Drug Metabolism and Disposition: 39 (12)

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About the cover: Comparision of gemfibrozil acyl-β-glucuronide (with the orientation of m-Me toward heme) with gemfibrozil (slate blue carbons) in the active site of the CYP2C8 enzyme. See the article by Jenkins et al. on page 2421 of this issue.

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Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC_I/AUC) RATIOS
In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”

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