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Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Markus Fridén, Fredrik Bergström, Hong Wan, Mikael Rehngren, Gustav Ahlin, Margareta Hammarlund-Udenaes and Ulf Bredberg
Drug Metabolism and Disposition March 2011, 39 (3) 353-362; DOI: https://doi.org/10.1124/dmd.110.035998
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Research ArticleArticle

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Markus Fridén, Fredrik Bergström, Hong Wan, Mikael Rehngren, Gustav Ahlin, Margareta Hammarlund-Udenaes and Ulf Bredberg
Drug Metabolism and Disposition March 1, 2011, 39 (3) 353-362; DOI: https://doi.org/10.1124/dmd.110.035998
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