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Research ArticleArticle

Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions

Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia
Drug Metabolism and Disposition September 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995

Article Information

vol. 38 no. 9 1612-1622
DOI 
https://doi.org/10.1124/dmd.110.032995
PubMed 
20516252
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 26, 2010
  • Accepted June 1, 2010
  • Published online August 18, 2010.

Article Versions

Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Mingxiang Liao,
  2. Arek R. Raczynski,
  3. Michael Chen,
  4. Bei-Ching Chuang,
  5. Qing Zhu,
  6. Rob Shipman,
  7. Jodi Morrison,
  8. David Lee,
  9. Frank W. Lee,
  10. Suresh K. Balani and
  11. Cindy Q. Xia
  1. Drug Metabolism and Pharmacokinetics, Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts (M.L., A.R.R., M.C., B.-C.C., Q.Z., F.W.L., S.K.B., C.Q.X.); and NoAb BioDiscoveries, Mississauga, Ontario, Canada (R.S., J.M., D.L.)
  1. Address correspondence to:
    Dr. Cindy Q. Xia, Department of Drug Metabolism and Pharmacokinetics, Drug Safety and Disposition, Millennium Pharmaceuticals, Inc., 35 Landsdowne St., Cambridge, MA 02139. E-mail: xia{at}mpi.com
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Research ArticleArticle

Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions

Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia
Drug Metabolism and Disposition September 1, 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995
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