; DOI: https://doi.org/10.1124/dmd.110.032847
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  Identification of Novel Metoclopramide Metabolites in Humans: In Vitro and In Vivo Studies

  Upendra A. Argikar, Javier Gomez, Din Ung, Henry P. Parkman and Swati Nagar

  Drug Metabolism and Disposition August 2010, 38 (8) 1295-1307; DOI: https://doi.org/10.1124/dmd.110.033357
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  Methadone: A Substrate and Mechanism-Based Inhibitor of CYP19 (Aromatase)

  Wenjie Jessie Lu, Robert Bies, Landry K. Kamden, Zeruesenay Desta and David A. Flockhart

  Drug Metabolism and Disposition August 2010, 38 (8) 1308-1313; DOI: https://doi.org/10.1124/dmd.110.032474
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  The N-Oxide Metabolite Contributes to Bladder Selectivity Resulting from Oral Propiverine: Muscarinic Receptor Binding and Pharmacokinetics

  Shizuo Yamada, Yoshihiko Ito, Yuko Taki, Masanao Seki, Masato Nanri, Fumiaki Yamashita, Kayo Morishita, Ikumi Komoto and Ken-ichiro Yoshida

  Drug Metabolism and Disposition August 2010, 38 (8) 1314-1321; DOI: https://doi.org/10.1124/dmd.110.033233
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  In Vitro-In Vivo Correlation for Intrinsic Clearance for Drugs Metabolized by Human Aldehyde Oxidase

  Michael Zientek, Ying Jiang, Kuresh Youdim and R. Scott Obach

  Drug Metabolism and Disposition August 2010, 38 (8) 1322-1327; DOI: https://doi.org/10.1124/dmd.110.033555
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  Metabolism of Flumatinib, a Novel Antineoplastic Tyrosine Kinase Inhibitor, in Chronic Myelogenous Leukemia Patients

  Aishen Gong, Xiaoyan Chen, Pan Deng and Dafang Zhong

  Drug Metabolism and Disposition August 2010, 38 (8) 1328-1340; DOI: https://doi.org/10.1124/dmd.110.032326
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  In Vitro to In Vivo Comparison of the Substrate Characteristics of Sorafenib Tosylate toward P-Glycoprotein

  M. J. Gnoth, S. Sandmann, K. Engel and M. Radtke

  Drug Metabolism and Disposition August 2010, 38 (8) 1341-1346; DOI: https://doi.org/10.1124/dmd.110.032052
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  Computational Prediction of Binding Affinity for CYP1A2-Ligand Complexes Using Empirical Free Energy Calculations

  Poongavanam Vasanthanathan, Lars Olsen, Flemming Steen Jørgensen, Nico P. E. Vermeulen and Chris Oostenbrink

  Drug Metabolism and Disposition August 2010, 38 (8) 1347-1354; DOI: https://doi.org/10.1124/dmd.110.032946
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  Central Nervous System Penetration for Small Molecule Therapeutic Agents Does Not Increase in Multiple Sclerosis- and Alzheimer's Disease-Related Animal Models Despite Reported Blood-Brain Barrier Disruption

  Ziqiang Cheng, Jinqiang Zhang, Houfu Liu, Yi Li, Yonggang Zhao and Eric Yang

  Drug Metabolism and Disposition August 2010, 38 (8) 1355-1361; DOI: https://doi.org/10.1124/dmd.110.033324
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  In Silico Classification of Major Clearance Pathways of Drugs with Their Physiochemical Parameters

  Makiko Kusama, Kouta Toshimoto, Kazuya Maeda, Yuka Hirai, Satoki Imai, Koji Chiba, Yutaka Akiyama and Yuichi Sugiyama

  Drug Metabolism and Disposition August 2010, 38 (8) 1362-1370; DOI: https://doi.org/10.1124/dmd.110.032789
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  Comparison of ATP-Binding Cassette Transporter Interactions with the Tyrosine Kinase Inhibitors Imatinib, Nilotinib, and Dasatinib

  Marius Dohse, Christian Scharenberg, Suneet Shukla, Robert W. Robey, Thorsten Volkmann, John F. Deeken, Cornelia Brendel, Suresh V. Ambudkar, Andreas Neubauer and Susan E. Bates

  Drug Metabolism and Disposition August 2010, 38 (8) 1371-1380; DOI: https://doi.org/10.1124/dmd.109.031302
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  Metabolism of Ramelteon in Human Liver Microsomes and Correlation with the Effect of Fluvoxamine on Ramelteon Pharmacokinetics

  R. Scott Obach and Tim F. Ryder

  Drug Metabolism and Disposition August 2010, 38 (8) 1381-1391; DOI: https://doi.org/10.1124/dmd.110.034009