Role of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH Conjugates

Vanina Rea; Sanja Dragovic; Jan Simon Boerma; Frans J. J. de Kanter; Nico P. E. Vermeulen; Jan N. M. Commandeur

doi:10.1124/dmd.111.041046

Research ArticleArticle

Role of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH Conjugates

Vanina Rea, Sanja Dragovic, Jan Simon Boerma, Frans J. J. de Kanter, Nico P. E. Vermeulen and Jan N. M. Commandeur

Drug Metabolism and Disposition December 2011, 39 (12) 2411-2420; DOI: https://doi.org/10.1124/dmd.111.041046

Vanina Rea

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Sanja Dragovic

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Jan Simon Boerma

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Frans J. J. de Kanter

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Nico P. E. Vermeulen

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Jan N. M. Commandeur

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Drug Metabolism and Disposition

Vol. 39, Issue 12

1 Dec 2011

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