Table of Contents

Articles

• You have access

  Morphine Brain Pharmacokinetics at Very Low Concentrations Studied with Accelerator Mass Spectrometry and Liquid Chromatography-Tandem Mass Spectrometry

  Muhammad Waqas Sadiq, Mehran Salehpour, Niklas Forsgard, Göran Possnert and Margareta Hammarlund-Udenaes

  Drug Metabolism and Disposition February 2011, 39 (2) 174-179; DOI: https://doi.org/10.1124/dmd.110.036434
• You have access

  Human CYP2S1 Metabolizes Cyclooxygenase- and Lipoxygenase-Derived Eicosanoids

  Peter Bui, Satoshi Imaizumi, Sudheer Reddy Beedanagari, Srinivasa T. Reddy and Oliver Hankinson

  Drug Metabolism and Disposition February 2011, 39 (2) 180-190; DOI: https://doi.org/10.1124/dmd.110.035121
• You have access

  CYP4F Enzymes Are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis

  Yi Jin, Markus Zollinger, Hubert Borell, Alfred Zimmerlin and Christopher J. Patten

  Drug Metabolism and Disposition February 2011, 39 (2) 191-198; DOI: https://doi.org/10.1124/dmd.110.035378
• You have access

  Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways

  Markus Zollinger, Hans-Peter Gschwind, Yi Jin, Claudia Sayer, Frédéric Zécri and Stefan Hartmann

  Drug Metabolism and Disposition February 2011, 39 (2) 199-207; DOI: https://doi.org/10.1124/dmd.110.035907
• You have access

  Glutaredoxin and Thioredoxin Can Be Involved in Producing the Pharmacologically Active Metabolite of a Thienopyridine Antiplatelet Agent, Prasugrel

  Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Kazuishi Kubota and Toshihiko Ikeda

  Drug Metabolism and Disposition February 2011, 39 (2) 208-214; DOI: https://doi.org/10.1124/dmd.110.035196
• You have access

  Disposition and Metabolism of [¹⁴C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans

  Cecilia Renzulli, Mike Nash, Mark Wright, Steven Thomas, Stefano Zamuner, Mario Pellegatti, Paolo Bettica and Gary Boyle

  Drug Metabolism and Disposition February 2011, 39 (2) 215-227; DOI: https://doi.org/10.1124/dmd.110.035386
• You have access

  Metabolism and Disposition of ¹⁴C-Labeled Peliglitazar in Humans

  Lifei Wang, Carey Munsick, Sean Chen, Samuel Bonacorsi, Peter T. Cheng, W. Griffith Humphreys and Donglu Zhang

  Drug Metabolism and Disposition February 2011, 39 (2) 228-238; DOI: https://doi.org/10.1124/dmd.110.035089
• You have access

  Effects of Ketoconazole on the In Vivo Biotransformation and Hepatobiliary Transport of the Thrombin Inhibitor AZD0837 in Pigs

  Elin M. Matsson, Johan E. Palm, Ulf G. Eriksson, Pernilla Bottner, Anna Lundahl, Lars Knutson and Hans Lennernäs

  Drug Metabolism and Disposition February 2011, 39 (2) 239-246; DOI: https://doi.org/10.1124/dmd.110.035022
• You have access

  Influence of Cremophor EL and Genetic Polymorphisms on the Pharmacokinetics of Paclitaxel and Its Metabolites Using a Mechanism-Based Model

  Martin N. Fransson, Henrik Gréen, Jan-Eric Litton and Lena E. Friberg

  Drug Metabolism and Disposition February 2011, 39 (2) 247-255; DOI: https://doi.org/10.1124/dmd.110.035394
• You have access

  Tissue Distribution and Elimination of [¹⁴C]Apixaban in Rats

  Lifei Wang, Kan He, Brad Maxwell, Scott J. Grossman, Larry M. Tremaine, W. Griffith Humphreys and Donglu Zhang

  Drug Metabolism and Disposition February 2011, 39 (2) 256-264; DOI: https://doi.org/10.1124/dmd.110.036442
• You have access

  Attenuation of Intestinal Absorption by Major Efflux Transporters: Quantitative Tools and Strategies Using a Caco-2 Model

  Xuena Lin, Suzanne Skolnik, Xiaohui Chen and Jianling Wang

  Drug Metabolism and Disposition February 2011, 39 (2) 265-274; DOI: https://doi.org/10.1124/dmd.110.034629
• You have access

  The Utility of In Vitro Data in Making Accurate Predictions of Human P-Glycoprotein-Mediated Drug-Drug Interactions: A Case Study for AZD5672

  Robert Elsby, Michael Gillen, Caroline Butters, Gemma Imisson, Pradeep Sharma, Veronica Smith and Dominic D. Surry

  Drug Metabolism and Disposition February 2011, 39 (2) 275-282; DOI: https://doi.org/10.1124/dmd.110.035881
• You have access

  Tissue Distribution and Characterization of Drug-Related Material in Rats and Dogs after Repeated Oral Administration of Casopitant

  Sabrina Pagliarusco, Silvia Martinucci, Ellenia Bordini, Lidia Miraglia, Domenico Cufari, Luca Ferrari and Mario Pellegatti

  Drug Metabolism and Disposition February 2011, 39 (2) 283-293; DOI: https://doi.org/10.1124/dmd.110.035063
• You have access

  A Pharmacokinetic Model for Evaluating the Impact of Hepatic and Intestinal First-Pass Loss of Saquinavir in the Rat

  R. Lledó-García, A. Nácher, V. G. Casabó and M. Merino-Sanjuán

  Drug Metabolism and Disposition February 2011, 39 (2) 294-301; DOI: https://doi.org/10.1124/dmd.110.034488
• You have access

  Elucidation of a Novel Bioactivation Pathway of a 3,4-Unsubstituted Isoxazole in Human Liver Microsomes: Formation of a Glutathione Adduct of a Cyanoacrolein Derivative after Isoxazole Ring Opening

  Jian Yu, James J. Folmer, Valerie Hoesch, James Doherty, James B. Campbell and Doug Burdette

  Drug Metabolism and Disposition February 2011, 39 (2) 302-311; DOI: https://doi.org/10.1124/dmd.110.036285
• You have access

  Brain Tissue Binding of Drugs: Evaluation and Validation of Solid Supported Porcine Brain Membrane Vesicles (TRANSIL) as a Novel High-Throughput Method

  Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller and Hinnerk Boriss

  Drug Metabolism and Disposition February 2011, 39 (2) 312-321; DOI: https://doi.org/10.1124/dmd.110.036095
• You have access

  Correlation between Bilirubin Glucuronidation and Estradiol-3-Gluronidation in the Presence of Model UDP-Glucuronosyltransferase 1A1 Substrates/Inhibitors

  Jin Zhou, Timothy S. Tracy and Rory P. Remmel

  Drug Metabolism and Disposition February 2011, 39 (2) 322-329; DOI: https://doi.org/10.1124/dmd.110.035030
• You have access

  Ethanol Induction of CYP2A5: Permissive Role for CYP2E1

  Yongke Lu, Jian Zhuge, Defeng Wu and Arthur I. Cederbaum

  Drug Metabolism and Disposition February 2011, 39 (2) 330-336; DOI: https://doi.org/10.1124/dmd.110.035691
• You have access

  Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening

  Yongmei Pan, Linhao Li, Gregory Kim, Sean Ekins, Hongbing Wang and Peter W. Swaan

  Drug Metabolism and Disposition February 2011, 39 (2) 337-344; DOI: https://doi.org/10.1124/dmd.110.035808
• You have access

  Inactivation of Cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a Thiophene-Containing Anticancer Drug

  Hsia-lien Lin, Haoming Zhang, Christine Medower, Paul F. Hollenberg and William W. Johnson

  Drug Metabolism and Disposition February 2011, 39 (2) 345-350; DOI: https://doi.org/10.1124/dmd.110.034074