Drug Metabolism and Disposition: 39 (5)

May 01, 2011; Volume 39,Issue 5

Short Communications

You have access
Differential Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) on Axitinib Brain Accumulation and Oral Plasma Pharmacokinetics
Birk Poller, Dilek Iusuf, Rolf W. Sparidans, Els Wagenaar, Jos H. Beijnen and Alfred H. Schinkel

Drug Metabolism and Disposition May 2011, 39 (5) 729-735; DOI: https://doi.org/10.1124/dmd.110.037317
You have access
In Vivo Magnetic Resonance Imaging to Detect Biliary Excretion of ¹⁹F-Labeled Drug in Mice
Jean-Pierre Raufman, Su Xu, Kunrong Cheng, Sandeep Khurana, Diana Johnson, Changxing Shao, Maureen A. Kane, Da Shi, Rao Gullapalli and James Polli

Drug Metabolism and Disposition May 2011, 39 (5) 736-739; DOI: https://doi.org/10.1124/dmd.110.037358

Articles

You have access
Metabolism of LY654322, a Growth Hormone Secretagogue, to an Unusual Diimidazopyridine Metabolite
Anthony G. Borel, Timothy M. Jones, Robert J. Barbuch, David A. Jackson, Palaniappan Kulanthaivel, Edward Mattiuz, Valentine J. Klimkowski, William J. Wheeler and Gregory A. Rener

Drug Metabolism and Disposition May 2011, 39 (5) 740-749; DOI: https://doi.org/10.1124/dmd.110.037598
You have access
Identification of the Metabolites of the Antioxidant Flavonoid 7-Mono-O-(β-hydroxyethyl)-rutoside in Mice
Hilde Jacobs, Ron Peters, Gertjan J. M. den Hartog, Wim J. F. van der Vijgh, Aalt Bast and Guido R. M. M. Haenen

Drug Metabolism and Disposition May 2011, 39 (5) 750-756; DOI: https://doi.org/10.1124/dmd.110.036525
You have access
Sorafenib and Sunitinib, Two Anticancer Drugs, Inhibit CYP3A4-Mediated and Activate CY3A5-Mediated Midazolam 1′-Hydroxylation
Minako Sugiyama, Ken-ichi Fujita, Norie Murayama, Yuko Akiyama, Hiroshi Yamazaki and Yasutsuna Sasaki

Drug Metabolism and Disposition May 2011, 39 (5) 757-762; DOI: https://doi.org/10.1124/dmd.110.037853
You have access
Novel Cytochrome P450-Mediated Ring Opening of the 1,3,4-Oxadiazole in Setileuton, a 5-Lipoxygenase Inhibitor
Cheri M. Maciolek, Bennett Ma, Karsten Menzel, Sebastien Laliberte, Kevin Bateman, Paul Krolikowski and Christoper R. Gibson

Drug Metabolism and Disposition May 2011, 39 (5) 763-770; DOI: https://doi.org/10.1124/dmd.110.037366
You have access
Influence of Drug Solubility and Lipophilicity on Transscleral Retinal Delivery of Six Corticosteroids
Ashish Thakur, Rajendra S. Kadam and Uday B. Kompella

Drug Metabolism and Disposition May 2011, 39 (5) 771-781; DOI: https://doi.org/10.1124/dmd.110.037408
You have access
Anandamide Oxidation by Wild-Type and Polymorphically Expressed CYP2B6 and CYP2D6
Chitra Sridar, Natasha T. Snider and Paul F. Hollenberg

Drug Metabolism and Disposition May 2011, 39 (5) 782-788; DOI: https://doi.org/10.1124/dmd.110.036707
You have access
Pharmacokinetic Interaction of the Antiparasitic Agents Ivermectin and Spinosad in Dogs
Stewart T. Dunn, Laura Hedges, Kathleen E. Sampson, Yurong Lai, Sean Mahabir, Larissa Balogh and Charles W. Locuson

Drug Metabolism and Disposition May 2011, 39 (5) 789-795; DOI: https://doi.org/10.1124/dmd.110.034827
You have access
Contribution of Carboxylesterase in Hamster to the Intestinal First-Pass Loss and Low Bioavailability of Ethyl Piperate, an Effective Lipid-Lowering Drug Candidate
Youli Lu, Narisu Bao, Gereltu Borjihan, Yanling Ma, Miaomiao Hu, Chen Yu, Shuijun Li, Jingying Jia, Ding Yang and Yiping Wang

Drug Metabolism and Disposition May 2011, 39 (5) 796-802; DOI: https://doi.org/10.1124/dmd.110.037614
You have access
Metabolism of the c-Fos/Activator Protein-1 Inhibitor T-5224 by Multiple Human UDP-Glucuronosyltransferase Isoforms
Shinsuke Uchihashi, Hiroyuki Fukumoto, Makoto Onoda, Hiroyoshi Hayakawa, Shin-ichi Ikushiro and Toshiyuki Sakaki

Drug Metabolism and Disposition May 2011, 39 (5) 803-813; DOI: https://doi.org/10.1124/dmd.110.037952
You have access
Organic Anion Transporter 3 Mediates the Efflux Transport of an Amphipathic Organic Anion, Dehydroepiandrosterone Sulfate, across the Blood-Brain Barrier in Mice
Mari Miyajima, Hiroyuki Kusuhara, Miki Fujishima, Yasuhisa Adachi and Yuichi Sugiyama

Drug Metabolism and Disposition May 2011, 39 (5) 814-819; DOI: https://doi.org/10.1124/dmd.110.036863
You have access
Human Pharmacokinetic Prediction of UDP-Glucuronosyltransferase Substrates with an Animal Scale-Up Approach
Tsuneo Deguchi, Nobuaki Watanabe, Atsushi Kurihara, Katsuhiro Igeta, Hidenori Ikenaga, Keiichi Fusegawa, Norio Suzuki, Shinji Murata, Masakazu Hirouchi, Yoshitake Furuta, Masaru Iwasaki, Osamu Okazaki and Takashi Izumi

Drug Metabolism and Disposition May 2011, 39 (5) 820-829; DOI: https://doi.org/10.1124/dmd.110.037457
You have access
Evaluation of the Effects of 20 Nonsynonymous Single Nucleotide Polymorphisms of CYP2C19 on S-Mephenytoin 4′-Hydroxylation and Omeprazole 5′-Hydroxylation
Huijuan Wang, Nianzhen An, Hao Wang, Yiwen Gao, Duan Liu, Ting Bian, Juanli Zhu and Chao Chen

Drug Metabolism and Disposition May 2011, 39 (5) 830-837; DOI: https://doi.org/10.1124/dmd.110.037549
You have access
CYP2C9-Mediated Metabolic Activation of Losartan Detected by a Highly Sensitive Cell-Based Screening Assay
Atsushi Iwamura, Tatsuki Fukami, Hiroko Hosomi, Miki Nakajima and Tsuyoshi Yokoi

Drug Metabolism and Disposition May 2011, 39 (5) 838-846; DOI: https://doi.org/10.1124/dmd.110.037259
You have access
In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5α-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole
Anna Lundahl, Mikael Hedeland, Ulf Bondesson and Hans Lennernäs

Drug Metabolism and Disposition May 2011, 39 (5) 847-857; DOI: https://doi.org/10.1124/dmd.110.035311
You have access
Optimal Experimental Design for Assessment of Enzyme Kinetics in a Drug Discovery Screening Environment
Erik Sjögren, Joakim Nyberg, Mats O. Magnusson, Hans Lennernäs, Andrew Hooker and Ulf Bredberg

Drug Metabolism and Disposition May 2011, 39 (5) 858-863; DOI: https://doi.org/10.1124/dmd.110.037309
You have access
Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data
Helen E. Cubitt, J. Brian Houston and Aleksandra Galetin

Drug Metabolism and Disposition May 2011, 39 (5) 864-873; DOI: https://doi.org/10.1124/dmd.110.036566
You have access
Differential Role of Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein in Toll-Like Receptor 2-Mediated Regulation of Gene Expression of Hepatic Cytokines and Drug-Metabolizing Enzymes
Romi Ghose, Tao Guo, Jesus G. Vallejo and Adarsh Gandhi

Drug Metabolism and Disposition May 2011, 39 (5) 874-881; DOI: https://doi.org/10.1124/dmd.110.037382
You have access
Liver-Selective Expression of Human Arylamine N-Acetyltransferase NAT2 in Transgenic Mice
Kim S. Sugamori, Debbie Brenneman and Denis M. Grant

Drug Metabolism and Disposition May 2011, 39 (5) 882-890; DOI: https://doi.org/10.1124/dmd.111.038216
You have access
Metabolism and Disposition of [¹⁴C]Brivanib Alaninate after Oral Administration to Rats, Monkeys, and Humans
Jiachang Gong, Jinping Gan, Janet Caceres-Cortes, Lisa J. Christopher, Vinod Arora, Eric Masson, Daphne Williams, Janice Pursley, Alban Allentoff, Michael Lago, Scott B. Tran and Ramaswamy A. Iyer

Drug Metabolism and Disposition May 2011, 39 (5) 891-903; DOI: https://doi.org/10.1124/dmd.110.037341
You have access
Reevaluation of the Microsomal Metabolism of Montelukast: Major Contribution by CYP2C8 at Clinically Relevant Concentrations
Anne M. Filppula, Jouko Laitila, Pertti J. Neuvonen and Janne T. Backman

Drug Metabolism and Disposition May 2011, 39 (5) 904-911; DOI: https://doi.org/10.1124/dmd.110.037689
You have access
The Development of UDP-Glucuronosyltransferases 1A1 and 1A6 in the Pediatric Liver
Shogo J. Miyagi and Abby C. Collier

Drug Metabolism and Disposition May 2011, 39 (5) 912-919; DOI: https://doi.org/10.1124/dmd.110.037192
You have access
Interactions of Green Tea Catechins with Organic Anion-Transporting Polypeptides
Megan Roth, Barbara N. Timmermann and Bruno Hagenbuch

Drug Metabolism and Disposition May 2011, 39 (5) 920-926; DOI: https://doi.org/10.1124/dmd.110.036640
You have access
Effect of the CYP2C8 Genotype on the Pharmacokinetics and Pharmacodynamics of Repaglinide
Dorota Tomalik-Scharte, Uwe Fuhr, Martin Hellmich, Dorothee Frank, Oxana Doroshyenko, Alexander Jetter and Julia C. Stingl

Drug Metabolism and Disposition May 2011, 39 (5) 927-932; DOI: https://doi.org/10.1124/dmd.110.036921

Accelerated Communication

You have access
Seasonal Variation in Blood Drug Concentrations and a Potential Relationship to Vitamin D
Jonatan D. Lindh, Marine L. Andersson, Erik Eliasson and Linda Björkhem-Bergman

Drug Metabolism and Disposition May 2011, 39 (5) 933-937; DOI: https://doi.org/10.1124/dmd.111.038125

Erratum

You have access
Correction to Table of Contents, volume 39, number 3, March 2011
Drug Metabolism and Disposition May 2011, 39 (5) 938; DOI: https://doi.org/10.1124/dmd.39.5.938

Main menu

User menu

Search

Table of Contents

Short Communications

Articles

Accelerated Communication

Erratum

In this issue

Jump to

Navigate

More Information

ASPET's Other Journals