Article Figures & Data
Tables
Parameter Estimate RSE LLP 95% CI RSE/RSE Prior Lower Upper % CLpac (l/h) 378 8.4 322 441 V1 (liters) 188 11 0.66 V2 (liters) 1100 8.2 0.54 V3 (liters) 222 14 0.68 Q2 (l/h) 123 10 0.45 Q3 (l/h) 181 13 0.57 Blin 7.89 10 0.84 BCrEL 3.62 9.1 0.91 Bmax (μmol/l) 0.0207 22 0.81 Km (μmol/l) 0.000123 36 0.83 ε1, pac (%) 24.4 4.7 22.3 26.8 IIVCLpac (CV %)a 15.3 39b 10.0 22.3 IIVBlin (CV %)a 101 34b 67.3 176 CL6αOH/fmpac (l/h) 2830 26 1850 4750 V6αOH/fmpac (liters) 1390 24 945 2230 BCrEL, 6αOH 43.0 40 24.4 99 Bnsp, 6αOH (μmol/l) 0.000754 12 0.000588 0.000947 ε1, 6αOH (%) 25.4 5.6 22.9 28.4 ε2, 6αOH, i=1 (μmol/l) 0.00447 30 0.00250 0.00772 IIVCL6αOH/fmpac (CV %)a 36.6 36b 25.1 53.8 CLp3OH/fmpac (l/h) 1470 16 1090 2020 Vp3OH/fmpac (l/h) 1140 13 883 1490 BCrEL, p3OH 8.60 32 5.24 16.1 Bnsp, p3OH (μmol/l) 0.00124 10 0.00103 0.00149 ε1, p3OH (%) 37.7 4.8 34.5 41.6 IIVfp3OH/fmpac 0.425c 29b 0.245c 0.769c CrEL50 (ml/l) 4.48 18 3.55 6.21 HillCrEL 2.71 13 2.20 3.39 IIVHillCrEL (CV %)a 40.1 38b 26.8 58.9 CLdiOH/fmmet (l/h) 831 15 606 1140 VdiOH/fmmet (liters) 167 23 97.1 246 ε1, diOH (%) 49.8 8.4 42.6 59.3 ε2, diOH (μmol/l) 0.00197 22 0.00134 0.00315 IIVCLdiOH/fmmet (CV %)a 60.7 39b 40.8 104 CLpac, clearance of unbound concentrations of paclitaxel; V1, V2, and V3, volumes of the central, first, and second peripheral compartment for unbound concentrations of paclitaxel; Q2 and Q3, intercompartmental clearances between the central and peripheral compartments for unbound concentrations of paclitaxel; Blin, linear binding to plasma components; BCrEL, binding directly proportional to CrEL concentration; Bmax, maximal binding to plasma components; Km, concentration at half of the maximal binding to plasma components; CL6αOH/fmpac and CLp3OH/fmpac, clearance of unbound concentrations of 6αOH-pac and p3OH-pac over fraction metabolized unbound paclitaxel; V6αOH/fmpac and Vp3OH/fmpac, volume of distribution of unbound concentrations of 6αOH-pac and p3OH-pac over fraction metabolized unbound paclitaxel; BCrEL, 6αOH and BCrEL, p3OH, maximal binding rate to CrEL of 6αOH-pac and p3OH-pac; Bnsp, 6αOH and Bnsp, p3OH, nonspecific CrEL component for 6αOH-pac and p3OH-pac; CrEL50, CrEL concentration at half-maximal binding rate; HillCrEL, Hill coefficient for CrEL concentration; CLdiOH/fmmet, clearance of unbound concentrations of diOH-pac over fraction metabolized unbound primary metabolite; VdiOH/fmmet, volume of distribution of unbound concentrations of diOH-pac over fraction metabolized unbound primary metabolite; ε1, proportional residual error for total concentrations; ε2, 6αOH, i=1, additive error for first sample for each individual of total concentration of 6αOH-pac; ε2, diOH, additive error for total concentration of diOH-pac; IIVCLpac, IIVBlin, IIVCL6αOH/fmpac, IIVfp3OH/fmpac, IIVHillCrEL, IIVCLdiOH/fmmet, interindividual variability in the designated parameter.
↵a Coefficient of variation, calculated as [exp(ω2) − 1]0.5.
↵b With respect to the variance term, ω2.
↵c Estimate given for the corresponding variance term, ω2, of β in eqs. 5 and 6.