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Drug Metabolism & Disposition

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Table of Contents

June 01, 2011; Volume 39,Issue 6

Short Communications

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    Role of Intestinal Cytochrome P450 (P450) in Modulating the Bioavailability of Oral Lovastatin: Insights from Studies on the Intestinal Epithelium-Specific P450 Reductase Knockout Mouse
    Yi Zhu, Jaime D'Agostino and Qing-Yu Zhang
    Drug Metabolism and Disposition June 2011, 39 (6) 939-943; DOI: https://doi.org/10.1124/dmd.110.037861
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    Cytochrome P450 2S1 is Reduced by NADPH-Cytochrome P450 Reductase
    Yi Xiao, Raku Shinkyo and F. Peter Guengerich
    Drug Metabolism and Disposition June 2011, 39 (6) 944-946; DOI: https://doi.org/10.1124/dmd.111.039321
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    The Tissue-Specific Toxicity of Methimazole in the Mouse Olfactory Mucosa Is Partly Mediated through Target-Tissue Metabolic Activation by CYP2A5
    Fang Xie, Xin Zhou, Mary Beth Genter, Melissa Behr, Jun Gu and Xinxin Ding
    Drug Metabolism and Disposition June 2011, 39 (6) 947-951; DOI: https://doi.org/10.1124/dmd.110.037895

Articles

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    Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening
    Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi, Patrick J. Rudewicz, Mark Reynolds, Eric Solon, Cornelis E. C. A. Hop, Harvey Wong and S. Cyrus Khojasteh
    Drug Metabolism and Disposition June 2011, 39 (6) 952-965; DOI: https://doi.org/10.1124/dmd.110.037374
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    Suppression of Cytochrome P450 Reductase (POR) Expression in Hepatoma Cells Replicates the Hepatic Lipidosis Observed in Hepatic POR-Null Mice
    Todd D. Porter, Subhashis Banerjee, Elzbieta I. Stolarczyk and Ling Zou
    Drug Metabolism and Disposition June 2011, 39 (6) 966-973; DOI: https://doi.org/10.1124/dmd.111.038562
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    Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction
    Leslie D. Nagy, Catherine S. Mocny, Laura E. Diffenderfer, David J. Hsi, Brendan F. Butler, Evan J. Arthur, Kyle J. Fletke, Jairam R. Palamanda, Amin A. Nomeir and Laura Lowe Furge
    Drug Metabolism and Disposition June 2011, 39 (6) 974-983; DOI: https://doi.org/10.1124/dmd.110.037630
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    Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes
    Takeo Nakanishi, Yuta Shibue, Yoko Fukuyama, Kenji Yoshida, Hajime Fukuda, Yoshiyuki Shirasaka and Ikumi Tamai
    Drug Metabolism and Disposition June 2011, 39 (6) 984-991; DOI: https://doi.org/10.1124/dmd.111.038059
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    Alteration of Hepatic but Not Renal Transporter Expression in Diet-Induced Obese Mice
    Vijay R. More and Angela L. Slitt
    Drug Metabolism and Disposition June 2011, 39 (6) 992-999; DOI: https://doi.org/10.1124/dmd.110.037507
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    ATP-Binding Cassette Transporter Expression in Human Placenta as a Function of Pregnancy Condition
    Cifford W. Mason, Irina A. Buhimschi, Catalin S. Buhimschi, Yafeng Dong, Carl P. Weiner and Peter W. Swaan
    Drug Metabolism and Disposition June 2011, 39 (6) 1000-1007; DOI: https://doi.org/10.1124/dmd.111.038166
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    Prediction of Human Renal Clearance from Preclinical Species for a Diverse Set of Drugs That Exhibit Both Active Secretion and Net Reabsorption
    Stuart W. Paine, Karelle Ménochet, Rebecca Denton, Dermot F. McGinnity and Robert J. Riley
    Drug Metabolism and Disposition June 2011, 39 (6) 1008-1013; DOI: https://doi.org/10.1124/dmd.110.037267
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    Studies on the Metabolism and Biological Activity of the Epimers of Sulindac
    David Brunell, Daphna Sagher, Shailaja Kesaraju, Nathan Brot and Herbert Weissbach
    Drug Metabolism and Disposition June 2011, 39 (6) 1014-1021; DOI: https://doi.org/10.1124/dmd.110.037663
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    Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib
    Hideo Takakusa, Michelle D. Wahlin, Chunsheng Zhao, Kelsey L. Hanson, Lee Sun New, Eric Chun Yong Chan and Sidney D. Nelson
    Drug Metabolism and Disposition June 2011, 39 (6) 1022-1030; DOI: https://doi.org/10.1124/dmd.110.037531
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    Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments
    Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama
    Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129
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    CYP3A Time-Dependent Inhibition Risk Assessment Validated with 400 Reference Drugs
    Alfred Zimmerlin, Markus Trunzer and Bernard Faller
    Drug Metabolism and Disposition June 2011, 39 (6) 1039-1046; DOI: https://doi.org/10.1124/dmd.110.037911
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    Influence of Non-Steroidal Anti-Inflammatory Drugs on Organic Anion Transporting Polypeptide (OATP) 1B1- and OATP1B3-Mediated Drug Transport
    Juergen Kindla, Fabian Müller, Maren Mieth, Martin F. Fromm and Jörg König
    Drug Metabolism and Disposition June 2011, 39 (6) 1047-1053; DOI: https://doi.org/10.1124/dmd.110.037622
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    A Refined Cytochrome P450 IC50 Shift Assay for Reliably Identifying CYP3A Time-Dependent Inhibitors
    Ping Li, Chuang Lu, Suresh K. Balani and Liang-Shang Gan
    Drug Metabolism and Disposition June 2011, 39 (6) 1054-1057; DOI: https://doi.org/10.1124/dmd.111.038208
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    Identification of Amiodarone Metabolites in Human Bile by Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
    Pan Deng, Tiangeng You, Xiaoyan Chen, Tao Yuan, Haihua Huang and Dafang Zhong
    Drug Metabolism and Disposition June 2011, 39 (6) 1058-1069; DOI: https://doi.org/10.1124/dmd.110.037671
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    Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir
    Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
    Drug Metabolism and Disposition June 2011, 39 (6) 1070-1078; DOI: https://doi.org/10.1124/dmd.110.037523
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    Pharmacokinetics and Metabolism in Rats, Dogs, and Monkeys of the Cathepsin K Inhibitor Odanacatib: Demethylation of a Methylsulfonyl Moiety as a Major Metabolic Pathway
    Kelem Kassahun, W. Cameron Black, Deborah Nicoll-Griffith, Ian McIntosh, Nathalie Chauret, Stephen Day, Elizabeth Rosenberg and Kenneth Koeplinger
    Drug Metabolism and Disposition June 2011, 39 (6) 1079-1087; DOI: https://doi.org/10.1124/dmd.110.037184
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    Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent
    Kazuya Takeuchi, Tomoko Sugiura, Saki Umeda, Kazuki Matsubara, Masato Horikawa, Noritaka Nakamichi, David L. Silver, Norihisa Ishiwata and Yukio Kato
    Drug Metabolism and Disposition June 2011, 39 (6) 1088-1096; DOI: https://doi.org/10.1124/dmd.110.037960
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    Role of Organic Anion-Transporting Polypeptides for Cellular Mesalazine (5-Aminosalicylic Acid) Uptake
    Jörg König, Hartmut Glaeser, Markus Keiser, Kathrin Mandery, Ulrich Klotz and Martin F. Fromm
    Drug Metabolism and Disposition June 2011, 39 (6) 1097-1102; DOI: https://doi.org/10.1124/dmd.110.034991
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    Pharmacokinetics of the Monohydroxy Derivative of Oxcarbazepine and Its Enantiomers after a Single Intravenous Dose Given as Racemate Compared with a Single Oral Dose of Oxcarbazepine
    G. Flesch, C. Czendlik, D. Renard and P. Lloyd
    Drug Metabolism and Disposition June 2011, 39 (6) 1103-1110; DOI: https://doi.org/10.1124/dmd.109.030593

Erratum

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    Correction to “Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans”
    Drug Metabolism and Disposition June 2011, 39 (6) 1111; DOI: https://doi.org/10.1124/dmd.39.6.1111
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Drug Metabolism and Disposition: 39 (6)
Drug Metabolism and Disposition
Vol. 39, Issue 6
1 Jun 2011
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