Table of Contents

Articles

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  Absorption, Distribution, Metabolism, and Excretion of [¹⁴C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening

  Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi, Patrick J. Rudewicz, Mark Reynolds, Eric Solon, Cornelis E. C. A. Hop, Harvey Wong and S. Cyrus Khojasteh

  Drug Metabolism and Disposition June 2011, 39 (6) 952-965; DOI: https://doi.org/10.1124/dmd.110.037374
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  Suppression of Cytochrome P450 Reductase (POR) Expression in Hepatoma Cells Replicates the Hepatic Lipidosis Observed in Hepatic POR-Null Mice

  Todd D. Porter, Subhashis Banerjee, Elzbieta I. Stolarczyk and Ling Zou

  Drug Metabolism and Disposition June 2011, 39 (6) 966-973; DOI: https://doi.org/10.1124/dmd.111.038562
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  Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction

  Leslie D. Nagy, Catherine S. Mocny, Laura E. Diffenderfer, David J. Hsi, Brendan F. Butler, Evan J. Arthur, Kyle J. Fletke, Jairam R. Palamanda, Amin A. Nomeir and Laura Lowe Furge

  Drug Metabolism and Disposition June 2011, 39 (6) 974-983; DOI: https://doi.org/10.1124/dmd.110.037630
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  Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes

  Takeo Nakanishi, Yuta Shibue, Yoko Fukuyama, Kenji Yoshida, Hajime Fukuda, Yoshiyuki Shirasaka and Ikumi Tamai

  Drug Metabolism and Disposition June 2011, 39 (6) 984-991; DOI: https://doi.org/10.1124/dmd.111.038059
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  Alteration of Hepatic but Not Renal Transporter Expression in Diet-Induced Obese Mice

  Vijay R. More and Angela L. Slitt

  Drug Metabolism and Disposition June 2011, 39 (6) 992-999; DOI: https://doi.org/10.1124/dmd.110.037507
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  ATP-Binding Cassette Transporter Expression in Human Placenta as a Function of Pregnancy Condition

  Cifford W. Mason, Irina A. Buhimschi, Catalin S. Buhimschi, Yafeng Dong, Carl P. Weiner and Peter W. Swaan

  Drug Metabolism and Disposition June 2011, 39 (6) 1000-1007; DOI: https://doi.org/10.1124/dmd.111.038166
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  Prediction of Human Renal Clearance from Preclinical Species for a Diverse Set of Drugs That Exhibit Both Active Secretion and Net Reabsorption

  Stuart W. Paine, Karelle Ménochet, Rebecca Denton, Dermot F. McGinnity and Robert J. Riley

  Drug Metabolism and Disposition June 2011, 39 (6) 1008-1013; DOI: https://doi.org/10.1124/dmd.110.037267
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  Studies on the Metabolism and Biological Activity of the Epimers of Sulindac

  David Brunell, Daphna Sagher, Shailaja Kesaraju, Nathan Brot and Herbert Weissbach

  Drug Metabolism and Disposition June 2011, 39 (6) 1014-1021; DOI: https://doi.org/10.1124/dmd.110.037663
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  Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib

  Hideo Takakusa, Michelle D. Wahlin, Chunsheng Zhao, Kelsey L. Hanson, Lee Sun New, Eric Chun Yong Chan and Sidney D. Nelson

  Drug Metabolism and Disposition June 2011, 39 (6) 1022-1030; DOI: https://doi.org/10.1124/dmd.110.037531
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  Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments

  Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama

  Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129
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  CYP3A Time-Dependent Inhibition Risk Assessment Validated with 400 Reference Drugs

  Alfred Zimmerlin, Markus Trunzer and Bernard Faller

  Drug Metabolism and Disposition June 2011, 39 (6) 1039-1046; DOI: https://doi.org/10.1124/dmd.110.037911
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  Influence of Non-Steroidal Anti-Inflammatory Drugs on Organic Anion Transporting Polypeptide (OATP) 1B1- and OATP1B3-Mediated Drug Transport

  Juergen Kindla, Fabian Müller, Maren Mieth, Martin F. Fromm and Jörg König

  Drug Metabolism and Disposition June 2011, 39 (6) 1047-1053; DOI: https://doi.org/10.1124/dmd.110.037622
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  A Refined Cytochrome P450 IC₅₀ Shift Assay for Reliably Identifying CYP3A Time-Dependent Inhibitors

  Ping Li, Chuang Lu, Suresh K. Balani and Liang-Shang Gan

  Drug Metabolism and Disposition June 2011, 39 (6) 1054-1057; DOI: https://doi.org/10.1124/dmd.111.038208
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  Identification of Amiodarone Metabolites in Human Bile by Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry

  Pan Deng, Tiangeng You, Xiaoyan Chen, Tao Yuan, Haihua Huang and Dafang Zhong

  Drug Metabolism and Disposition June 2011, 39 (6) 1058-1069; DOI: https://doi.org/10.1124/dmd.110.037671
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  Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir

  Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat

  Drug Metabolism and Disposition June 2011, 39 (6) 1070-1078; DOI: https://doi.org/10.1124/dmd.110.037523
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  Pharmacokinetics and Metabolism in Rats, Dogs, and Monkeys of the Cathepsin K Inhibitor Odanacatib: Demethylation of a Methylsulfonyl Moiety as a Major Metabolic Pathway

  Kelem Kassahun, W. Cameron Black, Deborah Nicoll-Griffith, Ian McIntosh, Nathalie Chauret, Stephen Day, Elizabeth Rosenberg and Kenneth Koeplinger

  Drug Metabolism and Disposition June 2011, 39 (6) 1079-1087; DOI: https://doi.org/10.1124/dmd.110.037184
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  Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent

  Kazuya Takeuchi, Tomoko Sugiura, Saki Umeda, Kazuki Matsubara, Masato Horikawa, Noritaka Nakamichi, David L. Silver, Norihisa Ishiwata and Yukio Kato

  Drug Metabolism and Disposition June 2011, 39 (6) 1088-1096; DOI: https://doi.org/10.1124/dmd.110.037960
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  Role of Organic Anion-Transporting Polypeptides for Cellular Mesalazine (5-Aminosalicylic Acid) Uptake

  Jörg König, Hartmut Glaeser, Markus Keiser, Kathrin Mandery, Ulrich Klotz and Martin F. Fromm

  Drug Metabolism and Disposition June 2011, 39 (6) 1097-1102; DOI: https://doi.org/10.1124/dmd.110.034991
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  Pharmacokinetics of the Monohydroxy Derivative of Oxcarbazepine and Its Enantiomers after a Single Intravenous Dose Given as Racemate Compared with a Single Oral Dose of Oxcarbazepine

  G. Flesch, C. Czendlik, D. Renard and P. Lloyd

  Drug Metabolism and Disposition June 2011, 39 (6) 1103-1110; DOI: https://doi.org/10.1124/dmd.109.030593