Table of Contents

Articles

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  Production of Ibuprofen Acyl Glucosides by Human UGT2B7

  Daniela Buchheit, Călin-Aurel Drăgan, Ellen I. Schmitt and Matthias Bureik

  Drug Metabolism and Disposition December 2011, 39 (12) 2174-2181; DOI: https://doi.org/10.1124/dmd.111.041640
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  Differences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis C

  Sarah J. Schrieber, Roy L. Hawke, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Catherine M. Meyers, Edward Doo and Michael. W. Fried

  Drug Metabolism and Disposition December 2011, 39 (12) 2182-2190; DOI: https://doi.org/10.1124/dmd.111.040212
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  Excretion, Metabolism, and Pharmacokinetics of CP-945,598, a Selective Cannabinoid Receptor Antagonist, in Rats, Mice, and Dogs

  Zhuang Miao, Dennis O. Scott, David A. Griffith, Robert Day and Chandra Prakash

  Drug Metabolism and Disposition December 2011, 39 (12) 2191-2208; DOI: https://doi.org/10.1124/dmd.111.040360
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  Cardiac Arrest and Therapeutic Hypothermia Decrease Isoform-Specific Cytochrome P450 Drug Metabolism

  Jiangquan Zhou, Philip E. Empey, Robert R. Bies, Patrick M. Kochanek and Samuel M. Poloyac

  Drug Metabolism and Disposition December 2011, 39 (12) 2209-2218; DOI: https://doi.org/10.1124/dmd.111.040642
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  Preclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics

  Ramesh Jayaraman, Venkatesh Pilla Reddy, Mohammed Khalid Pasha, Haishan Wang, Kanda Sangthongpitag, Pauline Yeo, Chang Yong Hu, Xiaofeng Wu, Liu Xin, Evelyn Goh, Lee Sun New and Kantharaj Ethirajulu

  Drug Metabolism and Disposition December 2011, 39 (12) 2219-2232; DOI: https://doi.org/10.1124/dmd.111.041558
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  Independent and Combined Effects of Ethanol Self-Administration and Nicotine Treatment on Hepatic CYP2E1 in African Green Monkeys

  C. S. Ferguson, S. Miksys, R. Palmour and R. F. Tyndale

  Drug Metabolism and Disposition December 2011, 39 (12) 2233-2241; DOI: https://doi.org/10.1124/dmd.111.040378
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  Complex N-Acetylation of Triethylenetetramine

  Marc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen and Tuomo A. Keinänen

  Drug Metabolism and Disposition December 2011, 39 (12) 2242-2249; DOI: https://doi.org/10.1124/dmd.111.041798
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  Effect of Dose Escalation on the In Vivo Oral Absorption and Disposition of Glycylsarcosine in Wild-Type and Pept1 Knockout Mice

  Dilara Jappar, Yongjun Hu and David E. Smith

  Drug Metabolism and Disposition December 2011, 39 (12) 2250-2257; DOI: https://doi.org/10.1124/dmd.111.041087
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  A Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human Tissue

  Alison M. Milne, Brian Burchell and Michael W. H. Coughtrie

  Drug Metabolism and Disposition December 2011, 39 (12) 2258-2263; DOI: https://doi.org/10.1124/dmd.111.041699
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  Biosynthesis and Identification of an N-Oxide/N-Glucuronide Metabolite and First Synthesis of an N-O-Glucuronide Metabolite of Lu AA21004

  Henriette Kold Uldam, Martin Juhl, Henrik Pedersen and Lars Dalgaard

  Drug Metabolism and Disposition December 2011, 39 (12) 2264-2274; DOI: https://doi.org/10.1124/dmd.111.040428
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  Systemic and Direct Nose-to-Brain Transport Pharmacokinetic Model for Remoxipride after Intravenous and Intranasal Administration

  Jasper Stevens, Bart A. Ploeger, Piet H. van der Graaf, Meindert Danhof and Elizabeth C. M. de Lange

  Drug Metabolism and Disposition December 2011, 39 (12) 2275-2282; DOI: https://doi.org/10.1124/dmd.111.040782
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  CYP2C19 Progress Curve Analysis and Mechanism-Based Inactivation by Three Methylenedioxyphenyl Compounds

  Kaisa A. Salminen, Achim Meyer, Peter Imming and Hannu Raunio

  Drug Metabolism and Disposition December 2011, 39 (12) 2283-2289; DOI: https://doi.org/10.1124/dmd.111.041319
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  Involvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of Troglitazone

  Ran Okada, Kazuya Maeda, Takahito Nishiyama, Shinsuke Aoyama, Zenzaburo Tozuka, Akira Hiratsuka, Toshihiko Ikeda, Hiroyuki Kusuhara and Yuichi Sugiyama

  Drug Metabolism and Disposition December 2011, 39 (12) 2290-2297; DOI: https://doi.org/10.1124/dmd.111.040469
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  Monomethylarsenic Diglutathione Transport by the Human Multidrug Resistance Protein 1 (MRP1/ABCC1)

  Michael W. Carew, Hua Naranmandura, Caley B. Shukalek, X. Chris Le and Elaine M. Leslie

  Drug Metabolism and Disposition December 2011, 39 (12) 2298-2304; DOI: https://doi.org/10.1124/dmd.111.041673
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  Characterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and Human

  Eric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. Perkins

  Drug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
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  Utility of P-Glycoprotein and Organic Cation Transporter 1 Double-Transfected LLC-PK1 Cells for Studying the Interaction of YM155 Monobromide, Novel Small-Molecule Survivin Suppressant, with P-Glycoprotein

  Megumi Iwai, Tsuyoshi Minematsu, Qun Li, Takafumi Iwatsubo and Takashi Usui

  Drug Metabolism and Disposition December 2011, 39 (12) 2314-2320; DOI: https://doi.org/10.1124/dmd.111.040733
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  Intestinal Ciprofloxacin Efflux: The Role of Breast Cancer Resistance Protein (ABCG2)

  I. S. Haslam, J. A. Wright, D. A. O'Reilly, D. J. Sherlock, T. Coleman and N. L. Simmons

  Drug Metabolism and Disposition December 2011, 39 (12) 2321-2328; DOI: https://doi.org/10.1124/dmd.111.038323
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  Complex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or Nelfinavir

  Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Vaishali Dixit, Pankaj Desai, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat

  Drug Metabolism and Disposition December 2011, 39 (12) 2329-2337; DOI: https://doi.org/10.1124/dmd.111.038646
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  Absorption and Metabolism of Chlorogenic Acids in Cultured Gastric Epithelial Monolayers

  Tracy L. Farrell, Tristan P. Dew, Laure Poquet, Peter Hanson and Gary Williamson

  Drug Metabolism and Disposition December 2011, 39 (12) 2338-2346; DOI: https://doi.org/10.1124/dmd.111.040147
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  Raloxifene Glucuronidation in Human Intestine, Kidney, and Liver Microsomes and in Human Liver Microsomes Genotyped for the UGT1A1*28 Polymorphism

  Tina Trdan Lušin, Jurij Trontelj and Aleš Mrhar

  Drug Metabolism and Disposition December 2011, 39 (12) 2347-2354; DOI: https://doi.org/10.1124/dmd.111.041897
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  Small Molecule Quantification by Liquid Chromatography-Mass Spectrometry for Metabolites of Drugs and Drug Candidates

  Upendra P. Dahal, Jeffrey P. Jones, John A. Davis and Dan A. Rock

  Drug Metabolism and Disposition December 2011, 39 (12) 2355-2360; DOI: https://doi.org/10.1124/dmd.111.040865
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  Hepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4

  Alison J. Wilby, Kazuya Maeda, Paul F. Courtney, Yasuyuki Debori, Peter J. H. Webborn, Yoshiaki Kitamura, Hiroyuki Kusuhara, Rob J. Riley and Yuichi Sugiyama

  Drug Metabolism and Disposition December 2011, 39 (12) 2361-2369; DOI: https://doi.org/10.1124/dmd.111.041814
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  Analysis and Prediction of Drug Transfer into Human Milk Taking into Consideration Secretion and Reuptake Clearances across the Mammary Epithelia

  Hiroki Koshimichi, Kousei Ito, Akihiro Hisaka, Masashi Honma and Hiroshi Suzuki

  Drug Metabolism and Disposition December 2011, 39 (12) 2370-2380; DOI: https://doi.org/10.1124/dmd.111.040972
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  Inhibition of Human Liver Aldehyde Oxidase: Implications for Potential Drug-Drug Interactions

  John T. Barr and Jeffrey P. Jones

  Drug Metabolism and Disposition December 2011, 39 (12) 2381-2386; DOI: https://doi.org/10.1124/dmd.111.041806
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  Effect of Culture Time on the Basal Expression Levels of Drug Transporters in Sandwich-Cultured Primary Rat Hepatocytes

  Eskouhie H. Tchaparian, Jessica S. Houghton, Craig Uyeda, Mark P. Grillo and Lixia Jin

  Drug Metabolism and Disposition December 2011, 39 (12) 2387-2394; DOI: https://doi.org/10.1124/dmd.111.039545
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  Variations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver Disease

  Rhiannon N. Hardwick, Craig D. Fisher, Mark J. Canet, George L. Scheffer and Nathan J. Cherrington

  Drug Metabolism and Disposition December 2011, 39 (12) 2395-2402; DOI: https://doi.org/10.1124/dmd.111.041012
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  Proluciferin Acetals as Bioluminogenic Substrates for Cytochrome P450 Activity and Probes for CYP3A Inhibition

  Poncho L. Meisenheimer, H. Tetsuo Uyeda, Dongping Ma, Mary Sobol, Mark G. McDougall, Cesear Corona, Dan Simpson, Dieter H. Klaubert and James J. Cali

  Drug Metabolism and Disposition December 2011, 39 (12) 2403-2410; DOI: https://doi.org/10.1124/dmd.111.041541
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  Role of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH Conjugates

  Vanina Rea, Sanja Dragovic, Jan Simon Boerma, Frans J. J. de Kanter, Nico P. E. Vermeulen and Jan N. M. Commandeur

  Drug Metabolism and Disposition December 2011, 39 (12) 2411-2420; DOI: https://doi.org/10.1124/dmd.111.041046
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  Studies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of Gemfibrozil

  S. M. Jenkins, T. Zvyaga, S. R. Johnson, J. Hurley, A. Wagner, R. Burrell, W. Turley, J. E. Leet, T. Philip and A. D. Rodrigues

  Drug Metabolism and Disposition December 2011, 39 (12) 2421-2430; DOI: https://doi.org/10.1124/dmd.111.041947
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  Thr302 Is the Site for the Covalent Modification of Human Cytochrome P450 2B6 Leading to Mechanism-Based Inactivation by tert-Butylphenylacetylene

  Hsia-lien Lin, Haoming Zhang, Matthew J. Pratt-Hyatt and Paul F. Hollenberg

  Drug Metabolism and Disposition December 2011, 39 (12) 2431-2439; DOI: https://doi.org/10.1124/dmd.111.042176
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  Development of a Highly Sensitive Method Using Liquid Chromatography-Multiple Reaction Monitoring to Quantify Membrane P-Glycoprotein in Biological Matrices and Relationship to Transport Function

  Tasso Miliotis, Liaqat Ali, Johan E. Palm, Anders J. Lundqvist, Martin Ahnoff, Tommy B. Andersson and Constanze Hilgendorf

  Drug Metabolism and Disposition December 2011, 39 (12) 2440-2449; DOI: https://doi.org/10.1124/dmd.111.040774