Advertisement
Research ArticleArticle

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Markus Fridén, Fredrik Bergström, Hong Wan, Mikael Rehngren, Gustav Ahlin, Margareta Hammarlund-Udenaes and Ulf Bredberg
Drug Metabolism and Disposition March 2011, 39 (3) 353-362; DOI: https://doi.org/10.1124/dmd.110.035998

Article Information

vol. 39 no. 3 353-362
DOI 
https://doi.org/10.1124/dmd.110.035998
PubMed 
21149540
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 20, 2010
  • Accepted December 13, 2010
  • Published online February 17, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Markus Fridén,
  2. Fredrik Bergström,
  3. Hong Wan,
  4. Mikael Rehngren,
  5. Gustav Ahlin,
  6. Margareta Hammarlund-Udenaes and
  7. Ulf Bredberg
  1. Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden (M.F., M.H.-U.); Discovery Drug Metabolism and Pharmacokinetics (M.F., M.R., U.B.) and Lead Generation, AstraZeneca R&D, Mölndal, Sweden (F.B., H.W.); and Pharmaceutical Screening and Informatics, Department of Pharmacy, Uppsala University, Uppsala, Sweden (G.A.)
  1. Address correspondence to:
    Dr. Markus Fridén, Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden. E-mail: markus.friden{at}farmbio.uu.se
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2017 to March 2023

AbstractFullPdf
Aug 201734030
Sep 201773322
Oct 201735930
Nov 201733825
Dec 201713720
Jan 201824528
Feb 201826439
Mar 201823822
Apr 201804940
May 201806542
Jun 201824435
Jul 201844136
Aug 201822937
Sep 201803613
Oct 201835321
Nov 201894432
Dec 2018391828
Jan 201929187
Feb 2019561615
Mar 2019781121
Apr 2019511723
May 2019503525
Jun 201920109
Jul 2019212016
Aug 201919917
Oct 2019551219
Nov 2019851414
Dec 2019521611
Jan 2020662111
Feb 2020401924
Mar 2020271413
May 20204347
Jun 20203886
Jul 202082713
Aug 202021612
Sep 2020331411
Oct 202057812
Nov 2020361615
Dec 2020481113
Jan 2021952623
Feb 2021713125
Mar 2021501611
Apr 20213777
May 2021511322
Jun 202134117
Jul 202139818
Aug 2021331520
Sep 2021581516
Oct 2021711014
Nov 2021951025
Dec 2021981115
Jan 2022931115
Feb 2022751016
Mar 20221321619
Apr 20221481826
May 20227497
Jun 2022601318
Jul 2022501832
Aug 2022861713
Sep 20221092220
Oct 2022473019
Nov 202277924
Dec 2022571722
Jan 202394169
Feb 2023731415
Mar 2023761211

Back to top

In this issue

Download PDF
Article Alerts
Email Article
Citation Tools

Research ArticleArticle

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Markus Fridén, Fredrik Bergström, Hong Wan, Mikael Rehngren, Gustav Ahlin, Margareta Hammarlund-Udenaes and Ulf Bredberg
Drug Metabolism and Disposition March 1, 2011, 39 (3) 353-362; DOI: https://doi.org/10.1124/dmd.110.035998
Reddit logo Twitter logo Facebook logo Mendeley logo

Jump to section

Advertisement