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Research ArticleArticle

Identification of Clinically Used Drugs That Activate Pregnane X Receptors

Sunita J. Shukla, Srilatha Sakamuru, Ruili Huang, Timothy A. Moeller, Paul Shinn, Danielle VanLeer, Douglas S. Auld, Christopher P. Austin and Menghang Xia
Drug Metabolism and Disposition January 2011, 39 (1) 151-159; DOI: https://doi.org/10.1124/dmd.110.035105
Sunita J. Shukla
National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland (S.J.S., S.S., R.H., P.S., D.V.L., D.S.A., C.P.A., M.X.); and Celsis in Vitro Technologies, Halethorpe, Maryland (T.A.M.)
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Srilatha Sakamuru
National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland (S.J.S., S.S., R.H., P.S., D.V.L., D.S.A., C.P.A., M.X.); and Celsis in Vitro Technologies, Halethorpe, Maryland (T.A.M.)
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Ruili Huang
National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland (S.J.S., S.S., R.H., P.S., D.V.L., D.S.A., C.P.A., M.X.); and Celsis in Vitro Technologies, Halethorpe, Maryland (T.A.M.)
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Timothy A. Moeller
National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland (S.J.S., S.S., R.H., P.S., D.V.L., D.S.A., C.P.A., M.X.); and Celsis in Vitro Technologies, Halethorpe, Maryland (T.A.M.)
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Paul Shinn
National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland (S.J.S., S.S., R.H., P.S., D.V.L., D.S.A., C.P.A., M.X.); and Celsis in Vitro Technologies, Halethorpe, Maryland (T.A.M.)
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Danielle VanLeer
National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland (S.J.S., S.S., R.H., P.S., D.V.L., D.S.A., C.P.A., M.X.); and Celsis in Vitro Technologies, Halethorpe, Maryland (T.A.M.)
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Douglas S. Auld
National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland (S.J.S., S.S., R.H., P.S., D.V.L., D.S.A., C.P.A., M.X.); and Celsis in Vitro Technologies, Halethorpe, Maryland (T.A.M.)
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Christopher P. Austin
National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland (S.J.S., S.S., R.H., P.S., D.V.L., D.S.A., C.P.A., M.X.); and Celsis in Vitro Technologies, Halethorpe, Maryland (T.A.M.)
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Menghang Xia
National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland (S.J.S., S.S., R.H., P.S., D.V.L., D.S.A., C.P.A., M.X.); and Celsis in Vitro Technologies, Halethorpe, Maryland (T.A.M.)
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Article Information

vol. 39 no. 1 151-159
DOI 
https://doi.org/10.1124/dmd.110.035105
PubMed 
20966043

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 22, 2010
  • Accepted October 21, 2010
  • Published online December 15, 2010.

Article Versions

  • Earlier version (October 21, 2010 - 06:26).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sunita J. Shukla,
  2. Srilatha Sakamuru,
  3. Ruili Huang,
  4. Timothy A. Moeller,
  5. Paul Shinn,
  6. Danielle VanLeer,
  7. Douglas S. Auld,
  8. Christopher P. Austin, and
  9. Menghang Xia
  1. National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland (S.J.S., S.S., R.H., P.S., D.V.L., D.S.A., C.P.A., M.X.); and Celsis in Vitro Technologies, Halethorpe, Maryland (T.A.M.)
  1. Address correspondence to:
    Dr. Menghang Xia, National Institutes of Health, 9800 Medical Center Dr., Rockville, MD 20850. E-mail: mxia{at}mail.nih.gov
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Drug Metabolism and Disposition: 39 (1)
Drug Metabolism and Disposition
Vol. 39, Issue 1
1 Jan 2011
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Research ArticleArticle

Identification of Clinically Used Drugs That Activate Pregnane X Receptors

Sunita J. Shukla, Srilatha Sakamuru, Ruili Huang, Timothy A. Moeller, Paul Shinn, Danielle VanLeer, Douglas S. Auld, Christopher P. Austin and Menghang Xia
Drug Metabolism and Disposition January 1, 2011, 39 (1) 151-159; DOI: https://doi.org/10.1124/dmd.110.035105

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Research ArticleArticle

Identification of Clinically Used Drugs That Activate Pregnane X Receptors

Sunita J. Shukla, Srilatha Sakamuru, Ruili Huang, Timothy A. Moeller, Paul Shinn, Danielle VanLeer, Douglas S. Auld, Christopher P. Austin and Menghang Xia
Drug Metabolism and Disposition January 1, 2011, 39 (1) 151-159; DOI: https://doi.org/10.1124/dmd.110.035105
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