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Drug Metabolism & Disposition

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Table of Contents

November 01, 2011; Volume 39,Issue 11

Announcement

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    Announcement
    James E. Barrett
    Drug Metabolism and Disposition November 2011, 39 (11) 1997; DOI: https://doi.org/10.1124/dmd.39.11.1997

Short Communications

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    Investigation on the Enantioselectivity of the Sulfation of the Methylenedioxymethamphetamine Metabolites 3,4-Dihydroxymethamphetamine and 4-Hydroxy-3-Methoxymethamphetamine using the Substrate-Depletion Approach
    Andrea E. Schwaninger, Markus R. Meyer and Hans H. Maurer
    Drug Metabolism and Disposition November 2011, 39 (11) 1998-2002; DOI: https://doi.org/10.1124/dmd.111.041129
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    Effect of Estradiol on Gene Expression Profile in Cynomolgus Macaque Liver: Implications for Drug-Metabolizing Enzymes
    Yasuhiro Uno and Go Kito
    Drug Metabolism and Disposition November 2011, 39 (11) 2003-2007; DOI: https://doi.org/10.1124/dmd.111.041004
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    Bioavailability of the Glucuronide and Sulfate Conjugates of Genistein and Daidzein in Breast Cancer Resistance Protein 1 Knockout Mice
    Ana I. Álvarez, Fernando Vallejo, Borja Barrera, Gracia Merino, Julio G. Prieto, Francisco Tomás-Barberán and Juan C. Espín
    Drug Metabolism and Disposition November 2011, 39 (11) 2008-2012; DOI: https://doi.org/10.1124/dmd.111.040881
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    The Deaminated Metabolite of Gemcitabine, 2′,2′-Difluorodeoxyuridine, Modulates the Rate of Gemcitabine Transport and Intracellular Phosphorylation via Deoxycytidine Kinase
    Lucy S. Hodge, Mitchell E. Taub and Timothy S. Tracy
    Drug Metabolism and Disposition November 2011, 39 (11) 2013-2016; DOI: https://doi.org/10.1124/dmd.111.040790
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    Pharmacokinetic Differences Corroborate Observed Low Tacrolimus Dosage in Native American Renal Transplant Patients
    Anita Grover, Lynda A. Frassetto, Leslie Z. Benet and Harini A. Chakkera
    Drug Metabolism and Disposition November 2011, 39 (11) 2017-2019; DOI: https://doi.org/10.1124/dmd.111.041350

Articles

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    The Proton Pump Inhibitor, Omeprazole, but Not Lansoprazole or Pantoprazole, Is a Metabolism-Dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel
    Brian W. Ogilvie, Phyllis Yerino, Faraz Kazmi, David B. Buckley, Amin Rostami-Hodjegan, Brandy L. Paris, Paul Toren and Andrew Parkinson
    Drug Metabolism and Disposition November 2011, 39 (11) 2020-2033; DOI: https://doi.org/10.1124/dmd.111.041293
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    Absorption and Disposition of Scutellarin in Rats: A Pharmacokinetic Explanation for the High Exposure of Its Isomeric Metabolite
    Chunying Gao, Xiaoyan Chen and Dafang Zhong
    Drug Metabolism and Disposition November 2011, 39 (11) 2034-2044; DOI: https://doi.org/10.1124/dmd.111.040550
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    Q172H Replacement Overcomes Effects on the Metabolism of Cyclophosphamide and Efavirenz Caused by CYP2B6 Variant with Arg262
    Noritaka Ariyoshi, Miyuki Ohara, Mayumi Kaneko, Sakino Afuso, Takuya Kumamoto, Hiroyoshi Nakamura, Itsuko Ishii, Tsutomu Ishikawa and Mitsukazu Kitada
    Drug Metabolism and Disposition November 2011, 39 (11) 2045-2048; DOI: https://doi.org/10.1124/dmd.111.039586
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    Cannabidiol, a Major Phytocannabinoid, As a Potent Atypical Inhibitor for CYP2D6
    Satoshi Yamaori, Yasuka Okamoto, Ikuo Yamamoto and Kazuhito Watanabe
    Drug Metabolism and Disposition November 2011, 39 (11) 2049-2056; DOI: https://doi.org/10.1124/dmd.111.041384
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    Progesterone Receptor Membrane Component 1 Modulates Human Cytochrome P450 Activities in an Isoform-Dependent Manner
    Shingo Oda, Miki Nakajima, Yasuyuki Toyoda, Tatsuki Fukami and Tsuyoshi Yokoi
    Drug Metabolism and Disposition November 2011, 39 (11) 2057-2065; DOI: https://doi.org/10.1124/dmd.111.040907
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    Evaluation of Three State-of-the-Art Metabolite Prediction Software Packages (Meteor, MetaSite, and StarDrop) through Independent and Synergistic Use
    H. T'jollyn, K. Boussery, R. J. Mortishire-Smith, K. Coe, B. De Boeck, J. F. Van Bocxlaer and G. Mannens
    Drug Metabolism and Disposition November 2011, 39 (11) 2066-2075; DOI: https://doi.org/10.1124/dmd.111.039982
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    Utilizing Drug-Drug Interaction Prediction Tools during Drug Development: Enhanced Decision Making Based on Clinical Risk
    Carole E. Shardlow, Grant T. Generaux, Christopher C. MacLauchlin, Nicoletta Pons, Konstantine W. Skordos and Jackie C. Bloomer
    Drug Metabolism and Disposition November 2011, 39 (11) 2076-2084; DOI: https://doi.org/10.1124/dmd.111.039214
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    Determination of Time-Dependent Inactivation of CYP3A4 in Cryopreserved Human Hepatocytes and Assessment of Human Drug-Drug Interactions
    Yuan Chen, Liling Liu, Mario Monshouwer and Adrian J. Fretland
    Drug Metabolism and Disposition November 2011, 39 (11) 2085-2092; DOI: https://doi.org/10.1124/dmd.111.040634
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    Digoxin Is Not a Substrate for Organic Anion-Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but Is a Substrate for a Sodium-Dependent Transporter Expressed in HEK293 Cells
    Mitchell E. Taub, Kirsten Mease, Rucha S. Sane, Cory A. Watson, Liangfu Chen, Harma Ellens, Brad Hirakawa, Eric L. Reyner, Marton Jani and Caroline A. Lee
    Drug Metabolism and Disposition November 2011, 39 (11) 2093-2102; DOI: https://doi.org/10.1124/dmd.111.040816
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    Species Differences in Distribution and Prediction of Human Vss from Preclinical Data
    Loren M. Berry, Chao Li and Zhiyang Zhao
    Drug Metabolism and Disposition November 2011, 39 (11) 2103-2116; DOI: https://doi.org/10.1124/dmd.111.040766
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    Bovine Serum Albumin Decreases Km Values of Human UDP-Glucuronosyltransferases 1A9 and 2B7 and Increases Vmax Values of UGT1A9
    Nenad Manevski, Paolo Svaluto Moreolo, Jari Yli-Kauhaluoma and Moshe Finel
    Drug Metabolism and Disposition November 2011, 39 (11) 2117-2129; DOI: https://doi.org/10.1124/dmd.111.041418
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    Cytochrome P450 Pig Liver Pie: Determination of Individual Cytochrome P450 Isoform Contents in Microsomes from Two Pig Livers Using Liquid Chromatography in Conjunction with Mass Spectrometry
    Brahim Achour, Jill Barber and Amin Rostami-Hodjegan
    Drug Metabolism and Disposition November 2011, 39 (11) 2130-2134; DOI: https://doi.org/10.1124/dmd.111.040618
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    Methionine Adenosyltransferase 2A/2B and Methylation: Gene Sequence Variation and Functional Genomics
    Kendra K. S. Nordgren, Yi Peng, Linda L. Pelleymounter, Irene Moon, Ryan Abo, Qiping Feng, Bruce Eckloff, Vivien C. Yee, Eric Wieben and Richard M. Weinshilboum
    Drug Metabolism and Disposition November 2011, 39 (11) 2135-2147; DOI: https://doi.org/10.1124/dmd.111.040857
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    PDZK1 Regulates Breast Cancer Resistance Protein in Small Intestine
    Takuya Shimizu, Tomoko Sugiura, Tomohiko Wakayama, Ai Kijima, Noritaka Nakamichi, Shoichi Iseki, David L. Silver and Yukio Kato
    Drug Metabolism and Disposition November 2011, 39 (11) 2148-2154; DOI: https://doi.org/10.1124/dmd.111.040295
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    Dose-Dependent Disposition of Methotrexate in Abcc2 and Abcc3 Gene Knockout Murine Models
    Zhan Wang, Qingyu Zhou, Gary D. Kruh and James M. Gallo
    Drug Metabolism and Disposition November 2011, 39 (11) 2155-2161; DOI: https://doi.org/10.1124/dmd.111.041228

Accelerated Communication

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    Effect of Dimethyl Sulfoxide on In Vitro Cytochrome P4501A2 Mediated Phenacetin O-Deethylation in Human Liver Microsomes
    Ramakrishna Nirogi, Vishwottam Kandikere, Gopinadh Bhyrapuneni, Ranjith Kumar Ponnamaneni, Raghava choudary Palacharla and Arunkumar Manoharan
    Drug Metabolism and Disposition November 2011, 39 (11) 2162-2164; DOI: https://doi.org/10.1124/dmd.111.041160
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In this issue

Drug Metabolism and Disposition: 39 (11)
Drug Metabolism and Disposition
Vol. 39, Issue 11
1 Nov 2011
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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