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Research ArticleArticle

Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes

Odette A. Fahmi, Mary Kish, Sherri Boldt and R. Scott Obach
Drug Metabolism and Disposition September 2010, 38 (9) 1605-1611; DOI: https://doi.org/10.1124/dmd.110.033126
Odette A. Fahmi
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Mary Kish
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Sherri Boldt
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R. Scott Obach
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Article Information

vol. 38 no. 9 1605-1611
DOI 
https://doi.org/10.1124/dmd.110.033126
PubMed 
20566695

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 9, 2010
  • Accepted June 21, 2010
  • Published online August 18, 2010.

Article Versions

  • Earlier version (June 21, 2010 - 10:45).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Odette A. Fahmi,
  2. Mary Kish,
  3. Sherri Boldt and
  4. R. Scott Obach
  1. Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. Global Research and Development, Groton, Connecticut
  1. Address correspondence to:
    Dr. Odette Fahmi, Pharmacokinetics, Dynamics and Metabolism Department, Pfizer Inc. Global Research & Development, Eastern Point Road, Groton, CT 06340. E-mail: odette.a.fahmi{at}pfizer.com
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Drug Metabolism and Disposition: 38 (9)
Drug Metabolism and Disposition
Vol. 38, Issue 9
1 Sep 2010
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Research ArticleArticle

Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes

Odette A. Fahmi, Mary Kish, Sherri Boldt and R. Scott Obach
Drug Metabolism and Disposition September 1, 2010, 38 (9) 1605-1611; DOI: https://doi.org/10.1124/dmd.110.033126

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Research ArticleArticle

Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes

Odette A. Fahmi, Mary Kish, Sherri Boldt and R. Scott Obach
Drug Metabolism and Disposition September 1, 2010, 38 (9) 1605-1611; DOI: https://doi.org/10.1124/dmd.110.033126
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