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Research ArticleArticle

Utility of P-Glycoprotein and Organic Cation Transporter 1 Double-Transfected LLC-PK1 Cells for Studying the Interaction of YM155 Monobromide, Novel Small-Molecule Survivin Suppressant, with P-Glycoprotein

Megumi Iwai, Tsuyoshi Minematsu, Qun Li, Takafumi Iwatsubo and Takashi Usui
Drug Metabolism and Disposition December 2011, 39 (12) 2314-2320; DOI: https://doi.org/10.1124/dmd.111.040733
Megumi Iwai
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Tsuyoshi Minematsu
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Qun Li
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Takafumi Iwatsubo
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Takashi Usui
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Article Information

vol. 39 no. 12 2314-2320
DOI 
https://doi.org/10.1124/dmd.111.040733
PubMed 
21918035

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 21, 2011
  • Accepted September 14, 2011
  • Published online November 21, 2011.

Article Versions

  • Earlier version (September 14, 2011 - 09:53).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Megumi Iwai,
  2. Tsuyoshi Minematsu,
  3. Qun Li,
  4. Takafumi Iwatsubo and
  5. Takashi Usui
  1. Drug Metabolism Research Laboratories, Astellas Pharma Inc., Osaka, Japan (M.I., T.M., T.I., T.U.); and Translational and Development Pharmacology, Applied Pharmacology Research Laboratories, Astellas Pharma Europe BV, Leiderdorp, The Netherlands (Q.L.)
  1. Address correspondence to:
    Megumi Iwai, Drug Metabolism Research Laboratories, Astellas Pharma Inc., 2-1-6, Kashima, Yodogawa-ku, Osaka, Japan. E-mail: megumi.iwai{at}astellas.com
  1. Part of this work were previously presented as follows: Iwai M, Minematsu T, Li Q, Iwatsubo T, and Usui T (2010) Involvement of multidrug resistance1 (MDR1) for the pharmacokinetics of YM155, a novel survivin suppressant. 9th International ISSX Meeting; 2010 Sept 4–8; Istanbul, Turkey. International Society for the Study of Xenobiotics, Washington, DC.

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Drug Metabolism and Disposition: 39 (12)
Drug Metabolism and Disposition
Vol. 39, Issue 12
1 Dec 2011
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Research ArticleArticle

INTERACTION OF YM155 WITH P-GLYCOPROTEIN

Megumi Iwai, Tsuyoshi Minematsu, Qun Li, Takafumi Iwatsubo and Takashi Usui
Drug Metabolism and Disposition December 1, 2011, 39 (12) 2314-2320; DOI: https://doi.org/10.1124/dmd.111.040733

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Research ArticleArticle

INTERACTION OF YM155 WITH P-GLYCOPROTEIN

Megumi Iwai, Tsuyoshi Minematsu, Qun Li, Takafumi Iwatsubo and Takashi Usui
Drug Metabolism and Disposition December 1, 2011, 39 (12) 2314-2320; DOI: https://doi.org/10.1124/dmd.111.040733
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