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Drug Metabolism & Disposition

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Table of Contents

January 01, 2011; Volume 39,Issue 1

Short Communications

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    Cigarette Smoke Extract Induces CYP2B6 through Constitutive Androstane Receptor in Hepatocytes
    Ikumi Washio, Makiko Maeda, Chika Sugiura, Ryota Shiga, Mitsuhiro Yoshida, Shinpei Nonen, Yasushi Fujio and Junichi Azuma
    Drug Metabolism and Disposition January 2011, 39 (1) 1-3; DOI: https://doi.org/10.1124/dmd.110.034504
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    Pregnancy Decreases Rat CYP1A2 Activity and Expression
    Alysa A. Walker, Leslie Dickmann and Nina Isoherranen
    Drug Metabolism and Disposition January 2011, 39 (1) 4-7; DOI: https://doi.org/10.1124/dmd.110.035766

Articles

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    Quantitative Investigation of the Impact of P-Glycoprotein Inhibition on Drug Transport across Blood-Brain Barrier in Rats
    Hiroshi Sugimoto, Hideki Hirabayashi, Yoshiaki Kimura, Atsutoshi Furuta, Nobuyuki Amano and Toshiya Moriwaki
    Drug Metabolism and Disposition January 2011, 39 (1) 8-14; DOI: https://doi.org/10.1124/dmd.110.035774
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    Whole-Body Physiologically Based Pharmacokinetic Model for Nutlin-3a in Mice after Intravenous and Oral Administration
    Fan Zhang, Michael Tagen, Stacy Throm, Jeremy Mallari, Laura Miller, R. Kiplin Guy, Michael A. Dyer, Richard T. Williams, Martine F. Roussel, Katie Nemeth, Fangyi Zhu, Jiakun Zhang, Min Lu, John C. Panetta, Nidal Boulos and Clinton F. Stewart
    Drug Metabolism and Disposition January 2011, 39 (1) 15-21; DOI: https://doi.org/10.1124/dmd.110.035915
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    Activation of the Acute Inflammatory Response Alters Cytochrome P450 Expression and Eicosanoid Metabolism
    Katherine N. Theken, Yangmei Deng, M. Alison Kannon, Tricia M. Miller, Samuel M. Poloyac and Craig R. Lee
    Drug Metabolism and Disposition January 2011, 39 (1) 22-29; DOI: https://doi.org/10.1124/dmd.110.035287
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    Identification of Human Liver Cytochrome P450 Enzymes Involved in the Metabolism of SCH 530348 (Vorapaxar), a Potent Oral Thrombin Protease-Activated Receptor 1 Antagonist
    Anima Ghosal, Xiaowen Lu, Natalia Penner, Lan Gao, Ragu Ramanathan, Swapan K. Chowdhury, Narendra S. Kishnani and Kevin B. Alton
    Drug Metabolism and Disposition January 2011, 39 (1) 30-38; DOI: https://doi.org/10.1124/dmd.110.035493
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    Inhibition of Human Sterol Δ7-Reductase and Other Postlanosterol Enzymes by LK-980, a Novel Inhibitor of Cholesterol Synthesis
    Jure Ačimovič, Tina Korošec, Matej Seliškar, Ingemar Bjorkhem, Katalin Monostory, Pal Szabo, Jean-Marc Pascussi, Ales Belič, Uroš Urleb, Darko Kocjan and Damjana Rozman
    Drug Metabolism and Disposition January 2011, 39 (1) 39-46; DOI: https://doi.org/10.1124/dmd.110.035840
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    Characterization of Digoxin Uptake in Sandwich-Cultured Human Hepatocytes
    Emi Kimoto, Jonathan Chupka, Yongling Xiao, Yi-an Bi and David B. Duignan
    Drug Metabolism and Disposition January 2011, 39 (1) 47-53; DOI: https://doi.org/10.1124/dmd.110.034298
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    Toxicological Evaluation of Acyl Glucuronides of Nonsteroidal Anti-Inflammatory Drugs Using Human Embryonic Kidney 293 Cells Stably Expressing Human UDP-Glucuronosyltransferase and Human Hepatocytes
    Toshihisa Koga, Ryoichi Fujiwara, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition January 2011, 39 (1) 54-60; DOI: https://doi.org/10.1124/dmd.110.035600
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    A Baeyer-Villiger Oxidation Specifically Catalyzed by Human Flavin-Containing Monooxygenase 5
    W. George Lai, Nadia Farah, George A. Moniz and Y. Nancy Wong
    Drug Metabolism and Disposition January 2011, 39 (1) 61-70; DOI: https://doi.org/10.1124/dmd.110.035360
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    Brain-Penetrating Tumor Necrosis Factor Decoy Receptor in the Mouse
    Qing-Hui Zhou, Ruben J. Boado, Eric Ka-Wai Hui, Jeff Zhiqiang Lu and William M. Pardridge
    Drug Metabolism and Disposition January 2011, 39 (1) 71-76; DOI: https://doi.org/10.1124/dmd.110.036012
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    Histone Deacetylase Inhibitors Increase Human Arylamine N-Acetyltransferase-1 Expression in Human Tumor Cells
    Scott Paterson, Kok L. Sin, Jacky M. Tiang, Rodney F. Minchin and Neville J. Butcher
    Drug Metabolism and Disposition January 2011, 39 (1) 77-82; DOI: https://doi.org/10.1124/dmd.110.036202
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    The Aryl Hydrocarbon Receptor Pathway and the Response to 3-Methylcholanthrene Are Altered in the Liver of Adrenalectomized Rats
    Anne K. Mullen Grey and David S. Riddick
    Drug Metabolism and Disposition January 2011, 39 (1) 83-91; DOI: https://doi.org/10.1124/dmd.110.035584
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    Effects of Pregnane X Receptor (NR1I2) and CYP2B6 Genetic Polymorphisms on the Induction of Bupropion Hydroxylation by Rifampin
    Jae Yong Chung, Joo-Youn Cho, Hyeong-Seok Lim, Jung-Ryul Kim, Kyung-Sang Yu, Kyoung Soo Lim, Sang-Goo Shin and In-Jin Jang
    Drug Metabolism and Disposition January 2011, 39 (1) 92-97; DOI: https://doi.org/10.1124/dmd.110.035246
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    In Vitro Cytochrome P450-Mediated Metabolism of Exemestane
    Landry K. Kamdem, David A. Flockhart and Zeruesenay Desta
    Drug Metabolism and Disposition January 2011, 39 (1) 98-105; DOI: https://doi.org/10.1124/dmd.110.032276
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    Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery
    Abdul Mutlib, Robert Espina, Karthick Vishwanathan, Kathlene Babalola, Zecheng Chen, Christoph Dehnhardt, Aranapakam Venkatesan, Tarek Mansour, Inder Chaudhary, Rasmy Talaat and JoAnn Scatina
    Drug Metabolism and Disposition January 2011, 39 (1) 106-116; DOI: https://doi.org/10.1124/dmd.110.032490
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    Organic Cation Transporter-Mediated Renal Secretion of Ipratropium and Tiotropium in Rats and Humans
    Takeo Nakanishi, Tsunemitsu Haruta, Yoshiyuki Shirasaka and Ikumi Tamai
    Drug Metabolism and Disposition January 2011, 39 (1) 117-122; DOI: https://doi.org/10.1124/dmd.110.035402
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    Plasma Stability-Dependent Circulation of Acyl Glucuronide Metabolites in Humans: How Circulating Metabolite Profiles of Muraglitazar and Peliglitazar Can Lead to Misleading Risk Assessment
    Donglu Zhang, Nirmala Raghavan, Lifei Wang, Yongjun Xue, Mary Obermeier, Stephanie Chen, Shiwei Tao, Hao Zhang, Peter T. Cheng, Wenying Li, Ragu Ramanathan, Zheng Yang and W. Griffith Humphreys
    Drug Metabolism and Disposition January 2011, 39 (1) 123-131; DOI: https://doi.org/10.1124/dmd.110.035048
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    Drug Efflux Transporter Multidrug Resistance-Associated Protein 5 Affects Sensitivity of Pancreatic Cancer Cell Lines to the Nucleoside Anticancer Drug 5-Fluorouracil
    Praveen K. Nambaru, Tobias Hübner, Kathleen Köck, Steffen Mews, Markus Grube, Léa Payen, Jérôme Guitton, Matthias Sendler, Gabriele Jedlitschky, Christian Rimmbach, Dieter Rosskopf, Dariusz W. Kowalczyk, Heyo K. Kroemer, Frank U. Weiss, Julia Mayerle, Markus M. Lerch and Christoph A. Ritter
    Drug Metabolism and Disposition January 2011, 39 (1) 132-139; DOI: https://doi.org/10.1124/dmd.110.033613
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    Generation of Human Chiral Metabolites of Simvastatin and Lovastatin by Bacterial CYP102A1 Mutants
    Keon-Hee Kim, Ji-Yeon Kang, Dong-Hyun Kim, Sun-Ha Park, Seon Ha Park, Dooil Kim, Ki Deok Park, Young Ju Lee, Heung-Chae Jung, Jae-Gu Pan, Taeho Ahn and Chul-Ho Yun
    Drug Metabolism and Disposition January 2011, 39 (1) 140-150; DOI: https://doi.org/10.1124/dmd.110.036392
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    Identification of Clinically Used Drugs That Activate Pregnane X Receptors
    Sunita J. Shukla, Srilatha Sakamuru, Ruili Huang, Timothy A. Moeller, Paul Shinn, Danielle VanLeer, Douglas S. Auld, Christopher P. Austin and Menghang Xia
    Drug Metabolism and Disposition January 2011, 39 (1) 151-159; DOI: https://doi.org/10.1124/dmd.110.035105
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In this issue

Drug Metabolism and Disposition: 39 (1)
Drug Metabolism and Disposition
Vol. 39, Issue 1
1 Jan 2011
  • Table of Contents
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