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Drug Metabolism & Disposition

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Table of Contents

October 01, 2011; Volume 39,Issue 10

Minireview

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    How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
    Eugenia Kraynov, Steven W. Martin, Susan Hurst, Odette A. Fahmi, Martin Dowty, Carol Cronenberger, Cho-Ming Loi, Bing Kuang, Owen Fields, Scott Fountain, Michel Awwad and Diane Wang
    Drug Metabolism and Disposition October 2011, 39 (10) 1779-1783; DOI: https://doi.org/10.1124/dmd.111.040808

Short Communications

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    Pharmacokinetics of Daikenchuto, a Traditional Japanese Medicine (Kampo) after Single Oral Administration to Healthy Japanese Volunteers
    Masaya Munekage, Hiroyuki Kitagawa, Kengo Ichikawa, Junko Watanabe, Katsuyuki Aoki, Toru Kono and Kazuhiro Hanazaki
    Drug Metabolism and Disposition October 2011, 39 (10) 1784-1788; DOI: https://doi.org/10.1124/dmd.111.040097
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    Measurement of Binding of Basic Drugs to Acidic Phospholipids Using Surface Plasmon Resonance and Incorporation of the Data into Mechanistic Tissue Composition Equations to Predict Steady-State Volume of Distribution
    Helen Small, Iain Gardner, Hannah M. Jones, John Davis and Malcolm Rowland
    Drug Metabolism and Disposition October 2011, 39 (10) 1789-1793; DOI: https://doi.org/10.1124/dmd.111.040253

Articles

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    Efflux Transport Is an Important Determinant of Ethinylestradiol Glucuronide and Ethinylestradiol Sulfate Pharmacokinetics
    Maciej J. Zamek-Gliszczynski, Jeffrey S. Day, Kathleen M. Hillgren and Diane L. Phillips
    Drug Metabolism and Disposition October 2011, 39 (10) 1794-1800; DOI: https://doi.org/10.1124/dmd.111.040162
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    Pharmacokinetic and Pharmacodynamic Modeling of the Effect of an Sodium-Glucose Cotransporter Inhibitor, Phlorizin, on Renal Glucose Transport in Rats
    Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Kimie Asanuma, Yoshinori Aso, Sachiya Ikeda and Masaki Ishigai
    Drug Metabolism and Disposition October 2011, 39 (10) 1801-1807; DOI: https://doi.org/10.1124/dmd.111.040048
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    Kinetic Characterization of Rat Hepatic Uptake of 16 Actively Transported Drugs
    Yoshiyuki Yabe, Aleksandra Galetin and J. Brian Houston
    Drug Metabolism and Disposition October 2011, 39 (10) 1808-1814; DOI: https://doi.org/10.1124/dmd.111.040477
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    Thioacetamide Intoxication Triggers Transcriptional Up-Regulation but Enzyme Inactivation of UDP-Glucuronosyltransferases
    Haiping Hao, Lifang Zhang, Shan Jiang, Shiqing Sun, Ping Gong, Yuan Xie, Xueyan Zhou and Guangji Wang
    Drug Metabolism and Disposition October 2011, 39 (10) 1815-1822; DOI: https://doi.org/10.1124/dmd.111.039172
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    Bioactivation Pathways of the Cannabinoid Receptor 1 Antagonist Rimonabant
    Moa Andresen Bergström, Emre M. Isin, Neal Castagnoli and Claire E. Milne
    Drug Metabolism and Disposition October 2011, 39 (10) 1823-1832; DOI: https://doi.org/10.1124/dmd.111.039412
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    Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-aryl-thiazole and 2-Aryl-4-benzoyl-imidazole for Improving Oral Bioavailability
    Chien-Ming Li, Jianjun Chen, Yan Lu, Ramesh Narayanan, Deanna N. Parke, Wei Li, Sunjoo Ahn, Duane D. Miller and James T. Dalton
    Drug Metabolism and Disposition October 2011, 39 (10) 1833-1839; DOI: https://doi.org/10.1124/dmd.110.036616
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    Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
    Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
    Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840
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    Mechanisms of Reduced Maternal and Fetal Lopinavir Exposure in a Rat Model of Gestational Diabetes
    Gregory J. Anger and Micheline Piquette-Miller
    Drug Metabolism and Disposition October 2011, 39 (10) 1850-1859; DOI: https://doi.org/10.1124/dmd.111.040626
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    Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether
    Masashi Honda, Yuka Muroi, Yuichiro Tamaki, Daisuke Saigusa, Naoto Suzuki, Yoshihisa Tomioka, Yoichi Matsubara, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka
    Drug Metabolism and Disposition October 2011, 39 (10) 1860-1865; DOI: https://doi.org/10.1124/dmd.111.040352
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    Enhancement of Oral Bioavailability of 20(S)-Ginsenoside Rh2 through Improved Understanding of Its Absorption and Efflux Mechanisms
    Zhen Yang, Song Gao, Jingrong Wang, Taijun Yin, Yang Teng, Baojian Wu, Ming You, Zhihong Jiang and Ming Hu
    Drug Metabolism and Disposition October 2011, 39 (10) 1866-1872; DOI: https://doi.org/10.1124/dmd.111.040006
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    Pharmacokinetics, Pharmacodynamics, Metabolism, Distribution, and Excretion of Carfilzomib in Rats
    Jinfu Yang, Zhengping Wang, Ying Fang, Jing Jiang, Frances Zhao, Hansen Wong, Mark K. Bennett, Christopher J. Molineaux and Christopher J. Kirk
    Drug Metabolism and Disposition October 2011, 39 (10) 1873-1882; DOI: https://doi.org/10.1124/dmd.111.039164
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    In Vitro and In Vivo Metabolism of a Selective δ-Opioid Receptor
    Jian Guo, Chungang Gu, Diansong Zhou, Charles S. Elmore, Khanh H. Bui and Scott W. Grimm
    Drug Metabolism and Disposition October 2011, 39 (10) 1883-1894; DOI: https://doi.org/10.1124/dmd.111.040980
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    Metabolite Profiles of Degarelix, a New Gonadotropin-Releasing Hormone Receptor Antagonist, in Rat, Dog, and Monkey
    Anders Sonesson, Wolfgang Koechling, Jacek Stalewski, László B. Tankó and Birgitte Buur Rasmussen
    Drug Metabolism and Disposition October 2011, 39 (10) 1895-1903; DOI: https://doi.org/10.1124/dmd.111.039883
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    Brain Regional Pharmacokinetics of p-Aminosalicylic Acid and Its N-Acetylated Metabolite: Effectiveness in Chelating Brain Manganese
    Lan Hong, Wendy Jiang, Hao Pan, Yueming Jiang, Su Zeng and Wei Zheng
    Drug Metabolism and Disposition October 2011, 39 (10) 1904-1909; DOI: https://doi.org/10.1124/dmd.111.040915
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    Enabling Clearance Predictions to Emerge from In Silico Actions of Quasi-Autonomous Hepatocyte Components
    Shahab Sheikh-Bahaei and C. Anthony Hunt
    Drug Metabolism and Disposition October 2011, 39 (10) 1910-1920; DOI: https://doi.org/10.1124/dmd.111.038703
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    Predictive Utility of In Vitro Rifampin Induction Data Generated in Fresh and Cryopreserved Human Hepatocytes, Fa2N-4, and HepaRG Cells
    Ian E. Templeton, J. Brian Houston and Aleksandra Galetin
    Drug Metabolism and Disposition October 2011, 39 (10) 1921-1929; DOI: https://doi.org/10.1124/dmd.111.040824
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    The Impact of Hepatic Uptake on the Pharmacokinetics of Organic Anions
    Philip Gardiner and Stuart W. Paine
    Drug Metabolism and Disposition October 2011, 39 (10) 1930-1938; DOI: https://doi.org/10.1124/dmd.111.039842
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    Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression
    Martin Mahro, Catarina Coelho, José Trincão, David Rodrigues, Mineko Terao, Enrico Garattini, Miguel Saggu, Friedhelm Lendzian, Peter Hildebrandt, Maria João Romão and Silke Leimkühler
    Drug Metabolism and Disposition October 2011, 39 (10) 1939-1945; DOI: https://doi.org/10.1124/dmd.111.040873
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    Distribution of KAI-9803, a Novel δ-Protein Kinase C Inhibitor, after Intravenous Administration to Rats
    Yoshihiro Miyaji, Sarah Walter, Leon Chen, Atsushi Kurihara, Tomoko Ishizuka, Motoko Saito, Kenji Kawai and Osamu Okazaki
    Drug Metabolism and Disposition October 2011, 39 (10) 1946-1953; DOI: https://doi.org/10.1124/dmd.111.040725
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    Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease
    April D. Lake, Petr Novak, Craig D. Fisher, Jonathan P. Jackson, Rhiannon N. Hardwick, D. Dean Billheimer, Walter T. Klimecki and Nathan J. Cherrington
    Drug Metabolism and Disposition October 2011, 39 (10) 1954-1960; DOI: https://doi.org/10.1124/dmd.111.040592
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    Clearance and Biodistribution of Liposomally Encapsulated Nitroxides: A Model for Targeted Delivery of Electron Paramagnetic Resonance Imaging Probes to Tumors
    Scott R. Burks, Eric A. Legenzov, Gerald M. Rosen and Joseph P. Y. Kao
    Drug Metabolism and Disposition October 2011, 39 (10) 1961-1966; DOI: https://doi.org/10.1124/dmd.111.039636
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    Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
    Krishna C. Chimalakonda, Stacie M. Bratton, Vi-Huyen Le, Kan Hui Yiew, Anna Dineva, Cindy L. Moran, Laura P. James, Jeffery H. Moran and Anna Radominska-Pandya
    Drug Metabolism and Disposition October 2011, 39 (10) 1967-1976; DOI: https://doi.org/10.1124/dmd.111.040709
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    Dose-Dependent Interaction between Gemfibrozil and Repaglinide in Humans: Strong Inhibition of CYP2C8 with Subtherapeutic Gemfibrozil Doses
    Johanna Honkalammi, Mikko Niemi, Pertti J. Neuvonen and Janne T. Backman
    Drug Metabolism and Disposition October 2011, 39 (10) 1977-1986; DOI: https://doi.org/10.1124/dmd.111.040931
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    CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload
    Stéphanie Madec, Virginie Cerec, Emmanuelle Plée-Gautier, Joseph Antoun, Denise Glaise, Jean-Pierre Salaun, Christiane Guguen-Guillouzo and Anne Corlu
    Drug Metabolism and Disposition October 2011, 39 (10) 1987-1996; DOI: https://doi.org/10.1124/dmd.110.036848
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Drug Metabolism and Disposition: 39 (10)
Drug Metabolism and Disposition
Vol. 39, Issue 10
1 Oct 2011
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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