Table of Contents

Articles

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  The Proton Pump Inhibitor, Omeprazole, but Not Lansoprazole or Pantoprazole, Is a Metabolism-Dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel

  Brian W. Ogilvie, Phyllis Yerino, Faraz Kazmi, David B. Buckley, Amin Rostami-Hodjegan, Brandy L. Paris, Paul Toren and Andrew Parkinson

  Drug Metabolism and Disposition November 2011, 39 (11) 2020-2033; DOI: https://doi.org/10.1124/dmd.111.041293
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  Absorption and Disposition of Scutellarin in Rats: A Pharmacokinetic Explanation for the High Exposure of Its Isomeric Metabolite

  Chunying Gao, Xiaoyan Chen and Dafang Zhong

  Drug Metabolism and Disposition November 2011, 39 (11) 2034-2044; DOI: https://doi.org/10.1124/dmd.111.040550
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  Q172H Replacement Overcomes Effects on the Metabolism of Cyclophosphamide and Efavirenz Caused by CYP2B6 Variant with Arg262

  Noritaka Ariyoshi, Miyuki Ohara, Mayumi Kaneko, Sakino Afuso, Takuya Kumamoto, Hiroyoshi Nakamura, Itsuko Ishii, Tsutomu Ishikawa and Mitsukazu Kitada

  Drug Metabolism and Disposition November 2011, 39 (11) 2045-2048; DOI: https://doi.org/10.1124/dmd.111.039586
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  Cannabidiol, a Major Phytocannabinoid, As a Potent Atypical Inhibitor for CYP2D6

  Satoshi Yamaori, Yasuka Okamoto, Ikuo Yamamoto and Kazuhito Watanabe

  Drug Metabolism and Disposition November 2011, 39 (11) 2049-2056; DOI: https://doi.org/10.1124/dmd.111.041384
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  Progesterone Receptor Membrane Component 1 Modulates Human Cytochrome P450 Activities in an Isoform-Dependent Manner

  Shingo Oda, Miki Nakajima, Yasuyuki Toyoda, Tatsuki Fukami and Tsuyoshi Yokoi

  Drug Metabolism and Disposition November 2011, 39 (11) 2057-2065; DOI: https://doi.org/10.1124/dmd.111.040907
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  Evaluation of Three State-of-the-Art Metabolite Prediction Software Packages (Meteor, MetaSite, and StarDrop) through Independent and Synergistic Use

  H. T'jollyn, K. Boussery, R. J. Mortishire-Smith, K. Coe, B. De Boeck, J. F. Van Bocxlaer and G. Mannens

  Drug Metabolism and Disposition November 2011, 39 (11) 2066-2075; DOI: https://doi.org/10.1124/dmd.111.039982
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  Utilizing Drug-Drug Interaction Prediction Tools during Drug Development: Enhanced Decision Making Based on Clinical Risk

  Carole E. Shardlow, Grant T. Generaux, Christopher C. MacLauchlin, Nicoletta Pons, Konstantine W. Skordos and Jackie C. Bloomer

  Drug Metabolism and Disposition November 2011, 39 (11) 2076-2084; DOI: https://doi.org/10.1124/dmd.111.039214
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  Determination of Time-Dependent Inactivation of CYP3A4 in Cryopreserved Human Hepatocytes and Assessment of Human Drug-Drug Interactions

  Yuan Chen, Liling Liu, Mario Monshouwer and Adrian J. Fretland

  Drug Metabolism and Disposition November 2011, 39 (11) 2085-2092; DOI: https://doi.org/10.1124/dmd.111.040634
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  Digoxin Is Not a Substrate for Organic Anion-Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but Is a Substrate for a Sodium-Dependent Transporter Expressed in HEK293 Cells

  Mitchell E. Taub, Kirsten Mease, Rucha S. Sane, Cory A. Watson, Liangfu Chen, Harma Ellens, Brad Hirakawa, Eric L. Reyner, Marton Jani and Caroline A. Lee

  Drug Metabolism and Disposition November 2011, 39 (11) 2093-2102; DOI: https://doi.org/10.1124/dmd.111.040816
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  Species Differences in Distribution and Prediction of Human V_ss from Preclinical Data

  Loren M. Berry, Chao Li and Zhiyang Zhao

  Drug Metabolism and Disposition November 2011, 39 (11) 2103-2116; DOI: https://doi.org/10.1124/dmd.111.040766
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  Bovine Serum Albumin Decreases K_m Values of Human UDP-Glucuronosyltransferases 1A9 and 2B7 and Increases V_max Values of UGT1A9

  Nenad Manevski, Paolo Svaluto Moreolo, Jari Yli-Kauhaluoma and Moshe Finel

  Drug Metabolism and Disposition November 2011, 39 (11) 2117-2129; DOI: https://doi.org/10.1124/dmd.111.041418
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  Cytochrome P450 Pig Liver Pie: Determination of Individual Cytochrome P450 Isoform Contents in Microsomes from Two Pig Livers Using Liquid Chromatography in Conjunction with Mass Spectrometry

  Brahim Achour, Jill Barber and Amin Rostami-Hodjegan

  Drug Metabolism and Disposition November 2011, 39 (11) 2130-2134; DOI: https://doi.org/10.1124/dmd.111.040618
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  Methionine Adenosyltransferase 2A/2B and Methylation: Gene Sequence Variation and Functional Genomics

  Kendra K. S. Nordgren, Yi Peng, Linda L. Pelleymounter, Irene Moon, Ryan Abo, Qiping Feng, Bruce Eckloff, Vivien C. Yee, Eric Wieben and Richard M. Weinshilboum

  Drug Metabolism and Disposition November 2011, 39 (11) 2135-2147; DOI: https://doi.org/10.1124/dmd.111.040857
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  PDZK1 Regulates Breast Cancer Resistance Protein in Small Intestine

  Takuya Shimizu, Tomoko Sugiura, Tomohiko Wakayama, Ai Kijima, Noritaka Nakamichi, Shoichi Iseki, David L. Silver and Yukio Kato

  Drug Metabolism and Disposition November 2011, 39 (11) 2148-2154; DOI: https://doi.org/10.1124/dmd.111.040295
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  Dose-Dependent Disposition of Methotrexate in Abcc2 and Abcc3 Gene Knockout Murine Models

  Zhan Wang, Qingyu Zhou, Gary D. Kruh and James M. Gallo

  Drug Metabolism and Disposition November 2011, 39 (11) 2155-2161; DOI: https://doi.org/10.1124/dmd.111.041228