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Research ArticleArticle

Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data

Helen E. Cubitt, J. Brian Houston and Aleksandra Galetin
Drug Metabolism and Disposition May 2011, 39 (5) 864-873; DOI: https://doi.org/10.1124/dmd.110.036566

Article Information

vol. 39 no. 5 864-873
DOI 
https://doi.org/10.1124/dmd.110.036566
PubMed 
21303923
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 30, 2010
  • Accepted February 8, 2011
  • Published online April 18, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Helen E. Cubitt1,
  2. J. Brian Houston and
  3. Aleksandra Galetin
  1. Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom
  1. Address correspondence to:
    Dr. A. Galetin, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK. E-mail: aleksandra.galetin{at}manchester.ac.uk

  1. Parts of this work were previously presented at the following conference: Cubitt HE, Houston JB, and Galetin A (2009) Comparison of intestinal and hepatic sulphation and glucuronidation for a range of drugs. 11th European Regional ISSX Meeting; 2009 May 17–20; Lisbon, Portugal. International Society for the Study of Xenobiotics, Washington, DC.

  • ↵1 Current affiliation: Simcyp Limited, Blades Enterprise Centre, Sheffield, United Kingdom.

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Research ArticleArticle

Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data

Helen E. Cubitt, J. Brian Houston and Aleksandra Galetin
Drug Metabolism and Disposition May 1, 2011, 39 (5) 864-873; DOI: https://doi.org/10.1124/dmd.110.036566
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