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Drug Metabolism & Disposition

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Table of Contents

April 01, 2011; Volume 39,Issue 4

Short Communication

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    The Intestine As an Important Contributor to Prasugrel Active Metabolite Formation In Vivo
    Katsunobu Hagihara, Miho Kazui, Hidenori Ikenaga, Toshihiko Nanba, Kiichi Fusegawa, Takashi Izumi, Toshihiko Ikeda and Atsushi Kurihara
    Drug Metabolism and Disposition April 2011, 39 (4) 565-570; DOI: https://doi.org/10.1124/dmd.110.035956

Articles

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    Hepatic Pharmacokinetics of Cationic Drugs in a High-Fat Emulsion-Induced Rat Model of Nonalcoholic Steatohepatitis
    Peng Li, Thomas A. Robertson, Camilla A. Thorling, Qian Zhang, Linda M. Fletcher, Darrell H. G. Crawford and Michael S. Roberts
    Drug Metabolism and Disposition April 2011, 39 (4) 571-579; DOI: https://doi.org/10.1124/dmd.110.036806
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    Metabolism and Excretion of Asenapine in Healthy Male Subjects
    S. F. M. van de Wetering-Krebbers, P. L. Jacobs, G. J. Kemperman, E. Spaans, P. A. M. Peeters, L. P. C. Delbressine and M. L. P. S. van Iersel
    Drug Metabolism and Disposition April 2011, 39 (4) 580-590; DOI: https://doi.org/10.1124/dmd.110.036715
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    Prediction of CYP3A-Mediated Drug-Drug Interactions Using Human Hepatocytes Suspended in Human Plasma
    Jialin Mao, Michael A. Mohutsky, John P. Harrelson, Steven A. Wrighton and Stephen D. Hall
    Drug Metabolism and Disposition April 2011, 39 (4) 591-602; DOI: https://doi.org/10.1124/dmd.110.036400
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    Pharmacokinetic Analysis of Continuous Erythropoietin Receptor Activator Disposition in Adult Sheep Using a Target-Mediated, Physiologic Recirculation Model and a Tracer Interaction Methodology
    Mohammed H. El-Komy, John A. Widness and Peter Veng-Pedersen
    Drug Metabolism and Disposition April 2011, 39 (4) 603-609; DOI: https://doi.org/10.1124/dmd.110.036236
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    Glucuronidation of the Red Clover Isoflavone Irilone by Liver Microsomes from Different Species and Human UDP-Glucuronosyltransferases
    Ronald Maul, Diana Siegl and Sabine E. Kulling
    Drug Metabolism and Disposition April 2011, 39 (4) 610-616; DOI: https://doi.org/10.1124/dmd.110.033076
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    Metabolism of Gambogic Acid in Rats: A Rare Intestinal Metabolic Pathway Responsible for Its Final Disposition
    Jing Yang, Li Ding, Linlin Hu, Wenjuan Qian, Shaohong Jin, Xiaoping Sun, Zhenzhong Wang and Wei Xiao
    Drug Metabolism and Disposition April 2011, 39 (4) 617-626; DOI: https://doi.org/10.1124/dmd.110.037044
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    In Vitro Metabolism of 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin in Human Liver Microsomes
    Nan Zheng, Peng Zou, Shaomeng Wang and Duxin Sun
    Drug Metabolism and Disposition April 2011, 39 (4) 627-635; DOI: https://doi.org/10.1124/dmd.110.036418
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    Biotransformation of a Novel Antimitotic Agent, I-387, by Mouse, Rat, Dog, Monkey, and Human Liver Microsomes and In Vivo Pharmacokinetics in Mice
    Sunjoo Ahn, Jeffrey D. Kearbey, Chien-Ming Li, Charles B. Duke, Duane D. Miller and James T. Dalton
    Drug Metabolism and Disposition April 2011, 39 (4) 636-643; DOI: https://doi.org/10.1124/dmd.110.036673
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    Characterization of Niflumic Acid as a Selective Inhibitor of Human Liver Microsomal UDP-Glucuronosyltransferase 1A9: Application to the Reaction Phenotyping of Acetaminophen Glucuronidation
    John O. Miners, Kushari Bowalgaha, David J. Elliot, Pawel Baranczewski and Kathleen M. Knights
    Drug Metabolism and Disposition April 2011, 39 (4) 644-652; DOI: https://doi.org/10.1124/dmd.110.037036
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    Pharmacokinetics, Metabolism, and Disposition of Rivoglitazone, a Novel Peroxisome Proliferator-Activated Receptor γ Agonist, in Rats and Monkeys
    Minoru Uchiyama, Haruo Iwabuchi, Fujiko Tsuruta, Koji Abe, Makoto Takahashi, Hiroko Koda, Minoru Oguchi, Osamu Okazaki and Takashi Izumi
    Drug Metabolism and Disposition April 2011, 39 (4) 653-666; DOI: https://doi.org/10.1124/dmd.110.036194
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    Role of Catechol-O-Methyltransferase in the Disposition of Luteolin in Rats
    Zhongjian Chen, Meng Chen, Hao Pan, Siyuan Sun, Liping Li, Su Zeng and Huidi Jiang
    Drug Metabolism and Disposition April 2011, 39 (4) 667-674; DOI: https://doi.org/10.1124/dmd.110.037333
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    Comparative Metabolism of Cinobufagin in Liver Microsomes from Mouse, Rat, Dog, Minipig, Monkey, and Human
    Xiao-Chi Ma, Jing Ning, Guang-Bo Ge, Si-Cheng Liang, Xiu-Li Wang, Bao-Jing Zhang, Shan-Shan Huang, Jing-Kui Li and Ling Yang
    Drug Metabolism and Disposition April 2011, 39 (4) 675-682; DOI: https://doi.org/10.1124/dmd.110.036830
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    Metabolic Pathways of the Camptothecin Analog AR-67
    Jamie Horn, Marta Milewska, Susanne M. Arnold and Markos Leggas
    Drug Metabolism and Disposition April 2011, 39 (4) 683-692; DOI: https://doi.org/10.1124/dmd.110.037390
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    In Vitro Metabolism of Oxymetazoline: Evidence for Bioactivation to a Reactive Metabolite
    Mukesh K. Mahajan, Vinita Uttamsingh, J. Scott Daniels, Liang-Shang Gan, Barbara W. LeDuc and David A. Williams
    Drug Metabolism and Disposition April 2011, 39 (4) 693-702; DOI: https://doi.org/10.1124/dmd.110.036004
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    In Vitro Evaluation of Potential Drug-Drug Interactions with Ticagrelor: Cytochrome P450 Reaction Phenotyping, Inhibition, Induction, and Differential Kinetics
    Diansong Zhou, Tommy B. Andersson and Scott W. Grimm
    Drug Metabolism and Disposition April 2011, 39 (4) 703-710; DOI: https://doi.org/10.1124/dmd.110.037143
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    Discovery of a Novel Allelic Variant of CYP2C8, CYP2C8*11, in Asian Populations and Its Clinical Effect on the Rosiglitazone Disposition In Vivo
    Chang-Woo Yeo, Su-Jun Lee, Sang Seop Lee, Soo Kyung Bae, Eun-Young Kim, Ji-Hong Shon, Byoung Doo Rhee and Jae-Gook Shin
    Drug Metabolism and Disposition April 2011, 39 (4) 711-716; DOI: https://doi.org/10.1124/dmd.110.035899
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    CYP2G2, Pseudogenized in Human, Is Expressed in Nasal Mucosa of Cynomolgus Monkey and Encodes a Functional Drug-Metabolizing Enzyme
    Yasuhiro Uno, Shotaro Uehara, Norie Murayama and Hiroshi Yamazaki
    Drug Metabolism and Disposition April 2011, 39 (4) 717-723; DOI: https://doi.org/10.1124/dmd.110.036574
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    Comparison of the Inhibitory Profiles of Itraconazole and Cimetidine in Cytochrome P450 3A4 Genetic Variants
    Takeshi Akiyoshi, Takashi Saito, Saori Murase, Mitsue Miyazaki, Norie Murayama, Hiroshi Yamazaki, F. Peter Guengerich, Katsunori Nakamura, Koujirou Yamamoto and Hisakazu Ohtani
    Drug Metabolism and Disposition April 2011, 39 (4) 724-728; DOI: https://doi.org/10.1124/dmd.110.036780
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In this issue

Drug Metabolism and Disposition: 39 (4)
Drug Metabolism and Disposition
Vol. 39, Issue 4
1 Apr 2011
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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