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The Deaminated Metabolite of Gemcitabine, 2′,2′-Difluorodeoxyuridine, Modulates the Rate of Gemcitabine Transport and Intracellular Phosphorylation via Deoxycytidine Kinase

Lucy S. Hodge, Mitchell E. Taub and Timothy S. Tracy
Drug Metabolism and Disposition November 2011, 39 (11) 2013-2016; DOI: https://doi.org/10.1124/dmd.111.040790

Article Information

vol. 39 no. 11 2013-2016
DOI 
https://doi.org/10.1124/dmd.111.040790
PubMed 
21832002
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 18, 2011
  • Accepted August 10, 2011
  • Published online October 18, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lucy S. Hodge,
  2. Mitchell E. Taub and
  3. Timothy S. Tracy1
  1. Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota (L.S.H., T.S.T.); and Department of Drug Metabolism and Pharmacokinetics, Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (M.E.T.)
  1. Address correspondence to:
    Lucy S. Hodge, PharmD, PhD, Department of Hematology, Mayo Clinic, 200 1st Street, SW, Rochester, MN 55905. E-mail: hodge.lucy{at}mayo.edu

  • ↵1 Current affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky.

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Rapid CommunicationShort Communication

dFdU AFFECTS TRANSPORT AND PHOSPHORYLATION OF GEMCITABINE

Lucy S. Hodge, Mitchell E. Taub and Timothy S. Tracy
Drug Metabolism and Disposition November 1, 2011, 39 (11) 2013-2016; DOI: https://doi.org/10.1124/dmd.111.040790
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