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Index by author

September 01, 2010; Volume 38,Issue 9

A

  1. Ahmad, Syed

    1. In Vitro Metabolism, Permeability, and Efflux of Bazedoxifene in Humans
      Li Shen, Syed Ahmad, SeongHee Park, William DeMaio, Aram Oganesian, Theresa Hultin, JoAnn Scatina, Peter Bungay and Appavu Chandrasekaran
      Drug Metabolism and Disposition September 2010, 38 (9) 1471-1479; DOI: https://doi.org/10.1124/dmd.109.030999

  2. Aida, Yoshie

    1. Methemoglobinemia Induced by 1,2-Dichloro-4-nitrobenzene in Mice with a Disrupted Glutathione S-Transferase Mu 1 Gene
      Shingo Arakawa, Takanori Maejima, Naoki Kiyosawa, Takashi Yamaguchi, Yukari Shibaya, Yoshie Aida, Ryota Kawai, Kazunori Fujimoto, Sunao Manabe and Wataru Takasaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1545-1552; DOI: https://doi.org/10.1124/dmd.110.033597

  3. Al Khansa, Ihab

    1. Liverbeads: A Practical and Relevant In Vitro Model for Gene Induction Investigations
      Ihab Al Khansa, Olivier Blanck, André Guillouzo and Rémi Bars
      Drug Metabolism and Disposition September 2010, 38 (9) 1598-1604; DOI: https://doi.org/10.1124/dmd.110.033753

  4. Amundsen, Rune

    1. Cyclosporine A, but Not Tacrolimus, Shows Relevant Inhibition of Organic Anion-Transporting Protein 1B1-Mediated Transport of Atorvastatin
      Rune Amundsen, Hege Christensen, Behnaz Zabihyan and Anders Åsberg
      Drug Metabolism and Disposition September 2010, 38 (9) 1499-1504; DOI: https://doi.org/10.1124/dmd.110.032268

  5. Annaert, Pieter

    1. In Situ Intestinal Perfusion in Knockout Mice Demonstrates Inhibition of Intestinal P-Glycoprotein by Ritonavir Causing Increased Darunavir Absorption
      Nico Holmstock, Raf Mols, Pieter Annaert and Patrick Augustijns
      Drug Metabolism and Disposition September 2010, 38 (9) 1407-1410; DOI: https://doi.org/10.1124/dmd.110.032771

  6. Arakawa, Shingo

    1. Methemoglobinemia Induced by 1,2-Dichloro-4-nitrobenzene in Mice with a Disrupted Glutathione S-Transferase Mu 1 Gene
      Shingo Arakawa, Takanori Maejima, Naoki Kiyosawa, Takashi Yamaguchi, Yukari Shibaya, Yoshie Aida, Ryota Kawai, Kazunori Fujimoto, Sunao Manabe and Wataru Takasaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1545-1552; DOI: https://doi.org/10.1124/dmd.110.033597

  7. Åsberg, Anders

    1. Cyclosporine A, but Not Tacrolimus, Shows Relevant Inhibition of Organic Anion-Transporting Protein 1B1-Mediated Transport of Atorvastatin
      Rune Amundsen, Hege Christensen, Behnaz Zabihyan and Anders Åsberg
      Drug Metabolism and Disposition September 2010, 38 (9) 1499-1504; DOI: https://doi.org/10.1124/dmd.110.032268

  8. Augustijns, Patrick

    1. In Situ Intestinal Perfusion in Knockout Mice Demonstrates Inhibition of Intestinal P-Glycoprotein by Ritonavir Causing Increased Darunavir Absorption
      Nico Holmstock, Raf Mols, Pieter Annaert and Patrick Augustijns
      Drug Metabolism and Disposition September 2010, 38 (9) 1407-1410; DOI: https://doi.org/10.1124/dmd.110.032771

B

  1. Baierl, Juergen

    1. The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Exhibits Time- and Dose-Dependent Localization in Kidney, Liver, and Intestine after Intravenous Dosing: Results from High Resolution Autoradiography in Rats
      Andreas Greischel, Rudolf Binder and Juergen Baierl
      Drug Metabolism and Disposition September 2010, 38 (9) 1443-1448; DOI: https://doi.org/10.1124/dmd.110.034199

  2. Balani, Suresh K.

    1. Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions
      Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia
      Drug Metabolism and Disposition September 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995

  3. Balbo, Silvia

    1. Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes
      Pramod Upadhyaya, J. Bradley Hochalter, Silvia Balbo, Edward J. McIntee and Stephen S. Hecht
      Drug Metabolism and Disposition September 2010, 38 (9) 1397-1402; DOI: https://doi.org/10.1124/dmd.110.034181

  4. Baldwin, William S.

    1. Constitutive Androgen Receptor-Null Mice Are Sensitive to the Toxic Effects of Parathion: Association with Reduced Cytochrome P450-Mediated Parathion Metabolism
      Linda C. Mota, Juan P. Hernandez and William S. Baldwin
      Drug Metabolism and Disposition September 2010, 38 (9) 1582-1588; DOI: https://doi.org/10.1124/dmd.110.032961

  5. Bars, Rémi

    1. Liverbeads: A Practical and Relevant In Vitro Model for Gene Induction Investigations
      Ihab Al Khansa, Olivier Blanck, André Guillouzo and Rémi Bars
      Drug Metabolism and Disposition September 2010, 38 (9) 1598-1604; DOI: https://doi.org/10.1124/dmd.110.033753

  6. Belvin, Marcia

    1. Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
      Laurent Salphati, Harvey Wong, Marcia Belvin, Delia Bradford, Kyle A. Edgar, Wei Wei Prior, Deepak Sampath and Jeffrey J. Wallin
      Drug Metabolism and Disposition September 2010, 38 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.110.032912

  7. Binder, Rudolf

    1. The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Exhibits Time- and Dose-Dependent Localization in Kidney, Liver, and Intestine after Intravenous Dosing: Results from High Resolution Autoradiography in Rats
      Andreas Greischel, Rudolf Binder and Juergen Baierl
      Drug Metabolism and Disposition September 2010, 38 (9) 1443-1448; DOI: https://doi.org/10.1124/dmd.110.034199

  8. Blanck, Olivier

    1. Liverbeads: A Practical and Relevant In Vitro Model for Gene Induction Investigations
      Ihab Al Khansa, Olivier Blanck, André Guillouzo and Rémi Bars
      Drug Metabolism and Disposition September 2010, 38 (9) 1598-1604; DOI: https://doi.org/10.1124/dmd.110.033753

  9. Boldt, Sherri

    1. Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes
      Odette A. Fahmi, Mary Kish, Sherri Boldt and R. Scott Obach
      Drug Metabolism and Disposition September 2010, 38 (9) 1605-1611; DOI: https://doi.org/10.1124/dmd.110.033126

  10. Bradford, Delia

    1. Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
      Laurent Salphati, Harvey Wong, Marcia Belvin, Delia Bradford, Kyle A. Edgar, Wei Wei Prior, Deepak Sampath and Jeffrey J. Wallin
      Drug Metabolism and Disposition September 2010, 38 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.110.032912

  11. Bungay, Peter

    1. In Vitro Metabolism, Permeability, and Efflux of Bazedoxifene in Humans
      Li Shen, Syed Ahmad, SeongHee Park, William DeMaio, Aram Oganesian, Theresa Hultin, JoAnn Scatina, Peter Bungay and Appavu Chandrasekaran
      Drug Metabolism and Disposition September 2010, 38 (9) 1471-1479; DOI: https://doi.org/10.1124/dmd.109.030999

  12. Butler, Kathleen

    1. Absorption, Distribution, Metabolism, and Excretion of Ticagrelor in Healthy Subjects
      Renli Teng, Stuart Oliver, Martin A. Hayes and Kathleen Butler
      Drug Metabolism and Disposition September 2010, 38 (9) 1514-1521; DOI: https://doi.org/10.1124/dmd.110.032250

C

  1. Castell, José V.

    1. Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo
      M. Teresa Donato, David Hallifax, Laura Picazo, José V. Castell, J. Brian Houston, M. José Gomez-Lechón and Agustin Lahoz
      Drug Metabolism and Disposition September 2010, 38 (9) 1449-1455; DOI: https://doi.org/10.1124/dmd.110.033605

  2. Chandrasekaran, Appavu

    1. In Vitro Metabolism, Permeability, and Efflux of Bazedoxifene in Humans
      Li Shen, Syed Ahmad, SeongHee Park, William DeMaio, Aram Oganesian, Theresa Hultin, JoAnn Scatina, Peter Bungay and Appavu Chandrasekaran
      Drug Metabolism and Disposition September 2010, 38 (9) 1471-1479; DOI: https://doi.org/10.1124/dmd.109.030999

  3. Chen, Chao

    1. Metabolism of Tanshinol Borneol Ester in Rat and Human Liver Microsomes
      Duan Liu, Xiaohui Zheng, Yitong Tang, Jing Zi, Yefei Nan, Shixiang Wang, Chaoni Xiao, Juanli Zhu and Chao Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1464-1470; DOI: https://doi.org/10.1124/dmd.110.033381

  4. Chen, Michael

    1. Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions
      Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia
      Drug Metabolism and Disposition September 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995

  5. Chen, Taosheng

    1. Protein Phosphatase 2Cβl Regulates Human Pregnane X Receptor-Mediated CYP3A4 Gene Expression in HepG2 Liver Carcinoma Cells
      Satyanarayana R. Pondugula, Alexander A. Tong, Jing Wu, Jimmy Cui and Taosheng Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1411-1416; DOI: https://doi.org/10.1124/dmd.110.032128

  6. Chiba, Koji

    1. Effect of the CYP2D6*10 Genotype on Tolterodine Pharmacokinetics
      Masayo Oishi, Koji Chiba, Bimal Malhotra and Toshio Suwa
      Drug Metabolism and Disposition September 2010, 38 (9) 1456-1463; DOI: https://doi.org/10.1124/dmd.110.033407

  7. Cho, Sool Yeon

    1. Discontinuous Drug Binding to Proteins: Binding of an Antineoplastic Benzyl Styryl Sulfone to Albumin and Enzymes In Vitro and in Phase I Clinical Trials
      Sool Yeon Cho, Takao Ohnuma, Lewis R. Silverman, James F. Holland and John Roboz
      Drug Metabolism and Disposition September 2010, 38 (9) 1480-1485; DOI: https://doi.org/10.1124/dmd.110.033001

  8. Christensen, Hege

    1. Cyclosporine A, but Not Tacrolimus, Shows Relevant Inhibition of Organic Anion-Transporting Protein 1B1-Mediated Transport of Atorvastatin
      Rune Amundsen, Hege Christensen, Behnaz Zabihyan and Anders Åsberg
      Drug Metabolism and Disposition September 2010, 38 (9) 1499-1504; DOI: https://doi.org/10.1124/dmd.110.032268

  9. Chuang, Bei-Ching

    1. Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions
      Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia
      Drug Metabolism and Disposition September 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995

  10. Claessens, Adam J.

    1. CYP2D6 Mediates 4-Hydroxylation of Clonidine In Vitro: Implication for Pregnancy-Induced Changes in Clonidine Clearance
      Adam J. Claessens, Linda J. Risler, Sara Eyal, Danny D. Shen, Thomas R. Easterling and Mary F. Hebert
      Drug Metabolism and Disposition September 2010, 38 (9) 1393-1396; DOI: https://doi.org/10.1124/dmd.110.033878

  11. Covas, Maria-Isabel

    1. Antioxidant Activities of Hydroxytyrosol Main Metabolites Do Not Contribute to Beneficial Health Effects after Olive Oil Ingestion
      Olha Khymenets, Montserat Fitó, Sonia Touriño, Daniel Muñoz-Aguayo, Mitona Pujadas, Josep Lluis Torres, Jesús Joglar, Magí Farré, Maria-Isabel Covas and Rafael de la Torre
      Drug Metabolism and Disposition September 2010, 38 (9) 1417-1421; DOI: https://doi.org/10.1124/dmd.110.032821

  12. Cui, Jimmy

    1. Protein Phosphatase 2Cβl Regulates Human Pregnane X Receptor-Mediated CYP3A4 Gene Expression in HepG2 Liver Carcinoma Cells
      Satyanarayana R. Pondugula, Alexander A. Tong, Jing Wu, Jimmy Cui and Taosheng Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1411-1416; DOI: https://doi.org/10.1124/dmd.110.032128

D

  1. de la Torre, Rafael

    1. Antioxidant Activities of Hydroxytyrosol Main Metabolites Do Not Contribute to Beneficial Health Effects after Olive Oil Ingestion
      Olha Khymenets, Montserat Fitó, Sonia Touriño, Daniel Muñoz-Aguayo, Mitona Pujadas, Josep Lluis Torres, Jesús Joglar, Magí Farré, Maria-Isabel Covas and Rafael de la Torre
      Drug Metabolism and Disposition September 2010, 38 (9) 1417-1421; DOI: https://doi.org/10.1124/dmd.110.032821

  2. DeMaio, William

    1. In Vitro Metabolism, Permeability, and Efflux of Bazedoxifene in Humans
      Li Shen, Syed Ahmad, SeongHee Park, William DeMaio, Aram Oganesian, Theresa Hultin, JoAnn Scatina, Peter Bungay and Appavu Chandrasekaran
      Drug Metabolism and Disposition September 2010, 38 (9) 1471-1479; DOI: https://doi.org/10.1124/dmd.109.030999

  3. Donato, M. Teresa

    1. Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo
      M. Teresa Donato, David Hallifax, Laura Picazo, José V. Castell, J. Brian Houston, M. José Gomez-Lechón and Agustin Lahoz
      Drug Metabolism and Disposition September 2010, 38 (9) 1449-1455; DOI: https://doi.org/10.1124/dmd.110.033605

  4. Dreifinger, Tali

    1. Role of P-Glycoprotein in Region-Specific Gastrointestinal Absorption of Talinolol in Rats
      Leonid Kagan, Tali Dreifinger, Donald E. Mager and Amnon Hoffman
      Drug Metabolism and Disposition September 2010, 38 (9) 1560-1566; DOI: https://doi.org/10.1124/dmd.110.033019

E

  1. Easterling, Thomas R.

    1. CYP2D6 Mediates 4-Hydroxylation of Clonidine In Vitro: Implication for Pregnancy-Induced Changes in Clonidine Clearance
      Adam J. Claessens, Linda J. Risler, Sara Eyal, Danny D. Shen, Thomas R. Easterling and Mary F. Hebert
      Drug Metabolism and Disposition September 2010, 38 (9) 1393-1396; DOI: https://doi.org/10.1124/dmd.110.033878

  2. Ebner, Thomas

    1. Dabigatran Acylglucuronide, the Major Human Metabolite of Dabigatran: In Vitro Formation, Stability, and Pharmacological Activity
      Thomas Ebner, Klaus Wagner and Wolfgang Wienen
      Drug Metabolism and Disposition September 2010, 38 (9) 1567-1575; DOI: https://doi.org/10.1124/dmd.110.033696

  3. Edgar, Kyle A.

    1. Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
      Laurent Salphati, Harvey Wong, Marcia Belvin, Delia Bradford, Kyle A. Edgar, Wei Wei Prior, Deepak Sampath and Jeffrey J. Wallin
      Drug Metabolism and Disposition September 2010, 38 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.110.032912

  4. Eyal, Sara

    1. CYP2D6 Mediates 4-Hydroxylation of Clonidine In Vitro: Implication for Pregnancy-Induced Changes in Clonidine Clearance
      Adam J. Claessens, Linda J. Risler, Sara Eyal, Danny D. Shen, Thomas R. Easterling and Mary F. Hebert
      Drug Metabolism and Disposition September 2010, 38 (9) 1393-1396; DOI: https://doi.org/10.1124/dmd.110.033878

F

  1. Fahmi, Odette A.

    1. Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes
      Odette A. Fahmi, Mary Kish, Sherri Boldt and R. Scott Obach
      Drug Metabolism and Disposition September 2010, 38 (9) 1605-1611; DOI: https://doi.org/10.1124/dmd.110.033126

  2. Farré, Magí

    1. Antioxidant Activities of Hydroxytyrosol Main Metabolites Do Not Contribute to Beneficial Health Effects after Olive Oil Ingestion
      Olha Khymenets, Montserat Fitó, Sonia Touriño, Daniel Muñoz-Aguayo, Mitona Pujadas, Josep Lluis Torres, Jesús Joglar, Magí Farré, Maria-Isabel Covas and Rafael de la Torre
      Drug Metabolism and Disposition September 2010, 38 (9) 1417-1421; DOI: https://doi.org/10.1124/dmd.110.032821

  3. Feidt, Diana M.

    1. Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes
      Diana M. Feidt, Kathrin Klein, Ute Hofmann, Stephan Riedmaier, Daniel Knobeloch, Wolfgang E. Thasler, Thomas S. Weiss, Matthias Schwab and Ulrich M. Zanger
      Drug Metabolism and Disposition September 2010, 38 (9) 1589-1597; DOI: https://doi.org/10.1124/dmd.110.033886

  4. Fitó, Montserat

    1. Antioxidant Activities of Hydroxytyrosol Main Metabolites Do Not Contribute to Beneficial Health Effects after Olive Oil Ingestion
      Olha Khymenets, Montserat Fitó, Sonia Touriño, Daniel Muñoz-Aguayo, Mitona Pujadas, Josep Lluis Torres, Jesús Joglar, Magí Farré, Maria-Isabel Covas and Rafael de la Torre
      Drug Metabolism and Disposition September 2010, 38 (9) 1417-1421; DOI: https://doi.org/10.1124/dmd.110.032821

  5. Fujimoto, Kazunori

    1. Methemoglobinemia Induced by 1,2-Dichloro-4-nitrobenzene in Mice with a Disrupted Glutathione S-Transferase Mu 1 Gene
      Shingo Arakawa, Takanori Maejima, Naoki Kiyosawa, Takashi Yamaguchi, Yukari Shibaya, Yoshie Aida, Ryota Kawai, Kazunori Fujimoto, Sunao Manabe and Wataru Takasaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1545-1552; DOI: https://doi.org/10.1124/dmd.110.033597

  6. Fukami, Tatsuki

    1. Arylacetamide Deacetylase Is a Determinant Enzyme for the Difference in Hydrolase Activities of Phenacetin and Acetaminophen
      Akinobu Watanabe, Tatsuki Fukami, Shiori Takahashi, Yuki Kobayashi, Nao Nakagawa, Miki Nakajima and Tsuyoshi Yokoi
      Drug Metabolism and Disposition September 2010, 38 (9) 1532-1537; DOI: https://doi.org/10.1124/dmd.110.033720

  7. Fukuda, Hajime

    1. Estimation of Transporters Involved in the Hepatobiliary Transport of TA-0201CA Using Sandwich-Cultured Rat Hepatocytes from Normal and Multidrug Resistance-Associated Protein 2-Deficient Rats
      Hajime Fukuda, Rikiya Ohashi, Noriko Ohashi, Hikaru Yabuuchi and Ikumi Tamai
      Drug Metabolism and Disposition September 2010, 38 (9) 1505-1513; DOI: https://doi.org/10.1124/dmd.110.033258

G

  1. Gomez-Lechón, M. José

    1. Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo
      M. Teresa Donato, David Hallifax, Laura Picazo, José V. Castell, J. Brian Houston, M. José Gomez-Lechón and Agustin Lahoz
      Drug Metabolism and Disposition September 2010, 38 (9) 1449-1455; DOI: https://doi.org/10.1124/dmd.110.033605

  2. Greischel, Andreas

    1. The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Exhibits Time- and Dose-Dependent Localization in Kidney, Liver, and Intestine after Intravenous Dosing: Results from High Resolution Autoradiography in Rats
      Andreas Greischel, Rudolf Binder and Juergen Baierl
      Drug Metabolism and Disposition September 2010, 38 (9) 1443-1448; DOI: https://doi.org/10.1124/dmd.110.034199

  3. Guillouzo, André

    1. Liverbeads: A Practical and Relevant In Vitro Model for Gene Induction Investigations
      Ihab Al Khansa, Olivier Blanck, André Guillouzo and Rémi Bars
      Drug Metabolism and Disposition September 2010, 38 (9) 1598-1604; DOI: https://doi.org/10.1124/dmd.110.033753

H

  1. Hallifax, David

    1. Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo
      M. Teresa Donato, David Hallifax, Laura Picazo, José V. Castell, J. Brian Houston, M. José Gomez-Lechón and Agustin Lahoz
      Drug Metabolism and Disposition September 2010, 38 (9) 1449-1455; DOI: https://doi.org/10.1124/dmd.110.033605

  2. Hayes, Martin A.

    1. Absorption, Distribution, Metabolism, and Excretion of Ticagrelor in Healthy Subjects
      Renli Teng, Stuart Oliver, Martin A. Hayes and Kathleen Butler
      Drug Metabolism and Disposition September 2010, 38 (9) 1514-1521; DOI: https://doi.org/10.1124/dmd.110.032250

  3. Hebert, Mary F.

    1. CYP2D6 Mediates 4-Hydroxylation of Clonidine In Vitro: Implication for Pregnancy-Induced Changes in Clonidine Clearance
      Adam J. Claessens, Linda J. Risler, Sara Eyal, Danny D. Shen, Thomas R. Easterling and Mary F. Hebert
      Drug Metabolism and Disposition September 2010, 38 (9) 1393-1396; DOI: https://doi.org/10.1124/dmd.110.033878
    2. Increased Glyburide Clearance in the Pregnant Mouse Model
      Lin Zhou, Yi Zhang, Mary F. Hebert, Jashvant D. Unadkat and Qingcheng Mao
      Drug Metabolism and Disposition September 2010, 38 (9) 1403-1406; DOI: https://doi.org/10.1124/dmd.110.033837

  4. Hecht, Stephen S.

    1. Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes
      Pramod Upadhyaya, J. Bradley Hochalter, Silvia Balbo, Edward J. McIntee and Stephen S. Hecht
      Drug Metabolism and Disposition September 2010, 38 (9) 1397-1402; DOI: https://doi.org/10.1124/dmd.110.034181

  5. Hernandez, Juan P.

    1. Constitutive Androgen Receptor-Null Mice Are Sensitive to the Toxic Effects of Parathion: Association with Reduced Cytochrome P450-Mediated Parathion Metabolism
      Linda C. Mota, Juan P. Hernandez and William S. Baldwin
      Drug Metabolism and Disposition September 2010, 38 (9) 1582-1588; DOI: https://doi.org/10.1124/dmd.110.032961

  6. Heyde, Bruce R.

    1. Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes
      Yiding Hu, Shengtian Yang, F. Barclay Shilliday, Bruce R. Heyde, Kathy M. Mandrell, Russell H. Robins, Jin Xie, Matthew T. Reding, Yurong Lai and David C. Thompson
      Drug Metabolism and Disposition September 2010, 38 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.110.032581

  7. Hochalter, J. Bradley

    1. Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes
      Pramod Upadhyaya, J. Bradley Hochalter, Silvia Balbo, Edward J. McIntee and Stephen S. Hecht
      Drug Metabolism and Disposition September 2010, 38 (9) 1397-1402; DOI: https://doi.org/10.1124/dmd.110.034181

  8. Hoffman, Amnon

    1. Role of P-Glycoprotein in Region-Specific Gastrointestinal Absorption of Talinolol in Rats
      Leonid Kagan, Tali Dreifinger, Donald E. Mager and Amnon Hoffman
      Drug Metabolism and Disposition September 2010, 38 (9) 1560-1566; DOI: https://doi.org/10.1124/dmd.110.033019

  9. Hofmann, Ute

    1. Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes
      Diana M. Feidt, Kathrin Klein, Ute Hofmann, Stephan Riedmaier, Daniel Knobeloch, Wolfgang E. Thasler, Thomas S. Weiss, Matthias Schwab and Ulrich M. Zanger
      Drug Metabolism and Disposition September 2010, 38 (9) 1589-1597; DOI: https://doi.org/10.1124/dmd.110.033886

  10. Holland, James F.

    1. Discontinuous Drug Binding to Proteins: Binding of an Antineoplastic Benzyl Styryl Sulfone to Albumin and Enzymes In Vitro and in Phase I Clinical Trials
      Sool Yeon Cho, Takao Ohnuma, Lewis R. Silverman, James F. Holland and John Roboz
      Drug Metabolism and Disposition September 2010, 38 (9) 1480-1485; DOI: https://doi.org/10.1124/dmd.110.033001

  11. Holmstock, Nico

    1. In Situ Intestinal Perfusion in Knockout Mice Demonstrates Inhibition of Intestinal P-Glycoprotein by Ritonavir Causing Increased Darunavir Absorption
      Nico Holmstock, Raf Mols, Pieter Annaert and Patrick Augustijns
      Drug Metabolism and Disposition September 2010, 38 (9) 1407-1410; DOI: https://doi.org/10.1124/dmd.110.032771

  12. Horiguchi, Norio

    1. Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor
      Daichi Takizawa, Satoru Kakizaki, Norio Horiguchi, Hiroki Tojima, Yuichi Yamazaki, Takeshi Ichikawa, Ken Sato and Masatomo Mori
      Drug Metabolism and Disposition September 2010, 38 (9) 1493-1498; DOI: https://doi.org/10.1124/dmd.110.032854

  13. Houston, J. Brian

    1. Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo
      M. Teresa Donato, David Hallifax, Laura Picazo, José V. Castell, J. Brian Houston, M. José Gomez-Lechón and Agustin Lahoz
      Drug Metabolism and Disposition September 2010, 38 (9) 1449-1455; DOI: https://doi.org/10.1124/dmd.110.033605

  14. Hu, Yiding

    1. Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes
      Yiding Hu, Shengtian Yang, F. Barclay Shilliday, Bruce R. Heyde, Kathy M. Mandrell, Russell H. Robins, Jin Xie, Matthew T. Reding, Yurong Lai and David C. Thompson
      Drug Metabolism and Disposition September 2010, 38 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.110.032581

  15. Hultin, Theresa

    1. In Vitro Metabolism, Permeability, and Efflux of Bazedoxifene in Humans
      Li Shen, Syed Ahmad, SeongHee Park, William DeMaio, Aram Oganesian, Theresa Hultin, JoAnn Scatina, Peter Bungay and Appavu Chandrasekaran
      Drug Metabolism and Disposition September 2010, 38 (9) 1471-1479; DOI: https://doi.org/10.1124/dmd.109.030999

I

  1. Ichikawa, Takeshi

    1. Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor
      Daichi Takizawa, Satoru Kakizaki, Norio Horiguchi, Hiroki Tojima, Yuichi Yamazaki, Takeshi Ichikawa, Ken Sato and Masatomo Mori
      Drug Metabolism and Disposition September 2010, 38 (9) 1493-1498; DOI: https://doi.org/10.1124/dmd.110.032854

J

  1. Janjetovic, Zorica

    1. Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D3, Producing 1α,20,23-Trihydroxyvitamin D3, Which Has Altered Biological Activity
      Edith K. Y. Tang, Wei Li, Zorica Janjetovic, Minh N. Nguyen, Zhao Wang, Andrzej Slominski and Robert C. Tuckey
      Drug Metabolism and Disposition September 2010, 38 (9) 1553-1559; DOI: https://doi.org/10.1124/dmd.110.034389

  2. Joglar, Jesús

    1. Antioxidant Activities of Hydroxytyrosol Main Metabolites Do Not Contribute to Beneficial Health Effects after Olive Oil Ingestion
      Olha Khymenets, Montserat Fitó, Sonia Touriño, Daniel Muñoz-Aguayo, Mitona Pujadas, Josep Lluis Torres, Jesús Joglar, Magí Farré, Maria-Isabel Covas and Rafael de la Torre
      Drug Metabolism and Disposition September 2010, 38 (9) 1417-1421; DOI: https://doi.org/10.1124/dmd.110.032821

K

  1. Kagan, Leonid

    1. Role of P-Glycoprotein in Region-Specific Gastrointestinal Absorption of Talinolol in Rats
      Leonid Kagan, Tali Dreifinger, Donald E. Mager and Amnon Hoffman
      Drug Metabolism and Disposition September 2010, 38 (9) 1560-1566; DOI: https://doi.org/10.1124/dmd.110.033019

  2. Kakizaki, Satoru

    1. Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor
      Daichi Takizawa, Satoru Kakizaki, Norio Horiguchi, Hiroki Tojima, Yuichi Yamazaki, Takeshi Ichikawa, Ken Sato and Masatomo Mori
      Drug Metabolism and Disposition September 2010, 38 (9) 1493-1498; DOI: https://doi.org/10.1124/dmd.110.032854

  3. Kawai, Ryota

    1. Methemoglobinemia Induced by 1,2-Dichloro-4-nitrobenzene in Mice with a Disrupted Glutathione S-Transferase Mu 1 Gene
      Shingo Arakawa, Takanori Maejima, Naoki Kiyosawa, Takashi Yamaguchi, Yukari Shibaya, Yoshie Aida, Ryota Kawai, Kazunori Fujimoto, Sunao Manabe and Wataru Takasaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1545-1552; DOI: https://doi.org/10.1124/dmd.110.033597

  4. Khymenets, Olha

    1. Antioxidant Activities of Hydroxytyrosol Main Metabolites Do Not Contribute to Beneficial Health Effects after Olive Oil Ingestion
      Olha Khymenets, Montserat Fitó, Sonia Touriño, Daniel Muñoz-Aguayo, Mitona Pujadas, Josep Lluis Torres, Jesús Joglar, Magí Farré, Maria-Isabel Covas and Rafael de la Torre
      Drug Metabolism and Disposition September 2010, 38 (9) 1417-1421; DOI: https://doi.org/10.1124/dmd.110.032821

  5. Kish, Mary

    1. Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes
      Odette A. Fahmi, Mary Kish, Sherri Boldt and R. Scott Obach
      Drug Metabolism and Disposition September 2010, 38 (9) 1605-1611; DOI: https://doi.org/10.1124/dmd.110.033126

  6. Kitagaki, Shinji

    1. Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier
      Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai and Emi Nakashima
      Drug Metabolism and Disposition September 2010, 38 (9) 1576-1581; DOI: https://doi.org/10.1124/dmd.110.033266

  7. Kiyosawa, Naoki

    1. Methemoglobinemia Induced by 1,2-Dichloro-4-nitrobenzene in Mice with a Disrupted Glutathione S-Transferase Mu 1 Gene
      Shingo Arakawa, Takanori Maejima, Naoki Kiyosawa, Takashi Yamaguchi, Yukari Shibaya, Yoshie Aida, Ryota Kawai, Kazunori Fujimoto, Sunao Manabe and Wataru Takasaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1545-1552; DOI: https://doi.org/10.1124/dmd.110.033597

  8. Klein, Kathrin

    1. Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes
      Diana M. Feidt, Kathrin Klein, Ute Hofmann, Stephan Riedmaier, Daniel Knobeloch, Wolfgang E. Thasler, Thomas S. Weiss, Matthias Schwab and Ulrich M. Zanger
      Drug Metabolism and Disposition September 2010, 38 (9) 1589-1597; DOI: https://doi.org/10.1124/dmd.110.033886

  9. Knobeloch, Daniel

    1. Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes
      Diana M. Feidt, Kathrin Klein, Ute Hofmann, Stephan Riedmaier, Daniel Knobeloch, Wolfgang E. Thasler, Thomas S. Weiss, Matthias Schwab and Ulrich M. Zanger
      Drug Metabolism and Disposition September 2010, 38 (9) 1589-1597; DOI: https://doi.org/10.1124/dmd.110.033886

  10. Kobayashi, Nobuhiro

    1. Identification of Valproic Acid Glucuronide Hydrolase As a Key Enzyme for the Interaction of Valproic Acid with Carbapenem Antibiotics
      Eiko Suzuki, Naotoshi Yamamura, Yuji Ogura, Daisuke Nakai, Kazuishi Kubota, Nobuhiro Kobayashi, Shin-ichi Miura and Osamu Okazaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1538-1544; DOI: https://doi.org/10.1124/dmd.110.032938

  11. Kobayashi, Yasuna

    1. Activation of Cyclosporin A Transport by a Novel λ Light Chain of Human Ig Surface Antigen-Related Gene in Xenopus laevis Oocytes
      Yasuna Kobayashi, Takahiro Umemoto, Masayuki Ohbayashi, Noriko Kohyama, Yutaka Sanada and Toshinori Yamamoto
      Drug Metabolism and Disposition September 2010, 38 (9) 1427-1435; DOI: https://doi.org/10.1124/dmd.109.030916
    2. Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier
      Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai and Emi Nakashima
      Drug Metabolism and Disposition September 2010, 38 (9) 1576-1581; DOI: https://doi.org/10.1124/dmd.110.033266

  12. Kobayashi, Yuki

    1. Arylacetamide Deacetylase Is a Determinant Enzyme for the Difference in Hydrolase Activities of Phenacetin and Acetaminophen
      Akinobu Watanabe, Tatsuki Fukami, Shiori Takahashi, Yuki Kobayashi, Nao Nakagawa, Miki Nakajima and Tsuyoshi Yokoi
      Drug Metabolism and Disposition September 2010, 38 (9) 1532-1537; DOI: https://doi.org/10.1124/dmd.110.033720

  13. Kohara, Sakae

    1. Cynomolgus Monkey CYP2D44 Newly Identified in Liver, Metabolizes Bufuralol, and Dextromethorphan
      Yasuhiro Uno, Shotaro Uehara, Sakae Kohara, Norie Murayama and Hiroshi Yamazaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1486-1492; DOI: https://doi.org/10.1124/dmd.110.033274

  14. Kohyama, Noriko

    1. Activation of Cyclosporin A Transport by a Novel λ Light Chain of Human Ig Surface Antigen-Related Gene in Xenopus laevis Oocytes
      Yasuna Kobayashi, Takahiro Umemoto, Masayuki Ohbayashi, Noriko Kohyama, Yutaka Sanada and Toshinori Yamamoto
      Drug Metabolism and Disposition September 2010, 38 (9) 1427-1435; DOI: https://doi.org/10.1124/dmd.109.030916

  15. Kose, Noriko

    1. Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier
      Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai and Emi Nakashima
      Drug Metabolism and Disposition September 2010, 38 (9) 1576-1581; DOI: https://doi.org/10.1124/dmd.110.033266

  16. Kubota, Kazuishi

    1. Identification of Valproic Acid Glucuronide Hydrolase As a Key Enzyme for the Interaction of Valproic Acid with Carbapenem Antibiotics
      Eiko Suzuki, Naotoshi Yamamura, Yuji Ogura, Daisuke Nakai, Kazuishi Kubota, Nobuhiro Kobayashi, Shin-ichi Miura and Osamu Okazaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1538-1544; DOI: https://doi.org/10.1124/dmd.110.032938

L

  1. Lahoz, Agustin

    1. Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo
      M. Teresa Donato, David Hallifax, Laura Picazo, José V. Castell, J. Brian Houston, M. José Gomez-Lechón and Agustin Lahoz
      Drug Metabolism and Disposition September 2010, 38 (9) 1449-1455; DOI: https://doi.org/10.1124/dmd.110.033605

  2. Lai, Yurong

    1. Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes
      Yiding Hu, Shengtian Yang, F. Barclay Shilliday, Bruce R. Heyde, Kathy M. Mandrell, Russell H. Robins, Jin Xie, Matthew T. Reding, Yurong Lai and David C. Thompson
      Drug Metabolism and Disposition September 2010, 38 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.110.032581

  3. Lee, David

    1. Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions
      Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia
      Drug Metabolism and Disposition September 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995

  4. Lee, Frank W.

    1. Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions
      Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia
      Drug Metabolism and Disposition September 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995

  5. Lee, Leslie B.

    1. Role of P-Glycoprotein and Breast Cancer Resistance Protein-1 in the Brain Penetration and Brain Pharmacodynamic Activity of the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
      Laurent Salphati, Leslie B. Lee, Jodie Pang, Emile G. Plise and Xiaolin Zhang
      Drug Metabolism and Disposition September 2010, 38 (9) 1422-1426; DOI: https://doi.org/10.1124/dmd.110.034256

  6. Li, Wei

    1. Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D3, Producing 1α,20,23-Trihydroxyvitamin D3, Which Has Altered Biological Activity
      Edith K. Y. Tang, Wei Li, Zorica Janjetovic, Minh N. Nguyen, Zhao Wang, Andrzej Slominski and Robert C. Tuckey
      Drug Metabolism and Disposition September 2010, 38 (9) 1553-1559; DOI: https://doi.org/10.1124/dmd.110.034389

  7. Liao, Mingxiang

    1. Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions
      Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia
      Drug Metabolism and Disposition September 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995

  8. Liu, Duan

    1. Metabolism of Tanshinol Borneol Ester in Rat and Human Liver Microsomes
      Duan Liu, Xiaohui Zheng, Yitong Tang, Jing Zi, Yefei Nan, Shixiang Wang, Chaoni Xiao, Juanli Zhu and Chao Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1464-1470; DOI: https://doi.org/10.1124/dmd.110.033381

M

  1. Maejima, Takanori

    1. Methemoglobinemia Induced by 1,2-Dichloro-4-nitrobenzene in Mice with a Disrupted Glutathione S-Transferase Mu 1 Gene
      Shingo Arakawa, Takanori Maejima, Naoki Kiyosawa, Takashi Yamaguchi, Yukari Shibaya, Yoshie Aida, Ryota Kawai, Kazunori Fujimoto, Sunao Manabe and Wataru Takasaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1545-1552; DOI: https://doi.org/10.1124/dmd.110.033597

  2. Mager, Donald E.

    1. Role of P-Glycoprotein in Region-Specific Gastrointestinal Absorption of Talinolol in Rats
      Leonid Kagan, Tali Dreifinger, Donald E. Mager and Amnon Hoffman
      Drug Metabolism and Disposition September 2010, 38 (9) 1560-1566; DOI: https://doi.org/10.1124/dmd.110.033019

  3. Malhotra, Bimal

    1. Effect of the CYP2D6*10 Genotype on Tolterodine Pharmacokinetics
      Masayo Oishi, Koji Chiba, Bimal Malhotra and Toshio Suwa
      Drug Metabolism and Disposition September 2010, 38 (9) 1456-1463; DOI: https://doi.org/10.1124/dmd.110.033407

  4. Manabe, Sunao

    1. Methemoglobinemia Induced by 1,2-Dichloro-4-nitrobenzene in Mice with a Disrupted Glutathione S-Transferase Mu 1 Gene
      Shingo Arakawa, Takanori Maejima, Naoki Kiyosawa, Takashi Yamaguchi, Yukari Shibaya, Yoshie Aida, Ryota Kawai, Kazunori Fujimoto, Sunao Manabe and Wataru Takasaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1545-1552; DOI: https://doi.org/10.1124/dmd.110.033597

  5. Mandrell, Kathy M.

    1. Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes
      Yiding Hu, Shengtian Yang, F. Barclay Shilliday, Bruce R. Heyde, Kathy M. Mandrell, Russell H. Robins, Jin Xie, Matthew T. Reding, Yurong Lai and David C. Thompson
      Drug Metabolism and Disposition September 2010, 38 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.110.032581

  6. Mao, Qingcheng

    1. Increased Glyburide Clearance in the Pregnant Mouse Model
      Lin Zhou, Yi Zhang, Mary F. Hebert, Jashvant D. Unadkat and Qingcheng Mao
      Drug Metabolism and Disposition September 2010, 38 (9) 1403-1406; DOI: https://doi.org/10.1124/dmd.110.033837

  7. McIntee, Edward J.

    1. Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes
      Pramod Upadhyaya, J. Bradley Hochalter, Silvia Balbo, Edward J. McIntee and Stephen S. Hecht
      Drug Metabolism and Disposition September 2010, 38 (9) 1397-1402; DOI: https://doi.org/10.1124/dmd.110.034181

  8. Miura, Shin-ichi

    1. Identification of Valproic Acid Glucuronide Hydrolase As a Key Enzyme for the Interaction of Valproic Acid with Carbapenem Antibiotics
      Eiko Suzuki, Naotoshi Yamamura, Yuji Ogura, Daisuke Nakai, Kazuishi Kubota, Nobuhiro Kobayashi, Shin-ichi Miura and Osamu Okazaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1538-1544; DOI: https://doi.org/10.1124/dmd.110.032938

  9. Miyakoshi, Naoki

    1. Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier
      Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai and Emi Nakashima
      Drug Metabolism and Disposition September 2010, 38 (9) 1576-1581; DOI: https://doi.org/10.1124/dmd.110.033266

  10. Mols, Raf

    1. In Situ Intestinal Perfusion in Knockout Mice Demonstrates Inhibition of Intestinal P-Glycoprotein by Ritonavir Causing Increased Darunavir Absorption
      Nico Holmstock, Raf Mols, Pieter Annaert and Patrick Augustijns
      Drug Metabolism and Disposition September 2010, 38 (9) 1407-1410; DOI: https://doi.org/10.1124/dmd.110.032771

  11. Mori, Masatomo

    1. Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor
      Daichi Takizawa, Satoru Kakizaki, Norio Horiguchi, Hiroki Tojima, Yuichi Yamazaki, Takeshi Ichikawa, Ken Sato and Masatomo Mori
      Drug Metabolism and Disposition September 2010, 38 (9) 1493-1498; DOI: https://doi.org/10.1124/dmd.110.032854

  12. Morrison, Jodi

    1. Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions
      Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia
      Drug Metabolism and Disposition September 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995

  13. Mota, Linda C.

    1. Constitutive Androgen Receptor-Null Mice Are Sensitive to the Toxic Effects of Parathion: Association with Reduced Cytochrome P450-Mediated Parathion Metabolism
      Linda C. Mota, Juan P. Hernandez and William S. Baldwin
      Drug Metabolism and Disposition September 2010, 38 (9) 1582-1588; DOI: https://doi.org/10.1124/dmd.110.032961

  14. Mukai, Chisato

    1. Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier
      Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai and Emi Nakashima
      Drug Metabolism and Disposition September 2010, 38 (9) 1576-1581; DOI: https://doi.org/10.1124/dmd.110.033266

  15. Muñoz-Aguayo, Daniel

    1. Antioxidant Activities of Hydroxytyrosol Main Metabolites Do Not Contribute to Beneficial Health Effects after Olive Oil Ingestion
      Olha Khymenets, Montserat Fitó, Sonia Touriño, Daniel Muñoz-Aguayo, Mitona Pujadas, Josep Lluis Torres, Jesús Joglar, Magí Farré, Maria-Isabel Covas and Rafael de la Torre
      Drug Metabolism and Disposition September 2010, 38 (9) 1417-1421; DOI: https://doi.org/10.1124/dmd.110.032821

  16. Murayama, Norie

    1. Cynomolgus Monkey CYP2D44 Newly Identified in Liver, Metabolizes Bufuralol, and Dextromethorphan
      Yasuhiro Uno, Shotaro Uehara, Sakae Kohara, Norie Murayama and Hiroshi Yamazaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1486-1492; DOI: https://doi.org/10.1124/dmd.110.033274

N

  1. Nakagawa, Nao

    1. Arylacetamide Deacetylase Is a Determinant Enzyme for the Difference in Hydrolase Activities of Phenacetin and Acetaminophen
      Akinobu Watanabe, Tatsuki Fukami, Shiori Takahashi, Yuki Kobayashi, Nao Nakagawa, Miki Nakajima and Tsuyoshi Yokoi
      Drug Metabolism and Disposition September 2010, 38 (9) 1532-1537; DOI: https://doi.org/10.1124/dmd.110.033720

  2. Nakai, Daisuke

    1. Identification of Valproic Acid Glucuronide Hydrolase As a Key Enzyme for the Interaction of Valproic Acid with Carbapenem Antibiotics
      Eiko Suzuki, Naotoshi Yamamura, Yuji Ogura, Daisuke Nakai, Kazuishi Kubota, Nobuhiro Kobayashi, Shin-ichi Miura and Osamu Okazaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1538-1544; DOI: https://doi.org/10.1124/dmd.110.032938

  3. Nakajima, Miki

    1. Arylacetamide Deacetylase Is a Determinant Enzyme for the Difference in Hydrolase Activities of Phenacetin and Acetaminophen
      Akinobu Watanabe, Tatsuki Fukami, Shiori Takahashi, Yuki Kobayashi, Nao Nakagawa, Miki Nakajima and Tsuyoshi Yokoi
      Drug Metabolism and Disposition September 2010, 38 (9) 1532-1537; DOI: https://doi.org/10.1124/dmd.110.033720

  4. Nakashima, Emi

    1. Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier
      Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai and Emi Nakashima
      Drug Metabolism and Disposition September 2010, 38 (9) 1576-1581; DOI: https://doi.org/10.1124/dmd.110.033266

  5. Nan, Yefei

    1. Metabolism of Tanshinol Borneol Ester in Rat and Human Liver Microsomes
      Duan Liu, Xiaohui Zheng, Yitong Tang, Jing Zi, Yefei Nan, Shixiang Wang, Chaoni Xiao, Juanli Zhu and Chao Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1464-1470; DOI: https://doi.org/10.1124/dmd.110.033381

  6. Nguyen, Minh N.

    1. Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D3, Producing 1α,20,23-Trihydroxyvitamin D3, Which Has Altered Biological Activity
      Edith K. Y. Tang, Wei Li, Zorica Janjetovic, Minh N. Nguyen, Zhao Wang, Andrzej Slominski and Robert C. Tuckey
      Drug Metabolism and Disposition September 2010, 38 (9) 1553-1559; DOI: https://doi.org/10.1124/dmd.110.034389

  7. Nishimura, Tomohiro

    1. Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier
      Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai and Emi Nakashima
      Drug Metabolism and Disposition September 2010, 38 (9) 1576-1581; DOI: https://doi.org/10.1124/dmd.110.033266

O

  1. Obach, R. Scott

    1. Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes
      Odette A. Fahmi, Mary Kish, Sherri Boldt and R. Scott Obach
      Drug Metabolism and Disposition September 2010, 38 (9) 1605-1611; DOI: https://doi.org/10.1124/dmd.110.033126

  2. Ochi, Kaori

    1. Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier
      Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai and Emi Nakashima
      Drug Metabolism and Disposition September 2010, 38 (9) 1576-1581; DOI: https://doi.org/10.1124/dmd.110.033266

  3. Oganesian, Aram

    1. In Vitro Metabolism, Permeability, and Efflux of Bazedoxifene in Humans
      Li Shen, Syed Ahmad, SeongHee Park, William DeMaio, Aram Oganesian, Theresa Hultin, JoAnn Scatina, Peter Bungay and Appavu Chandrasekaran
      Drug Metabolism and Disposition September 2010, 38 (9) 1471-1479; DOI: https://doi.org/10.1124/dmd.109.030999

  4. Ogura, Yuji

    1. Identification of Valproic Acid Glucuronide Hydrolase As a Key Enzyme for the Interaction of Valproic Acid with Carbapenem Antibiotics
      Eiko Suzuki, Naotoshi Yamamura, Yuji Ogura, Daisuke Nakai, Kazuishi Kubota, Nobuhiro Kobayashi, Shin-ichi Miura and Osamu Okazaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1538-1544; DOI: https://doi.org/10.1124/dmd.110.032938

  5. Ohashi, Noriko

    1. Estimation of Transporters Involved in the Hepatobiliary Transport of TA-0201CA Using Sandwich-Cultured Rat Hepatocytes from Normal and Multidrug Resistance-Associated Protein 2-Deficient Rats
      Hajime Fukuda, Rikiya Ohashi, Noriko Ohashi, Hikaru Yabuuchi and Ikumi Tamai
      Drug Metabolism and Disposition September 2010, 38 (9) 1505-1513; DOI: https://doi.org/10.1124/dmd.110.033258

  6. Ohashi, Rikiya

    1. Estimation of Transporters Involved in the Hepatobiliary Transport of TA-0201CA Using Sandwich-Cultured Rat Hepatocytes from Normal and Multidrug Resistance-Associated Protein 2-Deficient Rats
      Hajime Fukuda, Rikiya Ohashi, Noriko Ohashi, Hikaru Yabuuchi and Ikumi Tamai
      Drug Metabolism and Disposition September 2010, 38 (9) 1505-1513; DOI: https://doi.org/10.1124/dmd.110.033258

  7. Ohbayashi, Masayuki

    1. Activation of Cyclosporin A Transport by a Novel λ Light Chain of Human Ig Surface Antigen-Related Gene in Xenopus laevis Oocytes
      Yasuna Kobayashi, Takahiro Umemoto, Masayuki Ohbayashi, Noriko Kohyama, Yutaka Sanada and Toshinori Yamamoto
      Drug Metabolism and Disposition September 2010, 38 (9) 1427-1435; DOI: https://doi.org/10.1124/dmd.109.030916

  8. Ohnuma, Takao

    1. Discontinuous Drug Binding to Proteins: Binding of an Antineoplastic Benzyl Styryl Sulfone to Albumin and Enzymes In Vitro and in Phase I Clinical Trials
      Sool Yeon Cho, Takao Ohnuma, Lewis R. Silverman, James F. Holland and John Roboz
      Drug Metabolism and Disposition September 2010, 38 (9) 1480-1485; DOI: https://doi.org/10.1124/dmd.110.033001

  9. Oishi, Masayo

    1. Effect of the CYP2D6*10 Genotype on Tolterodine Pharmacokinetics
      Masayo Oishi, Koji Chiba, Bimal Malhotra and Toshio Suwa
      Drug Metabolism and Disposition September 2010, 38 (9) 1456-1463; DOI: https://doi.org/10.1124/dmd.110.033407

  10. Okazaki, Osamu

    1. Identification of Valproic Acid Glucuronide Hydrolase As a Key Enzyme for the Interaction of Valproic Acid with Carbapenem Antibiotics
      Eiko Suzuki, Naotoshi Yamamura, Yuji Ogura, Daisuke Nakai, Kazuishi Kubota, Nobuhiro Kobayashi, Shin-ichi Miura and Osamu Okazaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1538-1544; DOI: https://doi.org/10.1124/dmd.110.032938

  11. Oliver, Stuart

    1. Absorption, Distribution, Metabolism, and Excretion of Ticagrelor in Healthy Subjects
      Renli Teng, Stuart Oliver, Martin A. Hayes and Kathleen Butler
      Drug Metabolism and Disposition September 2010, 38 (9) 1514-1521; DOI: https://doi.org/10.1124/dmd.110.032250

P

  1. Pang, Jodie

    1. Role of P-Glycoprotein and Breast Cancer Resistance Protein-1 in the Brain Penetration and Brain Pharmacodynamic Activity of the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
      Laurent Salphati, Leslie B. Lee, Jodie Pang, Emile G. Plise and Xiaolin Zhang
      Drug Metabolism and Disposition September 2010, 38 (9) 1422-1426; DOI: https://doi.org/10.1124/dmd.110.034256

  2. Park, SeongHee

    1. In Vitro Metabolism, Permeability, and Efflux of Bazedoxifene in Humans
      Li Shen, Syed Ahmad, SeongHee Park, William DeMaio, Aram Oganesian, Theresa Hultin, JoAnn Scatina, Peter Bungay and Appavu Chandrasekaran
      Drug Metabolism and Disposition September 2010, 38 (9) 1471-1479; DOI: https://doi.org/10.1124/dmd.109.030999

  3. Picazo, Laura

    1. Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo
      M. Teresa Donato, David Hallifax, Laura Picazo, José V. Castell, J. Brian Houston, M. José Gomez-Lechón and Agustin Lahoz
      Drug Metabolism and Disposition September 2010, 38 (9) 1449-1455; DOI: https://doi.org/10.1124/dmd.110.033605

  4. Plise, Emile G.

    1. Role of P-Glycoprotein and Breast Cancer Resistance Protein-1 in the Brain Penetration and Brain Pharmacodynamic Activity of the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
      Laurent Salphati, Leslie B. Lee, Jodie Pang, Emile G. Plise and Xiaolin Zhang
      Drug Metabolism and Disposition September 2010, 38 (9) 1422-1426; DOI: https://doi.org/10.1124/dmd.110.034256

  5. Pondugula, Satyanarayana R.

    1. Protein Phosphatase 2Cβl Regulates Human Pregnane X Receptor-Mediated CYP3A4 Gene Expression in HepG2 Liver Carcinoma Cells
      Satyanarayana R. Pondugula, Alexander A. Tong, Jing Wu, Jimmy Cui and Taosheng Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1411-1416; DOI: https://doi.org/10.1124/dmd.110.032128

  6. Prior, Wei Wei

    1. Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
      Laurent Salphati, Harvey Wong, Marcia Belvin, Delia Bradford, Kyle A. Edgar, Wei Wei Prior, Deepak Sampath and Jeffrey J. Wallin
      Drug Metabolism and Disposition September 2010, 38 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.110.032912

  7. Pujadas, Mitona

    1. Antioxidant Activities of Hydroxytyrosol Main Metabolites Do Not Contribute to Beneficial Health Effects after Olive Oil Ingestion
      Olha Khymenets, Montserat Fitó, Sonia Touriño, Daniel Muñoz-Aguayo, Mitona Pujadas, Josep Lluis Torres, Jesús Joglar, Magí Farré, Maria-Isabel Covas and Rafael de la Torre
      Drug Metabolism and Disposition September 2010, 38 (9) 1417-1421; DOI: https://doi.org/10.1124/dmd.110.032821

R

  1. Raczynski, Arek R.

    1. Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions
      Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia
      Drug Metabolism and Disposition September 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995

  2. Reding, Matthew T.

    1. Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes
      Yiding Hu, Shengtian Yang, F. Barclay Shilliday, Bruce R. Heyde, Kathy M. Mandrell, Russell H. Robins, Jin Xie, Matthew T. Reding, Yurong Lai and David C. Thompson
      Drug Metabolism and Disposition September 2010, 38 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.110.032581

  3. Riedmaier, Stephan

    1. Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes
      Diana M. Feidt, Kathrin Klein, Ute Hofmann, Stephan Riedmaier, Daniel Knobeloch, Wolfgang E. Thasler, Thomas S. Weiss, Matthias Schwab and Ulrich M. Zanger
      Drug Metabolism and Disposition September 2010, 38 (9) 1589-1597; DOI: https://doi.org/10.1124/dmd.110.033886

  4. Risler, Linda J.

    1. CYP2D6 Mediates 4-Hydroxylation of Clonidine In Vitro: Implication for Pregnancy-Induced Changes in Clonidine Clearance
      Adam J. Claessens, Linda J. Risler, Sara Eyal, Danny D. Shen, Thomas R. Easterling and Mary F. Hebert
      Drug Metabolism and Disposition September 2010, 38 (9) 1393-1396; DOI: https://doi.org/10.1124/dmd.110.033878

  5. Robins, Russell H.

    1. Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes
      Yiding Hu, Shengtian Yang, F. Barclay Shilliday, Bruce R. Heyde, Kathy M. Mandrell, Russell H. Robins, Jin Xie, Matthew T. Reding, Yurong Lai and David C. Thompson
      Drug Metabolism and Disposition September 2010, 38 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.110.032581

  6. Roboz, John

    1. Discontinuous Drug Binding to Proteins: Binding of an Antineoplastic Benzyl Styryl Sulfone to Albumin and Enzymes In Vitro and in Phase I Clinical Trials
      Sool Yeon Cho, Takao Ohnuma, Lewis R. Silverman, James F. Holland and John Roboz
      Drug Metabolism and Disposition September 2010, 38 (9) 1480-1485; DOI: https://doi.org/10.1124/dmd.110.033001

S

  1. Sai, Yoshimichi

    1. Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier
      Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai and Emi Nakashima
      Drug Metabolism and Disposition September 2010, 38 (9) 1576-1581; DOI: https://doi.org/10.1124/dmd.110.033266

  2. Salphati, Laurent

    1. Role of P-Glycoprotein and Breast Cancer Resistance Protein-1 in the Brain Penetration and Brain Pharmacodynamic Activity of the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
      Laurent Salphati, Leslie B. Lee, Jodie Pang, Emile G. Plise and Xiaolin Zhang
      Drug Metabolism and Disposition September 2010, 38 (9) 1422-1426; DOI: https://doi.org/10.1124/dmd.110.034256
    2. Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
      Laurent Salphati, Harvey Wong, Marcia Belvin, Delia Bradford, Kyle A. Edgar, Wei Wei Prior, Deepak Sampath and Jeffrey J. Wallin
      Drug Metabolism and Disposition September 2010, 38 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.110.032912

  3. Sampath, Deepak

    1. Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
      Laurent Salphati, Harvey Wong, Marcia Belvin, Delia Bradford, Kyle A. Edgar, Wei Wei Prior, Deepak Sampath and Jeffrey J. Wallin
      Drug Metabolism and Disposition September 2010, 38 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.110.032912

  4. Sanada, Yutaka

    1. Activation of Cyclosporin A Transport by a Novel λ Light Chain of Human Ig Surface Antigen-Related Gene in Xenopus laevis Oocytes
      Yasuna Kobayashi, Takahiro Umemoto, Masayuki Ohbayashi, Noriko Kohyama, Yutaka Sanada and Toshinori Yamamoto
      Drug Metabolism and Disposition September 2010, 38 (9) 1427-1435; DOI: https://doi.org/10.1124/dmd.109.030916

  5. Sato, Ken

    1. Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor
      Daichi Takizawa, Satoru Kakizaki, Norio Horiguchi, Hiroki Tojima, Yuichi Yamazaki, Takeshi Ichikawa, Ken Sato and Masatomo Mori
      Drug Metabolism and Disposition September 2010, 38 (9) 1493-1498; DOI: https://doi.org/10.1124/dmd.110.032854

  6. Scatina, JoAnn

    1. In Vitro Metabolism, Permeability, and Efflux of Bazedoxifene in Humans
      Li Shen, Syed Ahmad, SeongHee Park, William DeMaio, Aram Oganesian, Theresa Hultin, JoAnn Scatina, Peter Bungay and Appavu Chandrasekaran
      Drug Metabolism and Disposition September 2010, 38 (9) 1471-1479; DOI: https://doi.org/10.1124/dmd.109.030999

  7. Schwab, Matthias

    1. Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes
      Diana M. Feidt, Kathrin Klein, Ute Hofmann, Stephan Riedmaier, Daniel Knobeloch, Wolfgang E. Thasler, Thomas S. Weiss, Matthias Schwab and Ulrich M. Zanger
      Drug Metabolism and Disposition September 2010, 38 (9) 1589-1597; DOI: https://doi.org/10.1124/dmd.110.033886

  8. Shen, Danny D.

    1. CYP2D6 Mediates 4-Hydroxylation of Clonidine In Vitro: Implication for Pregnancy-Induced Changes in Clonidine Clearance
      Adam J. Claessens, Linda J. Risler, Sara Eyal, Danny D. Shen, Thomas R. Easterling and Mary F. Hebert
      Drug Metabolism and Disposition September 2010, 38 (9) 1393-1396; DOI: https://doi.org/10.1124/dmd.110.033878

  9. Shen, Li

    1. In Vitro Metabolism, Permeability, and Efflux of Bazedoxifene in Humans
      Li Shen, Syed Ahmad, SeongHee Park, William DeMaio, Aram Oganesian, Theresa Hultin, JoAnn Scatina, Peter Bungay and Appavu Chandrasekaran
      Drug Metabolism and Disposition September 2010, 38 (9) 1471-1479; DOI: https://doi.org/10.1124/dmd.109.030999

  10. Shibaya, Yukari

    1. Methemoglobinemia Induced by 1,2-Dichloro-4-nitrobenzene in Mice with a Disrupted Glutathione S-Transferase Mu 1 Gene
      Shingo Arakawa, Takanori Maejima, Naoki Kiyosawa, Takashi Yamaguchi, Yukari Shibaya, Yoshie Aida, Ryota Kawai, Kazunori Fujimoto, Sunao Manabe and Wataru Takasaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1545-1552; DOI: https://doi.org/10.1124/dmd.110.033597

  11. Shilliday, F. Barclay

    1. Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes
      Yiding Hu, Shengtian Yang, F. Barclay Shilliday, Bruce R. Heyde, Kathy M. Mandrell, Russell H. Robins, Jin Xie, Matthew T. Reding, Yurong Lai and David C. Thompson
      Drug Metabolism and Disposition September 2010, 38 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.110.032581

  12. Shipman, Rob

    1. Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions
      Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia
      Drug Metabolism and Disposition September 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995

  13. Silverman, Lewis R.

    1. Discontinuous Drug Binding to Proteins: Binding of an Antineoplastic Benzyl Styryl Sulfone to Albumin and Enzymes In Vitro and in Phase I Clinical Trials
      Sool Yeon Cho, Takao Ohnuma, Lewis R. Silverman, James F. Holland and John Roboz
      Drug Metabolism and Disposition September 2010, 38 (9) 1480-1485; DOI: https://doi.org/10.1124/dmd.110.033001

  14. Slominski, Andrzej

    1. Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D3, Producing 1α,20,23-Trihydroxyvitamin D3, Which Has Altered Biological Activity
      Edith K. Y. Tang, Wei Li, Zorica Janjetovic, Minh N. Nguyen, Zhao Wang, Andrzej Slominski and Robert C. Tuckey
      Drug Metabolism and Disposition September 2010, 38 (9) 1553-1559; DOI: https://doi.org/10.1124/dmd.110.034389

  15. Suwa, Toshio

    1. Effect of the CYP2D6*10 Genotype on Tolterodine Pharmacokinetics
      Masayo Oishi, Koji Chiba, Bimal Malhotra and Toshio Suwa
      Drug Metabolism and Disposition September 2010, 38 (9) 1456-1463; DOI: https://doi.org/10.1124/dmd.110.033407

  16. Suzuki, Eiko

    1. Identification of Valproic Acid Glucuronide Hydrolase As a Key Enzyme for the Interaction of Valproic Acid with Carbapenem Antibiotics
      Eiko Suzuki, Naotoshi Yamamura, Yuji Ogura, Daisuke Nakai, Kazuishi Kubota, Nobuhiro Kobayashi, Shin-ichi Miura and Osamu Okazaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1538-1544; DOI: https://doi.org/10.1124/dmd.110.032938

T

  1. Takagi, Akinori

    1. Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier
      Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai and Emi Nakashima
      Drug Metabolism and Disposition September 2010, 38 (9) 1576-1581; DOI: https://doi.org/10.1124/dmd.110.033266

  2. Takahashi, Shiori

    1. Arylacetamide Deacetylase Is a Determinant Enzyme for the Difference in Hydrolase Activities of Phenacetin and Acetaminophen
      Akinobu Watanabe, Tatsuki Fukami, Shiori Takahashi, Yuki Kobayashi, Nao Nakagawa, Miki Nakajima and Tsuyoshi Yokoi
      Drug Metabolism and Disposition September 2010, 38 (9) 1532-1537; DOI: https://doi.org/10.1124/dmd.110.033720

  3. Takasaki, Wataru

    1. Methemoglobinemia Induced by 1,2-Dichloro-4-nitrobenzene in Mice with a Disrupted Glutathione S-Transferase Mu 1 Gene
      Shingo Arakawa, Takanori Maejima, Naoki Kiyosawa, Takashi Yamaguchi, Yukari Shibaya, Yoshie Aida, Ryota Kawai, Kazunori Fujimoto, Sunao Manabe and Wataru Takasaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1545-1552; DOI: https://doi.org/10.1124/dmd.110.033597

  4. Takizawa, Daichi

    1. Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor
      Daichi Takizawa, Satoru Kakizaki, Norio Horiguchi, Hiroki Tojima, Yuichi Yamazaki, Takeshi Ichikawa, Ken Sato and Masatomo Mori
      Drug Metabolism and Disposition September 2010, 38 (9) 1493-1498; DOI: https://doi.org/10.1124/dmd.110.032854

  5. Tamai, Ikumi

    1. Estimation of Transporters Involved in the Hepatobiliary Transport of TA-0201CA Using Sandwich-Cultured Rat Hepatocytes from Normal and Multidrug Resistance-Associated Protein 2-Deficient Rats
      Hajime Fukuda, Rikiya Ohashi, Noriko Ohashi, Hikaru Yabuuchi and Ikumi Tamai
      Drug Metabolism and Disposition September 2010, 38 (9) 1505-1513; DOI: https://doi.org/10.1124/dmd.110.033258

  6. Tanaka, Noriaki

    1. Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier
      Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai and Emi Nakashima
      Drug Metabolism and Disposition September 2010, 38 (9) 1576-1581; DOI: https://doi.org/10.1124/dmd.110.033266

  7. Tang, Edith K. Y.

    1. Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D3, Producing 1α,20,23-Trihydroxyvitamin D3, Which Has Altered Biological Activity
      Edith K. Y. Tang, Wei Li, Zorica Janjetovic, Minh N. Nguyen, Zhao Wang, Andrzej Slominski and Robert C. Tuckey
      Drug Metabolism and Disposition September 2010, 38 (9) 1553-1559; DOI: https://doi.org/10.1124/dmd.110.034389

  8. Tang, Yitong

    1. Metabolism of Tanshinol Borneol Ester in Rat and Human Liver Microsomes
      Duan Liu, Xiaohui Zheng, Yitong Tang, Jing Zi, Yefei Nan, Shixiang Wang, Chaoni Xiao, Juanli Zhu and Chao Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1464-1470; DOI: https://doi.org/10.1124/dmd.110.033381

  9. Teng, Renli

    1. Absorption, Distribution, Metabolism, and Excretion of Ticagrelor in Healthy Subjects
      Renli Teng, Stuart Oliver, Martin A. Hayes and Kathleen Butler
      Drug Metabolism and Disposition September 2010, 38 (9) 1514-1521; DOI: https://doi.org/10.1124/dmd.110.032250

  10. Thasler, Wolfgang E.

    1. Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes
      Diana M. Feidt, Kathrin Klein, Ute Hofmann, Stephan Riedmaier, Daniel Knobeloch, Wolfgang E. Thasler, Thomas S. Weiss, Matthias Schwab and Ulrich M. Zanger
      Drug Metabolism and Disposition September 2010, 38 (9) 1589-1597; DOI: https://doi.org/10.1124/dmd.110.033886

  11. Thompson, David C.

    1. Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes
      Yiding Hu, Shengtian Yang, F. Barclay Shilliday, Bruce R. Heyde, Kathy M. Mandrell, Russell H. Robins, Jin Xie, Matthew T. Reding, Yurong Lai and David C. Thompson
      Drug Metabolism and Disposition September 2010, 38 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.110.032581

  12. Tojima, Hiroki

    1. Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor
      Daichi Takizawa, Satoru Kakizaki, Norio Horiguchi, Hiroki Tojima, Yuichi Yamazaki, Takeshi Ichikawa, Ken Sato and Masatomo Mori
      Drug Metabolism and Disposition September 2010, 38 (9) 1493-1498; DOI: https://doi.org/10.1124/dmd.110.032854

  13. Tomi, Masatoshi

    1. Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier
      Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai and Emi Nakashima
      Drug Metabolism and Disposition September 2010, 38 (9) 1576-1581; DOI: https://doi.org/10.1124/dmd.110.033266

  14. Tong, Alexander A.

    1. Protein Phosphatase 2Cβl Regulates Human Pregnane X Receptor-Mediated CYP3A4 Gene Expression in HepG2 Liver Carcinoma Cells
      Satyanarayana R. Pondugula, Alexander A. Tong, Jing Wu, Jimmy Cui and Taosheng Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1411-1416; DOI: https://doi.org/10.1124/dmd.110.032128

  15. Torres, Josep Lluis

    1. Antioxidant Activities of Hydroxytyrosol Main Metabolites Do Not Contribute to Beneficial Health Effects after Olive Oil Ingestion
      Olha Khymenets, Montserat Fitó, Sonia Touriño, Daniel Muñoz-Aguayo, Mitona Pujadas, Josep Lluis Torres, Jesús Joglar, Magí Farré, Maria-Isabel Covas and Rafael de la Torre
      Drug Metabolism and Disposition September 2010, 38 (9) 1417-1421; DOI: https://doi.org/10.1124/dmd.110.032821

  16. Touriño, Sonia

    1. Antioxidant Activities of Hydroxytyrosol Main Metabolites Do Not Contribute to Beneficial Health Effects after Olive Oil Ingestion
      Olha Khymenets, Montserat Fitó, Sonia Touriño, Daniel Muñoz-Aguayo, Mitona Pujadas, Josep Lluis Torres, Jesús Joglar, Magí Farré, Maria-Isabel Covas and Rafael de la Torre
      Drug Metabolism and Disposition September 2010, 38 (9) 1417-1421; DOI: https://doi.org/10.1124/dmd.110.032821

  17. Tuckey, Robert C.

    1. Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D3, Producing 1α,20,23-Trihydroxyvitamin D3, Which Has Altered Biological Activity
      Edith K. Y. Tang, Wei Li, Zorica Janjetovic, Minh N. Nguyen, Zhao Wang, Andrzej Slominski and Robert C. Tuckey
      Drug Metabolism and Disposition September 2010, 38 (9) 1553-1559; DOI: https://doi.org/10.1124/dmd.110.034389

U

  1. Uehara, Shotaro

    1. Cynomolgus Monkey CYP2D44 Newly Identified in Liver, Metabolizes Bufuralol, and Dextromethorphan
      Yasuhiro Uno, Shotaro Uehara, Sakae Kohara, Norie Murayama and Hiroshi Yamazaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1486-1492; DOI: https://doi.org/10.1124/dmd.110.033274

  2. Umemoto, Takahiro

    1. Activation of Cyclosporin A Transport by a Novel λ Light Chain of Human Ig Surface Antigen-Related Gene in Xenopus laevis Oocytes
      Yasuna Kobayashi, Takahiro Umemoto, Masayuki Ohbayashi, Noriko Kohyama, Yutaka Sanada and Toshinori Yamamoto
      Drug Metabolism and Disposition September 2010, 38 (9) 1427-1435; DOI: https://doi.org/10.1124/dmd.109.030916

  3. Unadkat, Jashvant D.

    1. Increased Glyburide Clearance in the Pregnant Mouse Model
      Lin Zhou, Yi Zhang, Mary F. Hebert, Jashvant D. Unadkat and Qingcheng Mao
      Drug Metabolism and Disposition September 2010, 38 (9) 1403-1406; DOI: https://doi.org/10.1124/dmd.110.033837

  4. Uno, Yasuhiro

    1. Cynomolgus Monkey CYP2D44 Newly Identified in Liver, Metabolizes Bufuralol, and Dextromethorphan
      Yasuhiro Uno, Shotaro Uehara, Sakae Kohara, Norie Murayama and Hiroshi Yamazaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1486-1492; DOI: https://doi.org/10.1124/dmd.110.033274

  5. Upadhyaya, Pramod

    1. Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes
      Pramod Upadhyaya, J. Bradley Hochalter, Silvia Balbo, Edward J. McIntee and Stephen S. Hecht
      Drug Metabolism and Disposition September 2010, 38 (9) 1397-1402; DOI: https://doi.org/10.1124/dmd.110.034181

W

  1. Wagner, Klaus

    1. Dabigatran Acylglucuronide, the Major Human Metabolite of Dabigatran: In Vitro Formation, Stability, and Pharmacological Activity
      Thomas Ebner, Klaus Wagner and Wolfgang Wienen
      Drug Metabolism and Disposition September 2010, 38 (9) 1567-1575; DOI: https://doi.org/10.1124/dmd.110.033696

  2. Wallin, Jeffrey J.

    1. Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
      Laurent Salphati, Harvey Wong, Marcia Belvin, Delia Bradford, Kyle A. Edgar, Wei Wei Prior, Deepak Sampath and Jeffrey J. Wallin
      Drug Metabolism and Disposition September 2010, 38 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.110.032912

  3. Wang, Shixiang

    1. Metabolism of Tanshinol Borneol Ester in Rat and Human Liver Microsomes
      Duan Liu, Xiaohui Zheng, Yitong Tang, Jing Zi, Yefei Nan, Shixiang Wang, Chaoni Xiao, Juanli Zhu and Chao Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1464-1470; DOI: https://doi.org/10.1124/dmd.110.033381

  4. Wang, Zhao

    1. Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D3, Producing 1α,20,23-Trihydroxyvitamin D3, Which Has Altered Biological Activity
      Edith K. Y. Tang, Wei Li, Zorica Janjetovic, Minh N. Nguyen, Zhao Wang, Andrzej Slominski and Robert C. Tuckey
      Drug Metabolism and Disposition September 2010, 38 (9) 1553-1559; DOI: https://doi.org/10.1124/dmd.110.034389

  5. Watanabe, Akinobu

    1. Arylacetamide Deacetylase Is a Determinant Enzyme for the Difference in Hydrolase Activities of Phenacetin and Acetaminophen
      Akinobu Watanabe, Tatsuki Fukami, Shiori Takahashi, Yuki Kobayashi, Nao Nakagawa, Miki Nakajima and Tsuyoshi Yokoi
      Drug Metabolism and Disposition September 2010, 38 (9) 1532-1537; DOI: https://doi.org/10.1124/dmd.110.033720

  6. Weiss, Thomas S.

    1. Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes
      Diana M. Feidt, Kathrin Klein, Ute Hofmann, Stephan Riedmaier, Daniel Knobeloch, Wolfgang E. Thasler, Thomas S. Weiss, Matthias Schwab and Ulrich M. Zanger
      Drug Metabolism and Disposition September 2010, 38 (9) 1589-1597; DOI: https://doi.org/10.1124/dmd.110.033886

  7. Wienen, Wolfgang

    1. Dabigatran Acylglucuronide, the Major Human Metabolite of Dabigatran: In Vitro Formation, Stability, and Pharmacological Activity
      Thomas Ebner, Klaus Wagner and Wolfgang Wienen
      Drug Metabolism and Disposition September 2010, 38 (9) 1567-1575; DOI: https://doi.org/10.1124/dmd.110.033696

  8. Wong, Harvey

    1. Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
      Laurent Salphati, Harvey Wong, Marcia Belvin, Delia Bradford, Kyle A. Edgar, Wei Wei Prior, Deepak Sampath and Jeffrey J. Wallin
      Drug Metabolism and Disposition September 2010, 38 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.110.032912

  9. Wu, Jing

    1. Protein Phosphatase 2Cβl Regulates Human Pregnane X Receptor-Mediated CYP3A4 Gene Expression in HepG2 Liver Carcinoma Cells
      Satyanarayana R. Pondugula, Alexander A. Tong, Jing Wu, Jimmy Cui and Taosheng Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1411-1416; DOI: https://doi.org/10.1124/dmd.110.032128

X

  1. Xia, Cindy Q.

    1. Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions
      Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia
      Drug Metabolism and Disposition September 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995

  2. Xiao, Chaoni

    1. Metabolism of Tanshinol Borneol Ester in Rat and Human Liver Microsomes
      Duan Liu, Xiaohui Zheng, Yitong Tang, Jing Zi, Yefei Nan, Shixiang Wang, Chaoni Xiao, Juanli Zhu and Chao Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1464-1470; DOI: https://doi.org/10.1124/dmd.110.033381

  3. Xie, Jin

    1. Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes
      Yiding Hu, Shengtian Yang, F. Barclay Shilliday, Bruce R. Heyde, Kathy M. Mandrell, Russell H. Robins, Jin Xie, Matthew T. Reding, Yurong Lai and David C. Thompson
      Drug Metabolism and Disposition September 2010, 38 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.110.032581

Y

  1. Yabuuchi, Hikaru

    1. Estimation of Transporters Involved in the Hepatobiliary Transport of TA-0201CA Using Sandwich-Cultured Rat Hepatocytes from Normal and Multidrug Resistance-Associated Protein 2-Deficient Rats
      Hajime Fukuda, Rikiya Ohashi, Noriko Ohashi, Hikaru Yabuuchi and Ikumi Tamai
      Drug Metabolism and Disposition September 2010, 38 (9) 1505-1513; DOI: https://doi.org/10.1124/dmd.110.033258

  2. Yamaguchi, Takashi

    1. Methemoglobinemia Induced by 1,2-Dichloro-4-nitrobenzene in Mice with a Disrupted Glutathione S-Transferase Mu 1 Gene
      Shingo Arakawa, Takanori Maejima, Naoki Kiyosawa, Takashi Yamaguchi, Yukari Shibaya, Yoshie Aida, Ryota Kawai, Kazunori Fujimoto, Sunao Manabe and Wataru Takasaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1545-1552; DOI: https://doi.org/10.1124/dmd.110.033597

  3. Yamamoto, Toshinori

    1. Activation of Cyclosporin A Transport by a Novel λ Light Chain of Human Ig Surface Antigen-Related Gene in Xenopus laevis Oocytes
      Yasuna Kobayashi, Takahiro Umemoto, Masayuki Ohbayashi, Noriko Kohyama, Yutaka Sanada and Toshinori Yamamoto
      Drug Metabolism and Disposition September 2010, 38 (9) 1427-1435; DOI: https://doi.org/10.1124/dmd.109.030916

  4. Yamamura, Naotoshi

    1. Identification of Valproic Acid Glucuronide Hydrolase As a Key Enzyme for the Interaction of Valproic Acid with Carbapenem Antibiotics
      Eiko Suzuki, Naotoshi Yamamura, Yuji Ogura, Daisuke Nakai, Kazuishi Kubota, Nobuhiro Kobayashi, Shin-ichi Miura and Osamu Okazaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1538-1544; DOI: https://doi.org/10.1124/dmd.110.032938

  5. Yamazaki, Hiroshi

    1. Cynomolgus Monkey CYP2D44 Newly Identified in Liver, Metabolizes Bufuralol, and Dextromethorphan
      Yasuhiro Uno, Shotaro Uehara, Sakae Kohara, Norie Murayama and Hiroshi Yamazaki
      Drug Metabolism and Disposition September 2010, 38 (9) 1486-1492; DOI: https://doi.org/10.1124/dmd.110.033274

  6. Yamazaki, Yuichi

    1. Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor
      Daichi Takizawa, Satoru Kakizaki, Norio Horiguchi, Hiroki Tojima, Yuichi Yamazaki, Takeshi Ichikawa, Ken Sato and Masatomo Mori
      Drug Metabolism and Disposition September 2010, 38 (9) 1493-1498; DOI: https://doi.org/10.1124/dmd.110.032854

  7. Yang, Shengtian

    1. Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes
      Yiding Hu, Shengtian Yang, F. Barclay Shilliday, Bruce R. Heyde, Kathy M. Mandrell, Russell H. Robins, Jin Xie, Matthew T. Reding, Yurong Lai and David C. Thompson
      Drug Metabolism and Disposition September 2010, 38 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.110.032581

  8. Yokoi, Tsuyoshi

    1. Arylacetamide Deacetylase Is a Determinant Enzyme for the Difference in Hydrolase Activities of Phenacetin and Acetaminophen
      Akinobu Watanabe, Tatsuki Fukami, Shiori Takahashi, Yuki Kobayashi, Nao Nakagawa, Miki Nakajima and Tsuyoshi Yokoi
      Drug Metabolism and Disposition September 2010, 38 (9) 1532-1537; DOI: https://doi.org/10.1124/dmd.110.033720

Z

  1. Zabihyan, Behnaz

    1. Cyclosporine A, but Not Tacrolimus, Shows Relevant Inhibition of Organic Anion-Transporting Protein 1B1-Mediated Transport of Atorvastatin
      Rune Amundsen, Hege Christensen, Behnaz Zabihyan and Anders Åsberg
      Drug Metabolism and Disposition September 2010, 38 (9) 1499-1504; DOI: https://doi.org/10.1124/dmd.110.032268

  2. Zanger, Ulrich M.

    1. Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes
      Diana M. Feidt, Kathrin Klein, Ute Hofmann, Stephan Riedmaier, Daniel Knobeloch, Wolfgang E. Thasler, Thomas S. Weiss, Matthias Schwab and Ulrich M. Zanger
      Drug Metabolism and Disposition September 2010, 38 (9) 1589-1597; DOI: https://doi.org/10.1124/dmd.110.033886

  3. Zhang, Xiaolin

    1. Role of P-Glycoprotein and Breast Cancer Resistance Protein-1 in the Brain Penetration and Brain Pharmacodynamic Activity of the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
      Laurent Salphati, Leslie B. Lee, Jodie Pang, Emile G. Plise and Xiaolin Zhang
      Drug Metabolism and Disposition September 2010, 38 (9) 1422-1426; DOI: https://doi.org/10.1124/dmd.110.034256

  4. Zhang, Yi

    1. Increased Glyburide Clearance in the Pregnant Mouse Model
      Lin Zhou, Yi Zhang, Mary F. Hebert, Jashvant D. Unadkat and Qingcheng Mao
      Drug Metabolism and Disposition September 2010, 38 (9) 1403-1406; DOI: https://doi.org/10.1124/dmd.110.033837

  5. Zheng, Xiaohui

    1. Metabolism of Tanshinol Borneol Ester in Rat and Human Liver Microsomes
      Duan Liu, Xiaohui Zheng, Yitong Tang, Jing Zi, Yefei Nan, Shixiang Wang, Chaoni Xiao, Juanli Zhu and Chao Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1464-1470; DOI: https://doi.org/10.1124/dmd.110.033381

  6. Zhou, Lin

    1. Increased Glyburide Clearance in the Pregnant Mouse Model
      Lin Zhou, Yi Zhang, Mary F. Hebert, Jashvant D. Unadkat and Qingcheng Mao
      Drug Metabolism and Disposition September 2010, 38 (9) 1403-1406; DOI: https://doi.org/10.1124/dmd.110.033837

  7. Zhu, Juanli

    1. Metabolism of Tanshinol Borneol Ester in Rat and Human Liver Microsomes
      Duan Liu, Xiaohui Zheng, Yitong Tang, Jing Zi, Yefei Nan, Shixiang Wang, Chaoni Xiao, Juanli Zhu and Chao Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1464-1470; DOI: https://doi.org/10.1124/dmd.110.033381

  8. Zhu, Qing

    1. Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions
      Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia
      Drug Metabolism and Disposition September 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995

  9. Zi, Jing

    1. Metabolism of Tanshinol Borneol Ester in Rat and Human Liver Microsomes
      Duan Liu, Xiaohui Zheng, Yitong Tang, Jing Zi, Yefei Nan, Shixiang Wang, Chaoni Xiao, Juanli Zhu and Chao Chen
      Drug Metabolism and Disposition September 2010, 38 (9) 1464-1470; DOI: https://doi.org/10.1124/dmd.110.033381
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