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Drug Metabolism & Disposition

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    • Current Issue
    • Fast Forward
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Index by author

June 01, 2011; Volume 39,Issue 6
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

A

  1. Arthur, Evan J.

    1. You have access
      Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction
      Leslie D. Nagy, Catherine S. Mocny, Laura E. Diffenderfer, David J. Hsi, Brendan F. Butler, Evan J. Arthur, Kyle J. Fletke, Jairam R. Palamanda, Amin A. Nomeir and Laura Lowe Furge
      Drug Metabolism and Disposition June 2011, 39 (6) 974-983; DOI: https://doi.org/10.1124/dmd.110.037630

B

  1. Balani, Suresh K.

    1. You have access
      A Refined Cytochrome P450 IC50 Shift Assay for Reliably Identifying CYP3A Time-Dependent Inhibitors
      Ping Li, Chuang Lu, Suresh K. Balani and Liang-Shang Gan
      Drug Metabolism and Disposition June 2011, 39 (6) 1054-1057; DOI: https://doi.org/10.1124/dmd.111.038208
  2. Banerjee, Subhashis

    1. You have access
      Suppression of Cytochrome P450 Reductase (POR) Expression in Hepatoma Cells Replicates the Hepatic Lipidosis Observed in Hepatic POR-Null Mice
      Todd D. Porter, Subhashis Banerjee, Elzbieta I. Stolarczyk and Ling Zou
      Drug Metabolism and Disposition June 2011, 39 (6) 966-973; DOI: https://doi.org/10.1124/dmd.111.038562
  3. Behr, Melissa

    1. You have access
      The Tissue-Specific Toxicity of Methimazole in the Mouse Olfactory Mucosa Is Partly Mediated through Target-Tissue Metabolic Activation by CYP2A5
      Fang Xie, Xin Zhou, Mary Beth Genter, Melissa Behr, Jun Gu and Xinxin Ding
      Drug Metabolism and Disposition June 2011, 39 (6) 947-951; DOI: https://doi.org/10.1124/dmd.110.037895
  4. Black, W. Cameron

    1. You have access
      Pharmacokinetics and Metabolism in Rats, Dogs, and Monkeys of the Cathepsin K Inhibitor Odanacatib: Demethylation of a Methylsulfonyl Moiety as a Major Metabolic Pathway
      Kelem Kassahun, W. Cameron Black, Deborah Nicoll-Griffith, Ian McIntosh, Nathalie Chauret, Stephen Day, Elizabeth Rosenberg and Kenneth Koeplinger
      Drug Metabolism and Disposition June 2011, 39 (6) 1079-1087; DOI: https://doi.org/10.1124/dmd.110.037184
  5. Brot, Nathan

    1. You have access
      Studies on the Metabolism and Biological Activity of the Epimers of Sulindac
      David Brunell, Daphna Sagher, Shailaja Kesaraju, Nathan Brot and Herbert Weissbach
      Drug Metabolism and Disposition June 2011, 39 (6) 1014-1021; DOI: https://doi.org/10.1124/dmd.110.037663
  6. Brunell, David

    1. You have access
      Studies on the Metabolism and Biological Activity of the Epimers of Sulindac
      David Brunell, Daphna Sagher, Shailaja Kesaraju, Nathan Brot and Herbert Weissbach
      Drug Metabolism and Disposition June 2011, 39 (6) 1014-1021; DOI: https://doi.org/10.1124/dmd.110.037663
  7. Buhimschi, Catalin S.

    1. You have access
      ATP-Binding Cassette Transporter Expression in Human Placenta as a Function of Pregnancy Condition
      Cifford W. Mason, Irina A. Buhimschi, Catalin S. Buhimschi, Yafeng Dong, Carl P. Weiner and Peter W. Swaan
      Drug Metabolism and Disposition June 2011, 39 (6) 1000-1007; DOI: https://doi.org/10.1124/dmd.111.038166
  8. Buhimschi, Irina A.

    1. You have access
      ATP-Binding Cassette Transporter Expression in Human Placenta as a Function of Pregnancy Condition
      Cifford W. Mason, Irina A. Buhimschi, Catalin S. Buhimschi, Yafeng Dong, Carl P. Weiner and Peter W. Swaan
      Drug Metabolism and Disposition June 2011, 39 (6) 1000-1007; DOI: https://doi.org/10.1124/dmd.111.038166
  9. Butler, Brendan F.

    1. You have access
      Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction
      Leslie D. Nagy, Catherine S. Mocny, Laura E. Diffenderfer, David J. Hsi, Brendan F. Butler, Evan J. Arthur, Kyle J. Fletke, Jairam R. Palamanda, Amin A. Nomeir and Laura Lowe Furge
      Drug Metabolism and Disposition June 2011, 39 (6) 974-983; DOI: https://doi.org/10.1124/dmd.110.037630

C

  1. Chan, Eric Chun Yong

    1. You have access
      Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib
      Hideo Takakusa, Michelle D. Wahlin, Chunsheng Zhao, Kelsey L. Hanson, Lee Sun New, Eric Chun Yong Chan and Sidney D. Nelson
      Drug Metabolism and Disposition June 2011, 39 (6) 1022-1030; DOI: https://doi.org/10.1124/dmd.110.037531
  2. Chauret, Nathalie

    1. You have access
      Pharmacokinetics and Metabolism in Rats, Dogs, and Monkeys of the Cathepsin K Inhibitor Odanacatib: Demethylation of a Methylsulfonyl Moiety as a Major Metabolic Pathway
      Kelem Kassahun, W. Cameron Black, Deborah Nicoll-Griffith, Ian McIntosh, Nathalie Chauret, Stephen Day, Elizabeth Rosenberg and Kenneth Koeplinger
      Drug Metabolism and Disposition June 2011, 39 (6) 1079-1087; DOI: https://doi.org/10.1124/dmd.110.037184
  3. Chen, Xiaoyan

    1. You have access
      Identification of Amiodarone Metabolites in Human Bile by Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
      Pan Deng, Tiangeng You, Xiaoyan Chen, Tao Yuan, Haihua Huang and Dafang Zhong
      Drug Metabolism and Disposition June 2011, 39 (6) 1058-1069; DOI: https://doi.org/10.1124/dmd.110.037671
  4. Chen, Yung-Hsiang

    1. You have access
      Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening
      Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi, Patrick J. Rudewicz, Mark Reynolds, Eric Solon, Cornelis E. C. A. Hop, Harvey Wong and S. Cyrus Khojasteh
      Drug Metabolism and Disposition June 2011, 39 (6) 952-965; DOI: https://doi.org/10.1124/dmd.110.037374
  5. Collier, Ann C.

    1. You have access
      Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir
      Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition June 2011, 39 (6) 1070-1078; DOI: https://doi.org/10.1124/dmd.110.037523
  6. Czendlik, C.

    1. You have access
      Pharmacokinetics of the Monohydroxy Derivative of Oxcarbazepine and Its Enantiomers after a Single Intravenous Dose Given as Racemate Compared with a Single Oral Dose of Oxcarbazepine
      G. Flesch, C. Czendlik, D. Renard and P. Lloyd
      Drug Metabolism and Disposition June 2011, 39 (6) 1103-1110; DOI: https://doi.org/10.1124/dmd.109.030593

D

  1. D'Agostino, Jaime

    1. You have access
      Role of Intestinal Cytochrome P450 (P450) in Modulating the Bioavailability of Oral Lovastatin: Insights from Studies on the Intestinal Epithelium-Specific P450 Reductase Knockout Mouse
      Yi Zhu, Jaime D'Agostino and Qing-Yu Zhang
      Drug Metabolism and Disposition June 2011, 39 (6) 939-943; DOI: https://doi.org/10.1124/dmd.110.037861
  2. Day, Stephen

    1. You have access
      Pharmacokinetics and Metabolism in Rats, Dogs, and Monkeys of the Cathepsin K Inhibitor Odanacatib: Demethylation of a Methylsulfonyl Moiety as a Major Metabolic Pathway
      Kelem Kassahun, W. Cameron Black, Deborah Nicoll-Griffith, Ian McIntosh, Nathalie Chauret, Stephen Day, Elizabeth Rosenberg and Kenneth Koeplinger
      Drug Metabolism and Disposition June 2011, 39 (6) 1079-1087; DOI: https://doi.org/10.1124/dmd.110.037184
  3. Debori, Yasuyuki

    1. You have access
      Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments
      Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129
  4. Deese, Alan

    1. You have access
      Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening
      Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi, Patrick J. Rudewicz, Mark Reynolds, Eric Solon, Cornelis E. C. A. Hop, Harvey Wong and S. Cyrus Khojasteh
      Drug Metabolism and Disposition June 2011, 39 (6) 952-965; DOI: https://doi.org/10.1124/dmd.110.037374
  5. Deng, Pan

    1. You have access
      Identification of Amiodarone Metabolites in Human Bile by Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
      Pan Deng, Tiangeng You, Xiaoyan Chen, Tao Yuan, Haihua Huang and Dafang Zhong
      Drug Metabolism and Disposition June 2011, 39 (6) 1058-1069; DOI: https://doi.org/10.1124/dmd.110.037671
  6. Denton, Rebecca

    1. You have access
      Prediction of Human Renal Clearance from Preclinical Species for a Diverse Set of Drugs That Exhibit Both Active Secretion and Net Reabsorption
      Stuart W. Paine, Karelle Ménochet, Rebecca Denton, Dermot F. McGinnity and Robert J. Riley
      Drug Metabolism and Disposition June 2011, 39 (6) 1008-1013; DOI: https://doi.org/10.1124/dmd.110.037267
  7. Diffenderfer, Laura E.

    1. You have access
      Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction
      Leslie D. Nagy, Catherine S. Mocny, Laura E. Diffenderfer, David J. Hsi, Brendan F. Butler, Evan J. Arthur, Kyle J. Fletke, Jairam R. Palamanda, Amin A. Nomeir and Laura Lowe Furge
      Drug Metabolism and Disposition June 2011, 39 (6) 974-983; DOI: https://doi.org/10.1124/dmd.110.037630
  8. Ding, Xinxin

    1. You have access
      The Tissue-Specific Toxicity of Methimazole in the Mouse Olfactory Mucosa Is Partly Mediated through Target-Tissue Metabolic Activation by CYP2A5
      Fang Xie, Xin Zhou, Mary Beth Genter, Melissa Behr, Jun Gu and Xinxin Ding
      Drug Metabolism and Disposition June 2011, 39 (6) 947-951; DOI: https://doi.org/10.1124/dmd.110.037895
  9. Dong, Yafeng

    1. You have access
      ATP-Binding Cassette Transporter Expression in Human Placenta as a Function of Pregnancy Condition
      Cifford W. Mason, Irina A. Buhimschi, Catalin S. Buhimschi, Yafeng Dong, Carl P. Weiner and Peter W. Swaan
      Drug Metabolism and Disposition June 2011, 39 (6) 1000-1007; DOI: https://doi.org/10.1124/dmd.111.038166

F

  1. Faller, Bernard

    1. You have access
      CYP3A Time-Dependent Inhibition Risk Assessment Validated with 400 Reference Drugs
      Alfred Zimmerlin, Markus Trunzer and Bernard Faller
      Drug Metabolism and Disposition June 2011, 39 (6) 1039-1046; DOI: https://doi.org/10.1124/dmd.110.037911
  2. Flesch, G.

    1. You have access
      Pharmacokinetics of the Monohydroxy Derivative of Oxcarbazepine and Its Enantiomers after a Single Intravenous Dose Given as Racemate Compared with a Single Oral Dose of Oxcarbazepine
      G. Flesch, C. Czendlik, D. Renard and P. Lloyd
      Drug Metabolism and Disposition June 2011, 39 (6) 1103-1110; DOI: https://doi.org/10.1124/dmd.109.030593
  3. Fletke, Kyle J.

    1. You have access
      Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction
      Leslie D. Nagy, Catherine S. Mocny, Laura E. Diffenderfer, David J. Hsi, Brendan F. Butler, Evan J. Arthur, Kyle J. Fletke, Jairam R. Palamanda, Amin A. Nomeir and Laura Lowe Furge
      Drug Metabolism and Disposition June 2011, 39 (6) 974-983; DOI: https://doi.org/10.1124/dmd.110.037630
  4. Fromm, Martin F.

    1. You have access
      Influence of Non-Steroidal Anti-Inflammatory Drugs on Organic Anion Transporting Polypeptide (OATP) 1B1- and OATP1B3-Mediated Drug Transport
      Juergen Kindla, Fabian Müller, Maren Mieth, Martin F. Fromm and Jörg König
      Drug Metabolism and Disposition June 2011, 39 (6) 1047-1053; DOI: https://doi.org/10.1124/dmd.110.037622
    2. You have access
      Role of Organic Anion-Transporting Polypeptides for Cellular Mesalazine (5-Aminosalicylic Acid) Uptake
      Jörg König, Hartmut Glaeser, Markus Keiser, Kathrin Mandery, Ulrich Klotz and Martin F. Fromm
      Drug Metabolism and Disposition June 2011, 39 (6) 1097-1102; DOI: https://doi.org/10.1124/dmd.110.034991
  5. Fukuda, Hajime

    1. You have access
      Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes
      Takeo Nakanishi, Yuta Shibue, Yoko Fukuyama, Kenji Yoshida, Hajime Fukuda, Yoshiyuki Shirasaka and Ikumi Tamai
      Drug Metabolism and Disposition June 2011, 39 (6) 984-991; DOI: https://doi.org/10.1124/dmd.111.038059
  6. Fukuyama, Yoko

    1. You have access
      Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes
      Takeo Nakanishi, Yuta Shibue, Yoko Fukuyama, Kenji Yoshida, Hajime Fukuda, Yoshiyuki Shirasaka and Ikumi Tamai
      Drug Metabolism and Disposition June 2011, 39 (6) 984-991; DOI: https://doi.org/10.1124/dmd.111.038059
  7. Furge, Laura Lowe

    1. You have access
      Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction
      Leslie D. Nagy, Catherine S. Mocny, Laura E. Diffenderfer, David J. Hsi, Brendan F. Butler, Evan J. Arthur, Kyle J. Fletke, Jairam R. Palamanda, Amin A. Nomeir and Laura Lowe Furge
      Drug Metabolism and Disposition June 2011, 39 (6) 974-983; DOI: https://doi.org/10.1124/dmd.110.037630

G

  1. Gan, Liang-Shang

    1. You have access
      A Refined Cytochrome P450 IC50 Shift Assay for Reliably Identifying CYP3A Time-Dependent Inhibitors
      Ping Li, Chuang Lu, Suresh K. Balani and Liang-Shang Gan
      Drug Metabolism and Disposition June 2011, 39 (6) 1054-1057; DOI: https://doi.org/10.1124/dmd.111.038208
  2. Genter, Mary Beth

    1. You have access
      The Tissue-Specific Toxicity of Methimazole in the Mouse Olfactory Mucosa Is Partly Mediated through Target-Tissue Metabolic Activation by CYP2A5
      Fang Xie, Xin Zhou, Mary Beth Genter, Melissa Behr, Jun Gu and Xinxin Ding
      Drug Metabolism and Disposition June 2011, 39 (6) 947-951; DOI: https://doi.org/10.1124/dmd.110.037895
  3. Glaeser, Hartmut

    1. You have access
      Role of Organic Anion-Transporting Polypeptides for Cellular Mesalazine (5-Aminosalicylic Acid) Uptake
      Jörg König, Hartmut Glaeser, Markus Keiser, Kathrin Mandery, Ulrich Klotz and Martin F. Fromm
      Drug Metabolism and Disposition June 2011, 39 (6) 1097-1102; DOI: https://doi.org/10.1124/dmd.110.034991
  4. Gu, Jun

    1. You have access
      The Tissue-Specific Toxicity of Methimazole in the Mouse Olfactory Mucosa Is Partly Mediated through Target-Tissue Metabolic Activation by CYP2A5
      Fang Xie, Xin Zhou, Mary Beth Genter, Melissa Behr, Jun Gu and Xinxin Ding
      Drug Metabolism and Disposition June 2011, 39 (6) 947-951; DOI: https://doi.org/10.1124/dmd.110.037895
  5. Guengerich, F. Peter

    1. You have access
      Cytochrome P450 2S1 is Reduced by NADPH-Cytochrome P450 Reductase
      Yi Xiao, Raku Shinkyo and F. Peter Guengerich
      Drug Metabolism and Disposition June 2011, 39 (6) 944-946; DOI: https://doi.org/10.1124/dmd.111.039321

H

  1. Hanson, Kelsey L.

    1. You have access
      Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib
      Hideo Takakusa, Michelle D. Wahlin, Chunsheng Zhao, Kelsey L. Hanson, Lee Sun New, Eric Chun Yong Chan and Sidney D. Nelson
      Drug Metabolism and Disposition June 2011, 39 (6) 1022-1030; DOI: https://doi.org/10.1124/dmd.110.037531
  2. Hop, Cornelis E. C. A.

    1. You have access
      Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening
      Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi, Patrick J. Rudewicz, Mark Reynolds, Eric Solon, Cornelis E. C. A. Hop, Harvey Wong and S. Cyrus Khojasteh
      Drug Metabolism and Disposition June 2011, 39 (6) 952-965; DOI: https://doi.org/10.1124/dmd.110.037374
  3. Horikawa, Masato

    1. You have access
      Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent
      Kazuya Takeuchi, Tomoko Sugiura, Saki Umeda, Kazuki Matsubara, Masato Horikawa, Noritaka Nakamichi, David L. Silver, Norihisa Ishiwata and Yukio Kato
      Drug Metabolism and Disposition June 2011, 39 (6) 1088-1096; DOI: https://doi.org/10.1124/dmd.110.037960
  4. Horita, Shigeru

    1. You have access
      Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments
      Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129
  5. Hsi, David J.

    1. You have access
      Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction
      Leslie D. Nagy, Catherine S. Mocny, Laura E. Diffenderfer, David J. Hsi, Brendan F. Butler, Evan J. Arthur, Kyle J. Fletke, Jairam R. Palamanda, Amin A. Nomeir and Laura Lowe Furge
      Drug Metabolism and Disposition June 2011, 39 (6) 974-983; DOI: https://doi.org/10.1124/dmd.110.037630
  6. Hu, Zhuohan

    1. You have access
      Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments
      Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129
  7. Huang, Haihua

    1. You have access
      Identification of Amiodarone Metabolites in Human Bile by Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
      Pan Deng, Tiangeng You, Xiaoyan Chen, Tao Yuan, Haihua Huang and Dafang Zhong
      Drug Metabolism and Disposition June 2011, 39 (6) 1058-1069; DOI: https://doi.org/10.1124/dmd.110.037671

I

  1. Ishiwata, Norihisa

    1. You have access
      Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent
      Kazuya Takeuchi, Tomoko Sugiura, Saki Umeda, Kazuki Matsubara, Masato Horikawa, Noritaka Nakamichi, David L. Silver, Norihisa Ishiwata and Yukio Kato
      Drug Metabolism and Disposition June 2011, 39 (6) 1088-1096; DOI: https://doi.org/10.1124/dmd.110.037960

K

  1. Kassahun, Kelem

    1. You have access
      Pharmacokinetics and Metabolism in Rats, Dogs, and Monkeys of the Cathepsin K Inhibitor Odanacatib: Demethylation of a Methylsulfonyl Moiety as a Major Metabolic Pathway
      Kelem Kassahun, W. Cameron Black, Deborah Nicoll-Griffith, Ian McIntosh, Nathalie Chauret, Stephen Day, Elizabeth Rosenberg and Kenneth Koeplinger
      Drug Metabolism and Disposition June 2011, 39 (6) 1079-1087; DOI: https://doi.org/10.1124/dmd.110.037184
  2. Kato, Yukio

    1. You have access
      Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent
      Kazuya Takeuchi, Tomoko Sugiura, Saki Umeda, Kazuki Matsubara, Masato Horikawa, Noritaka Nakamichi, David L. Silver, Norihisa Ishiwata and Yukio Kato
      Drug Metabolism and Disposition June 2011, 39 (6) 1088-1096; DOI: https://doi.org/10.1124/dmd.110.037960
  3. Keiser, Markus

    1. You have access
      Role of Organic Anion-Transporting Polypeptides for Cellular Mesalazine (5-Aminosalicylic Acid) Uptake
      Jörg König, Hartmut Glaeser, Markus Keiser, Kathrin Mandery, Ulrich Klotz and Martin F. Fromm
      Drug Metabolism and Disposition June 2011, 39 (6) 1097-1102; DOI: https://doi.org/10.1124/dmd.110.034991
  4. Kesaraju, Shailaja

    1. You have access
      Studies on the Metabolism and Biological Activity of the Epimers of Sulindac
      David Brunell, Daphna Sagher, Shailaja Kesaraju, Nathan Brot and Herbert Weissbach
      Drug Metabolism and Disposition June 2011, 39 (6) 1014-1021; DOI: https://doi.org/10.1124/dmd.110.037663
  5. Kharasch, Evan D.

    1. You have access
      Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir
      Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition June 2011, 39 (6) 1070-1078; DOI: https://doi.org/10.1124/dmd.110.037523
  6. Khojasteh, S. Cyrus

    1. You have access
      Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening
      Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi, Patrick J. Rudewicz, Mark Reynolds, Eric Solon, Cornelis E. C. A. Hop, Harvey Wong and S. Cyrus Khojasteh
      Drug Metabolism and Disposition June 2011, 39 (6) 952-965; DOI: https://doi.org/10.1124/dmd.110.037374
  7. Kindla, Juergen

    1. You have access
      Influence of Non-Steroidal Anti-Inflammatory Drugs on Organic Anion Transporting Polypeptide (OATP) 1B1- and OATP1B3-Mediated Drug Transport
      Juergen Kindla, Fabian Müller, Maren Mieth, Martin F. Fromm and Jörg König
      Drug Metabolism and Disposition June 2011, 39 (6) 1047-1053; DOI: https://doi.org/10.1124/dmd.110.037622
  8. Kirby, Brian J.

    1. You have access
      Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir
      Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition June 2011, 39 (6) 1070-1078; DOI: https://doi.org/10.1124/dmd.110.037523
  9. Klotz, Ulrich

    1. You have access
      Role of Organic Anion-Transporting Polypeptides for Cellular Mesalazine (5-Aminosalicylic Acid) Uptake
      Jörg König, Hartmut Glaeser, Markus Keiser, Kathrin Mandery, Ulrich Klotz and Martin F. Fromm
      Drug Metabolism and Disposition June 2011, 39 (6) 1097-1102; DOI: https://doi.org/10.1124/dmd.110.034991
  10. Koeplinger, Kenneth

    1. You have access
      Pharmacokinetics and Metabolism in Rats, Dogs, and Monkeys of the Cathepsin K Inhibitor Odanacatib: Demethylation of a Methylsulfonyl Moiety as a Major Metabolic Pathway
      Kelem Kassahun, W. Cameron Black, Deborah Nicoll-Griffith, Ian McIntosh, Nathalie Chauret, Stephen Day, Elizabeth Rosenberg and Kenneth Koeplinger
      Drug Metabolism and Disposition June 2011, 39 (6) 1079-1087; DOI: https://doi.org/10.1124/dmd.110.037184
  11. Kondo, Tsunenori

    1. You have access
      Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments
      Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129
  12. König, Jörg

    1. You have access
      Influence of Non-Steroidal Anti-Inflammatory Drugs on Organic Anion Transporting Polypeptide (OATP) 1B1- and OATP1B3-Mediated Drug Transport
      Juergen Kindla, Fabian Müller, Maren Mieth, Martin F. Fromm and Jörg König
      Drug Metabolism and Disposition June 2011, 39 (6) 1047-1053; DOI: https://doi.org/10.1124/dmd.110.037622
    2. You have access
      Role of Organic Anion-Transporting Polypeptides for Cellular Mesalazine (5-Aminosalicylic Acid) Uptake
      Jörg König, Hartmut Glaeser, Markus Keiser, Kathrin Mandery, Ulrich Klotz and Martin F. Fromm
      Drug Metabolism and Disposition June 2011, 39 (6) 1097-1102; DOI: https://doi.org/10.1124/dmd.110.034991
  13. Kusuhara, Hiroyuki

    1. You have access
      Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments
      Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129

L

  1. Li, Ping

    1. You have access
      A Refined Cytochrome P450 IC50 Shift Assay for Reliably Identifying CYP3A Time-Dependent Inhibitors
      Ping Li, Chuang Lu, Suresh K. Balani and Liang-Shang Gan
      Drug Metabolism and Disposition June 2011, 39 (6) 1054-1057; DOI: https://doi.org/10.1124/dmd.111.038208
  2. Lloyd, P.

    1. You have access
      Pharmacokinetics of the Monohydroxy Derivative of Oxcarbazepine and Its Enantiomers after a Single Intravenous Dose Given as Racemate Compared with a Single Oral Dose of Oxcarbazepine
      G. Flesch, C. Czendlik, D. Renard and P. Lloyd
      Drug Metabolism and Disposition June 2011, 39 (6) 1103-1110; DOI: https://doi.org/10.1124/dmd.109.030593
  3. Lu, Chuang

    1. You have access
      A Refined Cytochrome P450 IC50 Shift Assay for Reliably Identifying CYP3A Time-Dependent Inhibitors
      Ping Li, Chuang Lu, Suresh K. Balani and Liang-Shang Gan
      Drug Metabolism and Disposition June 2011, 39 (6) 1054-1057; DOI: https://doi.org/10.1124/dmd.111.038208

M

  1. Maeda, Kazuya

    1. You have access
      Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments
      Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129
  2. Mandery, Kathrin

    1. You have access
      Role of Organic Anion-Transporting Polypeptides for Cellular Mesalazine (5-Aminosalicylic Acid) Uptake
      Jörg König, Hartmut Glaeser, Markus Keiser, Kathrin Mandery, Ulrich Klotz and Martin F. Fromm
      Drug Metabolism and Disposition June 2011, 39 (6) 1097-1102; DOI: https://doi.org/10.1124/dmd.110.034991
  3. Mason, Cifford W.

    1. You have access
      ATP-Binding Cassette Transporter Expression in Human Placenta as a Function of Pregnancy Condition
      Cifford W. Mason, Irina A. Buhimschi, Catalin S. Buhimschi, Yafeng Dong, Carl P. Weiner and Peter W. Swaan
      Drug Metabolism and Disposition June 2011, 39 (6) 1000-1007; DOI: https://doi.org/10.1124/dmd.111.038166
  4. Matsubara, Kazuki

    1. You have access
      Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent
      Kazuya Takeuchi, Tomoko Sugiura, Saki Umeda, Kazuki Matsubara, Masato Horikawa, Noritaka Nakamichi, David L. Silver, Norihisa Ishiwata and Yukio Kato
      Drug Metabolism and Disposition June 2011, 39 (6) 1088-1096; DOI: https://doi.org/10.1124/dmd.110.037960
  5. McGinnity, Dermot F.

    1. You have access
      Prediction of Human Renal Clearance from Preclinical Species for a Diverse Set of Drugs That Exhibit Both Active Secretion and Net Reabsorption
      Stuart W. Paine, Karelle Ménochet, Rebecca Denton, Dermot F. McGinnity and Robert J. Riley
      Drug Metabolism and Disposition June 2011, 39 (6) 1008-1013; DOI: https://doi.org/10.1124/dmd.110.037267
  6. McIntosh, Ian

    1. You have access
      Pharmacokinetics and Metabolism in Rats, Dogs, and Monkeys of the Cathepsin K Inhibitor Odanacatib: Demethylation of a Methylsulfonyl Moiety as a Major Metabolic Pathway
      Kelem Kassahun, W. Cameron Black, Deborah Nicoll-Griffith, Ian McIntosh, Nathalie Chauret, Stephen Day, Elizabeth Rosenberg and Kenneth Koeplinger
      Drug Metabolism and Disposition June 2011, 39 (6) 1079-1087; DOI: https://doi.org/10.1124/dmd.110.037184
  7. Ménochet, Karelle

    1. You have access
      Prediction of Human Renal Clearance from Preclinical Species for a Diverse Set of Drugs That Exhibit Both Active Secretion and Net Reabsorption
      Stuart W. Paine, Karelle Ménochet, Rebecca Denton, Dermot F. McGinnity and Robert J. Riley
      Drug Metabolism and Disposition June 2011, 39 (6) 1008-1013; DOI: https://doi.org/10.1124/dmd.110.037267
  8. Mieth, Maren

    1. You have access
      Influence of Non-Steroidal Anti-Inflammatory Drugs on Organic Anion Transporting Polypeptide (OATP) 1B1- and OATP1B3-Mediated Drug Transport
      Juergen Kindla, Fabian Müller, Maren Mieth, Martin F. Fromm and Jörg König
      Drug Metabolism and Disposition June 2011, 39 (6) 1047-1053; DOI: https://doi.org/10.1124/dmd.110.037622
  9. Mocny, Catherine S.

    1. You have access
      Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction
      Leslie D. Nagy, Catherine S. Mocny, Laura E. Diffenderfer, David J. Hsi, Brendan F. Butler, Evan J. Arthur, Kyle J. Fletke, Jairam R. Palamanda, Amin A. Nomeir and Laura Lowe Furge
      Drug Metabolism and Disposition June 2011, 39 (6) 974-983; DOI: https://doi.org/10.1124/dmd.110.037630
  10. More, Vijay R.

    1. You have access
      Alteration of Hepatic but Not Renal Transporter Expression in Diet-Induced Obese Mice
      Vijay R. More and Angela L. Slitt
      Drug Metabolism and Disposition June 2011, 39 (6) 992-999; DOI: https://doi.org/10.1124/dmd.110.037507
  11. Mulder, Teresa

    1. You have access
      Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening
      Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi, Patrick J. Rudewicz, Mark Reynolds, Eric Solon, Cornelis E. C. A. Hop, Harvey Wong and S. Cyrus Khojasteh
      Drug Metabolism and Disposition June 2011, 39 (6) 952-965; DOI: https://doi.org/10.1124/dmd.110.037374
  12. Müller, Fabian

    1. You have access
      Influence of Non-Steroidal Anti-Inflammatory Drugs on Organic Anion Transporting Polypeptide (OATP) 1B1- and OATP1B3-Mediated Drug Transport
      Juergen Kindla, Fabian Müller, Maren Mieth, Martin F. Fromm and Jörg König
      Drug Metabolism and Disposition June 2011, 39 (6) 1047-1053; DOI: https://doi.org/10.1124/dmd.110.037622

N

  1. Nagy, Leslie D.

    1. You have access
      Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction
      Leslie D. Nagy, Catherine S. Mocny, Laura E. Diffenderfer, David J. Hsi, Brendan F. Butler, Evan J. Arthur, Kyle J. Fletke, Jairam R. Palamanda, Amin A. Nomeir and Laura Lowe Furge
      Drug Metabolism and Disposition June 2011, 39 (6) 974-983; DOI: https://doi.org/10.1124/dmd.110.037630
  2. Nakamichi, Noritaka

    1. You have access
      Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent
      Kazuya Takeuchi, Tomoko Sugiura, Saki Umeda, Kazuki Matsubara, Masato Horikawa, Noritaka Nakamichi, David L. Silver, Norihisa Ishiwata and Yukio Kato
      Drug Metabolism and Disposition June 2011, 39 (6) 1088-1096; DOI: https://doi.org/10.1124/dmd.110.037960
  3. Nakanishi, Takeo

    1. You have access
      Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes
      Takeo Nakanishi, Yuta Shibue, Yoko Fukuyama, Kenji Yoshida, Hajime Fukuda, Yoshiyuki Shirasaka and Ikumi Tamai
      Drug Metabolism and Disposition June 2011, 39 (6) 984-991; DOI: https://doi.org/10.1124/dmd.111.038059
  4. Nakayama, Hideki

    1. You have access
      Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments
      Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129
  5. Nelson, Sidney D.

    1. You have access
      Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib
      Hideo Takakusa, Michelle D. Wahlin, Chunsheng Zhao, Kelsey L. Hanson, Lee Sun New, Eric Chun Yong Chan and Sidney D. Nelson
      Drug Metabolism and Disposition June 2011, 39 (6) 1022-1030; DOI: https://doi.org/10.1124/dmd.110.037531
  6. New, Lee Sun

    1. You have access
      Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib
      Hideo Takakusa, Michelle D. Wahlin, Chunsheng Zhao, Kelsey L. Hanson, Lee Sun New, Eric Chun Yong Chan and Sidney D. Nelson
      Drug Metabolism and Disposition June 2011, 39 (6) 1022-1030; DOI: https://doi.org/10.1124/dmd.110.037531
  7. Nicoll-Griffith, Deborah

    1. You have access
      Pharmacokinetics and Metabolism in Rats, Dogs, and Monkeys of the Cathepsin K Inhibitor Odanacatib: Demethylation of a Methylsulfonyl Moiety as a Major Metabolic Pathway
      Kelem Kassahun, W. Cameron Black, Deborah Nicoll-Griffith, Ian McIntosh, Nathalie Chauret, Stephen Day, Elizabeth Rosenberg and Kenneth Koeplinger
      Drug Metabolism and Disposition June 2011, 39 (6) 1079-1087; DOI: https://doi.org/10.1124/dmd.110.037184
  8. Nomeir, Amin A.

    1. You have access
      Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction
      Leslie D. Nagy, Catherine S. Mocny, Laura E. Diffenderfer, David J. Hsi, Brendan F. Butler, Evan J. Arthur, Kyle J. Fletke, Jairam R. Palamanda, Amin A. Nomeir and Laura Lowe Furge
      Drug Metabolism and Disposition June 2011, 39 (6) 974-983; DOI: https://doi.org/10.1124/dmd.110.037630

O

  1. Ogilvie, Brian W.

    1. You have access
      Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments
      Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129

P

  1. Paine, Stuart W.

    1. You have access
      Prediction of Human Renal Clearance from Preclinical Species for a Diverse Set of Drugs That Exhibit Both Active Secretion and Net Reabsorption
      Stuart W. Paine, Karelle Ménochet, Rebecca Denton, Dermot F. McGinnity and Robert J. Riley
      Drug Metabolism and Disposition June 2011, 39 (6) 1008-1013; DOI: https://doi.org/10.1124/dmd.110.037267
  2. Palamanda, Jairam R.

    1. You have access
      Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction
      Leslie D. Nagy, Catherine S. Mocny, Laura E. Diffenderfer, David J. Hsi, Brendan F. Butler, Evan J. Arthur, Kyle J. Fletke, Jairam R. Palamanda, Amin A. Nomeir and Laura Lowe Furge
      Drug Metabolism and Disposition June 2011, 39 (6) 974-983; DOI: https://doi.org/10.1124/dmd.110.037630
  3. Parkinson, Andrew

    1. You have access
      Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments
      Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129
  4. Porter, Todd D.

    1. You have access
      Suppression of Cytochrome P450 Reductase (POR) Expression in Hepatoma Cells Replicates the Hepatic Lipidosis Observed in Hepatic POR-Null Mice
      Todd D. Porter, Subhashis Banerjee, Elzbieta I. Stolarczyk and Ling Zou
      Drug Metabolism and Disposition June 2011, 39 (6) 966-973; DOI: https://doi.org/10.1124/dmd.111.038562

R

  1. Renard, D.

    1. You have access
      Pharmacokinetics of the Monohydroxy Derivative of Oxcarbazepine and Its Enantiomers after a Single Intravenous Dose Given as Racemate Compared with a Single Oral Dose of Oxcarbazepine
      G. Flesch, C. Czendlik, D. Renard and P. Lloyd
      Drug Metabolism and Disposition June 2011, 39 (6) 1103-1110; DOI: https://doi.org/10.1124/dmd.109.030593
  2. Reynolds, Mark

    1. You have access
      Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening
      Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi, Patrick J. Rudewicz, Mark Reynolds, Eric Solon, Cornelis E. C. A. Hop, Harvey Wong and S. Cyrus Khojasteh
      Drug Metabolism and Disposition June 2011, 39 (6) 952-965; DOI: https://doi.org/10.1124/dmd.110.037374
  3. Riley, Robert J.

    1. You have access
      Prediction of Human Renal Clearance from Preclinical Species for a Diverse Set of Drugs That Exhibit Both Active Secretion and Net Reabsorption
      Stuart W. Paine, Karelle Ménochet, Rebecca Denton, Dermot F. McGinnity and Robert J. Riley
      Drug Metabolism and Disposition June 2011, 39 (6) 1008-1013; DOI: https://doi.org/10.1124/dmd.110.037267
  4. Rosenberg, Elizabeth

    1. You have access
      Pharmacokinetics and Metabolism in Rats, Dogs, and Monkeys of the Cathepsin K Inhibitor Odanacatib: Demethylation of a Methylsulfonyl Moiety as a Major Metabolic Pathway
      Kelem Kassahun, W. Cameron Black, Deborah Nicoll-Griffith, Ian McIntosh, Nathalie Chauret, Stephen Day, Elizabeth Rosenberg and Kenneth Koeplinger
      Drug Metabolism and Disposition June 2011, 39 (6) 1079-1087; DOI: https://doi.org/10.1124/dmd.110.037184
  5. Rudewicz, Patrick J.

    1. You have access
      Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening
      Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi, Patrick J. Rudewicz, Mark Reynolds, Eric Solon, Cornelis E. C. A. Hop, Harvey Wong and S. Cyrus Khojasteh
      Drug Metabolism and Disposition June 2011, 39 (6) 952-965; DOI: https://doi.org/10.1124/dmd.110.037374

S

  1. Sagher, Daphna

    1. You have access
      Studies on the Metabolism and Biological Activity of the Epimers of Sulindac
      David Brunell, Daphna Sagher, Shailaja Kesaraju, Nathan Brot and Herbert Weissbach
      Drug Metabolism and Disposition June 2011, 39 (6) 1014-1021; DOI: https://doi.org/10.1124/dmd.110.037663
  2. Shibue, Yuta

    1. You have access
      Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes
      Takeo Nakanishi, Yuta Shibue, Yoko Fukuyama, Kenji Yoshida, Hajime Fukuda, Yoshiyuki Shirasaka and Ikumi Tamai
      Drug Metabolism and Disposition June 2011, 39 (6) 984-991; DOI: https://doi.org/10.1124/dmd.111.038059
  3. Shinkyo, Raku

    1. You have access
      Cytochrome P450 2S1 is Reduced by NADPH-Cytochrome P450 Reductase
      Yi Xiao, Raku Shinkyo and F. Peter Guengerich
      Drug Metabolism and Disposition June 2011, 39 (6) 944-946; DOI: https://doi.org/10.1124/dmd.111.039321
  4. Shirasaka, Yoshiyuki

    1. You have access
      Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes
      Takeo Nakanishi, Yuta Shibue, Yoko Fukuyama, Kenji Yoshida, Hajime Fukuda, Yoshiyuki Shirasaka and Ikumi Tamai
      Drug Metabolism and Disposition June 2011, 39 (6) 984-991; DOI: https://doi.org/10.1124/dmd.111.038059
  5. Silver, David L.

    1. You have access
      Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent
      Kazuya Takeuchi, Tomoko Sugiura, Saki Umeda, Kazuki Matsubara, Masato Horikawa, Noritaka Nakamichi, David L. Silver, Norihisa Ishiwata and Yukio Kato
      Drug Metabolism and Disposition June 2011, 39 (6) 1088-1096; DOI: https://doi.org/10.1124/dmd.110.037960
  6. Slitt, Angela L.

    1. You have access
      Alteration of Hepatic but Not Renal Transporter Expression in Diet-Induced Obese Mice
      Vijay R. More and Angela L. Slitt
      Drug Metabolism and Disposition June 2011, 39 (6) 992-999; DOI: https://doi.org/10.1124/dmd.110.037507
  7. Solon, Eric

    1. You have access
      Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening
      Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi, Patrick J. Rudewicz, Mark Reynolds, Eric Solon, Cornelis E. C. A. Hop, Harvey Wong and S. Cyrus Khojasteh
      Drug Metabolism and Disposition June 2011, 39 (6) 952-965; DOI: https://doi.org/10.1124/dmd.110.037374
  8. Stolarczyk, Elzbieta I.

    1. You have access
      Suppression of Cytochrome P450 Reductase (POR) Expression in Hepatoma Cells Replicates the Hepatic Lipidosis Observed in Hepatic POR-Null Mice
      Todd D. Porter, Subhashis Banerjee, Elzbieta I. Stolarczyk and Ling Zou
      Drug Metabolism and Disposition June 2011, 39 (6) 966-973; DOI: https://doi.org/10.1124/dmd.111.038562
  9. Sugiura, Tomoko

    1. You have access
      Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent
      Kazuya Takeuchi, Tomoko Sugiura, Saki Umeda, Kazuki Matsubara, Masato Horikawa, Noritaka Nakamichi, David L. Silver, Norihisa Ishiwata and Yukio Kato
      Drug Metabolism and Disposition June 2011, 39 (6) 1088-1096; DOI: https://doi.org/10.1124/dmd.110.037960
  10. Sugiyama, Yuichi

    1. You have access
      Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments
      Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129
  11. Swaan, Peter W.

    1. You have access
      ATP-Binding Cassette Transporter Expression in Human Placenta as a Function of Pregnancy Condition
      Cifford W. Mason, Irina A. Buhimschi, Catalin S. Buhimschi, Yafeng Dong, Carl P. Weiner and Peter W. Swaan
      Drug Metabolism and Disposition June 2011, 39 (6) 1000-1007; DOI: https://doi.org/10.1124/dmd.111.038166

T

  1. Takahashi, Ryan

    1. You have access
      Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening
      Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi, Patrick J. Rudewicz, Mark Reynolds, Eric Solon, Cornelis E. C. A. Hop, Harvey Wong and S. Cyrus Khojasteh
      Drug Metabolism and Disposition June 2011, 39 (6) 952-965; DOI: https://doi.org/10.1124/dmd.110.037374
  2. Takakusa, Hideo

    1. You have access
      Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib
      Hideo Takakusa, Michelle D. Wahlin, Chunsheng Zhao, Kelsey L. Hanson, Lee Sun New, Eric Chun Yong Chan and Sidney D. Nelson
      Drug Metabolism and Disposition June 2011, 39 (6) 1022-1030; DOI: https://doi.org/10.1124/dmd.110.037531
  3. Takeuchi, Kazuya

    1. You have access
      Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent
      Kazuya Takeuchi, Tomoko Sugiura, Saki Umeda, Kazuki Matsubara, Masato Horikawa, Noritaka Nakamichi, David L. Silver, Norihisa Ishiwata and Yukio Kato
      Drug Metabolism and Disposition June 2011, 39 (6) 1088-1096; DOI: https://doi.org/10.1124/dmd.110.037960
  4. Tamai, Ikumi

    1. You have access
      Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes
      Takeo Nakanishi, Yuta Shibue, Yoko Fukuyama, Kenji Yoshida, Hajime Fukuda, Yoshiyuki Shirasaka and Ikumi Tamai
      Drug Metabolism and Disposition June 2011, 39 (6) 984-991; DOI: https://doi.org/10.1124/dmd.111.038059
  5. Thummel, Kenneth E.

    1. You have access
      Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir
      Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition June 2011, 39 (6) 1070-1078; DOI: https://doi.org/10.1124/dmd.110.037523
  6. Trunzer, Markus

    1. You have access
      CYP3A Time-Dependent Inhibition Risk Assessment Validated with 400 Reference Drugs
      Alfred Zimmerlin, Markus Trunzer and Bernard Faller
      Drug Metabolism and Disposition June 2011, 39 (6) 1039-1046; DOI: https://doi.org/10.1124/dmd.110.037911

U

  1. Umeda, Saki

    1. You have access
      Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent
      Kazuya Takeuchi, Tomoko Sugiura, Saki Umeda, Kazuki Matsubara, Masato Horikawa, Noritaka Nakamichi, David L. Silver, Norihisa Ishiwata and Yukio Kato
      Drug Metabolism and Disposition June 2011, 39 (6) 1088-1096; DOI: https://doi.org/10.1124/dmd.110.037960
  2. Unadkat, Jashvant D.

    1. You have access
      Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir
      Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition June 2011, 39 (6) 1070-1078; DOI: https://doi.org/10.1124/dmd.110.037523

W

  1. Wahlin, Michelle D.

    1. You have access
      Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib
      Hideo Takakusa, Michelle D. Wahlin, Chunsheng Zhao, Kelsey L. Hanson, Lee Sun New, Eric Chun Yong Chan and Sidney D. Nelson
      Drug Metabolism and Disposition June 2011, 39 (6) 1022-1030; DOI: https://doi.org/10.1124/dmd.110.037531
  2. Watanabe, Takao

    1. You have access
      Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments
      Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129
  3. Watanabe, Tomoko

    1. You have access
      Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments
      Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2011, 39 (6) 1031-1038; DOI: https://doi.org/10.1124/dmd.110.036129
  4. Weiner, Carl P.

    1. You have access
      ATP-Binding Cassette Transporter Expression in Human Placenta as a Function of Pregnancy Condition
      Cifford W. Mason, Irina A. Buhimschi, Catalin S. Buhimschi, Yafeng Dong, Carl P. Weiner and Peter W. Swaan
      Drug Metabolism and Disposition June 2011, 39 (6) 1000-1007; DOI: https://doi.org/10.1124/dmd.111.038166
  5. Weissbach, Herbert

    1. You have access
      Studies on the Metabolism and Biological Activity of the Epimers of Sulindac
      David Brunell, Daphna Sagher, Shailaja Kesaraju, Nathan Brot and Herbert Weissbach
      Drug Metabolism and Disposition June 2011, 39 (6) 1014-1021; DOI: https://doi.org/10.1124/dmd.110.037663
  6. Whittington, Dale

    1. You have access
      Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir
      Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition June 2011, 39 (6) 1070-1078; DOI: https://doi.org/10.1124/dmd.110.037523
  7. Wong, Harvey

    1. You have access
      Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening
      Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi, Patrick J. Rudewicz, Mark Reynolds, Eric Solon, Cornelis E. C. A. Hop, Harvey Wong and S. Cyrus Khojasteh
      Drug Metabolism and Disposition June 2011, 39 (6) 952-965; DOI: https://doi.org/10.1124/dmd.110.037374

X

  1. Xiao, Yi

    1. You have access
      Cytochrome P450 2S1 is Reduced by NADPH-Cytochrome P450 Reductase
      Yi Xiao, Raku Shinkyo and F. Peter Guengerich
      Drug Metabolism and Disposition June 2011, 39 (6) 944-946; DOI: https://doi.org/10.1124/dmd.111.039321
  2. Xie, Fang

    1. You have access
      The Tissue-Specific Toxicity of Methimazole in the Mouse Olfactory Mucosa Is Partly Mediated through Target-Tissue Metabolic Activation by CYP2A5
      Fang Xie, Xin Zhou, Mary Beth Genter, Melissa Behr, Jun Gu and Xinxin Ding
      Drug Metabolism and Disposition June 2011, 39 (6) 947-951; DOI: https://doi.org/10.1124/dmd.110.037895

Y

  1. Yoshida, Kenji

    1. You have access
      Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes
      Takeo Nakanishi, Yuta Shibue, Yoko Fukuyama, Kenji Yoshida, Hajime Fukuda, Yoshiyuki Shirasaka and Ikumi Tamai
      Drug Metabolism and Disposition June 2011, 39 (6) 984-991; DOI: https://doi.org/10.1124/dmd.111.038059
  2. You, Tiangeng

    1. You have access
      Identification of Amiodarone Metabolites in Human Bile by Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
      Pan Deng, Tiangeng You, Xiaoyan Chen, Tao Yuan, Haihua Huang and Dafang Zhong
      Drug Metabolism and Disposition June 2011, 39 (6) 1058-1069; DOI: https://doi.org/10.1124/dmd.110.037671
  3. Yuan, Tao

    1. You have access
      Identification of Amiodarone Metabolites in Human Bile by Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
      Pan Deng, Tiangeng You, Xiaoyan Chen, Tao Yuan, Haihua Huang and Dafang Zhong
      Drug Metabolism and Disposition June 2011, 39 (6) 1058-1069; DOI: https://doi.org/10.1124/dmd.110.037671
  4. Yue, Qin

    1. You have access
      Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening
      Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi, Patrick J. Rudewicz, Mark Reynolds, Eric Solon, Cornelis E. C. A. Hop, Harvey Wong and S. Cyrus Khojasteh
      Drug Metabolism and Disposition June 2011, 39 (6) 952-965; DOI: https://doi.org/10.1124/dmd.110.037374

Z

  1. Zhang, Qing-Yu

    1. You have access
      Role of Intestinal Cytochrome P450 (P450) in Modulating the Bioavailability of Oral Lovastatin: Insights from Studies on the Intestinal Epithelium-Specific P450 Reductase Knockout Mouse
      Yi Zhu, Jaime D'Agostino and Qing-Yu Zhang
      Drug Metabolism and Disposition June 2011, 39 (6) 939-943; DOI: https://doi.org/10.1124/dmd.110.037861
  2. Zhao, Chunsheng

    1. You have access
      Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib
      Hideo Takakusa, Michelle D. Wahlin, Chunsheng Zhao, Kelsey L. Hanson, Lee Sun New, Eric Chun Yong Chan and Sidney D. Nelson
      Drug Metabolism and Disposition June 2011, 39 (6) 1022-1030; DOI: https://doi.org/10.1124/dmd.110.037531
  3. Zhong, Dafang

    1. You have access
      Identification of Amiodarone Metabolites in Human Bile by Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
      Pan Deng, Tiangeng You, Xiaoyan Chen, Tao Yuan, Haihua Huang and Dafang Zhong
      Drug Metabolism and Disposition June 2011, 39 (6) 1058-1069; DOI: https://doi.org/10.1124/dmd.110.037671
  4. Zhou, Xin

    1. You have access
      The Tissue-Specific Toxicity of Methimazole in the Mouse Olfactory Mucosa Is Partly Mediated through Target-Tissue Metabolic Activation by CYP2A5
      Fang Xie, Xin Zhou, Mary Beth Genter, Melissa Behr, Jun Gu and Xinxin Ding
      Drug Metabolism and Disposition June 2011, 39 (6) 947-951; DOI: https://doi.org/10.1124/dmd.110.037895
  5. Zhu, Yi

    1. You have access
      Role of Intestinal Cytochrome P450 (P450) in Modulating the Bioavailability of Oral Lovastatin: Insights from Studies on the Intestinal Epithelium-Specific P450 Reductase Knockout Mouse
      Yi Zhu, Jaime D'Agostino and Qing-Yu Zhang
      Drug Metabolism and Disposition June 2011, 39 (6) 939-943; DOI: https://doi.org/10.1124/dmd.110.037861
  6. Zimmerlin, Alfred

    1. You have access
      CYP3A Time-Dependent Inhibition Risk Assessment Validated with 400 Reference Drugs
      Alfred Zimmerlin, Markus Trunzer and Bernard Faller
      Drug Metabolism and Disposition June 2011, 39 (6) 1039-1046; DOI: https://doi.org/10.1124/dmd.110.037911
  7. Zou, Ling

    1. You have access
      Suppression of Cytochrome P450 Reductase (POR) Expression in Hepatoma Cells Replicates the Hepatic Lipidosis Observed in Hepatic POR-Null Mice
      Todd D. Porter, Subhashis Banerjee, Elzbieta I. Stolarczyk and Ling Zou
      Drug Metabolism and Disposition June 2011, 39 (6) 966-973; DOI: https://doi.org/10.1124/dmd.111.038562
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Drug Metabolism and Disposition: 39 (6)
Drug Metabolism and Disposition
Vol. 39, Issue 6
1 Jun 2011
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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