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Role of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH Conjugates

Vanina Rea, Sanja Dragovic, Jan Simon Boerma, Frans J. J. de Kanter, Nico P. E. Vermeulen and Jan N. M. Commandeur
Drug Metabolism and Disposition December 2011, 39 (12) 2411-2420; DOI: https://doi.org/10.1124/dmd.111.041046

Article Information

vol. 39 no. 12 2411-2420
DOI 
https://doi.org/10.1124/dmd.111.041046
PubMed 
21890734
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 6, 2011
  • Accepted September 2, 2011
  • Published online November 21, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Vanina Rea,
  2. Sanja Dragovic,
  3. Jan Simon Boerma,
  4. Frans J. J. de Kanter,
  5. Nico P. E. Vermeulen and
  6. Jan N. M. Commandeur
  1. Division of Molecular Toxicology, Leiden/Amsterdam Center for Drug Research (V.R., S.D., J.S.B., N.P.E.V., J.N.M.C.) and Division of Organic and Inorganic Chemistry (F.J.J.d.K.), Faculty of Sciences, Vrije Universiteit, Amsterdam, The Netherlands
  1. Address correspondence to:
    Jan N. M. Commandeur, Division of Molecular Toxicology, Leiden/Amsterdam Center for Drug Research, Faculty of Sciences, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands. E-mail: j.n.m.commandeur{at}vu.nl

  1. V.R. and S.D. contributed equally to this work.

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REGIOSELECTIVE METABOLISM OF CLOZAPINE BY CYP102A1 MUTANTS

Vanina Rea, Sanja Dragovic, Jan Simon Boerma, Frans J. J. de Kanter, Nico P. E. Vermeulen and Jan N. M. Commandeur
Drug Metabolism and Disposition December 1, 2011, 39 (12) 2411-2420; DOI: https://doi.org/10.1124/dmd.111.041046
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