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Index by author

February 01, 2011; Volume 39,Issue 2

A

  1. Aarons, Leon

    1. Critique of the Two-Fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-Drug Interactions
      Eleanor J. Guest, Leon Aarons, J. Brian Houston, Amin Rostami-Hodjegan and Aleksandra Galetin
      Drug Metabolism and Disposition February 2011, 39 (2) 170-173; DOI: https://doi.org/10.1124/dmd.110.036103

  2. Akiyama, Yuko

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  3. Ando, Yuichi

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

B

  1. Beedanagari, Sudheer Reddy

    1. Human CYP2S1 Metabolizes Cyclooxygenase- and Lipoxygenase-Derived Eicosanoids
      Peter Bui, Satoshi Imaizumi, Sudheer Reddy Beedanagari, Srinivasa T. Reddy and Oliver Hankinson
      Drug Metabolism and Disposition February 2011, 39 (2) 180-190; DOI: https://doi.org/10.1124/dmd.110.035121

  2. Bettica, Paolo

    1. Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans
      Cecilia Renzulli, Mike Nash, Mark Wright, Steven Thomas, Stefano Zamuner, Mario Pellegatti, Paolo Bettica and Gary Boyle
      Drug Metabolism and Disposition February 2011, 39 (2) 215-227; DOI: https://doi.org/10.1124/dmd.110.035386

  3. Bonacorsi, Samuel

    1. Metabolism and Disposition of 14C-Labeled Peliglitazar in Humans
      Lifei Wang, Carey Munsick, Sean Chen, Samuel Bonacorsi, Peter T. Cheng, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 228-238; DOI: https://doi.org/10.1124/dmd.110.035089

  4. Bordini, Ellenia

    1. Tissue Distribution and Characterization of Drug-Related Material in Rats and Dogs after Repeated Oral Administration of Casopitant
      Sabrina Pagliarusco, Silvia Martinucci, Ellenia Bordini, Lidia Miraglia, Domenico Cufari, Luca Ferrari and Mario Pellegatti
      Drug Metabolism and Disposition February 2011, 39 (2) 283-293; DOI: https://doi.org/10.1124/dmd.110.035063

  5. Borell, Hubert

    1. CYP4F Enzymes Are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis
      Yi Jin, Markus Zollinger, Hubert Borell, Alfred Zimmerlin and Christopher J. Patten
      Drug Metabolism and Disposition February 2011, 39 (2) 191-198; DOI: https://doi.org/10.1124/dmd.110.035378

  6. Boriss, Hinnerk

    1. Brain Tissue Binding of Drugs: Evaluation and Validation of Solid Supported Porcine Brain Membrane Vesicles (TRANSIL) as a Novel High-Throughput Method
      Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller and Hinnerk Boriss
      Drug Metabolism and Disposition February 2011, 39 (2) 312-321; DOI: https://doi.org/10.1124/dmd.110.036095

  7. Bottner, Pernilla

    1. Effects of Ketoconazole on the In Vivo Biotransformation and Hepatobiliary Transport of the Thrombin Inhibitor AZD0837 in Pigs
      Elin M. Matsson, Johan E. Palm, Ulf G. Eriksson, Pernilla Bottner, Anna Lundahl, Lars Knutson and Hans Lennernäs
      Drug Metabolism and Disposition February 2011, 39 (2) 239-246; DOI: https://doi.org/10.1124/dmd.110.035022

  8. Boyle, Gary

    1. Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans
      Cecilia Renzulli, Mike Nash, Mark Wright, Steven Thomas, Stefano Zamuner, Mario Pellegatti, Paolo Bettica and Gary Boyle
      Drug Metabolism and Disposition February 2011, 39 (2) 215-227; DOI: https://doi.org/10.1124/dmd.110.035386

  9. Braggio, Simone

    1. Brain Tissue Binding of Drugs: Evaluation and Validation of Solid Supported Porcine Brain Membrane Vesicles (TRANSIL) as a Novel High-Throughput Method
      Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller and Hinnerk Boriss
      Drug Metabolism and Disposition February 2011, 39 (2) 312-321; DOI: https://doi.org/10.1124/dmd.110.036095

  10. Bui, Peter

    1. Human CYP2S1 Metabolizes Cyclooxygenase- and Lipoxygenase-Derived Eicosanoids
      Peter Bui, Satoshi Imaizumi, Sudheer Reddy Beedanagari, Srinivasa T. Reddy and Oliver Hankinson
      Drug Metabolism and Disposition February 2011, 39 (2) 180-190; DOI: https://doi.org/10.1124/dmd.110.035121

  11. Burdette, Doug

    1. Elucidation of a Novel Bioactivation Pathway of a 3,4-Unsubstituted Isoxazole in Human Liver Microsomes: Formation of a Glutathione Adduct of a Cyanoacrolein Derivative after Isoxazole Ring Opening
      Jian Yu, James J. Folmer, Valerie Hoesch, James Doherty, James B. Campbell and Doug Burdette
      Drug Metabolism and Disposition February 2011, 39 (2) 302-311; DOI: https://doi.org/10.1124/dmd.110.036285

  12. Butters, Caroline

    1. The Utility of In Vitro Data in Making Accurate Predictions of Human P-Glycoprotein-Mediated Drug-Drug Interactions: A Case Study for AZD5672
      Robert Elsby, Michael Gillen, Caroline Butters, Gemma Imisson, Pradeep Sharma, Veronica Smith and Dominic D. Surry
      Drug Metabolism and Disposition February 2011, 39 (2) 275-282; DOI: https://doi.org/10.1124/dmd.110.035881

C

  1. Campbell, James B.

    1. Elucidation of a Novel Bioactivation Pathway of a 3,4-Unsubstituted Isoxazole in Human Liver Microsomes: Formation of a Glutathione Adduct of a Cyanoacrolein Derivative after Isoxazole Ring Opening
      Jian Yu, James J. Folmer, Valerie Hoesch, James Doherty, James B. Campbell and Doug Burdette
      Drug Metabolism and Disposition February 2011, 39 (2) 302-311; DOI: https://doi.org/10.1124/dmd.110.036285

  2. Casabó, V. G.

    1. A Pharmacokinetic Model for Evaluating the Impact of Hepatic and Intestinal First-Pass Loss of Saquinavir in the Rat
      R. Lledó-García, A. Nácher, V. G. Casabó and M. Merino-Sanjuán
      Drug Metabolism and Disposition February 2011, 39 (2) 294-301; DOI: https://doi.org/10.1124/dmd.110.034488

  3. Cederbaum, Arthur I.

    1. Ethanol Induction of CYP2A5: Permissive Role for CYP2E1
      Yongke Lu, Jian Zhuge, Defeng Wu and Arthur I. Cederbaum
      Drug Metabolism and Disposition February 2011, 39 (2) 330-336; DOI: https://doi.org/10.1124/dmd.110.035691

  4. Chen, Sean

    1. Metabolism and Disposition of 14C-Labeled Peliglitazar in Humans
      Lifei Wang, Carey Munsick, Sean Chen, Samuel Bonacorsi, Peter T. Cheng, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 228-238; DOI: https://doi.org/10.1124/dmd.110.035089

  5. Chen, Xiaohui

    1. Attenuation of Intestinal Absorption by Major Efflux Transporters: Quantitative Tools and Strategies Using a Caco-2 Model
      Xuena Lin, Suzanne Skolnik, Xiaohui Chen and Jianling Wang
      Drug Metabolism and Disposition February 2011, 39 (2) 265-274; DOI: https://doi.org/10.1124/dmd.110.034629

  6. Cheng, Peter T.

    1. Metabolism and Disposition of 14C-Labeled Peliglitazar in Humans
      Lifei Wang, Carey Munsick, Sean Chen, Samuel Bonacorsi, Peter T. Cheng, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 228-238; DOI: https://doi.org/10.1124/dmd.110.035089

  7. Corbioli, Silvia

    1. Brain Tissue Binding of Drugs: Evaluation and Validation of Solid Supported Porcine Brain Membrane Vesicles (TRANSIL) as a Novel High-Throughput Method
      Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller and Hinnerk Boriss
      Drug Metabolism and Disposition February 2011, 39 (2) 312-321; DOI: https://doi.org/10.1124/dmd.110.036095

  8. Cufari, Domenico

    1. Tissue Distribution and Characterization of Drug-Related Material in Rats and Dogs after Repeated Oral Administration of Casopitant
      Sabrina Pagliarusco, Silvia Martinucci, Ellenia Bordini, Lidia Miraglia, Domenico Cufari, Luca Ferrari and Mario Pellegatti
      Drug Metabolism and Disposition February 2011, 39 (2) 283-293; DOI: https://doi.org/10.1124/dmd.110.035063

D

  1. Doherty, James

    1. Elucidation of a Novel Bioactivation Pathway of a 3,4-Unsubstituted Isoxazole in Human Liver Microsomes: Formation of a Glutathione Adduct of a Cyanoacrolein Derivative after Isoxazole Ring Opening
      Jian Yu, James J. Folmer, Valerie Hoesch, James Doherty, James B. Campbell and Doug Burdette
      Drug Metabolism and Disposition February 2011, 39 (2) 302-311; DOI: https://doi.org/10.1124/dmd.110.036285

E

  1. Ekins, Sean

    1. Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening
      Yongmei Pan, Linhao Li, Gregory Kim, Sean Ekins, Hongbing Wang and Peter W. Swaan
      Drug Metabolism and Disposition February 2011, 39 (2) 337-344; DOI: https://doi.org/10.1124/dmd.110.035808

  2. Elsby, Robert

    1. The Utility of In Vitro Data in Making Accurate Predictions of Human P-Glycoprotein-Mediated Drug-Drug Interactions: A Case Study for AZD5672
      Robert Elsby, Michael Gillen, Caroline Butters, Gemma Imisson, Pradeep Sharma, Veronica Smith and Dominic D. Surry
      Drug Metabolism and Disposition February 2011, 39 (2) 275-282; DOI: https://doi.org/10.1124/dmd.110.035881

  3. Eriksson, Ulf G.

    1. Effects of Ketoconazole on the In Vivo Biotransformation and Hepatobiliary Transport of the Thrombin Inhibitor AZD0837 in Pigs
      Elin M. Matsson, Johan E. Palm, Ulf G. Eriksson, Pernilla Bottner, Anna Lundahl, Lars Knutson and Hans Lennernäs
      Drug Metabolism and Disposition February 2011, 39 (2) 239-246; DOI: https://doi.org/10.1124/dmd.110.035022

F

  1. Ferrari, Luca

    1. Tissue Distribution and Characterization of Drug-Related Material in Rats and Dogs after Repeated Oral Administration of Casopitant
      Sabrina Pagliarusco, Silvia Martinucci, Ellenia Bordini, Lidia Miraglia, Domenico Cufari, Luca Ferrari and Mario Pellegatti
      Drug Metabolism and Disposition February 2011, 39 (2) 283-293; DOI: https://doi.org/10.1124/dmd.110.035063

  2. Folmer, James J.

    1. Elucidation of a Novel Bioactivation Pathway of a 3,4-Unsubstituted Isoxazole in Human Liver Microsomes: Formation of a Glutathione Adduct of a Cyanoacrolein Derivative after Isoxazole Ring Opening
      Jian Yu, James J. Folmer, Valerie Hoesch, James Doherty, James B. Campbell and Doug Burdette
      Drug Metabolism and Disposition February 2011, 39 (2) 302-311; DOI: https://doi.org/10.1124/dmd.110.036285

  3. Fontana, Stefano

    1. Brain Tissue Binding of Drugs: Evaluation and Validation of Solid Supported Porcine Brain Membrane Vesicles (TRANSIL) as a Novel High-Throughput Method
      Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller and Hinnerk Boriss
      Drug Metabolism and Disposition February 2011, 39 (2) 312-321; DOI: https://doi.org/10.1124/dmd.110.036095

  4. Forsgard, Niklas

    1. Morphine Brain Pharmacokinetics at Very Low Concentrations Studied with Accelerator Mass Spectrometry and Liquid Chromatography-Tandem Mass Spectrometry
      Muhammad Waqas Sadiq, Mehran Salehpour, Niklas Forsgard, Göran Possnert and Margareta Hammarlund-Udenaes
      Drug Metabolism and Disposition February 2011, 39 (2) 174-179; DOI: https://doi.org/10.1124/dmd.110.036434

  5. Fransson, Martin N.

    1. Influence of Cremophor EL and Genetic Polymorphisms on the Pharmacokinetics of Paclitaxel and Its Metabolites Using a Mechanism-Based Model
      Martin N. Fransson, Henrik Gréen, Jan-Eric Litton and Lena E. Friberg
      Drug Metabolism and Disposition February 2011, 39 (2) 247-255; DOI: https://doi.org/10.1124/dmd.110.035394

  6. Friberg, Lena E.

    1. Influence of Cremophor EL and Genetic Polymorphisms on the Pharmacokinetics of Paclitaxel and Its Metabolites Using a Mechanism-Based Model
      Martin N. Fransson, Henrik Gréen, Jan-Eric Litton and Lena E. Friberg
      Drug Metabolism and Disposition February 2011, 39 (2) 247-255; DOI: https://doi.org/10.1124/dmd.110.035394

  7. Fujita, Ken-ichi

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

G

  1. Galetin, Aleksandra

    1. Critique of the Two-Fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-Drug Interactions
      Eleanor J. Guest, Leon Aarons, J. Brian Houston, Amin Rostami-Hodjegan and Aleksandra Galetin
      Drug Metabolism and Disposition February 2011, 39 (2) 170-173; DOI: https://doi.org/10.1124/dmd.110.036103

  2. Gillen, Michael

    1. The Utility of In Vitro Data in Making Accurate Predictions of Human P-Glycoprotein-Mediated Drug-Drug Interactions: A Case Study for AZD5672
      Robert Elsby, Michael Gillen, Caroline Butters, Gemma Imisson, Pradeep Sharma, Veronica Smith and Dominic D. Surry
      Drug Metabolism and Disposition February 2011, 39 (2) 275-282; DOI: https://doi.org/10.1124/dmd.110.035881

  3. Gréen, Henrik

    1. Influence of Cremophor EL and Genetic Polymorphisms on the Pharmacokinetics of Paclitaxel and Its Metabolites Using a Mechanism-Based Model
      Martin N. Fransson, Henrik Gréen, Jan-Eric Litton and Lena E. Friberg
      Drug Metabolism and Disposition February 2011, 39 (2) 247-255; DOI: https://doi.org/10.1124/dmd.110.035394

  4. Grossman, Scott J.

    1. Tissue Distribution and Elimination of [14C]Apixaban in Rats
      Lifei Wang, Kan He, Brad Maxwell, Scott J. Grossman, Larry M. Tremaine, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 256-264; DOI: https://doi.org/10.1124/dmd.110.036442

  5. Gschwind, Hans-Peter

    1. Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways
      Markus Zollinger, Hans-Peter Gschwind, Yi Jin, Claudia Sayer, Frédéric Zécri and Stefan Hartmann
      Drug Metabolism and Disposition February 2011, 39 (2) 199-207; DOI: https://doi.org/10.1124/dmd.110.035907

  6. Guest, Eleanor J.

    1. Critique of the Two-Fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-Drug Interactions
      Eleanor J. Guest, Leon Aarons, J. Brian Houston, Amin Rostami-Hodjegan and Aleksandra Galetin
      Drug Metabolism and Disposition February 2011, 39 (2) 170-173; DOI: https://doi.org/10.1124/dmd.110.036103

H

  1. Hagihara, Katsunobu

    1. Glutaredoxin and Thioredoxin Can Be Involved in Producing the Pharmacologically Active Metabolite of a Thienopyridine Antiplatelet Agent, Prasugrel
      Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Kazuishi Kubota and Toshihiko Ikeda
      Drug Metabolism and Disposition February 2011, 39 (2) 208-214; DOI: https://doi.org/10.1124/dmd.110.035196

  2. Hammarlund-Udenaes, Margareta

    1. Morphine Brain Pharmacokinetics at Very Low Concentrations Studied with Accelerator Mass Spectrometry and Liquid Chromatography-Tandem Mass Spectrometry
      Muhammad Waqas Sadiq, Mehran Salehpour, Niklas Forsgard, Göran Possnert and Margareta Hammarlund-Udenaes
      Drug Metabolism and Disposition February 2011, 39 (2) 174-179; DOI: https://doi.org/10.1124/dmd.110.036434

  3. Hankinson, Oliver

    1. Human CYP2S1 Metabolizes Cyclooxygenase- and Lipoxygenase-Derived Eicosanoids
      Peter Bui, Satoshi Imaizumi, Sudheer Reddy Beedanagari, Srinivasa T. Reddy and Oliver Hankinson
      Drug Metabolism and Disposition February 2011, 39 (2) 180-190; DOI: https://doi.org/10.1124/dmd.110.035121

  4. Hartmann, Stefan

    1. Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways
      Markus Zollinger, Hans-Peter Gschwind, Yi Jin, Claudia Sayer, Frédéric Zécri and Stefan Hartmann
      Drug Metabolism and Disposition February 2011, 39 (2) 199-207; DOI: https://doi.org/10.1124/dmd.110.035907

  5. He, Kan

    1. Tissue Distribution and Elimination of [14C]Apixaban in Rats
      Lifei Wang, Kan He, Brad Maxwell, Scott J. Grossman, Larry M. Tremaine, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 256-264; DOI: https://doi.org/10.1124/dmd.110.036442

  6. Helmdach, Lydia

    1. Brain Tissue Binding of Drugs: Evaluation and Validation of Solid Supported Porcine Brain Membrane Vesicles (TRANSIL) as a Novel High-Throughput Method
      Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller and Hinnerk Boriss
      Drug Metabolism and Disposition February 2011, 39 (2) 312-321; DOI: https://doi.org/10.1124/dmd.110.036095

  7. Hirose, Takashi

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  8. Hoesch, Valerie

    1. Elucidation of a Novel Bioactivation Pathway of a 3,4-Unsubstituted Isoxazole in Human Liver Microsomes: Formation of a Glutathione Adduct of a Cyanoacrolein Derivative after Isoxazole Ring Opening
      Jian Yu, James J. Folmer, Valerie Hoesch, James Doherty, James B. Campbell and Doug Burdette
      Drug Metabolism and Disposition February 2011, 39 (2) 302-311; DOI: https://doi.org/10.1124/dmd.110.036285

  9. Hollenberg, Paul F.

    1. Inactivation of Cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a Thiophene-Containing Anticancer Drug
      Hsia-lien Lin, Haoming Zhang, Christine Medower, Paul F. Hollenberg and William W. Johnson
      Drug Metabolism and Disposition February 2011, 39 (2) 345-350; DOI: https://doi.org/10.1124/dmd.110.034074

  10. Houston, J. Brian

    1. Critique of the Two-Fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-Drug Interactions
      Eleanor J. Guest, Leon Aarons, J. Brian Houston, Amin Rostami-Hodjegan and Aleksandra Galetin
      Drug Metabolism and Disposition February 2011, 39 (2) 170-173; DOI: https://doi.org/10.1124/dmd.110.036103

  11. Humphreys, W. Griffith

    1. Metabolism and Disposition of 14C-Labeled Peliglitazar in Humans
      Lifei Wang, Carey Munsick, Sean Chen, Samuel Bonacorsi, Peter T. Cheng, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 228-238; DOI: https://doi.org/10.1124/dmd.110.035089
    2. Tissue Distribution and Elimination of [14C]Apixaban in Rats
      Lifei Wang, Kan He, Brad Maxwell, Scott J. Grossman, Larry M. Tremaine, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 256-264; DOI: https://doi.org/10.1124/dmd.110.036442

I

  1. Ichikawa, Wataru

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  2. Ikeda, Toshihiko

    1. Glutaredoxin and Thioredoxin Can Be Involved in Producing the Pharmacologically Active Metabolite of a Thienopyridine Antiplatelet Agent, Prasugrel
      Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Kazuishi Kubota and Toshihiko Ikeda
      Drug Metabolism and Disposition February 2011, 39 (2) 208-214; DOI: https://doi.org/10.1124/dmd.110.035196

  3. Imaizumi, Satoshi

    1. Human CYP2S1 Metabolizes Cyclooxygenase- and Lipoxygenase-Derived Eicosanoids
      Peter Bui, Satoshi Imaizumi, Sudheer Reddy Beedanagari, Srinivasa T. Reddy and Oliver Hankinson
      Drug Metabolism and Disposition February 2011, 39 (2) 180-190; DOI: https://doi.org/10.1124/dmd.110.035121

  4. Imisson, Gemma

    1. The Utility of In Vitro Data in Making Accurate Predictions of Human P-Glycoprotein-Mediated Drug-Drug Interactions: A Case Study for AZD5672
      Robert Elsby, Michael Gillen, Caroline Butters, Gemma Imisson, Pradeep Sharma, Veronica Smith and Dominic D. Surry
      Drug Metabolism and Disposition February 2011, 39 (2) 275-282; DOI: https://doi.org/10.1124/dmd.110.035881

  5. Ishida, Hiroo

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

J

  1. Jeong, Hyunyoung

    1. Altered Cytochrome P450 Expression in Mice during Pregnancy
      Kwi Hye Koh, Hui Xie, Ai-Ming Yu and Hyunyoung Jeong
      Drug Metabolism and Disposition February 2011, 39 (2) 165-169; DOI: https://doi.org/10.1124/dmd.110.035790

  2. Jin, Yi

    1. CYP4F Enzymes Are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis
      Yi Jin, Markus Zollinger, Hubert Borell, Alfred Zimmerlin and Christopher J. Patten
      Drug Metabolism and Disposition February 2011, 39 (2) 191-198; DOI: https://doi.org/10.1124/dmd.110.035378
    2. Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways
      Markus Zollinger, Hans-Peter Gschwind, Yi Jin, Claudia Sayer, Frédéric Zécri and Stefan Hartmann
      Drug Metabolism and Disposition February 2011, 39 (2) 199-207; DOI: https://doi.org/10.1124/dmd.110.035907

  3. Johnson, William W.

    1. Inactivation of Cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a Thiophene-Containing Anticancer Drug
      Hsia-lien Lin, Haoming Zhang, Christine Medower, Paul F. Hollenberg and William W. Johnson
      Drug Metabolism and Disposition February 2011, 39 (2) 345-350; DOI: https://doi.org/10.1124/dmd.110.034074

K

  1. Kawara, Kaori

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  2. Kazui, Miho

    1. Glutaredoxin and Thioredoxin Can Be Involved in Producing the Pharmacologically Active Metabolite of a Thienopyridine Antiplatelet Agent, Prasugrel
      Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Kazuishi Kubota and Toshihiko Ikeda
      Drug Metabolism and Disposition February 2011, 39 (2) 208-214; DOI: https://doi.org/10.1124/dmd.110.035196

  3. Kim, Gregory

    1. Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening
      Yongmei Pan, Linhao Li, Gregory Kim, Sean Ekins, Hongbing Wang and Peter W. Swaan
      Drug Metabolism and Disposition February 2011, 39 (2) 337-344; DOI: https://doi.org/10.1124/dmd.110.035808

  4. Knutson, Lars

    1. Effects of Ketoconazole on the In Vivo Biotransformation and Hepatobiliary Transport of the Thrombin Inhibitor AZD0837 in Pigs
      Elin M. Matsson, Johan E. Palm, Ulf G. Eriksson, Pernilla Bottner, Anna Lundahl, Lars Knutson and Hans Lennernäs
      Drug Metabolism and Disposition February 2011, 39 (2) 239-246; DOI: https://doi.org/10.1124/dmd.110.035022

  5. Koh, Kwi Hye

    1. Altered Cytochrome P450 Expression in Mice during Pregnancy
      Kwi Hye Koh, Hui Xie, Ai-Ming Yu and Hyunyoung Jeong
      Drug Metabolism and Disposition February 2011, 39 (2) 165-169; DOI: https://doi.org/10.1124/dmd.110.035790

  6. Kubota, Kazuishi

    1. Glutaredoxin and Thioredoxin Can Be Involved in Producing the Pharmacologically Active Metabolite of a Thienopyridine Antiplatelet Agent, Prasugrel
      Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Kazuishi Kubota and Toshihiko Ikeda
      Drug Metabolism and Disposition February 2011, 39 (2) 208-214; DOI: https://doi.org/10.1124/dmd.110.035196

  7. Kurihara, Atsushi

    1. Glutaredoxin and Thioredoxin Can Be Involved in Producing the Pharmacologically Active Metabolite of a Thienopyridine Antiplatelet Agent, Prasugrel
      Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Kazuishi Kubota and Toshihiko Ikeda
      Drug Metabolism and Disposition February 2011, 39 (2) 208-214; DOI: https://doi.org/10.1124/dmd.110.035196

L

  1. Lennernäs, Hans

    1. Effects of Ketoconazole on the In Vivo Biotransformation and Hepatobiliary Transport of the Thrombin Inhibitor AZD0837 in Pigs
      Elin M. Matsson, Johan E. Palm, Ulf G. Eriksson, Pernilla Bottner, Anna Lundahl, Lars Knutson and Hans Lennernäs
      Drug Metabolism and Disposition February 2011, 39 (2) 239-246; DOI: https://doi.org/10.1124/dmd.110.035022

  2. Li, Linhao

    1. Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening
      Yongmei Pan, Linhao Li, Gregory Kim, Sean Ekins, Hongbing Wang and Peter W. Swaan
      Drug Metabolism and Disposition February 2011, 39 (2) 337-344; DOI: https://doi.org/10.1124/dmd.110.035808

  3. Lin, Hsia-lien

    1. Inactivation of Cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a Thiophene-Containing Anticancer Drug
      Hsia-lien Lin, Haoming Zhang, Christine Medower, Paul F. Hollenberg and William W. Johnson
      Drug Metabolism and Disposition February 2011, 39 (2) 345-350; DOI: https://doi.org/10.1124/dmd.110.034074

  4. Lin, Xuena

    1. Attenuation of Intestinal Absorption by Major Efflux Transporters: Quantitative Tools and Strategies Using a Caco-2 Model
      Xuena Lin, Suzanne Skolnik, Xiaohui Chen and Jianling Wang
      Drug Metabolism and Disposition February 2011, 39 (2) 265-274; DOI: https://doi.org/10.1124/dmd.110.034629

  5. Litton, Jan-Eric

    1. Influence of Cremophor EL and Genetic Polymorphisms on the Pharmacokinetics of Paclitaxel and Its Metabolites Using a Mechanism-Based Model
      Martin N. Fransson, Henrik Gréen, Jan-Eric Litton and Lena E. Friberg
      Drug Metabolism and Disposition February 2011, 39 (2) 247-255; DOI: https://doi.org/10.1124/dmd.110.035394

  6. Lledó-García, R.

    1. A Pharmacokinetic Model for Evaluating the Impact of Hepatic and Intestinal First-Pass Loss of Saquinavir in the Rat
      R. Lledó-García, A. Nácher, V. G. Casabó and M. Merino-Sanjuán
      Drug Metabolism and Disposition February 2011, 39 (2) 294-301; DOI: https://doi.org/10.1124/dmd.110.034488

  7. Longhi, Raffaele

    1. Brain Tissue Binding of Drugs: Evaluation and Validation of Solid Supported Porcine Brain Membrane Vesicles (TRANSIL) as a Novel High-Throughput Method
      Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller and Hinnerk Boriss
      Drug Metabolism and Disposition February 2011, 39 (2) 312-321; DOI: https://doi.org/10.1124/dmd.110.036095

  8. Lu, Yongke

    1. Ethanol Induction of CYP2A5: Permissive Role for CYP2E1
      Yongke Lu, Jian Zhuge, Defeng Wu and Arthur I. Cederbaum
      Drug Metabolism and Disposition February 2011, 39 (2) 330-336; DOI: https://doi.org/10.1124/dmd.110.035691

  9. Lundahl, Anna

    1. Effects of Ketoconazole on the In Vivo Biotransformation and Hepatobiliary Transport of the Thrombin Inhibitor AZD0837 in Pigs
      Elin M. Matsson, Johan E. Palm, Ulf G. Eriksson, Pernilla Bottner, Anna Lundahl, Lars Knutson and Hans Lennernäs
      Drug Metabolism and Disposition February 2011, 39 (2) 239-246; DOI: https://doi.org/10.1124/dmd.110.035022

M

  1. Martinucci, Silvia

    1. Tissue Distribution and Characterization of Drug-Related Material in Rats and Dogs after Repeated Oral Administration of Casopitant
      Sabrina Pagliarusco, Silvia Martinucci, Ellenia Bordini, Lidia Miraglia, Domenico Cufari, Luca Ferrari and Mario Pellegatti
      Drug Metabolism and Disposition February 2011, 39 (2) 283-293; DOI: https://doi.org/10.1124/dmd.110.035063

  2. Matsson, Elin M.

    1. Effects of Ketoconazole on the In Vivo Biotransformation and Hepatobiliary Transport of the Thrombin Inhibitor AZD0837 in Pigs
      Elin M. Matsson, Johan E. Palm, Ulf G. Eriksson, Pernilla Bottner, Anna Lundahl, Lars Knutson and Hans Lennernäs
      Drug Metabolism and Disposition February 2011, 39 (2) 239-246; DOI: https://doi.org/10.1124/dmd.110.035022

  3. Maxwell, Brad

    1. Tissue Distribution and Elimination of [14C]Apixaban in Rats
      Lifei Wang, Kan He, Brad Maxwell, Scott J. Grossman, Larry M. Tremaine, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 256-264; DOI: https://doi.org/10.1124/dmd.110.036442

  4. Medower, Christine

    1. Inactivation of Cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a Thiophene-Containing Anticancer Drug
      Hsia-lien Lin, Haoming Zhang, Christine Medower, Paul F. Hollenberg and William W. Johnson
      Drug Metabolism and Disposition February 2011, 39 (2) 345-350; DOI: https://doi.org/10.1124/dmd.110.034074

  5. Merino-Sanjuán, M.

    1. A Pharmacokinetic Model for Evaluating the Impact of Hepatic and Intestinal First-Pass Loss of Saquinavir in the Rat
      R. Lledó-García, A. Nácher, V. G. Casabó and M. Merino-Sanjuán
      Drug Metabolism and Disposition February 2011, 39 (2) 294-301; DOI: https://doi.org/10.1124/dmd.110.034488

  6. Miraglia, Lidia

    1. Tissue Distribution and Characterization of Drug-Related Material in Rats and Dogs after Repeated Oral Administration of Casopitant
      Sabrina Pagliarusco, Silvia Martinucci, Ellenia Bordini, Lidia Miraglia, Domenico Cufari, Luca Ferrari and Mario Pellegatti
      Drug Metabolism and Disposition February 2011, 39 (2) 283-293; DOI: https://doi.org/10.1124/dmd.110.035063

  7. Miwa, Keisuke

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  8. Miya, Toshimichi

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  9. Mizuno, Keiko

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  10. Munsick, Carey

    1. Metabolism and Disposition of 14C-Labeled Peliglitazar in Humans
      Lifei Wang, Carey Munsick, Sean Chen, Samuel Bonacorsi, Peter T. Cheng, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 228-238; DOI: https://doi.org/10.1124/dmd.110.035089

N

  1. Nácher, A.

    1. A Pharmacokinetic Model for Evaluating the Impact of Hepatic and Intestinal First-Pass Loss of Saquinavir in the Rat
      R. Lledó-García, A. Nácher, V. G. Casabó and M. Merino-Sanjuán
      Drug Metabolism and Disposition February 2011, 39 (2) 294-301; DOI: https://doi.org/10.1124/dmd.110.034488

  2. Nagashima, Fumio

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  3. Narabayashi, Masaru

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  4. Nash, Mike

    1. Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans
      Cecilia Renzulli, Mike Nash, Mark Wright, Steven Thomas, Stefano Zamuner, Mario Pellegatti, Paolo Bettica and Gary Boyle
      Drug Metabolism and Disposition February 2011, 39 (2) 215-227; DOI: https://doi.org/10.1124/dmd.110.035386

P

  1. Pagliarusco, Sabrina

    1. Tissue Distribution and Characterization of Drug-Related Material in Rats and Dogs after Repeated Oral Administration of Casopitant
      Sabrina Pagliarusco, Silvia Martinucci, Ellenia Bordini, Lidia Miraglia, Domenico Cufari, Luca Ferrari and Mario Pellegatti
      Drug Metabolism and Disposition February 2011, 39 (2) 283-293; DOI: https://doi.org/10.1124/dmd.110.035063

  2. Palm, Johan E.

    1. Effects of Ketoconazole on the In Vivo Biotransformation and Hepatobiliary Transport of the Thrombin Inhibitor AZD0837 in Pigs
      Elin M. Matsson, Johan E. Palm, Ulf G. Eriksson, Pernilla Bottner, Anna Lundahl, Lars Knutson and Hans Lennernäs
      Drug Metabolism and Disposition February 2011, 39 (2) 239-246; DOI: https://doi.org/10.1124/dmd.110.035022

  3. Pan, Yongmei

    1. Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening
      Yongmei Pan, Linhao Li, Gregory Kim, Sean Ekins, Hongbing Wang and Peter W. Swaan
      Drug Metabolism and Disposition February 2011, 39 (2) 337-344; DOI: https://doi.org/10.1124/dmd.110.035808

  4. Patten, Christopher J.

    1. CYP4F Enzymes Are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis
      Yi Jin, Markus Zollinger, Hubert Borell, Alfred Zimmerlin and Christopher J. Patten
      Drug Metabolism and Disposition February 2011, 39 (2) 191-198; DOI: https://doi.org/10.1124/dmd.110.035378

  5. Pellegatti, Mario

    1. Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans
      Cecilia Renzulli, Mike Nash, Mark Wright, Steven Thomas, Stefano Zamuner, Mario Pellegatti, Paolo Bettica and Gary Boyle
      Drug Metabolism and Disposition February 2011, 39 (2) 215-227; DOI: https://doi.org/10.1124/dmd.110.035386
    2. Tissue Distribution and Characterization of Drug-Related Material in Rats and Dogs after Repeated Oral Administration of Casopitant
      Sabrina Pagliarusco, Silvia Martinucci, Ellenia Bordini, Lidia Miraglia, Domenico Cufari, Luca Ferrari and Mario Pellegatti
      Drug Metabolism and Disposition February 2011, 39 (2) 283-293; DOI: https://doi.org/10.1124/dmd.110.035063

  6. Possnert, Göran

    1. Morphine Brain Pharmacokinetics at Very Low Concentrations Studied with Accelerator Mass Spectrometry and Liquid Chromatography-Tandem Mass Spectrometry
      Muhammad Waqas Sadiq, Mehran Salehpour, Niklas Forsgard, Göran Possnert and Margareta Hammarlund-Udenaes
      Drug Metabolism and Disposition February 2011, 39 (2) 174-179; DOI: https://doi.org/10.1124/dmd.110.036434

R

  1. Reddy, Srinivasa T.

    1. Human CYP2S1 Metabolizes Cyclooxygenase- and Lipoxygenase-Derived Eicosanoids
      Peter Bui, Satoshi Imaizumi, Sudheer Reddy Beedanagari, Srinivasa T. Reddy and Oliver Hankinson
      Drug Metabolism and Disposition February 2011, 39 (2) 180-190; DOI: https://doi.org/10.1124/dmd.110.035121

  2. Remmel, Rory P.

    1. Correlation between Bilirubin Glucuronidation and Estradiol-3-Gluronidation in the Presence of Model UDP-Glucuronosyltransferase 1A1 Substrates/Inhibitors
      Jin Zhou, Timothy S. Tracy and Rory P. Remmel
      Drug Metabolism and Disposition February 2011, 39 (2) 322-329; DOI: https://doi.org/10.1124/dmd.110.035030

  3. Renzulli, Cecilia

    1. Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans
      Cecilia Renzulli, Mike Nash, Mark Wright, Steven Thomas, Stefano Zamuner, Mario Pellegatti, Paolo Bettica and Gary Boyle
      Drug Metabolism and Disposition February 2011, 39 (2) 215-227; DOI: https://doi.org/10.1124/dmd.110.035386

  4. Rostami-Hodjegan, Amin

    1. Critique of the Two-Fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-Drug Interactions
      Eleanor J. Guest, Leon Aarons, J. Brian Houston, Amin Rostami-Hodjegan and Aleksandra Galetin
      Drug Metabolism and Disposition February 2011, 39 (2) 170-173; DOI: https://doi.org/10.1124/dmd.110.036103

S

  1. Sadiq, Muhammad Waqas

    1. Morphine Brain Pharmacokinetics at Very Low Concentrations Studied with Accelerator Mass Spectrometry and Liquid Chromatography-Tandem Mass Spectrometry
      Muhammad Waqas Sadiq, Mehran Salehpour, Niklas Forsgard, Göran Possnert and Margareta Hammarlund-Udenaes
      Drug Metabolism and Disposition February 2011, 39 (2) 174-179; DOI: https://doi.org/10.1124/dmd.110.036434

  2. Saji, Shigehira

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  3. Salehpour, Mehran

    1. Morphine Brain Pharmacokinetics at Very Low Concentrations Studied with Accelerator Mass Spectrometry and Liquid Chromatography-Tandem Mass Spectrometry
      Muhammad Waqas Sadiq, Mehran Salehpour, Niklas Forsgard, Göran Possnert and Margareta Hammarlund-Udenaes
      Drug Metabolism and Disposition February 2011, 39 (2) 174-179; DOI: https://doi.org/10.1124/dmd.110.036434

  4. Sasaki, Yasutsuna

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  5. Sayer, Claudia

    1. Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways
      Markus Zollinger, Hans-Peter Gschwind, Yi Jin, Claudia Sayer, Frédéric Zécri and Stefan Hartmann
      Drug Metabolism and Disposition February 2011, 39 (2) 199-207; DOI: https://doi.org/10.1124/dmd.110.035907

  6. Schiller, Jürgen

    1. Brain Tissue Binding of Drugs: Evaluation and Validation of Solid Supported Porcine Brain Membrane Vesicles (TRANSIL) as a Novel High-Throughput Method
      Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller and Hinnerk Boriss
      Drug Metabolism and Disposition February 2011, 39 (2) 312-321; DOI: https://doi.org/10.1124/dmd.110.036095

  7. Sharma, Pradeep

    1. The Utility of In Vitro Data in Making Accurate Predictions of Human P-Glycoprotein-Mediated Drug-Drug Interactions: A Case Study for AZD5672
      Robert Elsby, Michael Gillen, Caroline Butters, Gemma Imisson, Pradeep Sharma, Veronica Smith and Dominic D. Surry
      Drug Metabolism and Disposition February 2011, 39 (2) 275-282; DOI: https://doi.org/10.1124/dmd.110.035881

  8. Skolnik, Suzanne

    1. Attenuation of Intestinal Absorption by Major Efflux Transporters: Quantitative Tools and Strategies Using a Caco-2 Model
      Xuena Lin, Suzanne Skolnik, Xiaohui Chen and Jianling Wang
      Drug Metabolism and Disposition February 2011, 39 (2) 265-274; DOI: https://doi.org/10.1124/dmd.110.034629

  9. Smith, Veronica

    1. The Utility of In Vitro Data in Making Accurate Predictions of Human P-Glycoprotein-Mediated Drug-Drug Interactions: A Case Study for AZD5672
      Robert Elsby, Michael Gillen, Caroline Butters, Gemma Imisson, Pradeep Sharma, Veronica Smith and Dominic D. Surry
      Drug Metabolism and Disposition February 2011, 39 (2) 275-282; DOI: https://doi.org/10.1124/dmd.110.035881

  10. Sugiyama, Minako

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  11. Sunakawa, Yu

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  12. Surry, Dominic D.

    1. The Utility of In Vitro Data in Making Accurate Predictions of Human P-Glycoprotein-Mediated Drug-Drug Interactions: A Case Study for AZD5672
      Robert Elsby, Michael Gillen, Caroline Butters, Gemma Imisson, Pradeep Sharma, Veronica Smith and Dominic D. Surry
      Drug Metabolism and Disposition February 2011, 39 (2) 275-282; DOI: https://doi.org/10.1124/dmd.110.035881

  13. Swaan, Peter W.

    1. Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening
      Yongmei Pan, Linhao Li, Gregory Kim, Sean Ekins, Hongbing Wang and Peter W. Swaan
      Drug Metabolism and Disposition February 2011, 39 (2) 337-344; DOI: https://doi.org/10.1124/dmd.110.035808

T

  1. Thomas, Steven

    1. Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans
      Cecilia Renzulli, Mike Nash, Mark Wright, Steven Thomas, Stefano Zamuner, Mario Pellegatti, Paolo Bettica and Gary Boyle
      Drug Metabolism and Disposition February 2011, 39 (2) 215-227; DOI: https://doi.org/10.1124/dmd.110.035386

  2. Tracy, Timothy S.

    1. Correlation between Bilirubin Glucuronidation and Estradiol-3-Gluronidation in the Presence of Model UDP-Glucuronosyltransferase 1A1 Substrates/Inhibitors
      Jin Zhou, Timothy S. Tracy and Rory P. Remmel
      Drug Metabolism and Disposition February 2011, 39 (2) 322-329; DOI: https://doi.org/10.1124/dmd.110.035030

  3. Tremaine, Larry M.

    1. Tissue Distribution and Elimination of [14C]Apixaban in Rats
      Lifei Wang, Kan He, Brad Maxwell, Scott J. Grossman, Larry M. Tremaine, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 256-264; DOI: https://doi.org/10.1124/dmd.110.036442

V

  1. Vinco, Federicia

    1. Brain Tissue Binding of Drugs: Evaluation and Validation of Solid Supported Porcine Brain Membrane Vesicles (TRANSIL) as a Novel High-Throughput Method
      Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller and Hinnerk Boriss
      Drug Metabolism and Disposition February 2011, 39 (2) 312-321; DOI: https://doi.org/10.1124/dmd.110.036095

W

  1. Wang, Hongbing

    1. Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening
      Yongmei Pan, Linhao Li, Gregory Kim, Sean Ekins, Hongbing Wang and Peter W. Swaan
      Drug Metabolism and Disposition February 2011, 39 (2) 337-344; DOI: https://doi.org/10.1124/dmd.110.035808

  2. Wang, Jianling

    1. Attenuation of Intestinal Absorption by Major Efflux Transporters: Quantitative Tools and Strategies Using a Caco-2 Model
      Xuena Lin, Suzanne Skolnik, Xiaohui Chen and Jianling Wang
      Drug Metabolism and Disposition February 2011, 39 (2) 265-274; DOI: https://doi.org/10.1124/dmd.110.034629

  3. Wang, Lifei

    1. Metabolism and Disposition of 14C-Labeled Peliglitazar in Humans
      Lifei Wang, Carey Munsick, Sean Chen, Samuel Bonacorsi, Peter T. Cheng, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 228-238; DOI: https://doi.org/10.1124/dmd.110.035089
    2. Tissue Distribution and Elimination of [14C]Apixaban in Rats
      Lifei Wang, Kan He, Brad Maxwell, Scott J. Grossman, Larry M. Tremaine, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 256-264; DOI: https://doi.org/10.1124/dmd.110.036442

  4. Wright, Mark

    1. Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans
      Cecilia Renzulli, Mike Nash, Mark Wright, Steven Thomas, Stefano Zamuner, Mario Pellegatti, Paolo Bettica and Gary Boyle
      Drug Metabolism and Disposition February 2011, 39 (2) 215-227; DOI: https://doi.org/10.1124/dmd.110.035386

  5. Wu, Defeng

    1. Ethanol Induction of CYP2A5: Permissive Role for CYP2E1
      Yongke Lu, Jian Zhuge, Defeng Wu and Arthur I. Cederbaum
      Drug Metabolism and Disposition February 2011, 39 (2) 330-336; DOI: https://doi.org/10.1124/dmd.110.035691

X

  1. Xie, Hui

    1. Altered Cytochrome P450 Expression in Mice during Pregnancy
      Kwi Hye Koh, Hui Xie, Ai-Ming Yu and Hyunyoung Jeong
      Drug Metabolism and Disposition February 2011, 39 (2) 165-169; DOI: https://doi.org/10.1124/dmd.110.035790

Y

  1. Yamamoto, Wataru

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  2. Yamashita, Keishi

    1. Delayed Elimination of SN-38 in Cancer Patients with Severe Renal Failure
      Ken-ichi Fujita, Yu Sunakawa, Keisuke Miwa, Yuko Akiyama, Minako Sugiyama, Kaori Kawara, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Shigehira Saji, Wataru Ichikawa, Wataru Yamamoto, Fumio Nagashima, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose and Yasutsuna Sasaki
      Drug Metabolism and Disposition February 2011, 39 (2) 161-164; DOI: https://doi.org/10.1124/dmd.110.035451

  3. Yu, Ai-Ming

    1. Altered Cytochrome P450 Expression in Mice during Pregnancy
      Kwi Hye Koh, Hui Xie, Ai-Ming Yu and Hyunyoung Jeong
      Drug Metabolism and Disposition February 2011, 39 (2) 165-169; DOI: https://doi.org/10.1124/dmd.110.035790

  4. Yu, Jian

    1. Elucidation of a Novel Bioactivation Pathway of a 3,4-Unsubstituted Isoxazole in Human Liver Microsomes: Formation of a Glutathione Adduct of a Cyanoacrolein Derivative after Isoxazole Ring Opening
      Jian Yu, James J. Folmer, Valerie Hoesch, James Doherty, James B. Campbell and Doug Burdette
      Drug Metabolism and Disposition February 2011, 39 (2) 302-311; DOI: https://doi.org/10.1124/dmd.110.036285

Z

  1. Zamuner, Stefano

    1. Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans
      Cecilia Renzulli, Mike Nash, Mark Wright, Steven Thomas, Stefano Zamuner, Mario Pellegatti, Paolo Bettica and Gary Boyle
      Drug Metabolism and Disposition February 2011, 39 (2) 215-227; DOI: https://doi.org/10.1124/dmd.110.035386

  2. Zécri, Frédéric

    1. Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways
      Markus Zollinger, Hans-Peter Gschwind, Yi Jin, Claudia Sayer, Frédéric Zécri and Stefan Hartmann
      Drug Metabolism and Disposition February 2011, 39 (2) 199-207; DOI: https://doi.org/10.1124/dmd.110.035907

  3. Zhang, Donglu

    1. Metabolism and Disposition of 14C-Labeled Peliglitazar in Humans
      Lifei Wang, Carey Munsick, Sean Chen, Samuel Bonacorsi, Peter T. Cheng, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 228-238; DOI: https://doi.org/10.1124/dmd.110.035089
    2. Tissue Distribution and Elimination of [14C]Apixaban in Rats
      Lifei Wang, Kan He, Brad Maxwell, Scott J. Grossman, Larry M. Tremaine, W. Griffith Humphreys and Donglu Zhang
      Drug Metabolism and Disposition February 2011, 39 (2) 256-264; DOI: https://doi.org/10.1124/dmd.110.036442

  4. Zhang, Haoming

    1. Inactivation of Cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a Thiophene-Containing Anticancer Drug
      Hsia-lien Lin, Haoming Zhang, Christine Medower, Paul F. Hollenberg and William W. Johnson
      Drug Metabolism and Disposition February 2011, 39 (2) 345-350; DOI: https://doi.org/10.1124/dmd.110.034074

  5. Zhou, Jin

    1. Correlation between Bilirubin Glucuronidation and Estradiol-3-Gluronidation in the Presence of Model UDP-Glucuronosyltransferase 1A1 Substrates/Inhibitors
      Jin Zhou, Timothy S. Tracy and Rory P. Remmel
      Drug Metabolism and Disposition February 2011, 39 (2) 322-329; DOI: https://doi.org/10.1124/dmd.110.035030

  6. Zhuge, Jian

    1. Ethanol Induction of CYP2A5: Permissive Role for CYP2E1
      Yongke Lu, Jian Zhuge, Defeng Wu and Arthur I. Cederbaum
      Drug Metabolism and Disposition February 2011, 39 (2) 330-336; DOI: https://doi.org/10.1124/dmd.110.035691

  7. Zimmerlin, Alfred

    1. CYP4F Enzymes Are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis
      Yi Jin, Markus Zollinger, Hubert Borell, Alfred Zimmerlin and Christopher J. Patten
      Drug Metabolism and Disposition February 2011, 39 (2) 191-198; DOI: https://doi.org/10.1124/dmd.110.035378

  8. Zollinger, Markus

    1. CYP4F Enzymes Are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis
      Yi Jin, Markus Zollinger, Hubert Borell, Alfred Zimmerlin and Christopher J. Patten
      Drug Metabolism and Disposition February 2011, 39 (2) 191-198; DOI: https://doi.org/10.1124/dmd.110.035378
    2. Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways
      Markus Zollinger, Hans-Peter Gschwind, Yi Jin, Claudia Sayer, Frédéric Zécri and Stefan Hartmann
      Drug Metabolism and Disposition February 2011, 39 (2) 199-207; DOI: https://doi.org/10.1124/dmd.110.035907
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