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Drug Metabolism & Disposition

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Table of Contents

May 01, 2011; Volume 39,Issue 5

Short Communications

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    Differential Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) on Axitinib Brain Accumulation and Oral Plasma Pharmacokinetics
    Birk Poller, Dilek Iusuf, Rolf W. Sparidans, Els Wagenaar, Jos H. Beijnen and Alfred H. Schinkel
    Drug Metabolism and Disposition May 2011, 39 (5) 729-735; DOI: https://doi.org/10.1124/dmd.110.037317
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    In Vivo Magnetic Resonance Imaging to Detect Biliary Excretion of 19F-Labeled Drug in Mice
    Jean-Pierre Raufman, Su Xu, Kunrong Cheng, Sandeep Khurana, Diana Johnson, Changxing Shao, Maureen A. Kane, Da Shi, Rao Gullapalli and James Polli
    Drug Metabolism and Disposition May 2011, 39 (5) 736-739; DOI: https://doi.org/10.1124/dmd.110.037358

Articles

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    Metabolism of LY654322, a Growth Hormone Secretagogue, to an Unusual Diimidazopyridine Metabolite
    Anthony G. Borel, Timothy M. Jones, Robert J. Barbuch, David A. Jackson, Palaniappan Kulanthaivel, Edward Mattiuz, Valentine J. Klimkowski, William J. Wheeler and Gregory A. Rener
    Drug Metabolism and Disposition May 2011, 39 (5) 740-749; DOI: https://doi.org/10.1124/dmd.110.037598
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    Identification of the Metabolites of the Antioxidant Flavonoid 7-Mono-O-(β-hydroxyethyl)-rutoside in Mice
    Hilde Jacobs, Ron Peters, Gertjan J. M. den Hartog, Wim J. F. van der Vijgh, Aalt Bast and Guido R. M. M. Haenen
    Drug Metabolism and Disposition May 2011, 39 (5) 750-756; DOI: https://doi.org/10.1124/dmd.110.036525
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    Sorafenib and Sunitinib, Two Anticancer Drugs, Inhibit CYP3A4-Mediated and Activate CY3A5-Mediated Midazolam 1′-Hydroxylation
    Minako Sugiyama, Ken-ichi Fujita, Norie Murayama, Yuko Akiyama, Hiroshi Yamazaki and Yasutsuna Sasaki
    Drug Metabolism and Disposition May 2011, 39 (5) 757-762; DOI: https://doi.org/10.1124/dmd.110.037853
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    Novel Cytochrome P450-Mediated Ring Opening of the 1,3,4-Oxadiazole in Setileuton, a 5-Lipoxygenase Inhibitor
    Cheri M. Maciolek, Bennett Ma, Karsten Menzel, Sebastien Laliberte, Kevin Bateman, Paul Krolikowski and Christoper R. Gibson
    Drug Metabolism and Disposition May 2011, 39 (5) 763-770; DOI: https://doi.org/10.1124/dmd.110.037366
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    Influence of Drug Solubility and Lipophilicity on Transscleral Retinal Delivery of Six Corticosteroids
    Ashish Thakur, Rajendra S. Kadam and Uday B. Kompella
    Drug Metabolism and Disposition May 2011, 39 (5) 771-781; DOI: https://doi.org/10.1124/dmd.110.037408
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    Anandamide Oxidation by Wild-Type and Polymorphically Expressed CYP2B6 and CYP2D6
    Chitra Sridar, Natasha T. Snider and Paul F. Hollenberg
    Drug Metabolism and Disposition May 2011, 39 (5) 782-788; DOI: https://doi.org/10.1124/dmd.110.036707
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    Pharmacokinetic Interaction of the Antiparasitic Agents Ivermectin and Spinosad in Dogs
    Stewart T. Dunn, Laura Hedges, Kathleen E. Sampson, Yurong Lai, Sean Mahabir, Larissa Balogh and Charles W. Locuson
    Drug Metabolism and Disposition May 2011, 39 (5) 789-795; DOI: https://doi.org/10.1124/dmd.110.034827
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    Contribution of Carboxylesterase in Hamster to the Intestinal First-Pass Loss and Low Bioavailability of Ethyl Piperate, an Effective Lipid-Lowering Drug Candidate
    Youli Lu, Narisu Bao, Gereltu Borjihan, Yanling Ma, Miaomiao Hu, Chen Yu, Shuijun Li, Jingying Jia, Ding Yang and Yiping Wang
    Drug Metabolism and Disposition May 2011, 39 (5) 796-802; DOI: https://doi.org/10.1124/dmd.110.037614
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    Metabolism of the c-Fos/Activator Protein-1 Inhibitor T-5224 by Multiple Human UDP-Glucuronosyltransferase Isoforms
    Shinsuke Uchihashi, Hiroyuki Fukumoto, Makoto Onoda, Hiroyoshi Hayakawa, Shin-ichi Ikushiro and Toshiyuki Sakaki
    Drug Metabolism and Disposition May 2011, 39 (5) 803-813; DOI: https://doi.org/10.1124/dmd.110.037952
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    Organic Anion Transporter 3 Mediates the Efflux Transport of an Amphipathic Organic Anion, Dehydroepiandrosterone Sulfate, across the Blood-Brain Barrier in Mice
    Mari Miyajima, Hiroyuki Kusuhara, Miki Fujishima, Yasuhisa Adachi and Yuichi Sugiyama
    Drug Metabolism and Disposition May 2011, 39 (5) 814-819; DOI: https://doi.org/10.1124/dmd.110.036863
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    Human Pharmacokinetic Prediction of UDP-Glucuronosyltransferase Substrates with an Animal Scale-Up Approach
    Tsuneo Deguchi, Nobuaki Watanabe, Atsushi Kurihara, Katsuhiro Igeta, Hidenori Ikenaga, Keiichi Fusegawa, Norio Suzuki, Shinji Murata, Masakazu Hirouchi, Yoshitake Furuta, Masaru Iwasaki, Osamu Okazaki and Takashi Izumi
    Drug Metabolism and Disposition May 2011, 39 (5) 820-829; DOI: https://doi.org/10.1124/dmd.110.037457
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    Evaluation of the Effects of 20 Nonsynonymous Single Nucleotide Polymorphisms of CYP2C19 on S-Mephenytoin 4′-Hydroxylation and Omeprazole 5′-Hydroxylation
    Huijuan Wang, Nianzhen An, Hao Wang, Yiwen Gao, Duan Liu, Ting Bian, Juanli Zhu and Chao Chen
    Drug Metabolism and Disposition May 2011, 39 (5) 830-837; DOI: https://doi.org/10.1124/dmd.110.037549
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    CYP2C9-Mediated Metabolic Activation of Losartan Detected by a Highly Sensitive Cell-Based Screening Assay
    Atsushi Iwamura, Tatsuki Fukami, Hiroko Hosomi, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition May 2011, 39 (5) 838-846; DOI: https://doi.org/10.1124/dmd.110.037259
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    In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5α-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole
    Anna Lundahl, Mikael Hedeland, Ulf Bondesson and Hans Lennernäs
    Drug Metabolism and Disposition May 2011, 39 (5) 847-857; DOI: https://doi.org/10.1124/dmd.110.035311
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    Optimal Experimental Design for Assessment of Enzyme Kinetics in a Drug Discovery Screening Environment
    Erik Sjögren, Joakim Nyberg, Mats O. Magnusson, Hans Lennernäs, Andrew Hooker and Ulf Bredberg
    Drug Metabolism and Disposition May 2011, 39 (5) 858-863; DOI: https://doi.org/10.1124/dmd.110.037309
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    Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data
    Helen E. Cubitt, J. Brian Houston and Aleksandra Galetin
    Drug Metabolism and Disposition May 2011, 39 (5) 864-873; DOI: https://doi.org/10.1124/dmd.110.036566
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    Differential Role of Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein in Toll-Like Receptor 2-Mediated Regulation of Gene Expression of Hepatic Cytokines and Drug-Metabolizing Enzymes
    Romi Ghose, Tao Guo, Jesus G. Vallejo and Adarsh Gandhi
    Drug Metabolism and Disposition May 2011, 39 (5) 874-881; DOI: https://doi.org/10.1124/dmd.110.037382
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    Liver-Selective Expression of Human Arylamine N-Acetyltransferase NAT2 in Transgenic Mice
    Kim S. Sugamori, Debbie Brenneman and Denis M. Grant
    Drug Metabolism and Disposition May 2011, 39 (5) 882-890; DOI: https://doi.org/10.1124/dmd.111.038216
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    Metabolism and Disposition of [14C]Brivanib Alaninate after Oral Administration to Rats, Monkeys, and Humans
    Jiachang Gong, Jinping Gan, Janet Caceres-Cortes, Lisa J. Christopher, Vinod Arora, Eric Masson, Daphne Williams, Janice Pursley, Alban Allentoff, Michael Lago, Scott B. Tran and Ramaswamy A. Iyer
    Drug Metabolism and Disposition May 2011, 39 (5) 891-903; DOI: https://doi.org/10.1124/dmd.110.037341
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    Reevaluation of the Microsomal Metabolism of Montelukast: Major Contribution by CYP2C8 at Clinically Relevant Concentrations
    Anne M. Filppula, Jouko Laitila, Pertti J. Neuvonen and Janne T. Backman
    Drug Metabolism and Disposition May 2011, 39 (5) 904-911; DOI: https://doi.org/10.1124/dmd.110.037689
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    The Development of UDP-Glucuronosyltransferases 1A1 and 1A6 in the Pediatric Liver
    Shogo J. Miyagi and Abby C. Collier
    Drug Metabolism and Disposition May 2011, 39 (5) 912-919; DOI: https://doi.org/10.1124/dmd.110.037192
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    Interactions of Green Tea Catechins with Organic Anion-Transporting Polypeptides
    Megan Roth, Barbara N. Timmermann and Bruno Hagenbuch
    Drug Metabolism and Disposition May 2011, 39 (5) 920-926; DOI: https://doi.org/10.1124/dmd.110.036640
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    Effect of the CYP2C8 Genotype on the Pharmacokinetics and Pharmacodynamics of Repaglinide
    Dorota Tomalik-Scharte, Uwe Fuhr, Martin Hellmich, Dorothee Frank, Oxana Doroshyenko, Alexander Jetter and Julia C. Stingl
    Drug Metabolism and Disposition May 2011, 39 (5) 927-932; DOI: https://doi.org/10.1124/dmd.110.036921

Accelerated Communication

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    Seasonal Variation in Blood Drug Concentrations and a Potential Relationship to Vitamin D
    Jonatan D. Lindh, Marine L. Andersson, Erik Eliasson and Linda Björkhem-Bergman
    Drug Metabolism and Disposition May 2011, 39 (5) 933-937; DOI: https://doi.org/10.1124/dmd.111.038125

Erratum

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    Correction to Table of Contents, volume 39, number 3, March 2011
    Drug Metabolism and Disposition May 2011, 39 (5) 938; DOI: https://doi.org/10.1124/dmd.39.5.938
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Drug Metabolism and Disposition: 39 (5)
Drug Metabolism and Disposition
Vol. 39, Issue 5
1 May 2011
  • Table of Contents
  • Table of Contents (PDF)
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  • Index by author
  • Back Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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