Table of Contents

Articles

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  Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

  Markus Fridén, Fredrik Bergström, Hong Wan, Mikael Rehngren, Gustav Ahlin, Margareta Hammarlund-Udenaes and Ulf Bredberg

  Drug Metabolism and Disposition March 2011, 39 (3) 353-362; DOI: https://doi.org/10.1124/dmd.110.035998
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  Casopitant: In Vitro Data and SimCyp Simulation to Predict In Vivo Metabolic Interactions Involving Cytochrome P450 3A4

  Paola Motta, Nicoletta Pons, Sabrina Pagliarusco, Mario Pellegatti and Fiorenza Bonomo

  Drug Metabolism and Disposition March 2011, 39 (3) 363-372; DOI: https://doi.org/10.1124/dmd.110.035071
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  Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450

  Yuan Chen, Liling Liu, Khanh Nguyen and Adrian J. Fretland

  Drug Metabolism and Disposition March 2011, 39 (3) 373-382; DOI: https://doi.org/10.1124/dmd.110.035147
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  Prediction of Oral Pharmacokinetics of cMet Kinase Inhibitors in Humans: Physiologically Based Pharmacokinetic Model Versus Traditional One-Compartment Model

  Shinji Yamazaki, Judith Skaptason, David Romero, Sylvia Vekich, Hannah M. Jones, Weiwei Tan, Keith D. Wilner and Tatiana Koudriakova

  Drug Metabolism and Disposition March 2011, 39 (3) 383-393; DOI: https://doi.org/10.1124/dmd.110.035857
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  CYP3A-Mediated Generation of Aldehyde and Hydrazine in Atazanavir Metabolism

  Feng Li, Jie Lu, Laiyou Wang and Xiaochao Ma

  Drug Metabolism and Disposition March 2011, 39 (3) 394-401; DOI: https://doi.org/10.1124/dmd.110.036327
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  Pharmacokinetic and Pharmacodynamic Properties of Cholinesterase Inhibitors Donepezil, Tacrine, and Galantamine in Aged and Young Lister Hooded Rats

  Catherine W. Goh, Chiu Cheong Aw, Jasinda H. Lee, Christopher P. Chen and Edward R. Browne

  Drug Metabolism and Disposition March 2011, 39 (3) 402-411; DOI: https://doi.org/10.1124/dmd.110.035964
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  Simple, Direct, and Informative Method for the Assessment of CYP2C19 Enzyme Inactivation Kinetics

  Kaisa A. Salminen, Jukka Leppänen, Jarkko I. Venäläinen, Markku Pasanen, Seppo Auriola, Risto O. Juvonen and Hannu Raunio

  Drug Metabolism and Disposition March 2011, 39 (3) 412-418; DOI: https://doi.org/10.1124/dmd.110.036376
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  Opposite Effect of Diabetes Mellitus Induced by Streptozotocin on Oral and Intravenous Pharmacokinetics of Verapamil in Rats

  Nan Hu, Shanshan Xie, Li Liu, Xinting Wang, Xian Pan, Guanming Chen, Lulu Zhang, Haiyan Liu, Xiang Liu, Xiaodong Liu, Lin Xie and Guangji Wang

  Drug Metabolism and Disposition March 2011, 39 (3) 419-425; DOI: https://doi.org/10.1124/dmd.110.035642
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  The Bioflavonoid Kaempferol Is an Abcg2 Substrate and Inhibits Abcg2-Mediated Quercetin Efflux

  Guohua An, Jorge Gallegos and Marilyn E. Morris

  Drug Metabolism and Disposition March 2011, 39 (3) 426-432; DOI: https://doi.org/10.1124/dmd.110.035212
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  Validation of Isolated Metabolites from Drug Metabolism Studies as Analytical Standards by Quantitative NMR

  Gregory S. Walker, Tim F. Ryder, Raman Sharma, Evan B. Smith and Amy Freund

  Drug Metabolism and Disposition March 2011, 39 (3) 433-440; DOI: https://doi.org/10.1124/dmd.110.036343
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  Decreased Hepatic Breast Cancer Resistance Protein Expression and Function in Multidrug Resistance-Associated Protein 2-Deficient (TR⁻) Rats

  Wei Yue, Jin Kyung Lee, Koji Abe, Yuichi Sugiyama and Kim L. R. Brouwer

  Drug Metabolism and Disposition March 2011, 39 (3) 441-447; DOI: https://doi.org/10.1124/dmd.110.035188
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  Diabetes Mellitus Reduces Activity of Human UDP-Glucuronosyltransferase 2B7 in Liver and Kidney Leading to Decreased Formation of Mycophenolic Acid Acyl-Glucuronide Metabolite

  Miroslav Dostalek, Michael H. Court, Suwagmani Hazarika and Fatemeh Akhlaghi

  Drug Metabolism and Disposition March 2011, 39 (3) 448-455; DOI: https://doi.org/10.1124/dmd.110.036608
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  Effects of Cell Differentiation and Assay Conditions on the UDP-Glucuronosyltransferase Activity in Caco-2 Cells

  Hongbo Zhang, Ari Tolonen, Timo Rousu, Jouni Hirvonen and Moshe Finel

  Drug Metabolism and Disposition March 2011, 39 (3) 456-464; DOI: https://doi.org/10.1124/dmd.110.036582
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  Gestational and Pregnane X Receptor-Mediated Regulation of Placental ATP-Binding Cassette Drug Transporters in Mice

  Sarabjit S. Gahir and Micheline Piquette-Miller

  Drug Metabolism and Disposition March 2011, 39 (3) 465-471; DOI: https://doi.org/10.1124/dmd.110.034983
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  Identification of 20(S)-Protopanaxadiol Metabolites in Human Liver Microsomes and Human Hepatocytes

  Liang Li, Xiaoyan Chen, Dan Li and Dafang Zhong

  Drug Metabolism and Disposition March 2011, 39 (3) 472-483; DOI: https://doi.org/10.1124/dmd.110.036723
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  Repeated Injection of High Doses of Hemoglobin-Encapsulated Liposomes (Hemoglobin Vesicles) Induces Accelerated Blood Clearance in a Hemorrhagic Shock Rat Model

  Kazuaki Taguchi, Yasunori Iwao, Hiroshi Watanabe, Daisuke Kadowaki, Hiromi Sakai, Koichi Kobayashi, Hirohisa Horinouchi, Toru Maruyama and Masaki Otagiri

  Drug Metabolism and Disposition March 2011, 39 (3) 484-489; DOI: https://doi.org/10.1124/dmd.110.036913
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  Hepatocyte Nuclear Factor 4α Regulates Expression of the Mouse Female-Specific Cyp3a41 Gene in the Liver

  Wattanaporn Bhadhprasit, Tsutomu Sakuma, Yuki Kawasaki and Nobuo Nemoto

  Drug Metabolism and Disposition March 2011, 39 (3) 490-497; DOI: https://doi.org/10.1124/dmd.110.035980
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  Disposition and Metabolism of Cumene in F344 Rats and B6C3F1 Mice

  Ling-Jen Chen, Christopher J. Wegerski, Daniel J. Kramer, Leslie A. Thomas, Jacob D. McDonald, Kelly J. Dix and J. Michael Sanders

  Drug Metabolism and Disposition March 2011, 39 (3) 498-509; DOI: https://doi.org/10.1124/dmd.110.034769
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  Characterization of Human Liver Enzymes Involved in the Biotransformation of Boceprevir, a Hepatitis C Virus Protease Inhibitor

  Anima Ghosal, Yuan Yuan, Wei Tong, Ai-Duen Su, Chunyan Gu, Swapan K. Chowdhury, Narendra S. Kishnani and Kevin B. Alton

  Drug Metabolism and Disposition March 2011, 39 (3) 510-521; DOI: https://doi.org/10.1124/dmd.110.036996
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  Atazanavir Metabolism According to CYP3A5 Status: An In Vitro-In Vivo Assessment

  Michael F. Wempe and Peter L. Anderson

  Drug Metabolism and Disposition March 2011, 39 (3) 522-527; DOI: https://doi.org/10.1124/dmd.110.036178
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  Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes

  Lei Guo, Stacey Dial, Leming Shi, William Branham, Jie Liu, Jia-Long Fang, Bridgett Green, Helen Deng, Jim Kaput and Baitang Ning

  Drug Metabolism and Disposition March 2011, 39 (3) 528-538; DOI: https://doi.org/10.1124/dmd.110.035873
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  Comparison of In Vitro Metabolism of Ticlopidine by Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4

  Jyothi C. Talakad, Manish B. Shah, Gregory S. Walker, Cathie Xiang, James R. Halpert and Deepak Dalvie

  Drug Metabolism and Disposition March 2011, 39 (3) 539-550; DOI: https://doi.org/10.1124/dmd.110.037101
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  Control and Measurement of Plasma pH in Equilibrium Dialysis: Influence on Drug Plasma Protein Binding

  Ruth E. Curran, Christopher R. J. Claxton, Laura Hutchison, Paul J. Harradine, Iain J. Martin and Peter Littlewood

  Drug Metabolism and Disposition March 2011, 39 (3) 551-557; DOI: https://doi.org/10.1124/dmd.110.036988