Index by author
December 01, 2011; Volume 39,Issue 12
A
Afdhal, Nezam H.
- You have accessDifferences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis CSarah J. Schrieber, Roy L. Hawke, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Catherine M. Meyers, Edward Doo and Michael. W. FriedDrug Metabolism and Disposition December 2011, 39 (12) 2182-2190; DOI: https://doi.org/10.1124/dmd.111.040212
Ahnoff, Martin
- You have accessDevelopment of a Highly Sensitive Method Using Liquid Chromatography-Multiple Reaction Monitoring to Quantify Membrane P-Glycoprotein in Biological Matrices and Relationship to Transport FunctionTasso Miliotis, Liaqat Ali, Johan E. Palm, Anders J. Lundqvist, Martin Ahnoff, Tommy B. Andersson and Constanze HilgendorfDrug Metabolism and Disposition December 2011, 39 (12) 2440-2449; DOI: https://doi.org/10.1124/dmd.111.040774
Alhonen, Leena
- You have accessComplex N-Acetylation of TriethylenetetramineMarc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen and Tuomo A. KeinänenDrug Metabolism and Disposition December 2011, 39 (12) 2242-2249; DOI: https://doi.org/10.1124/dmd.111.041798
Ali, Liaqat
- You have accessDevelopment of a Highly Sensitive Method Using Liquid Chromatography-Multiple Reaction Monitoring to Quantify Membrane P-Glycoprotein in Biological Matrices and Relationship to Transport FunctionTasso Miliotis, Liaqat Ali, Johan E. Palm, Anders J. Lundqvist, Martin Ahnoff, Tommy B. Andersson and Constanze HilgendorfDrug Metabolism and Disposition December 2011, 39 (12) 2440-2449; DOI: https://doi.org/10.1124/dmd.111.040774
Andersson, Tommy B.
- You have accessDevelopment of a Highly Sensitive Method Using Liquid Chromatography-Multiple Reaction Monitoring to Quantify Membrane P-Glycoprotein in Biological Matrices and Relationship to Transport FunctionTasso Miliotis, Liaqat Ali, Johan E. Palm, Anders J. Lundqvist, Martin Ahnoff, Tommy B. Andersson and Constanze HilgendorfDrug Metabolism and Disposition December 2011, 39 (12) 2440-2449; DOI: https://doi.org/10.1124/dmd.111.040774
Aoyama, Shinsuke
- You have accessInvolvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of TroglitazoneRan Okada, Kazuya Maeda, Takahito Nishiyama, Shinsuke Aoyama, Zenzaburo Tozuka, Akira Hiratsuka, Toshihiko Ikeda, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2290-2297; DOI: https://doi.org/10.1124/dmd.111.040469
Arlt, Volker M.
- You have accessEffect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null MiceVolker M. Arlt, Rajinder Singh, Marie Stiborová, Gonçalo Gamboa da Costa, Eva Frei, James D. Evans, Peter B. Farmer, C. Roland Wolf, Colin J. Henderson and David H. PhillipsDrug Metabolism and Disposition December 2011, 39 (12) 2169-2173; DOI: https://doi.org/10.1124/dmd.111.041343
B
Bacon, James A.
- You have accessCharacterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and HumanEric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. PerkinsDrug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
Ballard, Peter
- You have accessCorrection for Nonspecific Binding to Various Components of Ultrafiltration Apparatus and Impact on Estimating In Vivo Rat Clearance for a Congeneric Series of 5-Ethyl, 5-n-Alkyl Barbituric AcidsPeter Ballard and Malcolm RowlandDrug Metabolism and Disposition December 2011, 39 (12) 2165-2168; DOI: https://doi.org/10.1124/dmd.111.040683
Barr, John T.
- You have accessInhibition of Human Liver Aldehyde Oxidase: Implications for Potential Drug-Drug InteractionsJohn T. Barr and Jeffrey P. JonesDrug Metabolism and Disposition December 2011, 39 (12) 2381-2386; DOI: https://doi.org/10.1124/dmd.111.041806
Belle, Steven H.
- You have accessDifferences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis CSarah J. Schrieber, Roy L. Hawke, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Catherine M. Meyers, Edward Doo and Michael. W. FriedDrug Metabolism and Disposition December 2011, 39 (12) 2182-2190; DOI: https://doi.org/10.1124/dmd.111.040212
Bender, David M.
- You have accessCharacterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and HumanEric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. PerkinsDrug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
Bies, Robert R.
- You have accessCardiac Arrest and Therapeutic Hypothermia Decrease Isoform-Specific Cytochrome P450 Drug MetabolismJiangquan Zhou, Philip E. Empey, Robert R. Bies, Patrick M. Kochanek and Samuel M. PoloyacDrug Metabolism and Disposition December 2011, 39 (12) 2209-2218; DOI: https://doi.org/10.1124/dmd.111.040642
Boerma, Jan Simon
- You have accessRole of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH ConjugatesVanina Rea, Sanja Dragovic, Jan Simon Boerma, Frans J. J. de Kanter, Nico P. E. Vermeulen and Jan N. M. CommandeurDrug Metabolism and Disposition December 2011, 39 (12) 2411-2420; DOI: https://doi.org/10.1124/dmd.111.041046
Buchheit, Daniela
- You have accessProduction of Ibuprofen Acyl Glucosides by Human UGT2B7Daniela Buchheit, Călin-Aurel Drăgan, Ellen I. Schmitt and Matthias BureikDrug Metabolism and Disposition December 2011, 39 (12) 2174-2181; DOI: https://doi.org/10.1124/dmd.111.041640
Burchell, Brian
- You have accessA Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human TissueAlison M. Milne, Brian Burchell and Michael W. H. CoughtrieDrug Metabolism and Disposition December 2011, 39 (12) 2258-2263; DOI: https://doi.org/10.1124/dmd.111.041699
Bureik, Matthias
- You have accessProduction of Ibuprofen Acyl Glucosides by Human UGT2B7Daniela Buchheit, Călin-Aurel Drăgan, Ellen I. Schmitt and Matthias BureikDrug Metabolism and Disposition December 2011, 39 (12) 2174-2181; DOI: https://doi.org/10.1124/dmd.111.041640
Burrell, R.
- You have accessStudies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of GemfibrozilS. M. Jenkins, T. Zvyaga, S. R. Johnson, J. Hurley, A. Wagner, R. Burrell, W. Turley, J. E. Leet, T. Philip and A. D. RodriguesDrug Metabolism and Disposition December 2011, 39 (12) 2421-2430; DOI: https://doi.org/10.1124/dmd.111.041947
C
Cali, James J.
- You have accessProluciferin Acetals as Bioluminogenic Substrates for Cytochrome P450 Activity and Probes for CYP3A InhibitionPoncho L. Meisenheimer, H. Tetsuo Uyeda, Dongping Ma, Mary Sobol, Mark G. McDougall, Cesear Corona, Dan Simpson, Dieter H. Klaubert and James J. CaliDrug Metabolism and Disposition December 2011, 39 (12) 2403-2410; DOI: https://doi.org/10.1124/dmd.111.041541
Canet, Mark J.
- You have accessVariations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver DiseaseRhiannon N. Hardwick, Craig D. Fisher, Mark J. Canet, George L. Scheffer and Nathan J. CherringtonDrug Metabolism and Disposition December 2011, 39 (12) 2395-2402; DOI: https://doi.org/10.1124/dmd.111.041012
Carew, Michael W.
- You have accessMonomethylarsenic Diglutathione Transport by the Human Multidrug Resistance Protein 1 (MRP1/ABCC1)Michael W. Carew, Hua Naranmandura, Caley B. Shukalek, X. Chris Le and Elaine M. LeslieDrug Metabolism and Disposition December 2011, 39 (12) 2298-2304; DOI: https://doi.org/10.1124/dmd.111.041673
Cerrada-Gimenez, Marc
- You have accessComplex N-Acetylation of TriethylenetetramineMarc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen and Tuomo A. KeinänenDrug Metabolism and Disposition December 2011, 39 (12) 2242-2249; DOI: https://doi.org/10.1124/dmd.111.041798
Cherrington, Nathan J.
- You have accessVariations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver DiseaseRhiannon N. Hardwick, Craig D. Fisher, Mark J. Canet, George L. Scheffer and Nathan J. CherringtonDrug Metabolism and Disposition December 2011, 39 (12) 2395-2402; DOI: https://doi.org/10.1124/dmd.111.041012
Coleman, T.
- You have accessIntestinal Ciprofloxacin Efflux: The Role of Breast Cancer Resistance Protein (ABCG2)I. S. Haslam, J. A. Wright, D. A. O'Reilly, D. J. Sherlock, T. Coleman and N. L. SimmonsDrug Metabolism and Disposition December 2011, 39 (12) 2321-2328; DOI: https://doi.org/10.1124/dmd.111.038323
Collier, Ann C.
- You have accessComplex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or NelfinavirBrian J. Kirby, Ann C. Collier, Evan D. Kharasch, Vaishali Dixit, Pankaj Desai, Dale Whittington, Kenneth E. Thummel and Jashvant D. UnadkatDrug Metabolism and Disposition December 2011, 39 (12) 2329-2337; DOI: https://doi.org/10.1124/dmd.111.038646
Commandeur, Jan N. M.
- You have accessRole of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH ConjugatesVanina Rea, Sanja Dragovic, Jan Simon Boerma, Frans J. J. de Kanter, Nico P. E. Vermeulen and Jan N. M. CommandeurDrug Metabolism and Disposition December 2011, 39 (12) 2411-2420; DOI: https://doi.org/10.1124/dmd.111.041046
Corona, Cesear
- You have accessProluciferin Acetals as Bioluminogenic Substrates for Cytochrome P450 Activity and Probes for CYP3A InhibitionPoncho L. Meisenheimer, H. Tetsuo Uyeda, Dongping Ma, Mary Sobol, Mark G. McDougall, Cesear Corona, Dan Simpson, Dieter H. Klaubert and James J. CaliDrug Metabolism and Disposition December 2011, 39 (12) 2403-2410; DOI: https://doi.org/10.1124/dmd.111.041541
Coughtrie, Michael W. H.
- You have accessA Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human TissueAlison M. Milne, Brian Burchell and Michael W. H. CoughtrieDrug Metabolism and Disposition December 2011, 39 (12) 2258-2263; DOI: https://doi.org/10.1124/dmd.111.041699
Courtney, Paul F.
- You have accessHepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4Alison J. Wilby, Kazuya Maeda, Paul F. Courtney, Yasuyuki Debori, Peter J. H. Webborn, Yoshiaki Kitamura, Hiroyuki Kusuhara, Rob J. Riley and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2361-2369; DOI: https://doi.org/10.1124/dmd.111.041814
D
Dahal, Upendra P.
- You have accessSmall Molecule Quantification by Liquid Chromatography-Mass Spectrometry for Metabolites of Drugs and Drug CandidatesUpendra P. Dahal, Jeffrey P. Jones, John A. Davis and Dan A. RockDrug Metabolism and Disposition December 2011, 39 (12) 2355-2360; DOI: https://doi.org/10.1124/dmd.111.040865
Dalgaard, Lars
- You have accessBiosynthesis and Identification of an N-Oxide/N-Glucuronide Metabolite and First Synthesis of an N-O-Glucuronide Metabolite of Lu AA21004Henriette Kold Uldam, Martin Juhl, Henrik Pedersen and Lars DalgaardDrug Metabolism and Disposition December 2011, 39 (12) 2264-2274; DOI: https://doi.org/10.1124/dmd.111.040428
Danhof, Meindert
- You have accessSystemic and Direct Nose-to-Brain Transport Pharmacokinetic Model for Remoxipride after Intravenous and Intranasal AdministrationJasper Stevens, Bart A. Ploeger, Piet H. van der Graaf, Meindert Danhof and Elizabeth C. M. de LangeDrug Metabolism and Disposition December 2011, 39 (12) 2275-2282; DOI: https://doi.org/10.1124/dmd.111.040782
Davis, John A.
- You have accessSmall Molecule Quantification by Liquid Chromatography-Mass Spectrometry for Metabolites of Drugs and Drug CandidatesUpendra P. Dahal, Jeffrey P. Jones, John A. Davis and Dan A. RockDrug Metabolism and Disposition December 2011, 39 (12) 2355-2360; DOI: https://doi.org/10.1124/dmd.111.040865
Day, Robert
- You have accessExcretion, Metabolism, and Pharmacokinetics of CP-945,598, a Selective Cannabinoid Receptor Antagonist, in Rats, Mice, and DogsZhuang Miao, Dennis O. Scott, David A. Griffith, Robert Day and Chandra PrakashDrug Metabolism and Disposition December 2011, 39 (12) 2191-2208; DOI: https://doi.org/10.1124/dmd.111.040360
Debori, Yasuyuki
- You have accessHepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4Alison J. Wilby, Kazuya Maeda, Paul F. Courtney, Yasuyuki Debori, Peter J. H. Webborn, Yoshiaki Kitamura, Hiroyuki Kusuhara, Rob J. Riley and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2361-2369; DOI: https://doi.org/10.1124/dmd.111.041814
de Kanter, Frans J. J.
- You have accessRole of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH ConjugatesVanina Rea, Sanja Dragovic, Jan Simon Boerma, Frans J. J. de Kanter, Nico P. E. Vermeulen and Jan N. M. CommandeurDrug Metabolism and Disposition December 2011, 39 (12) 2411-2420; DOI: https://doi.org/10.1124/dmd.111.041046
de Lange, Elizabeth C. M.
- You have accessSystemic and Direct Nose-to-Brain Transport Pharmacokinetic Model for Remoxipride after Intravenous and Intranasal AdministrationJasper Stevens, Bart A. Ploeger, Piet H. van der Graaf, Meindert Danhof and Elizabeth C. M. de LangeDrug Metabolism and Disposition December 2011, 39 (12) 2275-2282; DOI: https://doi.org/10.1124/dmd.111.040782
Desai, Pankaj
- You have accessComplex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or NelfinavirBrian J. Kirby, Ann C. Collier, Evan D. Kharasch, Vaishali Dixit, Pankaj Desai, Dale Whittington, Kenneth E. Thummel and Jashvant D. UnadkatDrug Metabolism and Disposition December 2011, 39 (12) 2329-2337; DOI: https://doi.org/10.1124/dmd.111.038646
Dew, Tristan P.
- You have accessAbsorption and Metabolism of Chlorogenic Acids in Cultured Gastric Epithelial MonolayersTracy L. Farrell, Tristan P. Dew, Laure Poquet, Peter Hanson and Gary WilliamsonDrug Metabolism and Disposition December 2011, 39 (12) 2338-2346; DOI: https://doi.org/10.1124/dmd.111.040147
Dixit, Vaishali
- You have accessComplex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or NelfinavirBrian J. Kirby, Ann C. Collier, Evan D. Kharasch, Vaishali Dixit, Pankaj Desai, Dale Whittington, Kenneth E. Thummel and Jashvant D. UnadkatDrug Metabolism and Disposition December 2011, 39 (12) 2329-2337; DOI: https://doi.org/10.1124/dmd.111.038646
Doo, Edward
- You have accessDifferences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis CSarah J. Schrieber, Roy L. Hawke, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Catherine M. Meyers, Edward Doo and Michael. W. FriedDrug Metabolism and Disposition December 2011, 39 (12) 2182-2190; DOI: https://doi.org/10.1124/dmd.111.040212
Drăgan, Călin-Aurel
- You have accessProduction of Ibuprofen Acyl Glucosides by Human UGT2B7Daniela Buchheit, Călin-Aurel Drăgan, Ellen I. Schmitt and Matthias BureikDrug Metabolism and Disposition December 2011, 39 (12) 2174-2181; DOI: https://doi.org/10.1124/dmd.111.041640
Dragovic, Sanja
- You have accessRole of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH ConjugatesVanina Rea, Sanja Dragovic, Jan Simon Boerma, Frans J. J. de Kanter, Nico P. E. Vermeulen and Jan N. M. CommandeurDrug Metabolism and Disposition December 2011, 39 (12) 2411-2420; DOI: https://doi.org/10.1124/dmd.111.041046
E
Ehsani, Mariam E.
- You have accessCharacterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and HumanEric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. PerkinsDrug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
Empey, Philip E.
- You have accessCardiac Arrest and Therapeutic Hypothermia Decrease Isoform-Specific Cytochrome P450 Drug MetabolismJiangquan Zhou, Philip E. Empey, Robert R. Bies, Patrick M. Kochanek and Samuel M. PoloyacDrug Metabolism and Disposition December 2011, 39 (12) 2209-2218; DOI: https://doi.org/10.1124/dmd.111.040642
Ethirajulu, Kantharaj
- You have accessPreclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human PharmacokineticsRamesh Jayaraman, Venkatesh Pilla Reddy, Mohammed Khalid Pasha, Haishan Wang, Kanda Sangthongpitag, Pauline Yeo, Chang Yong Hu, Xiaofeng Wu, Liu Xin, Evelyn Goh, Lee Sun New and Kantharaj EthirajuluDrug Metabolism and Disposition December 2011, 39 (12) 2219-2232; DOI: https://doi.org/10.1124/dmd.111.041558
Evans, James D.
- You have accessEffect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null MiceVolker M. Arlt, Rajinder Singh, Marie Stiborová, Gonçalo Gamboa da Costa, Eva Frei, James D. Evans, Peter B. Farmer, C. Roland Wolf, Colin J. Henderson and David H. PhillipsDrug Metabolism and Disposition December 2011, 39 (12) 2169-2173; DOI: https://doi.org/10.1124/dmd.111.041343
F
Farmer, Peter B.
- You have accessEffect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null MiceVolker M. Arlt, Rajinder Singh, Marie Stiborová, Gonçalo Gamboa da Costa, Eva Frei, James D. Evans, Peter B. Farmer, C. Roland Wolf, Colin J. Henderson and David H. PhillipsDrug Metabolism and Disposition December 2011, 39 (12) 2169-2173; DOI: https://doi.org/10.1124/dmd.111.041343
Farrell, Tracy L.
- You have accessAbsorption and Metabolism of Chlorogenic Acids in Cultured Gastric Epithelial MonolayersTracy L. Farrell, Tristan P. Dew, Laure Poquet, Peter Hanson and Gary WilliamsonDrug Metabolism and Disposition December 2011, 39 (12) 2338-2346; DOI: https://doi.org/10.1124/dmd.111.040147
Ferguson, C. S.
- You have accessIndependent and Combined Effects of Ethanol Self-Administration and Nicotine Treatment on Hepatic CYP2E1 in African Green MonkeysC. S. Ferguson, S. Miksys, R. Palmour and R. F. TyndaleDrug Metabolism and Disposition December 2011, 39 (12) 2233-2241; DOI: https://doi.org/10.1124/dmd.111.040378
Fisher, Craig D.
- You have accessVariations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver DiseaseRhiannon N. Hardwick, Craig D. Fisher, Mark J. Canet, George L. Scheffer and Nathan J. CherringtonDrug Metabolism and Disposition December 2011, 39 (12) 2395-2402; DOI: https://doi.org/10.1124/dmd.111.041012
Frei, Eva
- You have accessEffect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null MiceVolker M. Arlt, Rajinder Singh, Marie Stiborová, Gonçalo Gamboa da Costa, Eva Frei, James D. Evans, Peter B. Farmer, C. Roland Wolf, Colin J. Henderson and David H. PhillipsDrug Metabolism and Disposition December 2011, 39 (12) 2169-2173; DOI: https://doi.org/10.1124/dmd.111.041343
Fried, Michael. W.
- You have accessDifferences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis CSarah J. Schrieber, Roy L. Hawke, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Catherine M. Meyers, Edward Doo and Michael. W. FriedDrug Metabolism and Disposition December 2011, 39 (12) 2182-2190; DOI: https://doi.org/10.1124/dmd.111.040212
G
Gamboa da Costa, Gonçalo
- You have accessEffect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null MiceVolker M. Arlt, Rajinder Singh, Marie Stiborová, Gonçalo Gamboa da Costa, Eva Frei, James D. Evans, Peter B. Farmer, C. Roland Wolf, Colin J. Henderson and David H. PhillipsDrug Metabolism and Disposition December 2011, 39 (12) 2169-2173; DOI: https://doi.org/10.1124/dmd.111.041343
Goh, Evelyn
- You have accessPreclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human PharmacokineticsRamesh Jayaraman, Venkatesh Pilla Reddy, Mohammed Khalid Pasha, Haishan Wang, Kanda Sangthongpitag, Pauline Yeo, Chang Yong Hu, Xiaofeng Wu, Liu Xin, Evelyn Goh, Lee Sun New and Kantharaj EthirajuluDrug Metabolism and Disposition December 2011, 39 (12) 2219-2232; DOI: https://doi.org/10.1124/dmd.111.041558
Griffith, David A.
- You have accessExcretion, Metabolism, and Pharmacokinetics of CP-945,598, a Selective Cannabinoid Receptor Antagonist, in Rats, Mice, and DogsZhuang Miao, Dennis O. Scott, David A. Griffith, Robert Day and Chandra PrakashDrug Metabolism and Disposition December 2011, 39 (12) 2191-2208; DOI: https://doi.org/10.1124/dmd.111.040360
Grillo, Mark P.
- You have accessEffect of Culture Time on the Basal Expression Levels of Drug Transporters in Sandwich-Cultured Primary Rat HepatocytesEskouhie H. Tchaparian, Jessica S. Houghton, Craig Uyeda, Mark P. Grillo and Lixia JinDrug Metabolism and Disposition December 2011, 39 (12) 2387-2394; DOI: https://doi.org/10.1124/dmd.111.039545
Guo, Wen-Kai
- You have accessCharacterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and HumanEric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. PerkinsDrug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
H
Hanson, Peter
- You have accessAbsorption and Metabolism of Chlorogenic Acids in Cultured Gastric Epithelial MonolayersTracy L. Farrell, Tristan P. Dew, Laure Poquet, Peter Hanson and Gary WilliamsonDrug Metabolism and Disposition December 2011, 39 (12) 2338-2346; DOI: https://doi.org/10.1124/dmd.111.040147
Hardwick, Rhiannon N.
- You have accessVariations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver DiseaseRhiannon N. Hardwick, Craig D. Fisher, Mark J. Canet, George L. Scheffer and Nathan J. CherringtonDrug Metabolism and Disposition December 2011, 39 (12) 2395-2402; DOI: https://doi.org/10.1124/dmd.111.041012
Haslam, I. S.
- You have accessIntestinal Ciprofloxacin Efflux: The Role of Breast Cancer Resistance Protein (ABCG2)I. S. Haslam, J. A. Wright, D. A. O'Reilly, D. J. Sherlock, T. Coleman and N. L. SimmonsDrug Metabolism and Disposition December 2011, 39 (12) 2321-2328; DOI: https://doi.org/10.1124/dmd.111.038323
Hawke, Roy L.
- You have accessDifferences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis CSarah J. Schrieber, Roy L. Hawke, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Catherine M. Meyers, Edward Doo and Michael. W. FriedDrug Metabolism and Disposition December 2011, 39 (12) 2182-2190; DOI: https://doi.org/10.1124/dmd.111.040212
Hee Park, Myung
- You have accessComplex N-Acetylation of TriethylenetetramineMarc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen and Tuomo A. KeinänenDrug Metabolism and Disposition December 2011, 39 (12) 2242-2249; DOI: https://doi.org/10.1124/dmd.111.041798
Henderson, Colin J.
- You have accessEffect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null MiceVolker M. Arlt, Rajinder Singh, Marie Stiborová, Gonçalo Gamboa da Costa, Eva Frei, James D. Evans, Peter B. Farmer, C. Roland Wolf, Colin J. Henderson and David H. PhillipsDrug Metabolism and Disposition December 2011, 39 (12) 2169-2173; DOI: https://doi.org/10.1124/dmd.111.041343
Hilgendorf, Constanze
- You have accessDevelopment of a Highly Sensitive Method Using Liquid Chromatography-Multiple Reaction Monitoring to Quantify Membrane P-Glycoprotein in Biological Matrices and Relationship to Transport FunctionTasso Miliotis, Liaqat Ali, Johan E. Palm, Anders J. Lundqvist, Martin Ahnoff, Tommy B. Andersson and Constanze HilgendorfDrug Metabolism and Disposition December 2011, 39 (12) 2440-2449; DOI: https://doi.org/10.1124/dmd.111.040774
Hiratsuka, Akira
- You have accessInvolvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of TroglitazoneRan Okada, Kazuya Maeda, Takahito Nishiyama, Shinsuke Aoyama, Zenzaburo Tozuka, Akira Hiratsuka, Toshihiko Ikeda, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2290-2297; DOI: https://doi.org/10.1124/dmd.111.040469
Hisaka, Akihiro
- You have accessAnalysis and Prediction of Drug Transfer into Human Milk Taking into Consideration Secretion and Reuptake Clearances across the Mammary EpitheliaHiroki Koshimichi, Kousei Ito, Akihiro Hisaka, Masashi Honma and Hiroshi SuzukiDrug Metabolism and Disposition December 2011, 39 (12) 2370-2380; DOI: https://doi.org/10.1124/dmd.111.040972
Hollenberg, Paul F.
- You have accessThr302 Is the Site for the Covalent Modification of Human Cytochrome P450 2B6 Leading to Mechanism-Based Inactivation by tert-ButylphenylacetyleneHsia-lien Lin, Haoming Zhang, Matthew J. Pratt-Hyatt and Paul F. HollenbergDrug Metabolism and Disposition December 2011, 39 (12) 2431-2439; DOI: https://doi.org/10.1124/dmd.111.042176
Honma, Masashi
- You have accessAnalysis and Prediction of Drug Transfer into Human Milk Taking into Consideration Secretion and Reuptake Clearances across the Mammary EpitheliaHiroki Koshimichi, Kousei Ito, Akihiro Hisaka, Masashi Honma and Hiroshi SuzukiDrug Metabolism and Disposition December 2011, 39 (12) 2370-2380; DOI: https://doi.org/10.1124/dmd.111.040972
Houghton, Jessica S.
- You have accessEffect of Culture Time on the Basal Expression Levels of Drug Transporters in Sandwich-Cultured Primary Rat HepatocytesEskouhie H. Tchaparian, Jessica S. Houghton, Craig Uyeda, Mark P. Grillo and Lixia JinDrug Metabolism and Disposition December 2011, 39 (12) 2387-2394; DOI: https://doi.org/10.1124/dmd.111.039545
Hu, Yongjun
- You have accessEffect of Dose Escalation on the In Vivo Oral Absorption and Disposition of Glycylsarcosine in Wild-Type and Pept1 Knockout MiceDilara Jappar, Yongjun Hu and David E. SmithDrug Metabolism and Disposition December 2011, 39 (12) 2250-2257; DOI: https://doi.org/10.1124/dmd.111.041087
Hurley, J.
- You have accessStudies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of GemfibrozilS. M. Jenkins, T. Zvyaga, S. R. Johnson, J. Hurley, A. Wagner, R. Burrell, W. Turley, J. E. Leet, T. Philip and A. D. RodriguesDrug Metabolism and Disposition December 2011, 39 (12) 2421-2430; DOI: https://doi.org/10.1124/dmd.111.041947
Hyvönen, Mervi T.
- You have accessComplex N-Acetylation of TriethylenetetramineMarc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen and Tuomo A. KeinänenDrug Metabolism and Disposition December 2011, 39 (12) 2242-2249; DOI: https://doi.org/10.1124/dmd.111.041798
I
Ikeda, Toshihiko
- You have accessInvolvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of TroglitazoneRan Okada, Kazuya Maeda, Takahito Nishiyama, Shinsuke Aoyama, Zenzaburo Tozuka, Akira Hiratsuka, Toshihiko Ikeda, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2290-2297; DOI: https://doi.org/10.1124/dmd.111.040469
Imming, Peter
- You have accessCYP2C19 Progress Curve Analysis and Mechanism-Based Inactivation by Three Methylenedioxyphenyl CompoundsKaisa A. Salminen, Achim Meyer, Peter Imming and Hannu RaunioDrug Metabolism and Disposition December 2011, 39 (12) 2283-2289; DOI: https://doi.org/10.1124/dmd.111.041319
Ito, Kousei
- You have accessAnalysis and Prediction of Drug Transfer into Human Milk Taking into Consideration Secretion and Reuptake Clearances across the Mammary EpitheliaHiroki Koshimichi, Kousei Ito, Akihiro Hisaka, Masashi Honma and Hiroshi SuzukiDrug Metabolism and Disposition December 2011, 39 (12) 2370-2380; DOI: https://doi.org/10.1124/dmd.111.040972
Iwai, Megumi
- You have accessUtility of P-Glycoprotein and Organic Cation Transporter 1 Double-Transfected LLC-PK1 Cells for Studying the Interaction of YM155 Monobromide, Novel Small-Molecule Survivin Suppressant, with P-GlycoproteinMegumi Iwai, Tsuyoshi Minematsu, Qun Li, Takafumi Iwatsubo and Takashi UsuiDrug Metabolism and Disposition December 2011, 39 (12) 2314-2320; DOI: https://doi.org/10.1124/dmd.111.040733
Iwatsubo, Takafumi
- You have accessUtility of P-Glycoprotein and Organic Cation Transporter 1 Double-Transfected LLC-PK1 Cells for Studying the Interaction of YM155 Monobromide, Novel Small-Molecule Survivin Suppressant, with P-GlycoproteinMegumi Iwai, Tsuyoshi Minematsu, Qun Li, Takafumi Iwatsubo and Takashi UsuiDrug Metabolism and Disposition December 2011, 39 (12) 2314-2320; DOI: https://doi.org/10.1124/dmd.111.040733
J
Jappar, Dilara
- You have accessEffect of Dose Escalation on the In Vivo Oral Absorption and Disposition of Glycylsarcosine in Wild-Type and Pept1 Knockout MiceDilara Jappar, Yongjun Hu and David E. SmithDrug Metabolism and Disposition December 2011, 39 (12) 2250-2257; DOI: https://doi.org/10.1124/dmd.111.041087
Jayaraman, Ramesh
- You have accessPreclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human PharmacokineticsRamesh Jayaraman, Venkatesh Pilla Reddy, Mohammed Khalid Pasha, Haishan Wang, Kanda Sangthongpitag, Pauline Yeo, Chang Yong Hu, Xiaofeng Wu, Liu Xin, Evelyn Goh, Lee Sun New and Kantharaj EthirajuluDrug Metabolism and Disposition December 2011, 39 (12) 2219-2232; DOI: https://doi.org/10.1124/dmd.111.041558
Jenkins, S. M.
- You have accessStudies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of GemfibrozilS. M. Jenkins, T. Zvyaga, S. R. Johnson, J. Hurley, A. Wagner, R. Burrell, W. Turley, J. E. Leet, T. Philip and A. D. RodriguesDrug Metabolism and Disposition December 2011, 39 (12) 2421-2430; DOI: https://doi.org/10.1124/dmd.111.041947
Jin, Lixia
- You have accessEffect of Culture Time on the Basal Expression Levels of Drug Transporters in Sandwich-Cultured Primary Rat HepatocytesEskouhie H. Tchaparian, Jessica S. Houghton, Craig Uyeda, Mark P. Grillo and Lixia JinDrug Metabolism and Disposition December 2011, 39 (12) 2387-2394; DOI: https://doi.org/10.1124/dmd.111.039545
Johnson, S. R.
- You have accessStudies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of GemfibrozilS. M. Jenkins, T. Zvyaga, S. R. Johnson, J. Hurley, A. Wagner, R. Burrell, W. Turley, J. E. Leet, T. Philip and A. D. RodriguesDrug Metabolism and Disposition December 2011, 39 (12) 2421-2430; DOI: https://doi.org/10.1124/dmd.111.041947
Jones, Jeffrey P.
- You have accessInhibition of Human Liver Aldehyde Oxidase: Implications for Potential Drug-Drug InteractionsJohn T. Barr and Jeffrey P. JonesDrug Metabolism and Disposition December 2011, 39 (12) 2381-2386; DOI: https://doi.org/10.1124/dmd.111.041806
- You have accessSmall Molecule Quantification by Liquid Chromatography-Mass Spectrometry for Metabolites of Drugs and Drug CandidatesUpendra P. Dahal, Jeffrey P. Jones, John A. Davis and Dan A. RockDrug Metabolism and Disposition December 2011, 39 (12) 2355-2360; DOI: https://doi.org/10.1124/dmd.111.040865
Juhl, Martin
- You have accessBiosynthesis and Identification of an N-Oxide/N-Glucuronide Metabolite and First Synthesis of an N-O-Glucuronide Metabolite of Lu AA21004Henriette Kold Uldam, Martin Juhl, Henrik Pedersen and Lars DalgaardDrug Metabolism and Disposition December 2011, 39 (12) 2264-2274; DOI: https://doi.org/10.1124/dmd.111.040428
K
Keinänen, Tuomo A.
- You have accessComplex N-Acetylation of TriethylenetetramineMarc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen and Tuomo A. KeinänenDrug Metabolism and Disposition December 2011, 39 (12) 2242-2249; DOI: https://doi.org/10.1124/dmd.111.041798
Khalid Pasha, Mohammed
- You have accessPreclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human PharmacokineticsRamesh Jayaraman, Venkatesh Pilla Reddy, Mohammed Khalid Pasha, Haishan Wang, Kanda Sangthongpitag, Pauline Yeo, Chang Yong Hu, Xiaofeng Wu, Liu Xin, Evelyn Goh, Lee Sun New and Kantharaj EthirajuluDrug Metabolism and Disposition December 2011, 39 (12) 2219-2232; DOI: https://doi.org/10.1124/dmd.111.041558
Kharasch, Evan D.
- You have accessComplex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or NelfinavirBrian J. Kirby, Ann C. Collier, Evan D. Kharasch, Vaishali Dixit, Pankaj Desai, Dale Whittington, Kenneth E. Thummel and Jashvant D. UnadkatDrug Metabolism and Disposition December 2011, 39 (12) 2329-2337; DOI: https://doi.org/10.1124/dmd.111.038646
Kirby, Brian J.
- You have accessComplex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or NelfinavirBrian J. Kirby, Ann C. Collier, Evan D. Kharasch, Vaishali Dixit, Pankaj Desai, Dale Whittington, Kenneth E. Thummel and Jashvant D. UnadkatDrug Metabolism and Disposition December 2011, 39 (12) 2329-2337; DOI: https://doi.org/10.1124/dmd.111.038646
Kitamura, Yoshiaki
- You have accessHepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4Alison J. Wilby, Kazuya Maeda, Paul F. Courtney, Yasuyuki Debori, Peter J. H. Webborn, Yoshiaki Kitamura, Hiroyuki Kusuhara, Rob J. Riley and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2361-2369; DOI: https://doi.org/10.1124/dmd.111.041814
Klaubert, Dieter H.
- You have accessProluciferin Acetals as Bioluminogenic Substrates for Cytochrome P450 Activity and Probes for CYP3A InhibitionPoncho L. Meisenheimer, H. Tetsuo Uyeda, Dongping Ma, Mary Sobol, Mark G. McDougall, Cesear Corona, Dan Simpson, Dieter H. Klaubert and James J. CaliDrug Metabolism and Disposition December 2011, 39 (12) 2403-2410; DOI: https://doi.org/10.1124/dmd.111.041541
Kochanek, Patrick M.
- You have accessCardiac Arrest and Therapeutic Hypothermia Decrease Isoform-Specific Cytochrome P450 Drug MetabolismJiangquan Zhou, Philip E. Empey, Robert R. Bies, Patrick M. Kochanek and Samuel M. PoloyacDrug Metabolism and Disposition December 2011, 39 (12) 2209-2218; DOI: https://doi.org/10.1124/dmd.111.040642
Koshimichi, Hiroki
- You have accessAnalysis and Prediction of Drug Transfer into Human Milk Taking into Consideration Secretion and Reuptake Clearances across the Mammary EpitheliaHiroki Koshimichi, Kousei Ito, Akihiro Hisaka, Masashi Honma and Hiroshi SuzukiDrug Metabolism and Disposition December 2011, 39 (12) 2370-2380; DOI: https://doi.org/10.1124/dmd.111.040972
Kusuhara, Hiroyuki
- You have accessHepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4Alison J. Wilby, Kazuya Maeda, Paul F. Courtney, Yasuyuki Debori, Peter J. H. Webborn, Yoshiaki Kitamura, Hiroyuki Kusuhara, Rob J. Riley and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2361-2369; DOI: https://doi.org/10.1124/dmd.111.041814
- You have accessInvolvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of TroglitazoneRan Okada, Kazuya Maeda, Takahito Nishiyama, Shinsuke Aoyama, Zenzaburo Tozuka, Akira Hiratsuka, Toshihiko Ikeda, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2290-2297; DOI: https://doi.org/10.1124/dmd.111.040469
L
Le, X. Chris
- You have accessMonomethylarsenic Diglutathione Transport by the Human Multidrug Resistance Protein 1 (MRP1/ABCC1)Michael W. Carew, Hua Naranmandura, Caley B. Shukalek, X. Chris Le and Elaine M. LeslieDrug Metabolism and Disposition December 2011, 39 (12) 2298-2304; DOI: https://doi.org/10.1124/dmd.111.041673
Leet, J. E.
- You have accessStudies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of GemfibrozilS. M. Jenkins, T. Zvyaga, S. R. Johnson, J. Hurley, A. Wagner, R. Burrell, W. Turley, J. E. Leet, T. Philip and A. D. RodriguesDrug Metabolism and Disposition December 2011, 39 (12) 2421-2430; DOI: https://doi.org/10.1124/dmd.111.041947
Leslie, Elaine M.
- You have accessMonomethylarsenic Diglutathione Transport by the Human Multidrug Resistance Protein 1 (MRP1/ABCC1)Michael W. Carew, Hua Naranmandura, Caley B. Shukalek, X. Chris Le and Elaine M. LeslieDrug Metabolism and Disposition December 2011, 39 (12) 2298-2304; DOI: https://doi.org/10.1124/dmd.111.041673
Li, Qun
- You have accessUtility of P-Glycoprotein and Organic Cation Transporter 1 Double-Transfected LLC-PK1 Cells for Studying the Interaction of YM155 Monobromide, Novel Small-Molecule Survivin Suppressant, with P-GlycoproteinMegumi Iwai, Tsuyoshi Minematsu, Qun Li, Takafumi Iwatsubo and Takashi UsuiDrug Metabolism and Disposition December 2011, 39 (12) 2314-2320; DOI: https://doi.org/10.1124/dmd.111.040733
Lin, Hsia-lien
- You have accessThr302 Is the Site for the Covalent Modification of Human Cytochrome P450 2B6 Leading to Mechanism-Based Inactivation by tert-ButylphenylacetyleneHsia-lien Lin, Haoming Zhang, Matthew J. Pratt-Hyatt and Paul F. HollenbergDrug Metabolism and Disposition December 2011, 39 (12) 2431-2439; DOI: https://doi.org/10.1124/dmd.111.042176
Lowinger, Jennifer J.
- You have accessCharacterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and HumanEric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. PerkinsDrug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
Lundqvist, Anders J.
- You have accessDevelopment of a Highly Sensitive Method Using Liquid Chromatography-Multiple Reaction Monitoring to Quantify Membrane P-Glycoprotein in Biological Matrices and Relationship to Transport FunctionTasso Miliotis, Liaqat Ali, Johan E. Palm, Anders J. Lundqvist, Martin Ahnoff, Tommy B. Andersson and Constanze HilgendorfDrug Metabolism and Disposition December 2011, 39 (12) 2440-2449; DOI: https://doi.org/10.1124/dmd.111.040774
M
Ma, Dongping
- You have accessProluciferin Acetals as Bioluminogenic Substrates for Cytochrome P450 Activity and Probes for CYP3A InhibitionPoncho L. Meisenheimer, H. Tetsuo Uyeda, Dongping Ma, Mary Sobol, Mark G. McDougall, Cesear Corona, Dan Simpson, Dieter H. Klaubert and James J. CaliDrug Metabolism and Disposition December 2011, 39 (12) 2403-2410; DOI: https://doi.org/10.1124/dmd.111.041541
Maeda, Kazuya
- You have accessHepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4Alison J. Wilby, Kazuya Maeda, Paul F. Courtney, Yasuyuki Debori, Peter J. H. Webborn, Yoshiaki Kitamura, Hiroyuki Kusuhara, Rob J. Riley and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2361-2369; DOI: https://doi.org/10.1124/dmd.111.041814
- You have accessInvolvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of TroglitazoneRan Okada, Kazuya Maeda, Takahito Nishiyama, Shinsuke Aoyama, Zenzaburo Tozuka, Akira Hiratsuka, Toshihiko Ikeda, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2290-2297; DOI: https://doi.org/10.1124/dmd.111.040469
McDougall, Mark G.
- You have accessProluciferin Acetals as Bioluminogenic Substrates for Cytochrome P450 Activity and Probes for CYP3A InhibitionPoncho L. Meisenheimer, H. Tetsuo Uyeda, Dongping Ma, Mary Sobol, Mark G. McDougall, Cesear Corona, Dan Simpson, Dieter H. Klaubert and James J. CaliDrug Metabolism and Disposition December 2011, 39 (12) 2403-2410; DOI: https://doi.org/10.1124/dmd.111.041541
Meisenheimer, Poncho L.
- You have accessProluciferin Acetals as Bioluminogenic Substrates for Cytochrome P450 Activity and Probes for CYP3A InhibitionPoncho L. Meisenheimer, H. Tetsuo Uyeda, Dongping Ma, Mary Sobol, Mark G. McDougall, Cesear Corona, Dan Simpson, Dieter H. Klaubert and James J. CaliDrug Metabolism and Disposition December 2011, 39 (12) 2403-2410; DOI: https://doi.org/10.1124/dmd.111.041541
Meyer, Achim
- You have accessCYP2C19 Progress Curve Analysis and Mechanism-Based Inactivation by Three Methylenedioxyphenyl CompoundsKaisa A. Salminen, Achim Meyer, Peter Imming and Hannu RaunioDrug Metabolism and Disposition December 2011, 39 (12) 2283-2289; DOI: https://doi.org/10.1124/dmd.111.041319
Meyers, Catherine M.
- You have accessDifferences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis CSarah J. Schrieber, Roy L. Hawke, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Catherine M. Meyers, Edward Doo and Michael. W. FriedDrug Metabolism and Disposition December 2011, 39 (12) 2182-2190; DOI: https://doi.org/10.1124/dmd.111.040212
Miao, Zhuang
- You have accessExcretion, Metabolism, and Pharmacokinetics of CP-945,598, a Selective Cannabinoid Receptor Antagonist, in Rats, Mice, and DogsZhuang Miao, Dennis O. Scott, David A. Griffith, Robert Day and Chandra PrakashDrug Metabolism and Disposition December 2011, 39 (12) 2191-2208; DOI: https://doi.org/10.1124/dmd.111.040360
Miksys, S.
- You have accessIndependent and Combined Effects of Ethanol Self-Administration and Nicotine Treatment on Hepatic CYP2E1 in African Green MonkeysC. S. Ferguson, S. Miksys, R. Palmour and R. F. TyndaleDrug Metabolism and Disposition December 2011, 39 (12) 2233-2241; DOI: https://doi.org/10.1124/dmd.111.040378
Miliotis, Tasso
- You have accessDevelopment of a Highly Sensitive Method Using Liquid Chromatography-Multiple Reaction Monitoring to Quantify Membrane P-Glycoprotein in Biological Matrices and Relationship to Transport FunctionTasso Miliotis, Liaqat Ali, Johan E. Palm, Anders J. Lundqvist, Martin Ahnoff, Tommy B. Andersson and Constanze HilgendorfDrug Metabolism and Disposition December 2011, 39 (12) 2440-2449; DOI: https://doi.org/10.1124/dmd.111.040774
Milne, Alison M.
- You have accessA Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human TissueAlison M. Milne, Brian Burchell and Michael W. H. CoughtrieDrug Metabolism and Disposition December 2011, 39 (12) 2258-2263; DOI: https://doi.org/10.1124/dmd.111.041699
Minematsu, Tsuyoshi
- You have accessUtility of P-Glycoprotein and Organic Cation Transporter 1 Double-Transfected LLC-PK1 Cells for Studying the Interaction of YM155 Monobromide, Novel Small-Molecule Survivin Suppressant, with P-GlycoproteinMegumi Iwai, Tsuyoshi Minematsu, Qun Li, Takafumi Iwatsubo and Takashi UsuiDrug Metabolism and Disposition December 2011, 39 (12) 2314-2320; DOI: https://doi.org/10.1124/dmd.111.040733
Mrhar, Aleš
- You have accessRaloxifene Glucuronidation in Human Intestine, Kidney, and Liver Microsomes and in Human Liver Microsomes Genotyped for the UGT1A1*28 PolymorphismTina Trdan Lušin, Jurij Trontelj and Aleš MrharDrug Metabolism and Disposition December 2011, 39 (12) 2347-2354; DOI: https://doi.org/10.1124/dmd.111.041897
N
Naranmandura, Hua
- You have accessMonomethylarsenic Diglutathione Transport by the Human Multidrug Resistance Protein 1 (MRP1/ABCC1)Michael W. Carew, Hua Naranmandura, Caley B. Shukalek, X. Chris Le and Elaine M. LeslieDrug Metabolism and Disposition December 2011, 39 (12) 2298-2304; DOI: https://doi.org/10.1124/dmd.111.041673
Navarro, Victor J.
- You have accessDifferences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis CSarah J. Schrieber, Roy L. Hawke, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Catherine M. Meyers, Edward Doo and Michael. W. FriedDrug Metabolism and Disposition December 2011, 39 (12) 2182-2190; DOI: https://doi.org/10.1124/dmd.111.040212
Nishiyama, Takahito
- You have accessInvolvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of TroglitazoneRan Okada, Kazuya Maeda, Takahito Nishiyama, Shinsuke Aoyama, Zenzaburo Tozuka, Akira Hiratsuka, Toshihiko Ikeda, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2290-2297; DOI: https://doi.org/10.1124/dmd.111.040469
O
O'Reilly, D. A.
- You have accessIntestinal Ciprofloxacin Efflux: The Role of Breast Cancer Resistance Protein (ABCG2)I. S. Haslam, J. A. Wright, D. A. O'Reilly, D. J. Sherlock, T. Coleman and N. L. SimmonsDrug Metabolism and Disposition December 2011, 39 (12) 2321-2328; DOI: https://doi.org/10.1124/dmd.111.038323
Okada, Ran
- You have accessInvolvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of TroglitazoneRan Okada, Kazuya Maeda, Takahito Nishiyama, Shinsuke Aoyama, Zenzaburo Tozuka, Akira Hiratsuka, Toshihiko Ikeda, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2290-2297; DOI: https://doi.org/10.1124/dmd.111.040469
P
Palm, Johan E.
- You have accessDevelopment of a Highly Sensitive Method Using Liquid Chromatography-Multiple Reaction Monitoring to Quantify Membrane P-Glycoprotein in Biological Matrices and Relationship to Transport FunctionTasso Miliotis, Liaqat Ali, Johan E. Palm, Anders J. Lundqvist, Martin Ahnoff, Tommy B. Andersson and Constanze HilgendorfDrug Metabolism and Disposition December 2011, 39 (12) 2440-2449; DOI: https://doi.org/10.1124/dmd.111.040774
Palmour, R.
- You have accessIndependent and Combined Effects of Ethanol Self-Administration and Nicotine Treatment on Hepatic CYP2E1 in African Green MonkeysC. S. Ferguson, S. Miksys, R. Palmour and R. F. TyndaleDrug Metabolism and Disposition December 2011, 39 (12) 2233-2241; DOI: https://doi.org/10.1124/dmd.111.040378
Pedersen, Henrik
- You have accessBiosynthesis and Identification of an N-Oxide/N-Glucuronide Metabolite and First Synthesis of an N-O-Glucuronide Metabolite of Lu AA21004Henriette Kold Uldam, Martin Juhl, Henrik Pedersen and Lars DalgaardDrug Metabolism and Disposition December 2011, 39 (12) 2264-2274; DOI: https://doi.org/10.1124/dmd.111.040428
Perkins, Everett J.
- You have accessCharacterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and HumanEric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. PerkinsDrug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
Philip, T.
- You have accessStudies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of GemfibrozilS. M. Jenkins, T. Zvyaga, S. R. Johnson, J. Hurley, A. Wagner, R. Burrell, W. Turley, J. E. Leet, T. Philip and A. D. RodriguesDrug Metabolism and Disposition December 2011, 39 (12) 2421-2430; DOI: https://doi.org/10.1124/dmd.111.041947
Phillips, David H.
- You have accessEffect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null MiceVolker M. Arlt, Rajinder Singh, Marie Stiborová, Gonçalo Gamboa da Costa, Eva Frei, James D. Evans, Peter B. Farmer, C. Roland Wolf, Colin J. Henderson and David H. PhillipsDrug Metabolism and Disposition December 2011, 39 (12) 2169-2173; DOI: https://doi.org/10.1124/dmd.111.041343
Pilla Reddy, Venkatesh
- You have accessPreclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human PharmacokineticsRamesh Jayaraman, Venkatesh Pilla Reddy, Mohammed Khalid Pasha, Haishan Wang, Kanda Sangthongpitag, Pauline Yeo, Chang Yong Hu, Xiaofeng Wu, Liu Xin, Evelyn Goh, Lee Sun New and Kantharaj EthirajuluDrug Metabolism and Disposition December 2011, 39 (12) 2219-2232; DOI: https://doi.org/10.1124/dmd.111.041558
Ploeger, Bart A.
- You have accessSystemic and Direct Nose-to-Brain Transport Pharmacokinetic Model for Remoxipride after Intravenous and Intranasal AdministrationJasper Stevens, Bart A. Ploeger, Piet H. van der Graaf, Meindert Danhof and Elizabeth C. M. de LangeDrug Metabolism and Disposition December 2011, 39 (12) 2275-2282; DOI: https://doi.org/10.1124/dmd.111.040782
Poloyac, Samuel M.
- You have accessCardiac Arrest and Therapeutic Hypothermia Decrease Isoform-Specific Cytochrome P450 Drug MetabolismJiangquan Zhou, Philip E. Empey, Robert R. Bies, Patrick M. Kochanek and Samuel M. PoloyacDrug Metabolism and Disposition December 2011, 39 (12) 2209-2218; DOI: https://doi.org/10.1124/dmd.111.040642
Poquet, Laure
- You have accessAbsorption and Metabolism of Chlorogenic Acids in Cultured Gastric Epithelial MonolayersTracy L. Farrell, Tristan P. Dew, Laure Poquet, Peter Hanson and Gary WilliamsonDrug Metabolism and Disposition December 2011, 39 (12) 2338-2346; DOI: https://doi.org/10.1124/dmd.111.040147
Prakash, Chandra
- You have accessExcretion, Metabolism, and Pharmacokinetics of CP-945,598, a Selective Cannabinoid Receptor Antagonist, in Rats, Mice, and DogsZhuang Miao, Dennis O. Scott, David A. Griffith, Robert Day and Chandra PrakashDrug Metabolism and Disposition December 2011, 39 (12) 2191-2208; DOI: https://doi.org/10.1124/dmd.111.040360
Pratt-Hyatt, Matthew J.
- You have accessThr302 Is the Site for the Covalent Modification of Human Cytochrome P450 2B6 Leading to Mechanism-Based Inactivation by tert-ButylphenylacetyleneHsia-lien Lin, Haoming Zhang, Matthew J. Pratt-Hyatt and Paul F. HollenbergDrug Metabolism and Disposition December 2011, 39 (12) 2431-2439; DOI: https://doi.org/10.1124/dmd.111.042176
Q
Qian, Yue-Wei
- You have accessCharacterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and HumanEric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. PerkinsDrug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
R
Raunio, Hannu
- You have accessCYP2C19 Progress Curve Analysis and Mechanism-Based Inactivation by Three Methylenedioxyphenyl CompoundsKaisa A. Salminen, Achim Meyer, Peter Imming and Hannu RaunioDrug Metabolism and Disposition December 2011, 39 (12) 2283-2289; DOI: https://doi.org/10.1124/dmd.111.041319
Rea, Vanina
- You have accessRole of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH ConjugatesVanina Rea, Sanja Dragovic, Jan Simon Boerma, Frans J. J. de Kanter, Nico P. E. Vermeulen and Jan N. M. CommandeurDrug Metabolism and Disposition December 2011, 39 (12) 2411-2420; DOI: https://doi.org/10.1124/dmd.111.041046
Reddy, K. Rajender
- You have accessDifferences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis CSarah J. Schrieber, Roy L. Hawke, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Catherine M. Meyers, Edward Doo and Michael. W. FriedDrug Metabolism and Disposition December 2011, 39 (12) 2182-2190; DOI: https://doi.org/10.1124/dmd.111.040212
Riley, Rob J.
- You have accessHepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4Alison J. Wilby, Kazuya Maeda, Paul F. Courtney, Yasuyuki Debori, Peter J. H. Webborn, Yoshiaki Kitamura, Hiroyuki Kusuhara, Rob J. Riley and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2361-2369; DOI: https://doi.org/10.1124/dmd.111.041814
Rock, Dan A.
- You have accessSmall Molecule Quantification by Liquid Chromatography-Mass Spectrometry for Metabolites of Drugs and Drug CandidatesUpendra P. Dahal, Jeffrey P. Jones, John A. Davis and Dan A. RockDrug Metabolism and Disposition December 2011, 39 (12) 2355-2360; DOI: https://doi.org/10.1124/dmd.111.040865
Rodrigues, A. D.
- You have accessStudies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of GemfibrozilS. M. Jenkins, T. Zvyaga, S. R. Johnson, J. Hurley, A. Wagner, R. Burrell, W. Turley, J. E. Leet, T. Philip and A. D. RodriguesDrug Metabolism and Disposition December 2011, 39 (12) 2421-2430; DOI: https://doi.org/10.1124/dmd.111.041947
Rowland, Malcolm
- You have accessCorrection for Nonspecific Binding to Various Components of Ultrafiltration Apparatus and Impact on Estimating In Vivo Rat Clearance for a Congeneric Series of 5-Ethyl, 5-n-Alkyl Barbituric AcidsPeter Ballard and Malcolm RowlandDrug Metabolism and Disposition December 2011, 39 (12) 2165-2168; DOI: https://doi.org/10.1124/dmd.111.040683
Ruterbories, Kenneth J.
- You have accessCharacterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and HumanEric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. PerkinsDrug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
S
Salminen, Kaisa A.
- You have accessCYP2C19 Progress Curve Analysis and Mechanism-Based Inactivation by Three Methylenedioxyphenyl CompoundsKaisa A. Salminen, Achim Meyer, Peter Imming and Hannu RaunioDrug Metabolism and Disposition December 2011, 39 (12) 2283-2289; DOI: https://doi.org/10.1124/dmd.111.041319
Sangthongpitag, Kanda
- You have accessPreclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human PharmacokineticsRamesh Jayaraman, Venkatesh Pilla Reddy, Mohammed Khalid Pasha, Haishan Wang, Kanda Sangthongpitag, Pauline Yeo, Chang Yong Hu, Xiaofeng Wu, Liu Xin, Evelyn Goh, Lee Sun New and Kantharaj EthirajuluDrug Metabolism and Disposition December 2011, 39 (12) 2219-2232; DOI: https://doi.org/10.1124/dmd.111.041558
Scheffer, George L.
- You have accessVariations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver DiseaseRhiannon N. Hardwick, Craig D. Fisher, Mark J. Canet, George L. Scheffer and Nathan J. CherringtonDrug Metabolism and Disposition December 2011, 39 (12) 2395-2402; DOI: https://doi.org/10.1124/dmd.111.041012
Schmitt, Ellen I.
- You have accessProduction of Ibuprofen Acyl Glucosides by Human UGT2B7Daniela Buchheit, Călin-Aurel Drăgan, Ellen I. Schmitt and Matthias BureikDrug Metabolism and Disposition December 2011, 39 (12) 2174-2181; DOI: https://doi.org/10.1124/dmd.111.041640
Schrieber, Sarah J.
- You have accessDifferences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis CSarah J. Schrieber, Roy L. Hawke, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Catherine M. Meyers, Edward Doo and Michael. W. FriedDrug Metabolism and Disposition December 2011, 39 (12) 2182-2190; DOI: https://doi.org/10.1124/dmd.111.040212
Scott, Dennis O.
- You have accessExcretion, Metabolism, and Pharmacokinetics of CP-945,598, a Selective Cannabinoid Receptor Antagonist, in Rats, Mice, and DogsZhuang Miao, Dennis O. Scott, David A. Griffith, Robert Day and Chandra PrakashDrug Metabolism and Disposition December 2011, 39 (12) 2191-2208; DOI: https://doi.org/10.1124/dmd.111.040360
Sherlock, D. J.
- You have accessIntestinal Ciprofloxacin Efflux: The Role of Breast Cancer Resistance Protein (ABCG2)I. S. Haslam, J. A. Wright, D. A. O'Reilly, D. J. Sherlock, T. Coleman and N. L. SimmonsDrug Metabolism and Disposition December 2011, 39 (12) 2321-2328; DOI: https://doi.org/10.1124/dmd.111.038323
Shukalek, Caley B.
- You have accessMonomethylarsenic Diglutathione Transport by the Human Multidrug Resistance Protein 1 (MRP1/ABCC1)Michael W. Carew, Hua Naranmandura, Caley B. Shukalek, X. Chris Le and Elaine M. LeslieDrug Metabolism and Disposition December 2011, 39 (12) 2298-2304; DOI: https://doi.org/10.1124/dmd.111.041673
Simmons, N. L.
- You have accessIntestinal Ciprofloxacin Efflux: The Role of Breast Cancer Resistance Protein (ABCG2)I. S. Haslam, J. A. Wright, D. A. O'Reilly, D. J. Sherlock, T. Coleman and N. L. SimmonsDrug Metabolism and Disposition December 2011, 39 (12) 2321-2328; DOI: https://doi.org/10.1124/dmd.111.038323
Simpson, Dan
- You have accessProluciferin Acetals as Bioluminogenic Substrates for Cytochrome P450 Activity and Probes for CYP3A InhibitionPoncho L. Meisenheimer, H. Tetsuo Uyeda, Dongping Ma, Mary Sobol, Mark G. McDougall, Cesear Corona, Dan Simpson, Dieter H. Klaubert and James J. CaliDrug Metabolism and Disposition December 2011, 39 (12) 2403-2410; DOI: https://doi.org/10.1124/dmd.111.041541
Singh, Rajinder
- You have accessEffect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null MiceVolker M. Arlt, Rajinder Singh, Marie Stiborová, Gonçalo Gamboa da Costa, Eva Frei, James D. Evans, Peter B. Farmer, C. Roland Wolf, Colin J. Henderson and David H. PhillipsDrug Metabolism and Disposition December 2011, 39 (12) 2169-2173; DOI: https://doi.org/10.1124/dmd.111.041343
Smith, David E.
- You have accessEffect of Dose Escalation on the In Vivo Oral Absorption and Disposition of Glycylsarcosine in Wild-Type and Pept1 Knockout MiceDilara Jappar, Yongjun Hu and David E. SmithDrug Metabolism and Disposition December 2011, 39 (12) 2250-2257; DOI: https://doi.org/10.1124/dmd.111.041087
Smith, Philip C.
- You have accessDifferences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis CSarah J. Schrieber, Roy L. Hawke, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Catherine M. Meyers, Edward Doo and Michael. W. FriedDrug Metabolism and Disposition December 2011, 39 (12) 2182-2190; DOI: https://doi.org/10.1124/dmd.111.040212
Sobol, Mary
- You have accessProluciferin Acetals as Bioluminogenic Substrates for Cytochrome P450 Activity and Probes for CYP3A InhibitionPoncho L. Meisenheimer, H. Tetsuo Uyeda, Dongping Ma, Mary Sobol, Mark G. McDougall, Cesear Corona, Dan Simpson, Dieter H. Klaubert and James J. CaliDrug Metabolism and Disposition December 2011, 39 (12) 2403-2410; DOI: https://doi.org/10.1124/dmd.111.041541
Stevens, Jasper
- You have accessSystemic and Direct Nose-to-Brain Transport Pharmacokinetic Model for Remoxipride after Intravenous and Intranasal AdministrationJasper Stevens, Bart A. Ploeger, Piet H. van der Graaf, Meindert Danhof and Elizabeth C. M. de LangeDrug Metabolism and Disposition December 2011, 39 (12) 2275-2282; DOI: https://doi.org/10.1124/dmd.111.040782
Stiborová, Marie
- You have accessEffect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null MiceVolker M. Arlt, Rajinder Singh, Marie Stiborová, Gonçalo Gamboa da Costa, Eva Frei, James D. Evans, Peter B. Farmer, C. Roland Wolf, Colin J. Henderson and David H. PhillipsDrug Metabolism and Disposition December 2011, 39 (12) 2169-2173; DOI: https://doi.org/10.1124/dmd.111.041343
Sugiyama, Yuichi
- You have accessHepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4Alison J. Wilby, Kazuya Maeda, Paul F. Courtney, Yasuyuki Debori, Peter J. H. Webborn, Yoshiaki Kitamura, Hiroyuki Kusuhara, Rob J. Riley and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2361-2369; DOI: https://doi.org/10.1124/dmd.111.041814
- You have accessInvolvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of TroglitazoneRan Okada, Kazuya Maeda, Takahito Nishiyama, Shinsuke Aoyama, Zenzaburo Tozuka, Akira Hiratsuka, Toshihiko Ikeda, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2290-2297; DOI: https://doi.org/10.1124/dmd.111.040469
Sun New, Lee
- You have accessPreclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human PharmacokineticsRamesh Jayaraman, Venkatesh Pilla Reddy, Mohammed Khalid Pasha, Haishan Wang, Kanda Sangthongpitag, Pauline Yeo, Chang Yong Hu, Xiaofeng Wu, Liu Xin, Evelyn Goh, Lee Sun New and Kantharaj EthirajuluDrug Metabolism and Disposition December 2011, 39 (12) 2219-2232; DOI: https://doi.org/10.1124/dmd.111.041558
Suzuki, Hiroshi
- You have accessAnalysis and Prediction of Drug Transfer into Human Milk Taking into Consideration Secretion and Reuptake Clearances across the Mammary EpitheliaHiroki Koshimichi, Kousei Ito, Akihiro Hisaka, Masashi Honma and Hiroshi SuzukiDrug Metabolism and Disposition December 2011, 39 (12) 2370-2380; DOI: https://doi.org/10.1124/dmd.111.040972
T
Tchaparian, Eskouhie H.
- You have accessEffect of Culture Time on the Basal Expression Levels of Drug Transporters in Sandwich-Cultured Primary Rat HepatocytesEskouhie H. Tchaparian, Jessica S. Houghton, Craig Uyeda, Mark P. Grillo and Lixia JinDrug Metabolism and Disposition December 2011, 39 (12) 2387-2394; DOI: https://doi.org/10.1124/dmd.111.039545
Thummel, Kenneth E.
- You have accessComplex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or NelfinavirBrian J. Kirby, Ann C. Collier, Evan D. Kharasch, Vaishali Dixit, Pankaj Desai, Dale Whittington, Kenneth E. Thummel and Jashvant D. UnadkatDrug Metabolism and Disposition December 2011, 39 (12) 2329-2337; DOI: https://doi.org/10.1124/dmd.111.038646
Tozuka, Zenzaburo
- You have accessInvolvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of TroglitazoneRan Okada, Kazuya Maeda, Takahito Nishiyama, Shinsuke Aoyama, Zenzaburo Tozuka, Akira Hiratsuka, Toshihiko Ikeda, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2290-2297; DOI: https://doi.org/10.1124/dmd.111.040469
Trdan Lušin, Tina
- You have accessRaloxifene Glucuronidation in Human Intestine, Kidney, and Liver Microsomes and in Human Liver Microsomes Genotyped for the UGT1A1*28 PolymorphismTina Trdan Lušin, Jurij Trontelj and Aleš MrharDrug Metabolism and Disposition December 2011, 39 (12) 2347-2354; DOI: https://doi.org/10.1124/dmd.111.041897
Trontelj, Jurij
- You have accessRaloxifene Glucuronidation in Human Intestine, Kidney, and Liver Microsomes and in Human Liver Microsomes Genotyped for the UGT1A1*28 PolymorphismTina Trdan Lušin, Jurij Trontelj and Aleš MrharDrug Metabolism and Disposition December 2011, 39 (12) 2347-2354; DOI: https://doi.org/10.1124/dmd.111.041897
Turley, W.
- You have accessStudies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of GemfibrozilS. M. Jenkins, T. Zvyaga, S. R. Johnson, J. Hurley, A. Wagner, R. Burrell, W. Turley, J. E. Leet, T. Philip and A. D. RodriguesDrug Metabolism and Disposition December 2011, 39 (12) 2421-2430; DOI: https://doi.org/10.1124/dmd.111.041947
Tyndale, R. F.
- You have accessIndependent and Combined Effects of Ethanol Self-Administration and Nicotine Treatment on Hepatic CYP2E1 in African Green MonkeysC. S. Ferguson, S. Miksys, R. Palmour and R. F. TyndaleDrug Metabolism and Disposition December 2011, 39 (12) 2233-2241; DOI: https://doi.org/10.1124/dmd.111.040378
U
Uldam, Henriette Kold
- You have accessBiosynthesis and Identification of an N-Oxide/N-Glucuronide Metabolite and First Synthesis of an N-O-Glucuronide Metabolite of Lu AA21004Henriette Kold Uldam, Martin Juhl, Henrik Pedersen and Lars DalgaardDrug Metabolism and Disposition December 2011, 39 (12) 2264-2274; DOI: https://doi.org/10.1124/dmd.111.040428
Unadkat, Jashvant D.
- You have accessComplex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or NelfinavirBrian J. Kirby, Ann C. Collier, Evan D. Kharasch, Vaishali Dixit, Pankaj Desai, Dale Whittington, Kenneth E. Thummel and Jashvant D. UnadkatDrug Metabolism and Disposition December 2011, 39 (12) 2329-2337; DOI: https://doi.org/10.1124/dmd.111.038646
Usui, Takashi
- You have accessUtility of P-Glycoprotein and Organic Cation Transporter 1 Double-Transfected LLC-PK1 Cells for Studying the Interaction of YM155 Monobromide, Novel Small-Molecule Survivin Suppressant, with P-GlycoproteinMegumi Iwai, Tsuyoshi Minematsu, Qun Li, Takafumi Iwatsubo and Takashi UsuiDrug Metabolism and Disposition December 2011, 39 (12) 2314-2320; DOI: https://doi.org/10.1124/dmd.111.040733
Uyeda, Craig
- You have accessEffect of Culture Time on the Basal Expression Levels of Drug Transporters in Sandwich-Cultured Primary Rat HepatocytesEskouhie H. Tchaparian, Jessica S. Houghton, Craig Uyeda, Mark P. Grillo and Lixia JinDrug Metabolism and Disposition December 2011, 39 (12) 2387-2394; DOI: https://doi.org/10.1124/dmd.111.039545
Uyeda, H. Tetsuo
- You have accessProluciferin Acetals as Bioluminogenic Substrates for Cytochrome P450 Activity and Probes for CYP3A InhibitionPoncho L. Meisenheimer, H. Tetsuo Uyeda, Dongping Ma, Mary Sobol, Mark G. McDougall, Cesear Corona, Dan Simpson, Dieter H. Klaubert and James J. CaliDrug Metabolism and Disposition December 2011, 39 (12) 2403-2410; DOI: https://doi.org/10.1124/dmd.111.041541
V
van der Graaf, Piet H.
- You have accessSystemic and Direct Nose-to-Brain Transport Pharmacokinetic Model for Remoxipride after Intravenous and Intranasal AdministrationJasper Stevens, Bart A. Ploeger, Piet H. van der Graaf, Meindert Danhof and Elizabeth C. M. de LangeDrug Metabolism and Disposition December 2011, 39 (12) 2275-2282; DOI: https://doi.org/10.1124/dmd.111.040782
Vepsäläinen, Jouko
- You have accessComplex N-Acetylation of TriethylenetetramineMarc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen and Tuomo A. KeinänenDrug Metabolism and Disposition December 2011, 39 (12) 2242-2249; DOI: https://doi.org/10.1124/dmd.111.041798
Vermeulen, Nico P. E.
- You have accessRole of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH ConjugatesVanina Rea, Sanja Dragovic, Jan Simon Boerma, Frans J. J. de Kanter, Nico P. E. Vermeulen and Jan N. M. CommandeurDrug Metabolism and Disposition December 2011, 39 (12) 2411-2420; DOI: https://doi.org/10.1124/dmd.111.041046
W
Wagner, A.
- You have accessStudies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of GemfibrozilS. M. Jenkins, T. Zvyaga, S. R. Johnson, J. Hurley, A. Wagner, R. Burrell, W. Turley, J. E. Leet, T. Philip and A. D. RodriguesDrug Metabolism and Disposition December 2011, 39 (12) 2421-2430; DOI: https://doi.org/10.1124/dmd.111.041947
Wahed, Abdus S.
- You have accessDifferences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis CSarah J. Schrieber, Roy L. Hawke, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Catherine M. Meyers, Edward Doo and Michael. W. FriedDrug Metabolism and Disposition December 2011, 39 (12) 2182-2190; DOI: https://doi.org/10.1124/dmd.111.040212
Wang, Haishan
- You have accessPreclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human PharmacokineticsRamesh Jayaraman, Venkatesh Pilla Reddy, Mohammed Khalid Pasha, Haishan Wang, Kanda Sangthongpitag, Pauline Yeo, Chang Yong Hu, Xiaofeng Wu, Liu Xin, Evelyn Goh, Lee Sun New and Kantharaj EthirajuluDrug Metabolism and Disposition December 2011, 39 (12) 2219-2232; DOI: https://doi.org/10.1124/dmd.111.041558
Wang, He
- You have accessCharacterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and HumanEric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. PerkinsDrug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
Wang, Xiliang
- You have accessCharacterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and HumanEric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. PerkinsDrug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
Webborn, Peter J. H.
- You have accessHepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4Alison J. Wilby, Kazuya Maeda, Paul F. Courtney, Yasuyuki Debori, Peter J. H. Webborn, Yoshiaki Kitamura, Hiroyuki Kusuhara, Rob J. Riley and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2361-2369; DOI: https://doi.org/10.1124/dmd.111.041814
Weisell, Janne
- You have accessComplex N-Acetylation of TriethylenetetramineMarc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen and Tuomo A. KeinänenDrug Metabolism and Disposition December 2011, 39 (12) 2242-2249; DOI: https://doi.org/10.1124/dmd.111.041798
Wen, Zhiming
- You have accessDifferences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis CSarah J. Schrieber, Roy L. Hawke, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Catherine M. Meyers, Edward Doo and Michael. W. FriedDrug Metabolism and Disposition December 2011, 39 (12) 2182-2190; DOI: https://doi.org/10.1124/dmd.111.040212
Whittington, Dale
- You have accessComplex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or NelfinavirBrian J. Kirby, Ann C. Collier, Evan D. Kharasch, Vaishali Dixit, Pankaj Desai, Dale Whittington, Kenneth E. Thummel and Jashvant D. UnadkatDrug Metabolism and Disposition December 2011, 39 (12) 2329-2337; DOI: https://doi.org/10.1124/dmd.111.038646
Wilby, Alison J.
- You have accessHepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4Alison J. Wilby, Kazuya Maeda, Paul F. Courtney, Yasuyuki Debori, Peter J. H. Webborn, Yoshiaki Kitamura, Hiroyuki Kusuhara, Rob J. Riley and Yuichi SugiyamaDrug Metabolism and Disposition December 2011, 39 (12) 2361-2369; DOI: https://doi.org/10.1124/dmd.111.041814
Williams, Eric T.
- You have accessCharacterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and HumanEric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. PerkinsDrug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
Williamson, Gary
- You have accessAbsorption and Metabolism of Chlorogenic Acids in Cultured Gastric Epithelial MonolayersTracy L. Farrell, Tristan P. Dew, Laure Poquet, Peter Hanson and Gary WilliamsonDrug Metabolism and Disposition December 2011, 39 (12) 2338-2346; DOI: https://doi.org/10.1124/dmd.111.040147
Wolf, C. Roland
- You have accessEffect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null MiceVolker M. Arlt, Rajinder Singh, Marie Stiborová, Gonçalo Gamboa da Costa, Eva Frei, James D. Evans, Peter B. Farmer, C. Roland Wolf, Colin J. Henderson and David H. PhillipsDrug Metabolism and Disposition December 2011, 39 (12) 2169-2173; DOI: https://doi.org/10.1124/dmd.111.041343
Wright, J. A.
- You have accessIntestinal Ciprofloxacin Efflux: The Role of Breast Cancer Resistance Protein (ABCG2)I. S. Haslam, J. A. Wright, D. A. O'Reilly, D. J. Sherlock, T. Coleman and N. L. SimmonsDrug Metabolism and Disposition December 2011, 39 (12) 2321-2328; DOI: https://doi.org/10.1124/dmd.111.038323
Wrighton, Steven A.
- You have accessCharacterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and HumanEric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. PerkinsDrug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
Wu, Xiaofeng
- You have accessPreclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human PharmacokineticsRamesh Jayaraman, Venkatesh Pilla Reddy, Mohammed Khalid Pasha, Haishan Wang, Kanda Sangthongpitag, Pauline Yeo, Chang Yong Hu, Xiaofeng Wu, Liu Xin, Evelyn Goh, Lee Sun New and Kantharaj EthirajuluDrug Metabolism and Disposition December 2011, 39 (12) 2219-2232; DOI: https://doi.org/10.1124/dmd.111.041558
X
Xin, Liu
- You have accessPreclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human PharmacokineticsRamesh Jayaraman, Venkatesh Pilla Reddy, Mohammed Khalid Pasha, Haishan Wang, Kanda Sangthongpitag, Pauline Yeo, Chang Yong Hu, Xiaofeng Wu, Liu Xin, Evelyn Goh, Lee Sun New and Kantharaj EthirajuluDrug Metabolism and Disposition December 2011, 39 (12) 2219-2232; DOI: https://doi.org/10.1124/dmd.111.041558
Y
Yeo, Pauline
- You have accessPreclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human PharmacokineticsRamesh Jayaraman, Venkatesh Pilla Reddy, Mohammed Khalid Pasha, Haishan Wang, Kanda Sangthongpitag, Pauline Yeo, Chang Yong Hu, Xiaofeng Wu, Liu Xin, Evelyn Goh, Lee Sun New and Kantharaj EthirajuluDrug Metabolism and Disposition December 2011, 39 (12) 2219-2232; DOI: https://doi.org/10.1124/dmd.111.041558
Yong Hu, Chang
- You have accessPreclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human PharmacokineticsRamesh Jayaraman, Venkatesh Pilla Reddy, Mohammed Khalid Pasha, Haishan Wang, Kanda Sangthongpitag, Pauline Yeo, Chang Yong Hu, Xiaofeng Wu, Liu Xin, Evelyn Goh, Lee Sun New and Kantharaj EthirajuluDrug Metabolism and Disposition December 2011, 39 (12) 2219-2232; DOI: https://doi.org/10.1124/dmd.111.041558
Z
Zhang, Haoming
- You have accessThr302 Is the Site for the Covalent Modification of Human Cytochrome P450 2B6 Leading to Mechanism-Based Inactivation by tert-ButylphenylacetyleneHsia-lien Lin, Haoming Zhang, Matthew J. Pratt-Hyatt and Paul F. HollenbergDrug Metabolism and Disposition December 2011, 39 (12) 2431-2439; DOI: https://doi.org/10.1124/dmd.111.042176
Zhou, Jiangquan
- You have accessCardiac Arrest and Therapeutic Hypothermia Decrease Isoform-Specific Cytochrome P450 Drug MetabolismJiangquan Zhou, Philip E. Empey, Robert R. Bies, Patrick M. Kochanek and Samuel M. PoloyacDrug Metabolism and Disposition December 2011, 39 (12) 2209-2218; DOI: https://doi.org/10.1124/dmd.111.040642
Zvyaga, T.
- You have accessStudies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of GemfibrozilS. M. Jenkins, T. Zvyaga, S. R. Johnson, J. Hurley, A. Wagner, R. Burrell, W. Turley, J. E. Leet, T. Philip and A. D. RodriguesDrug Metabolism and Disposition December 2011, 39 (12) 2421-2430; DOI: https://doi.org/10.1124/dmd.111.041947
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