Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleArticle

Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans

Cecilia Renzulli, Mike Nash, Mark Wright, Steven Thomas, Stefano Zamuner, Mario Pellegatti, Paolo Bettica and Gary Boyle
Drug Metabolism and Disposition February 2011, 39 (2) 215-227; DOI: https://doi.org/10.1124/dmd.110.035386
Cecilia Renzulli
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mike Nash
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark Wright
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Steven Thomas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stefano Zamuner
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mario Pellegatti
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paolo Bettica
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gary Boyle
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

vol. 39 no. 2 215-227
DOI 
https://doi.org/10.1124/dmd.110.035386
PubMed 
21045199

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 11, 2010
  • Accepted November 2, 2010
  • Published online January 18, 2011.

Article Versions

  • Earlier version (November 2, 2010 - 12:12).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Cecilia Renzulli,
  2. Mike Nash,
  3. Mark Wright,
  4. Steven Thomas,
  5. Stefano Zamuner,
  6. Mario Pellegatti,
  7. Paolo Bettica and
  8. Gary Boyle
  1. Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Research and Development, Verona, Italy (C.R., M.P.); Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Research and Development, Ware, United Kingdom (M.N., M.W., S.T., G.B.); Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline Research and Development, Verona, Italy (S.Z.); and Discovery Medicine, GlaxoSmithKline Research and Development, Verona, Italy (P.B.)
  1. Address correspondence to:
    Gary Boyle, DMPK, GlaxoSmithKline, Ware, UK. E-mail: gary.w.boyle{at}gsk.com
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2017 to June 2023

AbstractFullPdf
Aug 201721417
Sep 201702414
Oct 20171206
Nov 201702211
Dec 201712211
Jan 201801810
Feb 201821711
Mar 201841817
Apr 201831825
May 20180218
Jun 20182118
Jul 2018297
Aug 201811311
Sep 20180147
Oct 20182312
Nov 201806024
Dec 201830142
Jan 20194435
Feb 20197417
Mar 20195215
Apr 20193107
May 20191414
Jun 20192216
Jul 20191721
Aug 20191923
Oct 20192812
Nov 20193100
Dec 20192703
Jan 20203435
Feb 20202412
Mar 20201713
May 2020820
Jun 20202014
Jul 20201101
Aug 2020303
Sep 20201220
Oct 20201603
Nov 2020811
Dec 20202223
Jan 20211115
Feb 2021191012
Mar 20211534
Apr 20211210
May 20213210
Jun 20213242
Jul 20211813
Aug 20211131
Sep 20212401
Oct 20211941
Nov 20211566
Dec 20212711
Jan 20221731
Feb 20221021
Mar 20222610
Apr 20228124
May 2022712
Jun 20221811
Jul 20221819
Aug 20222343
Sep 20222120
Oct 20222224
Nov 20221632
Dec 20222524
Jan 20232160
Feb 20232735
Mar 20231821
Apr 20231444
May 20232853
Jun 20231012

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 39 (2)
Drug Metabolism and Disposition
Vol. 39, Issue 2
1 Feb 2011
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans

Cecilia Renzulli, Mike Nash, Mark Wright, Steven Thomas, Stefano Zamuner, Mario Pellegatti, Paolo Bettica and Gary Boyle
Drug Metabolism and Disposition February 1, 2011, 39 (2) 215-227; DOI: https://doi.org/10.1124/dmd.110.035386

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans

Cecilia Renzulli, Mike Nash, Mark Wright, Steven Thomas, Stefano Zamuner, Mario Pellegatti, Paolo Bettica and Gary Boyle
Drug Metabolism and Disposition February 1, 2011, 39 (2) 215-227; DOI: https://doi.org/10.1124/dmd.110.035386
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Authorship Contributions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Proteomic Assessment of a Preclinical Model of Preeclampsia
  • Sex- and lifestyle-related factors affect hepatic CYP levels
  • Adipocyte PXR does not play an essential role in obesity.
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics