Research ArticleArticle
Plasma Stability-Dependent Circulation of Acyl Glucuronide Metabolites in Humans: How Circulating Metabolite Profiles of Muraglitazar and Peliglitazar Can Lead to Misleading Risk Assessment
Donglu Zhang, Nirmala Raghavan, Lifei Wang, Yongjun Xue, Mary Obermeier, Stephanie Chen, Shiwei Tao, Hao Zhang, Peter T. Cheng, Wenying Li, Ragu Ramanathan, Zheng Yang and W. Griffith Humphreys
Drug Metabolism and Disposition January 2011, 39 (1) 123-131; DOI: https://doi.org/10.1124/dmd.110.035048
Donglu Zhang
Pharmaceutical Candidate Optimization (D.Z., N.R., L.W., Y.X., M.O., W.L., R.R., Z.Y., W.G.H.) and Discovery Chemistry (S.C., S.T., H.Z., P.T.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
Nirmala Raghavan
Pharmaceutical Candidate Optimization (D.Z., N.R., L.W., Y.X., M.O., W.L., R.R., Z.Y., W.G.H.) and Discovery Chemistry (S.C., S.T., H.Z., P.T.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
Lifei Wang
Pharmaceutical Candidate Optimization (D.Z., N.R., L.W., Y.X., M.O., W.L., R.R., Z.Y., W.G.H.) and Discovery Chemistry (S.C., S.T., H.Z., P.T.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
Yongjun Xue
Pharmaceutical Candidate Optimization (D.Z., N.R., L.W., Y.X., M.O., W.L., R.R., Z.Y., W.G.H.) and Discovery Chemistry (S.C., S.T., H.Z., P.T.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
Mary Obermeier
Pharmaceutical Candidate Optimization (D.Z., N.R., L.W., Y.X., M.O., W.L., R.R., Z.Y., W.G.H.) and Discovery Chemistry (S.C., S.T., H.Z., P.T.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
Stephanie Chen
Pharmaceutical Candidate Optimization (D.Z., N.R., L.W., Y.X., M.O., W.L., R.R., Z.Y., W.G.H.) and Discovery Chemistry (S.C., S.T., H.Z., P.T.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
Shiwei Tao
Pharmaceutical Candidate Optimization (D.Z., N.R., L.W., Y.X., M.O., W.L., R.R., Z.Y., W.G.H.) and Discovery Chemistry (S.C., S.T., H.Z., P.T.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
Hao Zhang
Pharmaceutical Candidate Optimization (D.Z., N.R., L.W., Y.X., M.O., W.L., R.R., Z.Y., W.G.H.) and Discovery Chemistry (S.C., S.T., H.Z., P.T.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
Peter T. Cheng
Pharmaceutical Candidate Optimization (D.Z., N.R., L.W., Y.X., M.O., W.L., R.R., Z.Y., W.G.H.) and Discovery Chemistry (S.C., S.T., H.Z., P.T.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
Wenying Li
Pharmaceutical Candidate Optimization (D.Z., N.R., L.W., Y.X., M.O., W.L., R.R., Z.Y., W.G.H.) and Discovery Chemistry (S.C., S.T., H.Z., P.T.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
Ragu Ramanathan
Pharmaceutical Candidate Optimization (D.Z., N.R., L.W., Y.X., M.O., W.L., R.R., Z.Y., W.G.H.) and Discovery Chemistry (S.C., S.T., H.Z., P.T.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
Zheng Yang
Pharmaceutical Candidate Optimization (D.Z., N.R., L.W., Y.X., M.O., W.L., R.R., Z.Y., W.G.H.) and Discovery Chemistry (S.C., S.T., H.Z., P.T.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
W. Griffith Humphreys
Pharmaceutical Candidate Optimization (D.Z., N.R., L.W., Y.X., M.O., W.L., R.R., Z.Y., W.G.H.) and Discovery Chemistry (S.C., S.T., H.Z., P.T.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Research ArticleArticle
Plasma Stability-Dependent Circulation of Acyl Glucuronide Metabolites in Humans: How Circulating Metabolite Profiles of Muraglitazar and Peliglitazar Can Lead to Misleading Risk Assessment
Donglu Zhang, Nirmala Raghavan, Lifei Wang, Yongjun Xue, Mary Obermeier, Stephanie Chen, Shiwei Tao, Hao Zhang, Peter T. Cheng, Wenying Li, Ragu Ramanathan, Zheng Yang and W. Griffith Humphreys
Drug Metabolism and Disposition January 1, 2011, 39 (1) 123-131; DOI: https://doi.org/10.1124/dmd.110.035048
Research ArticleArticle
Plasma Stability-Dependent Circulation of Acyl Glucuronide Metabolites in Humans: How Circulating Metabolite Profiles of Muraglitazar and Peliglitazar Can Lead to Misleading Risk Assessment
Donglu Zhang, Nirmala Raghavan, Lifei Wang, Yongjun Xue, Mary Obermeier, Stephanie Chen, Shiwei Tao, Hao Zhang, Peter T. Cheng, Wenying Li, Ragu Ramanathan, Zheng Yang and W. Griffith Humphreys
Drug Metabolism and Disposition January 1, 2011, 39 (1) 123-131; DOI: https://doi.org/10.1124/dmd.110.035048
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