Table of Contents

Articles

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  Hepatic Pharmacokinetics of Cationic Drugs in a High-Fat Emulsion-Induced Rat Model of Nonalcoholic Steatohepatitis

  Peng Li, Thomas A. Robertson, Camilla A. Thorling, Qian Zhang, Linda M. Fletcher, Darrell H. G. Crawford and Michael S. Roberts

  Drug Metabolism and Disposition April 2011, 39 (4) 571-579; DOI: https://doi.org/10.1124/dmd.110.036806
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  Metabolism and Excretion of Asenapine in Healthy Male Subjects

  S. F. M. van de Wetering-Krebbers, P. L. Jacobs, G. J. Kemperman, E. Spaans, P. A. M. Peeters, L. P. C. Delbressine and M. L. P. S. van Iersel

  Drug Metabolism and Disposition April 2011, 39 (4) 580-590; DOI: https://doi.org/10.1124/dmd.110.036715
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  Prediction of CYP3A-Mediated Drug-Drug Interactions Using Human Hepatocytes Suspended in Human Plasma

  Jialin Mao, Michael A. Mohutsky, John P. Harrelson, Steven A. Wrighton and Stephen D. Hall

  Drug Metabolism and Disposition April 2011, 39 (4) 591-602; DOI: https://doi.org/10.1124/dmd.110.036400
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  Pharmacokinetic Analysis of Continuous Erythropoietin Receptor Activator Disposition in Adult Sheep Using a Target-Mediated, Physiologic Recirculation Model and a Tracer Interaction Methodology

  Mohammed H. El-Komy, John A. Widness and Peter Veng-Pedersen

  Drug Metabolism and Disposition April 2011, 39 (4) 603-609; DOI: https://doi.org/10.1124/dmd.110.036236
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  Glucuronidation of the Red Clover Isoflavone Irilone by Liver Microsomes from Different Species and Human UDP-Glucuronosyltransferases

  Ronald Maul, Diana Siegl and Sabine E. Kulling

  Drug Metabolism and Disposition April 2011, 39 (4) 610-616; DOI: https://doi.org/10.1124/dmd.110.033076
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  Metabolism of Gambogic Acid in Rats: A Rare Intestinal Metabolic Pathway Responsible for Its Final Disposition

  Jing Yang, Li Ding, Linlin Hu, Wenjuan Qian, Shaohong Jin, Xiaoping Sun, Zhenzhong Wang and Wei Xiao

  Drug Metabolism and Disposition April 2011, 39 (4) 617-626; DOI: https://doi.org/10.1124/dmd.110.037044
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  In Vitro Metabolism of 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin in Human Liver Microsomes

  Nan Zheng, Peng Zou, Shaomeng Wang and Duxin Sun

  Drug Metabolism and Disposition April 2011, 39 (4) 627-635; DOI: https://doi.org/10.1124/dmd.110.036418
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  Biotransformation of a Novel Antimitotic Agent, I-387, by Mouse, Rat, Dog, Monkey, and Human Liver Microsomes and In Vivo Pharmacokinetics in Mice

  Sunjoo Ahn, Jeffrey D. Kearbey, Chien-Ming Li, Charles B. Duke, Duane D. Miller and James T. Dalton

  Drug Metabolism and Disposition April 2011, 39 (4) 636-643; DOI: https://doi.org/10.1124/dmd.110.036673
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  Characterization of Niflumic Acid as a Selective Inhibitor of Human Liver Microsomal UDP-Glucuronosyltransferase 1A9: Application to the Reaction Phenotyping of Acetaminophen Glucuronidation

  John O. Miners, Kushari Bowalgaha, David J. Elliot, Pawel Baranczewski and Kathleen M. Knights

  Drug Metabolism and Disposition April 2011, 39 (4) 644-652; DOI: https://doi.org/10.1124/dmd.110.037036
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  Pharmacokinetics, Metabolism, and Disposition of Rivoglitazone, a Novel Peroxisome Proliferator-Activated Receptor γ Agonist, in Rats and Monkeys

  Minoru Uchiyama, Haruo Iwabuchi, Fujiko Tsuruta, Koji Abe, Makoto Takahashi, Hiroko Koda, Minoru Oguchi, Osamu Okazaki and Takashi Izumi

  Drug Metabolism and Disposition April 2011, 39 (4) 653-666; DOI: https://doi.org/10.1124/dmd.110.036194
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  Role of Catechol-O-Methyltransferase in the Disposition of Luteolin in Rats

  Zhongjian Chen, Meng Chen, Hao Pan, Siyuan Sun, Liping Li, Su Zeng and Huidi Jiang

  Drug Metabolism and Disposition April 2011, 39 (4) 667-674; DOI: https://doi.org/10.1124/dmd.110.037333
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  Comparative Metabolism of Cinobufagin in Liver Microsomes from Mouse, Rat, Dog, Minipig, Monkey, and Human

  Xiao-Chi Ma, Jing Ning, Guang-Bo Ge, Si-Cheng Liang, Xiu-Li Wang, Bao-Jing Zhang, Shan-Shan Huang, Jing-Kui Li and Ling Yang

  Drug Metabolism and Disposition April 2011, 39 (4) 675-682; DOI: https://doi.org/10.1124/dmd.110.036830
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  Metabolic Pathways of the Camptothecin Analog AR-67

  Jamie Horn, Marta Milewska, Susanne M. Arnold and Markos Leggas

  Drug Metabolism and Disposition April 2011, 39 (4) 683-692; DOI: https://doi.org/10.1124/dmd.110.037390
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  In Vitro Metabolism of Oxymetazoline: Evidence for Bioactivation to a Reactive Metabolite

  Mukesh K. Mahajan, Vinita Uttamsingh, J. Scott Daniels, Liang-Shang Gan, Barbara W. LeDuc and David A. Williams

  Drug Metabolism and Disposition April 2011, 39 (4) 693-702; DOI: https://doi.org/10.1124/dmd.110.036004
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  In Vitro Evaluation of Potential Drug-Drug Interactions with Ticagrelor: Cytochrome P450 Reaction Phenotyping, Inhibition, Induction, and Differential Kinetics

  Diansong Zhou, Tommy B. Andersson and Scott W. Grimm

  Drug Metabolism and Disposition April 2011, 39 (4) 703-710; DOI: https://doi.org/10.1124/dmd.110.037143
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  Discovery of a Novel Allelic Variant of CYP2C8, CYP2C8*11, in Asian Populations and Its Clinical Effect on the Rosiglitazone Disposition In Vivo

  Chang-Woo Yeo, Su-Jun Lee, Sang Seop Lee, Soo Kyung Bae, Eun-Young Kim, Ji-Hong Shon, Byoung Doo Rhee and Jae-Gook Shin

  Drug Metabolism and Disposition April 2011, 39 (4) 711-716; DOI: https://doi.org/10.1124/dmd.110.035899
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  CYP2G2, Pseudogenized in Human, Is Expressed in Nasal Mucosa of Cynomolgus Monkey and Encodes a Functional Drug-Metabolizing Enzyme

  Yasuhiro Uno, Shotaro Uehara, Norie Murayama and Hiroshi Yamazaki

  Drug Metabolism and Disposition April 2011, 39 (4) 717-723; DOI: https://doi.org/10.1124/dmd.110.036574
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  Comparison of the Inhibitory Profiles of Itraconazole and Cimetidine in Cytochrome P450 3A4 Genetic Variants

  Takeshi Akiyoshi, Takashi Saito, Saori Murase, Mitsue Miyazaki, Norie Murayama, Hiroshi Yamazaki, F. Peter Guengerich, Katsunori Nakamura, Koujirou Yamamoto and Hisakazu Ohtani

  Drug Metabolism and Disposition April 2011, 39 (4) 724-728; DOI: https://doi.org/10.1124/dmd.110.036780