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Index by author

October 01, 2011; Volume 39,Issue 10

A

  1. Ahn, Sunjoo

    1. Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-aryl-thiazole and 2-Aryl-4-benzoyl-imidazole for Improving Oral Bioavailability
      Chien-Ming Li, Jianjun Chen, Yan Lu, Ramesh Narayanan, Deanna N. Parke, Wei Li, Sunjoo Ahn, Duane D. Miller and James T. Dalton
      Drug Metabolism and Disposition October 2011, 39 (10) 1833-1839; DOI: https://doi.org/10.1124/dmd.110.036616

  2. Anger, Gregory J.

    1. Mechanisms of Reduced Maternal and Fetal Lopinavir Exposure in a Rat Model of Gestational Diabetes
      Gregory J. Anger and Micheline Piquette-Miller
      Drug Metabolism and Disposition October 2011, 39 (10) 1850-1859; DOI: https://doi.org/10.1124/dmd.111.040626

  3. Antoun, Joseph

    1. CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload
      Stéphanie Madec, Virginie Cerec, Emmanuelle Plée-Gautier, Joseph Antoun, Denise Glaise, Jean-Pierre Salaun, Christiane Guguen-Guillouzo and Anne Corlu
      Drug Metabolism and Disposition October 2011, 39 (10) 1987-1996; DOI: https://doi.org/10.1124/dmd.110.036848

  4. Aoki, Katsuyuki

    1. Pharmacokinetics of Daikenchuto, a Traditional Japanese Medicine (Kampo) after Single Oral Administration to Healthy Japanese Volunteers
      Masaya Munekage, Hiroyuki Kitagawa, Kengo Ichikawa, Junko Watanabe, Katsuyuki Aoki, Toru Kono and Kazuhiro Hanazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1784-1788; DOI: https://doi.org/10.1124/dmd.111.040097

  5. Asanuma, Kimie

    1. Pharmacokinetic and Pharmacodynamic Modeling of the Effect of an Sodium-Glucose Cotransporter Inhibitor, Phlorizin, on Renal Glucose Transport in Rats
      Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Kimie Asanuma, Yoshinori Aso, Sachiya Ikeda and Masaki Ishigai
      Drug Metabolism and Disposition October 2011, 39 (10) 1801-1807; DOI: https://doi.org/10.1124/dmd.111.040048

  6. Aso, Yoshinori

    1. Pharmacokinetic and Pharmacodynamic Modeling of the Effect of an Sodium-Glucose Cotransporter Inhibitor, Phlorizin, on Renal Glucose Transport in Rats
      Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Kimie Asanuma, Yoshinori Aso, Sachiya Ikeda and Masaki Ishigai
      Drug Metabolism and Disposition October 2011, 39 (10) 1801-1807; DOI: https://doi.org/10.1124/dmd.111.040048

  7. Awwad, Michel

    1. How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
      Eugenia Kraynov, Steven W. Martin, Susan Hurst, Odette A. Fahmi, Martin Dowty, Carol Cronenberger, Cho-Ming Loi, Bing Kuang, Owen Fields, Scott Fountain, Michel Awwad and Diane Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1779-1783; DOI: https://doi.org/10.1124/dmd.111.040808

B

  1. Backman, Janne T.

    1. Dose-Dependent Interaction between Gemfibrozil and Repaglinide in Humans: Strong Inhibition of CYP2C8 with Subtherapeutic Gemfibrozil Doses
      Johanna Honkalammi, Mikko Niemi, Pertti J. Neuvonen and Janne T. Backman
      Drug Metabolism and Disposition October 2011, 39 (10) 1977-1986; DOI: https://doi.org/10.1124/dmd.111.040931

  2. Baumgardner, Matthew

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  3. Bennett, Mark K.

    1. Pharmacokinetics, Pharmacodynamics, Metabolism, Distribution, and Excretion of Carfilzomib in Rats
      Jinfu Yang, Zhengping Wang, Ying Fang, Jing Jiang, Frances Zhao, Hansen Wong, Mark K. Bennett, Christopher J. Molineaux and Christopher J. Kirk
      Drug Metabolism and Disposition October 2011, 39 (10) 1873-1882; DOI: https://doi.org/10.1124/dmd.111.039164

  4. Bergström, Moa Andresen

    1. Bioactivation Pathways of the Cannabinoid Receptor 1 Antagonist Rimonabant
      Moa Andresen Bergström, Emre M. Isin, Neal Castagnoli and Claire E. Milne
      Drug Metabolism and Disposition October 2011, 39 (10) 1823-1832; DOI: https://doi.org/10.1124/dmd.111.039412

  5. Billheimer, D. Dean

    1. Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease
      April D. Lake, Petr Novak, Craig D. Fisher, Jonathan P. Jackson, Rhiannon N. Hardwick, D. Dean Billheimer, Walter T. Klimecki and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2011, 39 (10) 1954-1960; DOI: https://doi.org/10.1124/dmd.111.040592

  6. Boggs, Jason

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  7. Bratton, Stacie M.

    1. Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
      Krishna C. Chimalakonda, Stacie M. Bratton, Vi-Huyen Le, Kan Hui Yiew, Anna Dineva, Cindy L. Moran, Laura P. James, Jeffery H. Moran and Anna Radominska-Pandya
      Drug Metabolism and Disposition October 2011, 39 (10) 1967-1976; DOI: https://doi.org/10.1124/dmd.111.040709

  8. Bui, Khanh H.

    1. In Vitro and In Vivo Metabolism of a Selective δ-Opioid Receptor
      Jian Guo, Chungang Gu, Diansong Zhou, Charles S. Elmore, Khanh H. Bui and Scott W. Grimm
      Drug Metabolism and Disposition October 2011, 39 (10) 1883-1894; DOI: https://doi.org/10.1124/dmd.111.040980

  9. Burks, Scott R.

    1. Clearance and Biodistribution of Liposomally Encapsulated Nitroxides: A Model for Targeted Delivery of Electron Paramagnetic Resonance Imaging Probes to Tumors
      Scott R. Burks, Eric A. Legenzov, Gerald M. Rosen and Joseph P. Y. Kao
      Drug Metabolism and Disposition October 2011, 39 (10) 1961-1966; DOI: https://doi.org/10.1124/dmd.111.039636

C

  1. Castagnoli, Neal

    1. Bioactivation Pathways of the Cannabinoid Receptor 1 Antagonist Rimonabant
      Moa Andresen Bergström, Emre M. Isin, Neal Castagnoli and Claire E. Milne
      Drug Metabolism and Disposition October 2011, 39 (10) 1823-1832; DOI: https://doi.org/10.1124/dmd.111.039412

  2. Cerec, Virginie

    1. CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload
      Stéphanie Madec, Virginie Cerec, Emmanuelle Plée-Gautier, Joseph Antoun, Denise Glaise, Jean-Pierre Salaun, Christiane Guguen-Guillouzo and Anne Corlu
      Drug Metabolism and Disposition October 2011, 39 (10) 1987-1996; DOI: https://doi.org/10.1124/dmd.110.036848

  3. Chen, Jianjun

    1. Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-aryl-thiazole and 2-Aryl-4-benzoyl-imidazole for Improving Oral Bioavailability
      Chien-Ming Li, Jianjun Chen, Yan Lu, Ramesh Narayanan, Deanna N. Parke, Wei Li, Sunjoo Ahn, Duane D. Miller and James T. Dalton
      Drug Metabolism and Disposition October 2011, 39 (10) 1833-1839; DOI: https://doi.org/10.1124/dmd.110.036616

  4. Chen, Leon

    1. Distribution of KAI-9803, a Novel δ-Protein Kinase C Inhibitor, after Intravenous Administration to Rats
      Yoshihiro Miyaji, Sarah Walter, Leon Chen, Atsushi Kurihara, Tomoko Ishizuka, Motoko Saito, Kenji Kawai and Osamu Okazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1946-1953; DOI: https://doi.org/10.1124/dmd.111.040725

  5. Cherrington, Nathan J.

    1. Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease
      April D. Lake, Petr Novak, Craig D. Fisher, Jonathan P. Jackson, Rhiannon N. Hardwick, D. Dean Billheimer, Walter T. Klimecki and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2011, 39 (10) 1954-1960; DOI: https://doi.org/10.1124/dmd.111.040592

  6. Chimalakonda, Krishna C.

    1. Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
      Krishna C. Chimalakonda, Stacie M. Bratton, Vi-Huyen Le, Kan Hui Yiew, Anna Dineva, Cindy L. Moran, Laura P. James, Jeffery H. Moran and Anna Radominska-Pandya
      Drug Metabolism and Disposition October 2011, 39 (10) 1967-1976; DOI: https://doi.org/10.1124/dmd.111.040709

  7. Coelho, Catarina

    1. Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression
      Martin Mahro, Catarina Coelho, José Trincão, David Rodrigues, Mineko Terao, Enrico Garattini, Miguel Saggu, Friedhelm Lendzian, Peter Hildebrandt, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition October 2011, 39 (10) 1939-1945; DOI: https://doi.org/10.1124/dmd.111.040873

  8. Coraggio, Melis

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  9. Corlu, Anne

    1. CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload
      Stéphanie Madec, Virginie Cerec, Emmanuelle Plée-Gautier, Joseph Antoun, Denise Glaise, Jean-Pierre Salaun, Christiane Guguen-Guillouzo and Anne Corlu
      Drug Metabolism and Disposition October 2011, 39 (10) 1987-1996; DOI: https://doi.org/10.1124/dmd.110.036848

  10. Cronenberger, Carol

    1. How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
      Eugenia Kraynov, Steven W. Martin, Susan Hurst, Odette A. Fahmi, Martin Dowty, Carol Cronenberger, Cho-Ming Loi, Bing Kuang, Owen Fields, Scott Fountain, Michel Awwad and Diane Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1779-1783; DOI: https://doi.org/10.1124/dmd.111.040808

  11. Currie, Kevin S.

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

D

  1. Dalton, James T.

    1. Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-aryl-thiazole and 2-Aryl-4-benzoyl-imidazole for Improving Oral Bioavailability
      Chien-Ming Li, Jianjun Chen, Yan Lu, Ramesh Narayanan, Deanna N. Parke, Wei Li, Sunjoo Ahn, Duane D. Miller and James T. Dalton
      Drug Metabolism and Disposition October 2011, 39 (10) 1833-1839; DOI: https://doi.org/10.1124/dmd.110.036616

  2. Davis, John

    1. Measurement of Binding of Basic Drugs to Acidic Phospholipids Using Surface Plasmon Resonance and Incorporation of the Data into Mechanistic Tissue Composition Equations to Predict Steady-State Volume of Distribution
      Helen Small, Iain Gardner, Hannah M. Jones, John Davis and Malcolm Rowland
      Drug Metabolism and Disposition October 2011, 39 (10) 1789-1793; DOI: https://doi.org/10.1124/dmd.111.040253

  3. Davis, John C.

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  4. Day, Jeffrey S.

    1. Efflux Transport Is an Important Determinant of Ethinylestradiol Glucuronide and Ethinylestradiol Sulfate Pharmacokinetics
      Maciej J. Zamek-Gliszczynski, Jeffrey S. Day, Kathleen M. Hillgren and Diane L. Phillips
      Drug Metabolism and Disposition October 2011, 39 (10) 1794-1800; DOI: https://doi.org/10.1124/dmd.111.040162

  5. Deese, Alan

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  6. Dineva, Anna

    1. Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
      Krishna C. Chimalakonda, Stacie M. Bratton, Vi-Huyen Le, Kan Hui Yiew, Anna Dineva, Cindy L. Moran, Laura P. James, Jeffery H. Moran and Anna Radominska-Pandya
      Drug Metabolism and Disposition October 2011, 39 (10) 1967-1976; DOI: https://doi.org/10.1124/dmd.111.040709

  7. Dowty, Martin

    1. How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
      Eugenia Kraynov, Steven W. Martin, Susan Hurst, Odette A. Fahmi, Martin Dowty, Carol Cronenberger, Cho-Ming Loi, Bing Kuang, Owen Fields, Scott Fountain, Michel Awwad and Diane Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1779-1783; DOI: https://doi.org/10.1124/dmd.111.040808

E

  1. Elmore, Charles S.

    1. In Vitro and In Vivo Metabolism of a Selective δ-Opioid Receptor
      Jian Guo, Chungang Gu, Diansong Zhou, Charles S. Elmore, Khanh H. Bui and Scott W. Grimm
      Drug Metabolism and Disposition October 2011, 39 (10) 1883-1894; DOI: https://doi.org/10.1124/dmd.111.040980

F

  1. Fahmi, Odette A.

    1. How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
      Eugenia Kraynov, Steven W. Martin, Susan Hurst, Odette A. Fahmi, Martin Dowty, Carol Cronenberger, Cho-Ming Loi, Bing Kuang, Owen Fields, Scott Fountain, Michel Awwad and Diane Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1779-1783; DOI: https://doi.org/10.1124/dmd.111.040808

  2. Fang, Ying

    1. Pharmacokinetics, Pharmacodynamics, Metabolism, Distribution, and Excretion of Carfilzomib in Rats
      Jinfu Yang, Zhengping Wang, Ying Fang, Jing Jiang, Frances Zhao, Hansen Wong, Mark K. Bennett, Christopher J. Molineaux and Christopher J. Kirk
      Drug Metabolism and Disposition October 2011, 39 (10) 1873-1882; DOI: https://doi.org/10.1124/dmd.111.039164

  3. Fields, Owen

    1. How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
      Eugenia Kraynov, Steven W. Martin, Susan Hurst, Odette A. Fahmi, Martin Dowty, Carol Cronenberger, Cho-Ming Loi, Bing Kuang, Owen Fields, Scott Fountain, Michel Awwad and Diane Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1779-1783; DOI: https://doi.org/10.1124/dmd.111.040808

  4. Fisher, Craig D.

    1. Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease
      April D. Lake, Petr Novak, Craig D. Fisher, Jonathan P. Jackson, Rhiannon N. Hardwick, D. Dean Billheimer, Walter T. Klimecki and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2011, 39 (10) 1954-1960; DOI: https://doi.org/10.1124/dmd.111.040592

  5. Fountain, Scott

    1. How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
      Eugenia Kraynov, Steven W. Martin, Susan Hurst, Odette A. Fahmi, Martin Dowty, Carol Cronenberger, Cho-Ming Loi, Bing Kuang, Owen Fields, Scott Fountain, Michel Awwad and Diane Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1779-1783; DOI: https://doi.org/10.1124/dmd.111.040808

G

  1. Galetin, Aleksandra

    1. Predictive Utility of In Vitro Rifampin Induction Data Generated in Fresh and Cryopreserved Human Hepatocytes, Fa2N-4, and HepaRG Cells
      Ian E. Templeton, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition October 2011, 39 (10) 1921-1929; DOI: https://doi.org/10.1124/dmd.111.040824
    2. Kinetic Characterization of Rat Hepatic Uptake of 16 Actively Transported Drugs
      Yoshiyuki Yabe, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition October 2011, 39 (10) 1808-1814; DOI: https://doi.org/10.1124/dmd.111.040477

  2. Gao, Song

    1. Enhancement of Oral Bioavailability of 20(S)-Ginsenoside Rh2 through Improved Understanding of Its Absorption and Efflux Mechanisms
      Zhen Yang, Song Gao, Jingrong Wang, Taijun Yin, Yang Teng, Baojian Wu, Ming You, Zhihong Jiang and Ming Hu
      Drug Metabolism and Disposition October 2011, 39 (10) 1866-1872; DOI: https://doi.org/10.1124/dmd.111.040006

  3. Garattini, Enrico

    1. Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression
      Martin Mahro, Catarina Coelho, José Trincão, David Rodrigues, Mineko Terao, Enrico Garattini, Miguel Saggu, Friedhelm Lendzian, Peter Hildebrandt, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition October 2011, 39 (10) 1939-1945; DOI: https://doi.org/10.1124/dmd.111.040873

  4. Gardiner, Philip

    1. The Impact of Hepatic Uptake on the Pharmacokinetics of Organic Anions
      Philip Gardiner and Stuart W. Paine
      Drug Metabolism and Disposition October 2011, 39 (10) 1930-1938; DOI: https://doi.org/10.1124/dmd.111.039842

  5. Gardner, Iain

    1. Measurement of Binding of Basic Drugs to Acidic Phospholipids Using Surface Plasmon Resonance and Incorporation of the Data into Mechanistic Tissue Composition Equations to Predict Steady-State Volume of Distribution
      Helen Small, Iain Gardner, Hannah M. Jones, John Davis and Malcolm Rowland
      Drug Metabolism and Disposition October 2011, 39 (10) 1789-1793; DOI: https://doi.org/10.1124/dmd.111.040253

  6. Glaise, Denise

    1. CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload
      Stéphanie Madec, Virginie Cerec, Emmanuelle Plée-Gautier, Joseph Antoun, Denise Glaise, Jean-Pierre Salaun, Christiane Guguen-Guillouzo and Anne Corlu
      Drug Metabolism and Disposition October 2011, 39 (10) 1987-1996; DOI: https://doi.org/10.1124/dmd.110.036848

  7. Gong, Ping

    1. Thioacetamide Intoxication Triggers Transcriptional Up-Regulation but Enzyme Inactivation of UDP-Glucuronosyltransferases
      Haiping Hao, Lifang Zhang, Shan Jiang, Shiqing Sun, Ping Gong, Yuan Xie, Xueyan Zhou and Guangji Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1815-1822; DOI: https://doi.org/10.1124/dmd.111.039172

  8. Gopaul, Sashi

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  9. Grimm, Scott W.

    1. In Vitro and In Vivo Metabolism of a Selective δ-Opioid Receptor
      Jian Guo, Chungang Gu, Diansong Zhou, Charles S. Elmore, Khanh H. Bui and Scott W. Grimm
      Drug Metabolism and Disposition October 2011, 39 (10) 1883-1894; DOI: https://doi.org/10.1124/dmd.111.040980

  10. Gu, Chungang

    1. In Vitro and In Vivo Metabolism of a Selective δ-Opioid Receptor
      Jian Guo, Chungang Gu, Diansong Zhou, Charles S. Elmore, Khanh H. Bui and Scott W. Grimm
      Drug Metabolism and Disposition October 2011, 39 (10) 1883-1894; DOI: https://doi.org/10.1124/dmd.111.040980

  11. Guguen-Guillouzo, Christiane

    1. CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload
      Stéphanie Madec, Virginie Cerec, Emmanuelle Plée-Gautier, Joseph Antoun, Denise Glaise, Jean-Pierre Salaun, Christiane Guguen-Guillouzo and Anne Corlu
      Drug Metabolism and Disposition October 2011, 39 (10) 1987-1996; DOI: https://doi.org/10.1124/dmd.110.036848

  12. Guo, Jian

    1. In Vitro and In Vivo Metabolism of a Selective δ-Opioid Receptor
      Jian Guo, Chungang Gu, Diansong Zhou, Charles S. Elmore, Khanh H. Bui and Scott W. Grimm
      Drug Metabolism and Disposition October 2011, 39 (10) 1883-1894; DOI: https://doi.org/10.1124/dmd.111.040980

H

  1. Halladay, Jason S.

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  2. Hanazaki, Kazuhiro

    1. Pharmacokinetics of Daikenchuto, a Traditional Japanese Medicine (Kampo) after Single Oral Administration to Healthy Japanese Volunteers
      Masaya Munekage, Hiroyuki Kitagawa, Kengo Ichikawa, Junko Watanabe, Katsuyuki Aoki, Toru Kono and Kazuhiro Hanazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1784-1788; DOI: https://doi.org/10.1124/dmd.111.040097

  3. Hao, Haiping

    1. Thioacetamide Intoxication Triggers Transcriptional Up-Regulation but Enzyme Inactivation of UDP-Glucuronosyltransferases
      Haiping Hao, Lifang Zhang, Shan Jiang, Shiqing Sun, Ping Gong, Yuan Xie, Xueyan Zhou and Guangji Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1815-1822; DOI: https://doi.org/10.1124/dmd.111.039172

  4. Hardwick, Rhiannon N.

    1. Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease
      April D. Lake, Petr Novak, Craig D. Fisher, Jonathan P. Jackson, Rhiannon N. Hardwick, D. Dean Billheimer, Walter T. Klimecki and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2011, 39 (10) 1954-1960; DOI: https://doi.org/10.1124/dmd.111.040592

  5. Hildebrandt, Peter

    1. Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression
      Martin Mahro, Catarina Coelho, José Trincão, David Rodrigues, Mineko Terao, Enrico Garattini, Miguel Saggu, Friedhelm Lendzian, Peter Hildebrandt, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition October 2011, 39 (10) 1939-1945; DOI: https://doi.org/10.1124/dmd.111.040873

  6. Hillgren, Kathleen M.

    1. Efflux Transport Is an Important Determinant of Ethinylestradiol Glucuronide and Ethinylestradiol Sulfate Pharmacokinetics
      Maciej J. Zamek-Gliszczynski, Jeffrey S. Day, Kathleen M. Hillgren and Diane L. Phillips
      Drug Metabolism and Disposition October 2011, 39 (10) 1794-1800; DOI: https://doi.org/10.1124/dmd.111.040162

  7. Hirasawa, Noriyasu

    1. Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether
      Masashi Honda, Yuka Muroi, Yuichiro Tamaki, Daisuke Saigusa, Naoto Suzuki, Yoshihisa Tomioka, Yoichi Matsubara, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka
      Drug Metabolism and Disposition October 2011, 39 (10) 1860-1865; DOI: https://doi.org/10.1124/dmd.111.040352

  8. Hiratsuka, Masahiro

    1. Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether
      Masashi Honda, Yuka Muroi, Yuichiro Tamaki, Daisuke Saigusa, Naoto Suzuki, Yoshihisa Tomioka, Yoichi Matsubara, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka
      Drug Metabolism and Disposition October 2011, 39 (10) 1860-1865; DOI: https://doi.org/10.1124/dmd.111.040352

  9. Honda, Masashi

    1. Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether
      Masashi Honda, Yuka Muroi, Yuichiro Tamaki, Daisuke Saigusa, Naoto Suzuki, Yoshihisa Tomioka, Yoichi Matsubara, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka
      Drug Metabolism and Disposition October 2011, 39 (10) 1860-1865; DOI: https://doi.org/10.1124/dmd.111.040352

  10. Hong, Lan

    1. Brain Regional Pharmacokinetics of p-Aminosalicylic Acid and Its N-Acetylated Metabolite: Effectiveness in Chelating Brain Manganese
      Lan Hong, Wendy Jiang, Hao Pan, Yueming Jiang, Su Zeng and Wei Zheng
      Drug Metabolism and Disposition October 2011, 39 (10) 1904-1909; DOI: https://doi.org/10.1124/dmd.111.040915

  11. Honkalammi, Johanna

    1. Dose-Dependent Interaction between Gemfibrozil and Repaglinide in Humans: Strong Inhibition of CYP2C8 with Subtherapeutic Gemfibrozil Doses
      Johanna Honkalammi, Mikko Niemi, Pertti J. Neuvonen and Janne T. Backman
      Drug Metabolism and Disposition October 2011, 39 (10) 1977-1986; DOI: https://doi.org/10.1124/dmd.111.040931

  12. Hop, Cornelis E. C. A.

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  13. Houston, J. Brian

    1. Predictive Utility of In Vitro Rifampin Induction Data Generated in Fresh and Cryopreserved Human Hepatocytes, Fa2N-4, and HepaRG Cells
      Ian E. Templeton, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition October 2011, 39 (10) 1921-1929; DOI: https://doi.org/10.1124/dmd.111.040824
    2. Kinetic Characterization of Rat Hepatic Uptake of 16 Actively Transported Drugs
      Yoshiyuki Yabe, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition October 2011, 39 (10) 1808-1814; DOI: https://doi.org/10.1124/dmd.111.040477

  14. Hu, Ming

    1. Enhancement of Oral Bioavailability of 20(S)-Ginsenoside Rh2 through Improved Understanding of Its Absorption and Efflux Mechanisms
      Zhen Yang, Song Gao, Jingrong Wang, Taijun Yin, Yang Teng, Baojian Wu, Ming You, Zhihong Jiang and Ming Hu
      Drug Metabolism and Disposition October 2011, 39 (10) 1866-1872; DOI: https://doi.org/10.1124/dmd.111.040006

  15. Hunt, C. Anthony

    1. Enabling Clearance Predictions to Emerge from In Silico Actions of Quasi-Autonomous Hepatocyte Components
      Shahab Sheikh-Bahaei and C. Anthony Hunt
      Drug Metabolism and Disposition October 2011, 39 (10) 1910-1920; DOI: https://doi.org/10.1124/dmd.111.038703

  16. Hurst, Susan

    1. How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
      Eugenia Kraynov, Steven W. Martin, Susan Hurst, Odette A. Fahmi, Martin Dowty, Carol Cronenberger, Cho-Ming Loi, Bing Kuang, Owen Fields, Scott Fountain, Michel Awwad and Diane Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1779-1783; DOI: https://doi.org/10.1124/dmd.111.040808

I

  1. Ichikawa, Kengo

    1. Pharmacokinetics of Daikenchuto, a Traditional Japanese Medicine (Kampo) after Single Oral Administration to Healthy Japanese Volunteers
      Masaya Munekage, Hiroyuki Kitagawa, Kengo Ichikawa, Junko Watanabe, Katsuyuki Aoki, Toru Kono and Kazuhiro Hanazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1784-1788; DOI: https://doi.org/10.1124/dmd.111.040097

  2. Ikeda, Sachiya

    1. Pharmacokinetic and Pharmacodynamic Modeling of the Effect of an Sodium-Glucose Cotransporter Inhibitor, Phlorizin, on Renal Glucose Transport in Rats
      Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Kimie Asanuma, Yoshinori Aso, Sachiya Ikeda and Masaki Ishigai
      Drug Metabolism and Disposition October 2011, 39 (10) 1801-1807; DOI: https://doi.org/10.1124/dmd.111.040048

  3. Ishigai, Masaki

    1. Pharmacokinetic and Pharmacodynamic Modeling of the Effect of an Sodium-Glucose Cotransporter Inhibitor, Phlorizin, on Renal Glucose Transport in Rats
      Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Kimie Asanuma, Yoshinori Aso, Sachiya Ikeda and Masaki Ishigai
      Drug Metabolism and Disposition October 2011, 39 (10) 1801-1807; DOI: https://doi.org/10.1124/dmd.111.040048

  4. Ishizuka, Tomoko

    1. Distribution of KAI-9803, a Novel δ-Protein Kinase C Inhibitor, after Intravenous Administration to Rats
      Yoshihiro Miyaji, Sarah Walter, Leon Chen, Atsushi Kurihara, Tomoko Ishizuka, Motoko Saito, Kenji Kawai and Osamu Okazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1946-1953; DOI: https://doi.org/10.1124/dmd.111.040725

  5. Isin, Emre M.

    1. Bioactivation Pathways of the Cannabinoid Receptor 1 Antagonist Rimonabant
      Moa Andresen Bergström, Emre M. Isin, Neal Castagnoli and Claire E. Milne
      Drug Metabolism and Disposition October 2011, 39 (10) 1823-1832; DOI: https://doi.org/10.1124/dmd.111.039412

J

  1. Jackson, Jonathan P.

    1. Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease
      April D. Lake, Petr Novak, Craig D. Fisher, Jonathan P. Jackson, Rhiannon N. Hardwick, D. Dean Billheimer, Walter T. Klimecki and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2011, 39 (10) 1954-1960; DOI: https://doi.org/10.1124/dmd.111.040592

  2. James, Laura P.

    1. Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
      Krishna C. Chimalakonda, Stacie M. Bratton, Vi-Huyen Le, Kan Hui Yiew, Anna Dineva, Cindy L. Moran, Laura P. James, Jeffery H. Moran and Anna Radominska-Pandya
      Drug Metabolism and Disposition October 2011, 39 (10) 1967-1976; DOI: https://doi.org/10.1124/dmd.111.040709

  3. Jiang, Jing

    1. Pharmacokinetics, Pharmacodynamics, Metabolism, Distribution, and Excretion of Carfilzomib in Rats
      Jinfu Yang, Zhengping Wang, Ying Fang, Jing Jiang, Frances Zhao, Hansen Wong, Mark K. Bennett, Christopher J. Molineaux and Christopher J. Kirk
      Drug Metabolism and Disposition October 2011, 39 (10) 1873-1882; DOI: https://doi.org/10.1124/dmd.111.039164

  4. Jiang, Shan

    1. Thioacetamide Intoxication Triggers Transcriptional Up-Regulation but Enzyme Inactivation of UDP-Glucuronosyltransferases
      Haiping Hao, Lifang Zhang, Shan Jiang, Shiqing Sun, Ping Gong, Yuan Xie, Xueyan Zhou and Guangji Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1815-1822; DOI: https://doi.org/10.1124/dmd.111.039172

  5. Jiang, Wendy

    1. Brain Regional Pharmacokinetics of p-Aminosalicylic Acid and Its N-Acetylated Metabolite: Effectiveness in Chelating Brain Manganese
      Lan Hong, Wendy Jiang, Hao Pan, Yueming Jiang, Su Zeng and Wei Zheng
      Drug Metabolism and Disposition October 2011, 39 (10) 1904-1909; DOI: https://doi.org/10.1124/dmd.111.040915

  6. Jiang, Yueming

    1. Brain Regional Pharmacokinetics of p-Aminosalicylic Acid and Its N-Acetylated Metabolite: Effectiveness in Chelating Brain Manganese
      Lan Hong, Wendy Jiang, Hao Pan, Yueming Jiang, Su Zeng and Wei Zheng
      Drug Metabolism and Disposition October 2011, 39 (10) 1904-1909; DOI: https://doi.org/10.1124/dmd.111.040915

  7. Jiang, Zhihong

    1. Enhancement of Oral Bioavailability of 20(S)-Ginsenoside Rh2 through Improved Understanding of Its Absorption and Efflux Mechanisms
      Zhen Yang, Song Gao, Jingrong Wang, Taijun Yin, Yang Teng, Baojian Wu, Ming You, Zhihong Jiang and Ming Hu
      Drug Metabolism and Disposition October 2011, 39 (10) 1866-1872; DOI: https://doi.org/10.1124/dmd.111.040006

  8. Jones, Hannah M.

    1. Measurement of Binding of Basic Drugs to Acidic Phospholipids Using Surface Plasmon Resonance and Incorporation of the Data into Mechanistic Tissue Composition Equations to Predict Steady-State Volume of Distribution
      Helen Small, Iain Gardner, Hannah M. Jones, John Davis and Malcolm Rowland
      Drug Metabolism and Disposition October 2011, 39 (10) 1789-1793; DOI: https://doi.org/10.1124/dmd.111.040253

K

  1. Kao, Joseph P. Y.

    1. Clearance and Biodistribution of Liposomally Encapsulated Nitroxides: A Model for Targeted Delivery of Electron Paramagnetic Resonance Imaging Probes to Tumors
      Scott R. Burks, Eric A. Legenzov, Gerald M. Rosen and Joseph P. Y. Kao
      Drug Metabolism and Disposition October 2011, 39 (10) 1961-1966; DOI: https://doi.org/10.1124/dmd.111.039636

  2. Kato, Motohiro

    1. Pharmacokinetic and Pharmacodynamic Modeling of the Effect of an Sodium-Glucose Cotransporter Inhibitor, Phlorizin, on Renal Glucose Transport in Rats
      Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Kimie Asanuma, Yoshinori Aso, Sachiya Ikeda and Masaki Ishigai
      Drug Metabolism and Disposition October 2011, 39 (10) 1801-1807; DOI: https://doi.org/10.1124/dmd.111.040048

  3. Kawai, Kenji

    1. Distribution of KAI-9803, a Novel δ-Protein Kinase C Inhibitor, after Intravenous Administration to Rats
      Yoshihiro Miyaji, Sarah Walter, Leon Chen, Atsushi Kurihara, Tomoko Ishizuka, Motoko Saito, Kenji Kawai and Osamu Okazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1946-1953; DOI: https://doi.org/10.1124/dmd.111.040725

  4. Khojasteh, S. Cyrus

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  5. Kirk, Christopher J.

    1. Pharmacokinetics, Pharmacodynamics, Metabolism, Distribution, and Excretion of Carfilzomib in Rats
      Jinfu Yang, Zhengping Wang, Ying Fang, Jing Jiang, Frances Zhao, Hansen Wong, Mark K. Bennett, Christopher J. Molineaux and Christopher J. Kirk
      Drug Metabolism and Disposition October 2011, 39 (10) 1873-1882; DOI: https://doi.org/10.1124/dmd.111.039164

  6. Kitagawa, Hiroyuki

    1. Pharmacokinetics of Daikenchuto, a Traditional Japanese Medicine (Kampo) after Single Oral Administration to Healthy Japanese Volunteers
      Masaya Munekage, Hiroyuki Kitagawa, Kengo Ichikawa, Junko Watanabe, Katsuyuki Aoki, Toru Kono and Kazuhiro Hanazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1784-1788; DOI: https://doi.org/10.1124/dmd.111.040097

  7. Klimecki, Walter T.

    1. Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease
      April D. Lake, Petr Novak, Craig D. Fisher, Jonathan P. Jackson, Rhiannon N. Hardwick, D. Dean Billheimer, Walter T. Klimecki and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2011, 39 (10) 1954-1960; DOI: https://doi.org/10.1124/dmd.111.040592

  8. Koechling, Wolfgang

    1. Metabolite Profiles of Degarelix, a New Gonadotropin-Releasing Hormone Receptor Antagonist, in Rat, Dog, and Monkey
      Anders Sonesson, Wolfgang Koechling, Jacek Stalewski, László B. Tankó and Birgitte Buur Rasmussen
      Drug Metabolism and Disposition October 2011, 39 (10) 1895-1903; DOI: https://doi.org/10.1124/dmd.111.039883

  9. Kono, Toru

    1. Pharmacokinetics of Daikenchuto, a Traditional Japanese Medicine (Kampo) after Single Oral Administration to Healthy Japanese Volunteers
      Masaya Munekage, Hiroyuki Kitagawa, Kengo Ichikawa, Junko Watanabe, Katsuyuki Aoki, Toru Kono and Kazuhiro Hanazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1784-1788; DOI: https://doi.org/10.1124/dmd.111.040097

  10. Kraynov, Eugenia

    1. How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
      Eugenia Kraynov, Steven W. Martin, Susan Hurst, Odette A. Fahmi, Martin Dowty, Carol Cronenberger, Cho-Ming Loi, Bing Kuang, Owen Fields, Scott Fountain, Michel Awwad and Diane Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1779-1783; DOI: https://doi.org/10.1124/dmd.111.040808

  11. Kuang, Bing

    1. How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
      Eugenia Kraynov, Steven W. Martin, Susan Hurst, Odette A. Fahmi, Martin Dowty, Carol Cronenberger, Cho-Ming Loi, Bing Kuang, Owen Fields, Scott Fountain, Michel Awwad and Diane Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1779-1783; DOI: https://doi.org/10.1124/dmd.111.040808

  12. Kuebler, Peter

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  13. Kurihara, Atsushi

    1. Distribution of KAI-9803, a Novel δ-Protein Kinase C Inhibitor, after Intravenous Administration to Rats
      Yoshihiro Miyaji, Sarah Walter, Leon Chen, Atsushi Kurihara, Tomoko Ishizuka, Motoko Saito, Kenji Kawai and Osamu Okazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1946-1953; DOI: https://doi.org/10.1124/dmd.111.040725

L

  1. La, Hank

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  2. Lake, April D.

    1. Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease
      April D. Lake, Petr Novak, Craig D. Fisher, Jonathan P. Jackson, Rhiannon N. Hardwick, D. Dean Billheimer, Walter T. Klimecki and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2011, 39 (10) 1954-1960; DOI: https://doi.org/10.1124/dmd.111.040592

  3. Le, Hoa

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  4. Le, Vi-Huyen

    1. Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
      Krishna C. Chimalakonda, Stacie M. Bratton, Vi-Huyen Le, Kan Hui Yiew, Anna Dineva, Cindy L. Moran, Laura P. James, Jeffery H. Moran and Anna Radominska-Pandya
      Drug Metabolism and Disposition October 2011, 39 (10) 1967-1976; DOI: https://doi.org/10.1124/dmd.111.040709

  5. Legenzov, Eric A.

    1. Clearance and Biodistribution of Liposomally Encapsulated Nitroxides: A Model for Targeted Delivery of Electron Paramagnetic Resonance Imaging Probes to Tumors
      Scott R. Burks, Eric A. Legenzov, Gerald M. Rosen and Joseph P. Y. Kao
      Drug Metabolism and Disposition October 2011, 39 (10) 1961-1966; DOI: https://doi.org/10.1124/dmd.111.039636

  6. Leimkühler, Silke

    1. Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression
      Martin Mahro, Catarina Coelho, José Trincão, David Rodrigues, Mineko Terao, Enrico Garattini, Miguel Saggu, Friedhelm Lendzian, Peter Hildebrandt, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition October 2011, 39 (10) 1939-1945; DOI: https://doi.org/10.1124/dmd.111.040873

  7. Lendzian, Friedhelm

    1. Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression
      Martin Mahro, Catarina Coelho, José Trincão, David Rodrigues, Mineko Terao, Enrico Garattini, Miguel Saggu, Friedhelm Lendzian, Peter Hildebrandt, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition October 2011, 39 (10) 1939-1945; DOI: https://doi.org/10.1124/dmd.111.040873

  8. Li, Chien-Ming

    1. Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-aryl-thiazole and 2-Aryl-4-benzoyl-imidazole for Improving Oral Bioavailability
      Chien-Ming Li, Jianjun Chen, Yan Lu, Ramesh Narayanan, Deanna N. Parke, Wei Li, Sunjoo Ahn, Duane D. Miller and James T. Dalton
      Drug Metabolism and Disposition October 2011, 39 (10) 1833-1839; DOI: https://doi.org/10.1124/dmd.110.036616

  9. Li, Wei

    1. Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-aryl-thiazole and 2-Aryl-4-benzoyl-imidazole for Improving Oral Bioavailability
      Chien-Ming Li, Jianjun Chen, Yan Lu, Ramesh Narayanan, Deanna N. Parke, Wei Li, Sunjoo Ahn, Duane D. Miller and James T. Dalton
      Drug Metabolism and Disposition October 2011, 39 (10) 1833-1839; DOI: https://doi.org/10.1124/dmd.110.036616

  10. Liao, X. Charlene

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  11. Liu, Lichuan

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  12. Loi, Cho-Ming

    1. How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
      Eugenia Kraynov, Steven W. Martin, Susan Hurst, Odette A. Fahmi, Martin Dowty, Carol Cronenberger, Cho-Ming Loi, Bing Kuang, Owen Fields, Scott Fountain, Michel Awwad and Diane Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1779-1783; DOI: https://doi.org/10.1124/dmd.111.040808

  13. Lu, Yan

    1. Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-aryl-thiazole and 2-Aryl-4-benzoyl-imidazole for Improving Oral Bioavailability
      Chien-Ming Li, Jianjun Chen, Yan Lu, Ramesh Narayanan, Deanna N. Parke, Wei Li, Sunjoo Ahn, Duane D. Miller and James T. Dalton
      Drug Metabolism and Disposition October 2011, 39 (10) 1833-1839; DOI: https://doi.org/10.1124/dmd.110.036616

  14. Lubach, Joseph W.

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

M

  1. Madec, Stéphanie

    1. CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload
      Stéphanie Madec, Virginie Cerec, Emmanuelle Plée-Gautier, Joseph Antoun, Denise Glaise, Jean-Pierre Salaun, Christiane Guguen-Guillouzo and Anne Corlu
      Drug Metabolism and Disposition October 2011, 39 (10) 1987-1996; DOI: https://doi.org/10.1124/dmd.110.036848

  2. Mahro, Martin

    1. Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression
      Martin Mahro, Catarina Coelho, José Trincão, David Rodrigues, Mineko Terao, Enrico Garattini, Miguel Saggu, Friedhelm Lendzian, Peter Hildebrandt, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition October 2011, 39 (10) 1939-1945; DOI: https://doi.org/10.1124/dmd.111.040873

  3. Martin, Steven W.

    1. How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
      Eugenia Kraynov, Steven W. Martin, Susan Hurst, Odette A. Fahmi, Martin Dowty, Carol Cronenberger, Cho-Ming Loi, Bing Kuang, Owen Fields, Scott Fountain, Michel Awwad and Diane Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1779-1783; DOI: https://doi.org/10.1124/dmd.111.040808

  4. Matsubara, Yoichi

    1. Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether
      Masashi Honda, Yuka Muroi, Yuichiro Tamaki, Daisuke Saigusa, Naoto Suzuki, Yoshihisa Tomioka, Yoichi Matsubara, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka
      Drug Metabolism and Disposition October 2011, 39 (10) 1860-1865; DOI: https://doi.org/10.1124/dmd.111.040352

  5. Miller, Duane D.

    1. Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-aryl-thiazole and 2-Aryl-4-benzoyl-imidazole for Improving Oral Bioavailability
      Chien-Ming Li, Jianjun Chen, Yan Lu, Ramesh Narayanan, Deanna N. Parke, Wei Li, Sunjoo Ahn, Duane D. Miller and James T. Dalton
      Drug Metabolism and Disposition October 2011, 39 (10) 1833-1839; DOI: https://doi.org/10.1124/dmd.110.036616

  6. Milne, Claire E.

    1. Bioactivation Pathways of the Cannabinoid Receptor 1 Antagonist Rimonabant
      Moa Andresen Bergström, Emre M. Isin, Neal Castagnoli and Claire E. Milne
      Drug Metabolism and Disposition October 2011, 39 (10) 1823-1832; DOI: https://doi.org/10.1124/dmd.111.039412

  7. Miyaji, Yoshihiro

    1. Distribution of KAI-9803, a Novel δ-Protein Kinase C Inhibitor, after Intravenous Administration to Rats
      Yoshihiro Miyaji, Sarah Walter, Leon Chen, Atsushi Kurihara, Tomoko Ishizuka, Motoko Saito, Kenji Kawai and Osamu Okazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1946-1953; DOI: https://doi.org/10.1124/dmd.111.040725

  8. Molineaux, Christopher J.

    1. Pharmacokinetics, Pharmacodynamics, Metabolism, Distribution, and Excretion of Carfilzomib in Rats
      Jinfu Yang, Zhengping Wang, Ying Fang, Jing Jiang, Frances Zhao, Hansen Wong, Mark K. Bennett, Christopher J. Molineaux and Christopher J. Kirk
      Drug Metabolism and Disposition October 2011, 39 (10) 1873-1882; DOI: https://doi.org/10.1124/dmd.111.039164

  9. Moran, Cindy L.

    1. Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
      Krishna C. Chimalakonda, Stacie M. Bratton, Vi-Huyen Le, Kan Hui Yiew, Anna Dineva, Cindy L. Moran, Laura P. James, Jeffery H. Moran and Anna Radominska-Pandya
      Drug Metabolism and Disposition October 2011, 39 (10) 1967-1976; DOI: https://doi.org/10.1124/dmd.111.040709

  10. Moran, Jeffery H.

    1. Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
      Krishna C. Chimalakonda, Stacie M. Bratton, Vi-Huyen Le, Kan Hui Yiew, Anna Dineva, Cindy L. Moran, Laura P. James, Jeffery H. Moran and Anna Radominska-Pandya
      Drug Metabolism and Disposition October 2011, 39 (10) 1967-1976; DOI: https://doi.org/10.1124/dmd.111.040709

  11. Munekage, Masaya

    1. Pharmacokinetics of Daikenchuto, a Traditional Japanese Medicine (Kampo) after Single Oral Administration to Healthy Japanese Volunteers
      Masaya Munekage, Hiroyuki Kitagawa, Kengo Ichikawa, Junko Watanabe, Katsuyuki Aoki, Toru Kono and Kazuhiro Hanazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1784-1788; DOI: https://doi.org/10.1124/dmd.111.040097

  12. Muroi, Yuka

    1. Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether
      Masashi Honda, Yuka Muroi, Yuichiro Tamaki, Daisuke Saigusa, Naoto Suzuki, Yoshihisa Tomioka, Yoichi Matsubara, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka
      Drug Metabolism and Disposition October 2011, 39 (10) 1860-1865; DOI: https://doi.org/10.1124/dmd.111.040352

N

  1. Narayanan, Ramesh

    1. Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-aryl-thiazole and 2-Aryl-4-benzoyl-imidazole for Improving Oral Bioavailability
      Chien-Ming Li, Jianjun Chen, Yan Lu, Ramesh Narayanan, Deanna N. Parke, Wei Li, Sunjoo Ahn, Duane D. Miller and James T. Dalton
      Drug Metabolism and Disposition October 2011, 39 (10) 1833-1839; DOI: https://doi.org/10.1124/dmd.110.036616

  2. Neuvonen, Pertti J.

    1. Dose-Dependent Interaction between Gemfibrozil and Repaglinide in Humans: Strong Inhibition of CYP2C8 with Subtherapeutic Gemfibrozil Doses
      Johanna Honkalammi, Mikko Niemi, Pertti J. Neuvonen and Janne T. Backman
      Drug Metabolism and Disposition October 2011, 39 (10) 1977-1986; DOI: https://doi.org/10.1124/dmd.111.040931

  3. Niemi, Mikko

    1. Dose-Dependent Interaction between Gemfibrozil and Repaglinide in Humans: Strong Inhibition of CYP2C8 with Subtherapeutic Gemfibrozil Doses
      Johanna Honkalammi, Mikko Niemi, Pertti J. Neuvonen and Janne T. Backman
      Drug Metabolism and Disposition October 2011, 39 (10) 1977-1986; DOI: https://doi.org/10.1124/dmd.111.040931

  4. Novak, Petr

    1. Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease
      April D. Lake, Petr Novak, Craig D. Fisher, Jonathan P. Jackson, Rhiannon N. Hardwick, D. Dean Billheimer, Walter T. Klimecki and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2011, 39 (10) 1954-1960; DOI: https://doi.org/10.1124/dmd.111.040592

O

  1. Oda, Akifumi

    1. Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether
      Masashi Honda, Yuka Muroi, Yuichiro Tamaki, Daisuke Saigusa, Naoto Suzuki, Yoshihisa Tomioka, Yoichi Matsubara, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka
      Drug Metabolism and Disposition October 2011, 39 (10) 1860-1865; DOI: https://doi.org/10.1124/dmd.111.040352

  2. Okazaki, Osamu

    1. Distribution of KAI-9803, a Novel δ-Protein Kinase C Inhibitor, after Intravenous Administration to Rats
      Yoshihiro Miyaji, Sarah Walter, Leon Chen, Atsushi Kurihara, Tomoko Ishizuka, Motoko Saito, Kenji Kawai and Osamu Okazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1946-1953; DOI: https://doi.org/10.1124/dmd.111.040725

P

  1. Paine, Stuart W.

    1. The Impact of Hepatic Uptake on the Pharmacokinetics of Organic Anions
      Philip Gardiner and Stuart W. Paine
      Drug Metabolism and Disposition October 2011, 39 (10) 1930-1938; DOI: https://doi.org/10.1124/dmd.111.039842

  2. Pan, Hao

    1. Brain Regional Pharmacokinetics of p-Aminosalicylic Acid and Its N-Acetylated Metabolite: Effectiveness in Chelating Brain Manganese
      Lan Hong, Wendy Jiang, Hao Pan, Yueming Jiang, Su Zeng and Wei Zheng
      Drug Metabolism and Disposition October 2011, 39 (10) 1904-1909; DOI: https://doi.org/10.1124/dmd.111.040915

  3. Parke, Deanna N.

    1. Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-aryl-thiazole and 2-Aryl-4-benzoyl-imidazole for Improving Oral Bioavailability
      Chien-Ming Li, Jianjun Chen, Yan Lu, Ramesh Narayanan, Deanna N. Parke, Wei Li, Sunjoo Ahn, Duane D. Miller and James T. Dalton
      Drug Metabolism and Disposition October 2011, 39 (10) 1833-1839; DOI: https://doi.org/10.1124/dmd.110.036616

  4. Phillips, Diane L.

    1. Efflux Transport Is an Important Determinant of Ethinylestradiol Glucuronide and Ethinylestradiol Sulfate Pharmacokinetics
      Maciej J. Zamek-Gliszczynski, Jeffrey S. Day, Kathleen M. Hillgren and Diane L. Phillips
      Drug Metabolism and Disposition October 2011, 39 (10) 1794-1800; DOI: https://doi.org/10.1124/dmd.111.040162

  5. Piquette-Miller, Micheline

    1. Mechanisms of Reduced Maternal and Fetal Lopinavir Exposure in a Rat Model of Gestational Diabetes
      Gregory J. Anger and Micheline Piquette-Miller
      Drug Metabolism and Disposition October 2011, 39 (10) 1850-1859; DOI: https://doi.org/10.1124/dmd.111.040626

  6. Plée-Gautier, Emmanuelle

    1. CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload
      Stéphanie Madec, Virginie Cerec, Emmanuelle Plée-Gautier, Joseph Antoun, Denise Glaise, Jean-Pierre Salaun, Christiane Guguen-Guillouzo and Anne Corlu
      Drug Metabolism and Disposition October 2011, 39 (10) 1987-1996; DOI: https://doi.org/10.1124/dmd.110.036848

R

  1. Radominska-Pandya, Anna

    1. Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
      Krishna C. Chimalakonda, Stacie M. Bratton, Vi-Huyen Le, Kan Hui Yiew, Anna Dineva, Cindy L. Moran, Laura P. James, Jeffery H. Moran and Anna Radominska-Pandya
      Drug Metabolism and Disposition October 2011, 39 (10) 1967-1976; DOI: https://doi.org/10.1124/dmd.111.040709

  2. Rasmussen, Birgitte Buur

    1. Metabolite Profiles of Degarelix, a New Gonadotropin-Releasing Hormone Receptor Antagonist, in Rat, Dog, and Monkey
      Anders Sonesson, Wolfgang Koechling, Jacek Stalewski, László B. Tankó and Birgitte Buur Rasmussen
      Drug Metabolism and Disposition October 2011, 39 (10) 1895-1903; DOI: https://doi.org/10.1124/dmd.111.039883

  3. Rodrigues, David

    1. Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression
      Martin Mahro, Catarina Coelho, José Trincão, David Rodrigues, Mineko Terao, Enrico Garattini, Miguel Saggu, Friedhelm Lendzian, Peter Hildebrandt, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition October 2011, 39 (10) 1939-1945; DOI: https://doi.org/10.1124/dmd.111.040873

  4. Romão, Maria João

    1. Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression
      Martin Mahro, Catarina Coelho, José Trincão, David Rodrigues, Mineko Terao, Enrico Garattini, Miguel Saggu, Friedhelm Lendzian, Peter Hildebrandt, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition October 2011, 39 (10) 1939-1945; DOI: https://doi.org/10.1124/dmd.111.040873

  5. Rosen, Gerald M.

    1. Clearance and Biodistribution of Liposomally Encapsulated Nitroxides: A Model for Targeted Delivery of Electron Paramagnetic Resonance Imaging Probes to Tumors
      Scott R. Burks, Eric A. Legenzov, Gerald M. Rosen and Joseph P. Y. Kao
      Drug Metabolism and Disposition October 2011, 39 (10) 1961-1966; DOI: https://doi.org/10.1124/dmd.111.039636

  6. Rowland, Malcolm

    1. Measurement of Binding of Basic Drugs to Acidic Phospholipids Using Surface Plasmon Resonance and Incorporation of the Data into Mechanistic Tissue Composition Equations to Predict Steady-State Volume of Distribution
      Helen Small, Iain Gardner, Hannah M. Jones, John Davis and Malcolm Rowland
      Drug Metabolism and Disposition October 2011, 39 (10) 1789-1793; DOI: https://doi.org/10.1124/dmd.111.040253

S

  1. Saggu, Miguel

    1. Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression
      Martin Mahro, Catarina Coelho, José Trincão, David Rodrigues, Mineko Terao, Enrico Garattini, Miguel Saggu, Friedhelm Lendzian, Peter Hildebrandt, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition October 2011, 39 (10) 1939-1945; DOI: https://doi.org/10.1124/dmd.111.040873

  2. Saigusa, Daisuke

    1. Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether
      Masashi Honda, Yuka Muroi, Yuichiro Tamaki, Daisuke Saigusa, Naoto Suzuki, Yoshihisa Tomioka, Yoichi Matsubara, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka
      Drug Metabolism and Disposition October 2011, 39 (10) 1860-1865; DOI: https://doi.org/10.1124/dmd.111.040352

  3. Saito, Motoko

    1. Distribution of KAI-9803, a Novel δ-Protein Kinase C Inhibitor, after Intravenous Administration to Rats
      Yoshihiro Miyaji, Sarah Walter, Leon Chen, Atsushi Kurihara, Tomoko Ishizuka, Motoko Saito, Kenji Kawai and Osamu Okazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1946-1953; DOI: https://doi.org/10.1124/dmd.111.040725

  4. Salaun, Jean-Pierre

    1. CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload
      Stéphanie Madec, Virginie Cerec, Emmanuelle Plée-Gautier, Joseph Antoun, Denise Glaise, Jean-Pierre Salaun, Christiane Guguen-Guillouzo and Anne Corlu
      Drug Metabolism and Disposition October 2011, 39 (10) 1987-1996; DOI: https://doi.org/10.1124/dmd.110.036848

  5. Sheikh-Bahaei, Shahab

    1. Enabling Clearance Predictions to Emerge from In Silico Actions of Quasi-Autonomous Hepatocyte Components
      Shahab Sheikh-Bahaei and C. Anthony Hunt
      Drug Metabolism and Disposition October 2011, 39 (10) 1910-1920; DOI: https://doi.org/10.1124/dmd.111.038703

  6. Shin, Young

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  7. Small, Helen

    1. Measurement of Binding of Basic Drugs to Acidic Phospholipids Using Surface Plasmon Resonance and Incorporation of the Data into Mechanistic Tissue Composition Equations to Predict Steady-State Volume of Distribution
      Helen Small, Iain Gardner, Hannah M. Jones, John Davis and Malcolm Rowland
      Drug Metabolism and Disposition October 2011, 39 (10) 1789-1793; DOI: https://doi.org/10.1124/dmd.111.040253

  8. Sonesson, Anders

    1. Metabolite Profiles of Degarelix, a New Gonadotropin-Releasing Hormone Receptor Antagonist, in Rat, Dog, and Monkey
      Anders Sonesson, Wolfgang Koechling, Jacek Stalewski, László B. Tankó and Birgitte Buur Rasmussen
      Drug Metabolism and Disposition October 2011, 39 (10) 1895-1903; DOI: https://doi.org/10.1124/dmd.111.039883

  9. Sowell, C. Gregory

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  10. Stalewski, Jacek

    1. Metabolite Profiles of Degarelix, a New Gonadotropin-Releasing Hormone Receptor Antagonist, in Rat, Dog, and Monkey
      Anders Sonesson, Wolfgang Koechling, Jacek Stalewski, László B. Tankó and Birgitte Buur Rasmussen
      Drug Metabolism and Disposition October 2011, 39 (10) 1895-1903; DOI: https://doi.org/10.1124/dmd.111.039883

  11. Sun, Shiqing

    1. Thioacetamide Intoxication Triggers Transcriptional Up-Regulation but Enzyme Inactivation of UDP-Glucuronosyltransferases
      Haiping Hao, Lifang Zhang, Shan Jiang, Shiqing Sun, Ping Gong, Yuan Xie, Xueyan Zhou and Guangji Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1815-1822; DOI: https://doi.org/10.1124/dmd.111.039172

  12. Suzuki, Masayuki

    1. Pharmacokinetic and Pharmacodynamic Modeling of the Effect of an Sodium-Glucose Cotransporter Inhibitor, Phlorizin, on Renal Glucose Transport in Rats
      Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Kimie Asanuma, Yoshinori Aso, Sachiya Ikeda and Masaki Ishigai
      Drug Metabolism and Disposition October 2011, 39 (10) 1801-1807; DOI: https://doi.org/10.1124/dmd.111.040048

  13. Suzuki, Naoto

    1. Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether
      Masashi Honda, Yuka Muroi, Yuichiro Tamaki, Daisuke Saigusa, Naoto Suzuki, Yoshihisa Tomioka, Yoichi Matsubara, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka
      Drug Metabolism and Disposition October 2011, 39 (10) 1860-1865; DOI: https://doi.org/10.1124/dmd.111.040352

T

  1. Tamaki, Yuichiro

    1. Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether
      Masashi Honda, Yuka Muroi, Yuichiro Tamaki, Daisuke Saigusa, Naoto Suzuki, Yoshihisa Tomioka, Yoichi Matsubara, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka
      Drug Metabolism and Disposition October 2011, 39 (10) 1860-1865; DOI: https://doi.org/10.1124/dmd.111.040352

  2. Tankó, László B.

    1. Metabolite Profiles of Degarelix, a New Gonadotropin-Releasing Hormone Receptor Antagonist, in Rat, Dog, and Monkey
      Anders Sonesson, Wolfgang Koechling, Jacek Stalewski, László B. Tankó and Birgitte Buur Rasmussen
      Drug Metabolism and Disposition October 2011, 39 (10) 1895-1903; DOI: https://doi.org/10.1124/dmd.111.039883

  3. Templeton, Ian E.

    1. Predictive Utility of In Vitro Rifampin Induction Data Generated in Fresh and Cryopreserved Human Hepatocytes, Fa2N-4, and HepaRG Cells
      Ian E. Templeton, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition October 2011, 39 (10) 1921-1929; DOI: https://doi.org/10.1124/dmd.111.040824

  4. Teng, Yang

    1. Enhancement of Oral Bioavailability of 20(S)-Ginsenoside Rh2 through Improved Understanding of Its Absorption and Efflux Mechanisms
      Zhen Yang, Song Gao, Jingrong Wang, Taijun Yin, Yang Teng, Baojian Wu, Ming You, Zhihong Jiang and Ming Hu
      Drug Metabolism and Disposition October 2011, 39 (10) 1866-1872; DOI: https://doi.org/10.1124/dmd.111.040006

  5. Terao, Mineko

    1. Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression
      Martin Mahro, Catarina Coelho, José Trincão, David Rodrigues, Mineko Terao, Enrico Garattini, Miguel Saggu, Friedhelm Lendzian, Peter Hildebrandt, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition October 2011, 39 (10) 1939-1945; DOI: https://doi.org/10.1124/dmd.111.040873

  6. Tomioka, Yoshihisa

    1. Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether
      Masashi Honda, Yuka Muroi, Yuichiro Tamaki, Daisuke Saigusa, Naoto Suzuki, Yoshihisa Tomioka, Yoichi Matsubara, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka
      Drug Metabolism and Disposition October 2011, 39 (10) 1860-1865; DOI: https://doi.org/10.1124/dmd.111.040352

  7. Trincão, José

    1. Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression
      Martin Mahro, Catarina Coelho, José Trincão, David Rodrigues, Mineko Terao, Enrico Garattini, Miguel Saggu, Friedhelm Lendzian, Peter Hildebrandt, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition October 2011, 39 (10) 1939-1945; DOI: https://doi.org/10.1124/dmd.111.040873

W

  1. Walter, Sarah

    1. Distribution of KAI-9803, a Novel δ-Protein Kinase C Inhibitor, after Intravenous Administration to Rats
      Yoshihiro Miyaji, Sarah Walter, Leon Chen, Atsushi Kurihara, Tomoko Ishizuka, Motoko Saito, Kenji Kawai and Osamu Okazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1946-1953; DOI: https://doi.org/10.1124/dmd.111.040725

  2. Wang, Diane

    1. How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
      Eugenia Kraynov, Steven W. Martin, Susan Hurst, Odette A. Fahmi, Martin Dowty, Carol Cronenberger, Cho-Ming Loi, Bing Kuang, Owen Fields, Scott Fountain, Michel Awwad and Diane Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1779-1783; DOI: https://doi.org/10.1124/dmd.111.040808

  3. Wang, Guangji

    1. Thioacetamide Intoxication Triggers Transcriptional Up-Regulation but Enzyme Inactivation of UDP-Glucuronosyltransferases
      Haiping Hao, Lifang Zhang, Shan Jiang, Shiqing Sun, Ping Gong, Yuan Xie, Xueyan Zhou and Guangji Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1815-1822; DOI: https://doi.org/10.1124/dmd.111.039172

  4. Wang, Jingrong

    1. Enhancement of Oral Bioavailability of 20(S)-Ginsenoside Rh2 through Improved Understanding of Its Absorption and Efflux Mechanisms
      Zhen Yang, Song Gao, Jingrong Wang, Taijun Yin, Yang Teng, Baojian Wu, Ming You, Zhihong Jiang and Ming Hu
      Drug Metabolism and Disposition October 2011, 39 (10) 1866-1872; DOI: https://doi.org/10.1124/dmd.111.040006

  5. Wang, Zhengping

    1. Pharmacokinetics, Pharmacodynamics, Metabolism, Distribution, and Excretion of Carfilzomib in Rats
      Jinfu Yang, Zhengping Wang, Ying Fang, Jing Jiang, Frances Zhao, Hansen Wong, Mark K. Bennett, Christopher J. Molineaux and Christopher J. Kirk
      Drug Metabolism and Disposition October 2011, 39 (10) 1873-1882; DOI: https://doi.org/10.1124/dmd.111.039164

  6. Watanabe, Junko

    1. Pharmacokinetics of Daikenchuto, a Traditional Japanese Medicine (Kampo) after Single Oral Administration to Healthy Japanese Volunteers
      Masaya Munekage, Hiroyuki Kitagawa, Kengo Ichikawa, Junko Watanabe, Katsuyuki Aoki, Toru Kono and Kazuhiro Hanazaki
      Drug Metabolism and Disposition October 2011, 39 (10) 1784-1788; DOI: https://doi.org/10.1124/dmd.111.040097

  7. Wong, Hansen

    1. Pharmacokinetics, Pharmacodynamics, Metabolism, Distribution, and Excretion of Carfilzomib in Rats
      Jinfu Yang, Zhengping Wang, Ying Fang, Jing Jiang, Frances Zhao, Hansen Wong, Mark K. Bennett, Christopher J. Molineaux and Christopher J. Kirk
      Drug Metabolism and Disposition October 2011, 39 (10) 1873-1882; DOI: https://doi.org/10.1124/dmd.111.039164

  8. Wong, Harvey

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  9. Wong, Susan

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

  10. Wu, Baojian

    1. Enhancement of Oral Bioavailability of 20(S)-Ginsenoside Rh2 through Improved Understanding of Its Absorption and Efflux Mechanisms
      Zhen Yang, Song Gao, Jingrong Wang, Taijun Yin, Yang Teng, Baojian Wu, Ming You, Zhihong Jiang and Ming Hu
      Drug Metabolism and Disposition October 2011, 39 (10) 1866-1872; DOI: https://doi.org/10.1124/dmd.111.040006

X

  1. Xie, Yuan

    1. Thioacetamide Intoxication Triggers Transcriptional Up-Regulation but Enzyme Inactivation of UDP-Glucuronosyltransferases
      Haiping Hao, Lifang Zhang, Shan Jiang, Shiqing Sun, Ping Gong, Yuan Xie, Xueyan Zhou and Guangji Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1815-1822; DOI: https://doi.org/10.1124/dmd.111.039172

Y

  1. Yabe, Yoshiyuki

    1. Kinetic Characterization of Rat Hepatic Uptake of 16 Actively Transported Drugs
      Yoshiyuki Yabe, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition October 2011, 39 (10) 1808-1814; DOI: https://doi.org/10.1124/dmd.111.040477

  2. Yamaguchi, Koji

    1. Pharmacokinetic and Pharmacodynamic Modeling of the Effect of an Sodium-Glucose Cotransporter Inhibitor, Phlorizin, on Renal Glucose Transport in Rats
      Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Kimie Asanuma, Yoshinori Aso, Sachiya Ikeda and Masaki Ishigai
      Drug Metabolism and Disposition October 2011, 39 (10) 1801-1807; DOI: https://doi.org/10.1124/dmd.111.040048

  3. Yang, Jinfu

    1. Pharmacokinetics, Pharmacodynamics, Metabolism, Distribution, and Excretion of Carfilzomib in Rats
      Jinfu Yang, Zhengping Wang, Ying Fang, Jing Jiang, Frances Zhao, Hansen Wong, Mark K. Bennett, Christopher J. Molineaux and Christopher J. Kirk
      Drug Metabolism and Disposition October 2011, 39 (10) 1873-1882; DOI: https://doi.org/10.1124/dmd.111.039164

  4. Yang, Zhen

    1. Enhancement of Oral Bioavailability of 20(S)-Ginsenoside Rh2 through Improved Understanding of Its Absorption and Efflux Mechanisms
      Zhen Yang, Song Gao, Jingrong Wang, Taijun Yin, Yang Teng, Baojian Wu, Ming You, Zhihong Jiang and Ming Hu
      Drug Metabolism and Disposition October 2011, 39 (10) 1866-1872; DOI: https://doi.org/10.1124/dmd.111.040006

  5. Yiew, Kan Hui

    1. Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
      Krishna C. Chimalakonda, Stacie M. Bratton, Vi-Huyen Le, Kan Hui Yiew, Anna Dineva, Cindy L. Moran, Laura P. James, Jeffery H. Moran and Anna Radominska-Pandya
      Drug Metabolism and Disposition October 2011, 39 (10) 1967-1976; DOI: https://doi.org/10.1124/dmd.111.040709

  6. Yin, Taijun

    1. Enhancement of Oral Bioavailability of 20(S)-Ginsenoside Rh2 through Improved Understanding of Its Absorption and Efflux Mechanisms
      Zhen Yang, Song Gao, Jingrong Wang, Taijun Yin, Yang Teng, Baojian Wu, Ming You, Zhihong Jiang and Ming Hu
      Drug Metabolism and Disposition October 2011, 39 (10) 1866-1872; DOI: https://doi.org/10.1124/dmd.111.040006

  7. You, Ming

    1. Enhancement of Oral Bioavailability of 20(S)-Ginsenoside Rh2 through Improved Understanding of Its Absorption and Efflux Mechanisms
      Zhen Yang, Song Gao, Jingrong Wang, Taijun Yin, Yang Teng, Baojian Wu, Ming You, Zhihong Jiang and Ming Hu
      Drug Metabolism and Disposition October 2011, 39 (10) 1866-1872; DOI: https://doi.org/10.1124/dmd.111.040006

  8. Young, Wendy B.

    1. Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
      Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. Davis, X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop and Harvey Wong
      Drug Metabolism and Disposition October 2011, 39 (10) 1840-1849; DOI: https://doi.org/10.1124/dmd.111.040840

Z

  1. Zamek-Gliszczynski, Maciej J.

    1. Efflux Transport Is an Important Determinant of Ethinylestradiol Glucuronide and Ethinylestradiol Sulfate Pharmacokinetics
      Maciej J. Zamek-Gliszczynski, Jeffrey S. Day, Kathleen M. Hillgren and Diane L. Phillips
      Drug Metabolism and Disposition October 2011, 39 (10) 1794-1800; DOI: https://doi.org/10.1124/dmd.111.040162

  2. Zeng, Su

    1. Brain Regional Pharmacokinetics of p-Aminosalicylic Acid and Its N-Acetylated Metabolite: Effectiveness in Chelating Brain Manganese
      Lan Hong, Wendy Jiang, Hao Pan, Yueming Jiang, Su Zeng and Wei Zheng
      Drug Metabolism and Disposition October 2011, 39 (10) 1904-1909; DOI: https://doi.org/10.1124/dmd.111.040915

  3. Zhang, Lifang

    1. Thioacetamide Intoxication Triggers Transcriptional Up-Regulation but Enzyme Inactivation of UDP-Glucuronosyltransferases
      Haiping Hao, Lifang Zhang, Shan Jiang, Shiqing Sun, Ping Gong, Yuan Xie, Xueyan Zhou and Guangji Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1815-1822; DOI: https://doi.org/10.1124/dmd.111.039172

  4. Zhao, Frances

    1. Pharmacokinetics, Pharmacodynamics, Metabolism, Distribution, and Excretion of Carfilzomib in Rats
      Jinfu Yang, Zhengping Wang, Ying Fang, Jing Jiang, Frances Zhao, Hansen Wong, Mark K. Bennett, Christopher J. Molineaux and Christopher J. Kirk
      Drug Metabolism and Disposition October 2011, 39 (10) 1873-1882; DOI: https://doi.org/10.1124/dmd.111.039164

  5. Zheng, Wei

    1. Brain Regional Pharmacokinetics of p-Aminosalicylic Acid and Its N-Acetylated Metabolite: Effectiveness in Chelating Brain Manganese
      Lan Hong, Wendy Jiang, Hao Pan, Yueming Jiang, Su Zeng and Wei Zheng
      Drug Metabolism and Disposition October 2011, 39 (10) 1904-1909; DOI: https://doi.org/10.1124/dmd.111.040915

  6. Zhou, Diansong

    1. In Vitro and In Vivo Metabolism of a Selective δ-Opioid Receptor
      Jian Guo, Chungang Gu, Diansong Zhou, Charles S. Elmore, Khanh H. Bui and Scott W. Grimm
      Drug Metabolism and Disposition October 2011, 39 (10) 1883-1894; DOI: https://doi.org/10.1124/dmd.111.040980

  7. Zhou, Xueyan

    1. Thioacetamide Intoxication Triggers Transcriptional Up-Regulation but Enzyme Inactivation of UDP-Glucuronosyltransferases
      Haiping Hao, Lifang Zhang, Shan Jiang, Shiqing Sun, Ping Gong, Yuan Xie, Xueyan Zhou and Guangji Wang
      Drug Metabolism and Disposition October 2011, 39 (10) 1815-1822; DOI: https://doi.org/10.1124/dmd.111.039172
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