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Determination of Time-Dependent Inactivation of CYP3A4 in Cryopreserved Human Hepatocytes and Assessment of Human Drug-Drug Interactions

Yuan Chen, Liling Liu, Mario Monshouwer and Adrian J. Fretland
Drug Metabolism and Disposition November 2011, 39 (11) 2085-2092; DOI: https://doi.org/10.1124/dmd.111.040634

Article Information

vol. 39 no. 11 2085-2092
DOI 
https://doi.org/10.1124/dmd.111.040634
PubMed 
21835977
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 17, 2011
  • Accepted August 11, 2011
  • Published online October 18, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yuan Chen,
  2. Liling Liu1,
  3. Mario Monshouwer2 and
  4. Adrian J. Fretland1
  1. Department of Drug Metabolism and Pharmacokinetics, Roche-Palo Alto, LLC, Palo Alto, California
  1. Address correspondence to:
    Dr. Yuan Chen, Department of Drug Metabolism and Pharmacokinetics, Genentech, A Member of the Roche Group, M/S 41 2A, 1 DNA Way, South San Francisco, CA 94080. E-mail: chen.yuan{at}gene.com

  1. This work was previously presented in part as follows: Chen Y, Liu L, Monshouwer M, and Fretland AJ (2010) Evaluation of time-dependent CYP3A4 inhibition using cryopreserved human hepatocyte. 2010 AAPS Annual Meeting and Exposition; 2010 Nov 14–18; New Orleans, LA. AAPS, Arlington, VA.

  • ↵1 Current affiliation: Roche Pharma Research and Early Development, Early ADME Department, Roche-Nutley, Nutley, New Jersey.

  • ↵2 Current affiliation: Pharmaceutical Companies of Johnson and Johnson, Beerse, Belgium.

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ASSESSMENT OF CYP3A4 TDI IN HEPATOCYTES AND HUMAN DDI

Yuan Chen, Liling Liu, Mario Monshouwer and Adrian J. Fretland
Drug Metabolism and Disposition November 1, 2011, 39 (11) 2085-2092; DOI: https://doi.org/10.1124/dmd.111.040634
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