Drug Metabolism and Disposition: 39 (8)

August 01, 2011; Volume 39,Issue 8

Short Communications

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Prolonged Toxic Effects After Cocaine Challenge in Butyrylcholinesterase/Plasma Carboxylesterase Double Knockout Mice: A Model for Butyrylcholinesterase-Deficient Humans
Ellen G. Duysen and Oksana Lockridge

Drug Metabolism and Disposition August 2011, 39 (8) 1321-1323; DOI: https://doi.org/10.1124/dmd.111.039917
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Effects of Ketamine on Human UDP-Glucuronosyltransferases In Vitro Predict Potential Drug-Drug Interactions Arising from Ketamine Inhibition of Codeine and Morphine Glucuronidation
Verawan Uchaipichat, Pritsana Raungrut, Nuy Chau, Benjamas Janchawee, Allan M. Evans and John O. Miners

Drug Metabolism and Disposition August 2011, 39 (8) 1324-1328; DOI: https://doi.org/10.1124/dmd.111.039727
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Characterization of Recombinant Human Carboxylesterases: Fluorescein Diacetate as a Probe Substrate for Human Carboxylesterase 2
Jie Wang, Eric T. Williams, Joanne Bourgea, Y. Nancy Wong and Christopher J. Patten

Drug Metabolism and Disposition August 2011, 39 (8) 1329-1333; DOI: https://doi.org/10.1124/dmd.111.039628
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Subcellular Location and Molecular Mobility of Human Cytosolic Sulfotransferase 1C1 in Living Human Embryonic Kidney 293 Cells
Jonathan J. Sheng and George K. Acquaah-Mensah

Drug Metabolism and Disposition August 2011, 39 (8) 1334-1337; DOI: https://doi.org/10.1124/dmd.111.039537

Articles

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Impact of Abcc2 [Multidrug Resistance-Associated Protein (Mrp) 2], Abcc3 (Mrp3), and Abcg2 (Breast Cancer Resistance Protein) on the Oral Pharmacokinetics of Methotrexate and Its Main Metabolite 7-Hydroxymethotrexate
Maria L. H. Vlaming, Anita van Esch, Evita van de Steeg, Zeliha Pala, Els Wagenaar, Olaf van Tellingen and Alfred H. Schinkel

Drug Metabolism and Disposition August 2011, 39 (8) 1338-1344; DOI: https://doi.org/10.1124/dmd.111.038794
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Human Paraoxonase 1 Is the Enzyme Responsible for Pilocarpine Hydrolysis
Tomomi Hioki, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi

Drug Metabolism and Disposition August 2011, 39 (8) 1345-1352; DOI: https://doi.org/10.1124/dmd.111.038141
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In Vitro Age-Dependent Enzymatic Metabolism of Chlorpyrifos and Chlorpyrifos-Oxon in Human Hepatic Microsomes and Chlorpyrifos-Oxon in Plasma
Jordan Ned Smith, Charles Timchalk, Michael J. Bartels and Torka S. Poet

Drug Metabolism and Disposition August 2011, 39 (8) 1353-1362; DOI: https://doi.org/10.1124/dmd.111.038745
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Effects of Chronic Renal Failure on Kidney Drug Transporters and Cytochrome P450 in Rats
Judith Naud, Josée Michaud, Stéphanie Beauchemin, Marie-Josée Hébert, Michel Roger, Stéphane Lefrancois, Francois A. Leblond and Vincent Pichette

Drug Metabolism and Disposition August 2011, 39 (8) 1363-1369; DOI: https://doi.org/10.1124/dmd.111.039115
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An Evaluation of the Dilution Method for Identifying Metabolism-Dependent Inhibitors of Cytochrome P450 Enzymes
Andrew Parkinson, Faraz Kazmi, David B. Buckley, Phyllis Yerino, Brandy L. Paris, Jeff Holsapple, Paul Toren, Steve M. Otradovec and Brian W. Ogilvie

Drug Metabolism and Disposition August 2011, 39 (8) 1370-1387; DOI: https://doi.org/10.1124/dmd.111.038596
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Development of a Highly Sensitive Cytotoxicity Assay System for CYP3A4-Mediated Metabolic Activation
Hiroko Hosomi, Tatsuki Fukami, Atsushi Iwamura, Miki Nakajima and Tsuyoshi Yokoi

Drug Metabolism and Disposition August 2011, 39 (8) 1388-1395; DOI: https://doi.org/10.1124/dmd.110.037077
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Preclinical and Clinical Pharmacokinetics of PF-02413873, a Nonsteroidal Progesterone Receptor Antagonist
Peter J. Bungay, Sarah Tweedy, David C. Howe, Karl R. Gibson, Hannah M. Jones and Natalie M. Mount

Drug Metabolism and Disposition August 2011, 39 (8) 1396-1405; DOI: https://doi.org/10.1124/dmd.110.037234
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Microsomal Quercetin Glucuronidation in Rat Small Intestine Depends on Age and Segment
Bradley W. Bolling, Michael H. Court, Jeffrey B. Blumberg and C.-Y. Oliver Chen

Drug Metabolism and Disposition August 2011, 39 (8) 1406-1414; DOI: https://doi.org/10.1124/dmd.111.038406
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Effects of Interleukin-6 (IL-6) and an Anti-IL-6 Monoclonal Antibody on Drug-Metabolizing Enzymes in Human Hepatocyte Culture
Leslie J. Dickmann, Sonal K. Patel, Dan A. Rock, Larry C. Wienkers and J. Greg Slatter

Drug Metabolism and Disposition August 2011, 39 (8) 1415-1422; DOI: https://doi.org/10.1124/dmd.111.038679
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The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s
Agnieszka Potega, Emilia Dabrowska, Magdalena Niemira, Agata Kot-Wasik, Sebastien Ronseaux, Colin J. Henderson, C. Roland Wolf and Zofia Mazerska

Drug Metabolism and Disposition August 2011, 39 (8) 1423-1432; DOI: https://doi.org/10.1124/dmd.111.038984
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Identification of Cytochrome P450 Oxidoreductase Gene Variants That Are Significantly Associated with the Interindividual Variations in Warfarin Maintenance Dose
Xiuling Zhang, Lei Li, Xinxin Ding and Laurence S. Kaminsky

Drug Metabolism and Disposition August 2011, 39 (8) 1433-1439; DOI: https://doi.org/10.1124/dmd.111.038836
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Acute Doxorubicin Toxicity Differentially Alters Cytochrome P450 Expression and Arachidonic Acid Metabolism in Rat Kidney and Liver
Beshay N. M. Zordoky, Anwar Anwar-Mohamed, Mona E. Aboutabl and Ayman O. S. El-Kadi

Drug Metabolism and Disposition August 2011, 39 (8) 1440-1450; DOI: https://doi.org/10.1124/dmd.111.039123
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Farnesoid X Receptor Activation by Chenodeoxycholic Acid Induces Detoxifying Enzymes through AMP-Activated Protein Kinase and Extracellular Signal-Regulated Kinase 1/2-Mediated Phosphorylation of CCAAT/Enhancer Binding Protein β
Kyoung Noh, Young Mi Kim, Young Woo Kim and Sang Geon Kim

Drug Metabolism and Disposition August 2011, 39 (8) 1451-1459; DOI: https://doi.org/10.1124/dmd.111.038414
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A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry
Richard A. Graham, Bert L. Lum, Glenn Morrison, Ilsung Chang, Karin Jorga, Brian Dean, Young G. Shin, Qin Yue, Teresa Mulder, Vikram Malhi, Minli Xie, Jennifer A. Low and Cornelis E. C. A. Hop

Drug Metabolism and Disposition August 2011, 39 (8) 1460-1467; DOI: https://doi.org/10.1124/dmd.111.039339

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