Research ArticleArticle
Whole-Body Physiologically Based Pharmacokinetic Model for Nutlin-3a in Mice after Intravenous and Oral Administration
Fan Zhang, Michael Tagen, Stacy Throm, Jeremy Mallari, Laura Miller, R. Kiplin Guy, Michael A. Dyer, Richard T. Williams, Martine F. Roussel, Katie Nemeth, Fangyi Zhu, Jiakun Zhang, Min Lu, John C. Panetta, Nidal Boulos and Clinton F. Stewart
Drug Metabolism and Disposition January 2011, 39 (1) 15-21; DOI: https://doi.org/10.1124/dmd.110.035915
Fan Zhang
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
Michael Tagen
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
Stacy Throm
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
Jeremy Mallari
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
Laura Miller
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
R. Kiplin Guy
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
Michael A. Dyer
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
Richard T. Williams
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
Martine F. Roussel
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
Katie Nemeth
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
Fangyi Zhu
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
Jiakun Zhang
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
Min Lu
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
John C. Panetta
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
Nidal Boulos
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
Clinton F. Stewart
Departments of Pharmaceutical Sciences (F.Z., M.T., S.T., L.M., C.F.S., J.C.P.), Chemical Biology (J.M., R.K.G., F.Z., M.L.), Developmental Neurobiology (K.N., J.Z., M.A.D.), Oncology (R.T.W., N.B.), and Tumor Cell Biology (M.F.R.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Sciences (F.Z., C.F.S., J.C.P.), College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
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Research ArticleArticle
Whole-Body Physiologically Based Pharmacokinetic Model for Nutlin-3a in Mice after Intravenous and Oral Administration
Fan Zhang, Michael Tagen, Stacy Throm, Jeremy Mallari, Laura Miller, R. Kiplin Guy, Michael A. Dyer, Richard T. Williams, Martine F. Roussel, Katie Nemeth, Fangyi Zhu, Jiakun Zhang, Min Lu, John C. Panetta, Nidal Boulos and Clinton F. Stewart
Drug Metabolism and Disposition January 1, 2011, 39 (1) 15-21; DOI: https://doi.org/10.1124/dmd.110.035915
Research ArticleArticle
Whole-Body Physiologically Based Pharmacokinetic Model for Nutlin-3a in Mice after Intravenous and Oral Administration
Fan Zhang, Michael Tagen, Stacy Throm, Jeremy Mallari, Laura Miller, R. Kiplin Guy, Michael A. Dyer, Richard T. Williams, Martine F. Roussel, Katie Nemeth, Fangyi Zhu, Jiakun Zhang, Min Lu, John C. Panetta, Nidal Boulos and Clinton F. Stewart
Drug Metabolism and Disposition January 1, 2011, 39 (1) 15-21; DOI: https://doi.org/10.1124/dmd.110.035915
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