Table of Contents

Articles

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  Efflux Transport Is an Important Determinant of Ethinylestradiol Glucuronide and Ethinylestradiol Sulfate Pharmacokinetics

  Maciej J. Zamek-Gliszczynski, Jeffrey S. Day, Kathleen M. Hillgren and Diane L. Phillips

  Drug Metabolism and Disposition October 2011, 39 (10) 1794-1800; DOI: https://doi.org/10.1124/dmd.111.040162
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  Pharmacokinetic and Pharmacodynamic Modeling of the Effect of an Sodium-Glucose Cotransporter Inhibitor, Phlorizin, on Renal Glucose Transport in Rats

  Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Kimie Asanuma, Yoshinori Aso, Sachiya Ikeda and Masaki Ishigai

  Drug Metabolism and Disposition October 2011, 39 (10) 1801-1807; DOI: https://doi.org/10.1124/dmd.111.040048
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  Kinetic Characterization of Rat Hepatic Uptake of 16 Actively Transported Drugs

  Yoshiyuki Yabe, Aleksandra Galetin and J. Brian Houston

  Drug Metabolism and Disposition October 2011, 39 (10) 1808-1814; DOI: https://doi.org/10.1124/dmd.111.040477
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  Thioacetamide Intoxication Triggers Transcriptional Up-Regulation but Enzyme Inactivation of UDP-Glucuronosyltransferases

  Haiping Hao, Lifang Zhang, Shan Jiang, Shiqing Sun, Ping Gong, Yuan Xie, Xueyan Zhou and Guangji Wang

  Drug Metabolism and Disposition October 2011, 39 (10) 1815-1822; DOI: https://doi.org/10.1124/dmd.111.039172
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  Bioactivation Pathways of the Cannabinoid Receptor 1 Antagonist Rimonabant

  Moa Andresen Bergström, Emre M. Isin, Neal Castagnoli and Claire E. Milne

  Drug Metabolism and Disposition October 2011, 39 (10) 1823-1832; DOI: https://doi.org/10.1124/dmd.111.039412
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  Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-aryl-thiazole and 2-Aryl-4-benzoyl-imidazole for Improving Oral Bioavailability

  Chien-Ming Li, Jianjun Chen, Yan Lu, Ramesh Narayanan, Deanna N. Parke, Wei Li, Sunjoo Ahn, Duane D. Miller and James T. Dalton

  Drug Metabolism and Disposition October 2011, 39 (10) 1833-1839; DOI: https://doi.org/10.1124/dmd.110.036616
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  Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor

  Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong

  Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840
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  Mechanisms of Reduced Maternal and Fetal Lopinavir Exposure in a Rat Model of Gestational Diabetes

  Gregory J. Anger and Micheline Piquette-Miller

  Drug Metabolism and Disposition October 2011, 39 (10) 1850-1859; DOI: https://doi.org/10.1124/dmd.111.040626
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  Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether

  Masashi Honda, Yuka Muroi, Yuichiro Tamaki, Daisuke Saigusa, Naoto Suzuki, Yoshihisa Tomioka, Yoichi Matsubara, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka

  Drug Metabolism and Disposition October 2011, 39 (10) 1860-1865; DOI: https://doi.org/10.1124/dmd.111.040352
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  Enhancement of Oral Bioavailability of 20(S)-Ginsenoside Rh2 through Improved Understanding of Its Absorption and Efflux Mechanisms

  Zhen Yang, Song Gao, Jingrong Wang, Taijun Yin, Yang Teng, Baojian Wu, Ming You, Zhihong Jiang and Ming Hu

  Drug Metabolism and Disposition October 2011, 39 (10) 1866-1872; DOI: https://doi.org/10.1124/dmd.111.040006
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  Pharmacokinetics, Pharmacodynamics, Metabolism, Distribution, and Excretion of Carfilzomib in Rats

  Jinfu Yang, Zhengping Wang, Ying Fang, Jing Jiang, Frances Zhao, Hansen Wong, Mark K. Bennett, Christopher J. Molineaux and Christopher J. Kirk

  Drug Metabolism and Disposition October 2011, 39 (10) 1873-1882; DOI: https://doi.org/10.1124/dmd.111.039164
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  In Vitro and In Vivo Metabolism of a Selective δ-Opioid Receptor

  Jian Guo, Chungang Gu, Diansong Zhou, Charles S. Elmore, Khanh H. Bui and Scott W. Grimm

  Drug Metabolism and Disposition October 2011, 39 (10) 1883-1894; DOI: https://doi.org/10.1124/dmd.111.040980
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  Metabolite Profiles of Degarelix, a New Gonadotropin-Releasing Hormone Receptor Antagonist, in Rat, Dog, and Monkey

  Anders Sonesson, Wolfgang Koechling, Jacek Stalewski, László B. Tankó and Birgitte Buur Rasmussen

  Drug Metabolism and Disposition October 2011, 39 (10) 1895-1903; DOI: https://doi.org/10.1124/dmd.111.039883
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  Brain Regional Pharmacokinetics of p-Aminosalicylic Acid and Its N-Acetylated Metabolite: Effectiveness in Chelating Brain Manganese

  Lan Hong, Wendy Jiang, Hao Pan, Yueming Jiang, Su Zeng and Wei Zheng

  Drug Metabolism and Disposition October 2011, 39 (10) 1904-1909; DOI: https://doi.org/10.1124/dmd.111.040915
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  Enabling Clearance Predictions to Emerge from In Silico Actions of Quasi-Autonomous Hepatocyte Components

  Shahab Sheikh-Bahaei and C. Anthony Hunt

  Drug Metabolism and Disposition October 2011, 39 (10) 1910-1920; DOI: https://doi.org/10.1124/dmd.111.038703
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  Predictive Utility of In Vitro Rifampin Induction Data Generated in Fresh and Cryopreserved Human Hepatocytes, Fa2N-4, and HepaRG Cells

  Ian E. Templeton, J. Brian Houston and Aleksandra Galetin

  Drug Metabolism and Disposition October 2011, 39 (10) 1921-1929; DOI: https://doi.org/10.1124/dmd.111.040824
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  The Impact of Hepatic Uptake on the Pharmacokinetics of Organic Anions

  Philip Gardiner and Stuart W. Paine

  Drug Metabolism and Disposition October 2011, 39 (10) 1930-1938; DOI: https://doi.org/10.1124/dmd.111.039842
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  Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression

  Martin Mahro, Catarina Coelho, José Trincão, David Rodrigues, Mineko Terao, Enrico Garattini, Miguel Saggu, Friedhelm Lendzian, Peter Hildebrandt, Maria João Romão and Silke Leimkühler

  Drug Metabolism and Disposition October 2011, 39 (10) 1939-1945; DOI: https://doi.org/10.1124/dmd.111.040873
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  Distribution of KAI-9803, a Novel δ-Protein Kinase C Inhibitor, after Intravenous Administration to Rats

  Yoshihiro Miyaji, Sarah Walter, Leon Chen, Atsushi Kurihara, Tomoko Ishizuka, Motoko Saito, Kenji Kawai and Osamu Okazaki

  Drug Metabolism and Disposition October 2011, 39 (10) 1946-1953; DOI: https://doi.org/10.1124/dmd.111.040725
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  Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease

  April D. Lake, Petr Novak, Craig D. Fisher, Jonathan P. Jackson, Rhiannon N. Hardwick, D. Dean Billheimer, Walter T. Klimecki and Nathan J. Cherrington

  Drug Metabolism and Disposition October 2011, 39 (10) 1954-1960; DOI: https://doi.org/10.1124/dmd.111.040592
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  Clearance and Biodistribution of Liposomally Encapsulated Nitroxides: A Model for Targeted Delivery of Electron Paramagnetic Resonance Imaging Probes to Tumors

  Scott R. Burks, Eric A. Legenzov, Gerald M. Rosen and Joseph P. Y. Kao

  Drug Metabolism and Disposition October 2011, 39 (10) 1961-1966; DOI: https://doi.org/10.1124/dmd.111.039636
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  Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases

  Krishna C. Chimalakonda, Stacie M. Bratton, Vi-Huyen Le, Kan Hui Yiew, Anna Dineva, Cindy L. Moran, Laura P. James, Jeffery H. Moran and Anna Radominska-Pandya

  Drug Metabolism and Disposition October 2011, 39 (10) 1967-1976; DOI: https://doi.org/10.1124/dmd.111.040709
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  Dose-Dependent Interaction between Gemfibrozil and Repaglinide in Humans: Strong Inhibition of CYP2C8 with Subtherapeutic Gemfibrozil Doses

  Johanna Honkalammi, Mikko Niemi, Pertti J. Neuvonen and Janne T. Backman

  Drug Metabolism and Disposition October 2011, 39 (10) 1977-1986; DOI: https://doi.org/10.1124/dmd.111.040931
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  CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload

  Stéphanie Madec, Virginie Cerec, Emmanuelle Plée-Gautier, Joseph Antoun, Denise Glaise, Jean-Pierre Salaun, Christiane Guguen-Guillouzo and Anne Corlu

  Drug Metabolism and Disposition October 2011, 39 (10) 1987-1996; DOI: https://doi.org/10.1124/dmd.110.036848