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Research ArticleArticle

Identification of Human Liver Cytochrome P450 Enzymes Involved in the Metabolism of SCH 530348 (Vorapaxar), a Potent Oral Thrombin Protease-Activated Receptor 1 Antagonist

Anima Ghosal, Xiaowen Lu, Natalia Penner, Lan Gao, Ragu Ramanathan, Swapan K. Chowdhury, Narendra S. Kishnani and Kevin B. Alton
Drug Metabolism and Disposition January 2011, 39 (1) 30-38; DOI: https://doi.org/10.1124/dmd.110.035493

Article Information

vol. 39 no. 1 30-38
DOI 
https://doi.org/10.1124/dmd.110.035493
PubMed 
20926621
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 14, 2010
  • Accepted October 6, 2010
  • Published online December 15, 2010.

Article Versions

Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Anima Ghosal,
  2. Xiaowen Lu,
  3. Natalia Penner,
  4. Lan Gao,
  5. Ragu Ramanathan,
  6. Swapan K. Chowdhury,
  7. Narendra S. Kishnani, and
  8. Kevin B. Alton
  1. Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Kenilworth, New Jersey
  1. Address correspondence to:
    Dr. Anima Ghosal, Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 2015 Galloping Hill Road, K-15-1945, Kenilworth, NJ 07033. E-mail: anima.ghosal{at}spcorp.com
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Research ArticleArticle

Identification of Human Liver Cytochrome P450 Enzymes Involved in the Metabolism of SCH 530348 (Vorapaxar), a Potent Oral Thrombin Protease-Activated Receptor 1 Antagonist

Anima Ghosal, Xiaowen Lu, Natalia Penner, Lan Gao, Ragu Ramanathan, Swapan K. Chowdhury, Narendra S. Kishnani and Kevin B. Alton
Drug Metabolism and Disposition January 1, 2011, 39 (1) 30-38; DOI: https://doi.org/10.1124/dmd.110.035493
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